• amino
  • The 5′-leader ribozyme recognizes a specific amino acid and self-charges to the 3′-end of RNA. (nih.gov)
  • proteins
  • We hypothesized that, beside putative effector proteins, small RNAs (sRNA) are delivered by B. tabaci into the phloem, where they may play a role in manipulating host plant defenses. (frontiersin.org)
  • Azacitidine's incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of proteins. (wikipedia.org)
  • microRNA
  • Mature microRNA is then loaded into microRNA ribonucleoprotein complex RISC (RNA-induced silencing complex) and guided to target mRNAs with near perfect complimentarily at 3'UTR. (wikipedia.org)
  • small
  • At the time, the lin-4 small RNA was thought to be a nematode idiosyncrasy. (wikipedia.org)
  • In 2000, a second small RNA was characterized: let-7 RNA, which represses lin-41 to promote a later developmental transition in C. elegans. (wikipedia.org)
  • A year later, the lin-4 and let-7 RNAs were found to be part of a large class of small RNAs present in C. elegans, Drosophila and human cells. (wikipedia.org)
  • acid
  • Hydrolytic deamination of the cytosine amine group then occurs, catalyzed by the proton transfer from the nearby glutamic acid residue, and the enzymatic structure is conserved by a proline residue. (wikipedia.org)
  • class
  • The many RNAs of this class resembled the lin-4 and let-7 RNAs, except their expression patterns were usually inconsistent with a role in regulating the timing of development. (wikipedia.org)
  • species
  • Likewise, experiments show that a single miRNA species can reduce the stability of hundreds of unique messenger RNAs. (wikipedia.org)
  • Messenger
  • Estimates of the average number of unique messenger RNAs that are targets for repression by a typical miRNA vary, depending on the estimation method, but multiple approaches show that mammalian miRNAs can have many unique targets. (wikipedia.org)
  • thought
  • It is thought to have antineoplastic activity via two mechanisms - at low doses, by inhibiting of DNA methyltransferase, causing hypomethylation of DNA, and at high doses, by its direct cytotoxicity to abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA, resulting in cell death. (wikipedia.org)
  • function
  • The antiviral properties of A1 extend to both DNA and RNA due to its deamination function, which can hinder DNA replication and consequently suppress further infection by HIV or HBV. (wikipedia.org)
  • cell
  • A CAR therapy for cancer, using a technique called adoptive cell transfer, has been approved by the US Food and Drug Administration for use against acute lymphoblastic leukemia. (wikipedia.org)