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  • In the USA, while there are several available drugs for use as short-term adjuncts to weight loss including diethylpropion, benzphetamine, phentermine and phendimetrazine, here the authors will focus on those agents intended for longer term treatment: orlistat, phentermine/topiramate modified release, lorcaserin and, as yet unapproved, naltrexone/bupropion. (medscape.com)
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  • [ 203 ] Orlistat has been shown to be effective at producing modest weight loss in diabetics, can prevent progression to diabetes in the 'at risk' population and can lead to some improvement in CV risk factors, including cholesterol, systolic and diastolic blood pressure. (medscape.com)
  • [ 83 ] A meta-analysis found the mean weight loss for orlistat-treated patients was 2.89 kg (95% CI: 2.27-3.51 kg) at 12 months. (medscape.com)
  • At 1 year mean weight loss from baseline was 6.2% (±0.5%) in those on orlistat versus 4.3% (±0.5%) in the placebo group. (medscape.com)
  • [ 85 ] A later 1-year, multicenter RCT to assess the effect of orlistat and hypocaloric diet in Type 2 diabetics on metformin showed that orlistat-treated patients lost significantly more weight at 1 year compared with placebo (4.7 ± 0.3 kg vs 1.8 ± 0.3 kg, respectively). (medscape.com)
  • [ 86 ] With regards to prevention of diabetes in an at risk population, the XENDOS study, a 4-year RCT, found that orlistat plus lifestyle measures resulted in a lower incidence of diabetes over the 4-year study and a greater weight loss compared with lifestyle changes alone. (medscape.com)
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  • Under these plans, claims for weight reduction medications and for physician supervision of weight reduction programs will be denied based on that exclusion. (aetna.com)
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  • Combination weight loss medications include phentermine/topiramate extended release and bupropion/naltrexone. (pharmacytimes.com)
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  • If deemed ineffective (weight loss less than 5% at 3 mo) or if there are safety or tolerability issues at any time, it is recommended that the medication be discontinued and alternative medications or referral for alternative treatment approaches be considered. (medscape.com)
  • In patients with type 2 diabetes mellitus who are overweight or obese, antidiabetic medications that have additional actions to promote weight loss (such as glucagonlike peptide-1 [GLP-1] analogs or sodium-glucose-linked transporter-2 [SGLT-2] inhibitors) are suggested, in addition to the first-line agent for type 2 diabetes mellitus and obesity, metformin. (medscape.com)
  • In women with a BMI of 27 kg/m 2 or more with comorbidities or a BMI of 30 kg/m 2 or more, seeking contraception, oral contraceptives are suggested over injectable medications because of weight gain with injectables, provided that women are well informed about the risks and benefits (ie, oral contraceptives are not contraindicated). (medscape.com)
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  • Here at Atlanta Endocrine Associates, we've successfully helped many of our patients in Atlanta, Georgia, lose weight and keep it off with the help of anti-obesity medications. (atlantaendocrine.com)
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