ProteinsEducational webinarsEpitopeCharacterizationQuantificationAntibacterialAntibodiesSyntheticAmino acidsLibrariesIntactSynthesisLipidProtein sequenceMolecularBrainImmuneKinaseEpitopesSmallTechnologyAnalysisResearchersDevelopmentSERAShortColleaguesDataTargetLibraryHighlyLiveLearnStudySubmitFoundSurfaceHumanLife
Proteins4
- The portable size ZipChip Interface directly mounts onto select models of Thermo Scientific mass spectrometers, and creates a seamless CE/ESI-MS workflow that offers fast CE separation, nano-spray level sensitivity, and HRAM spectrometry for the characterization of intact proteins, antibody drug conjugates (ADCs), antibody subunits, peptides, and metabolites. (thermofisher.com)
- The reason why Peter Lansbury and others used the term 'natively unfolded' for a-synuclein and other proteins, especially peptides, is that they do not exist, to a significant degree, in the same kind of stable structure that larger native proteins like myoglobin do. (alzforum.org)
- The article provides guidelines to ensure best practises when protein mapping using the emerging technology called fast photochemical oxidation of proteins (FPOP). (bioinfor.com)
- UHPLC and GFC separations for proteins, peptides, and other biomolecules. (phenomenex.com.hk)
Educational webinars2
- Supported by Elsevier, we publish high impact peer-reviewed journals, organize academic conferences, broadcast educational webinars and so much more. (materialstoday.com)
- Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global life science, food and medical device community. (prweb.com)
Epitope6
- Serimmune's Serum Epitope Repertoire Analysis (SERA) technology platform applies bacterial display peptide libraries, next-generation sequencing, machine learning and custom bioinformatics to reveal the many diverse antigens stimulating immunity. (serimmune.com)
- All applications in biotherapeutic discovery and development such as epitope mapping and binning and antibody screening are impossible, or at least highly cumbersome, with labeled techniques. (drugdiscoverynews.com)
- By comparing responses to different amino acid sequences, a T-cell epitope map can be built up which allows the scientist to predict what modification can be designed into the Factor VIII molecule to make it less immunogenic. (genengnews.com)
- These include EpiScreen™, a T-cell epitope mapping technology that screens peptides for their immunostimulatory properties, and EpiScreen DC:T cell assay, which screens biologics for their immunogenicity. (genengnews.com)
- T cell epitope mapping, the selection of target peptides from any protein sequence, is a powerful resource for the development of novel protein therapeutics. (epivax.com)
- HX-MS can be used to study a wide range of structural properties including protein folding, ligand binding and allostery, and epitope mapping in the development of therapeutic antibodies. (diwou.com)
Characterization5
- Merck Millipore] Replacing the MAP/HAP test is a first step to reducing the overall timeline for CHO cell line characterization from months to mere weeks. (cacheby.com)
- At launch, Admescope's service offering for biological drugs consists of protein molecular weight and structural characterization, targeted protein quantification, peptide mapping and detection of post-translational modifications, and protein pharmacokinetics. (drugdiscoverynews.com)
- PEAKS effectively performs peptide and protein identification, PTM and mutation characterization, as well as results validation, visualization and reporting. (bioinfor.com)
- In the characterization phase, raw LC-MS/MS data from a tryptic digest of the target molecule was loaded into a dedicated peptide mapping data processing workflow. (genedata.com)
- Extremely inert 1.8µm particle with LMW separation range of 1K-450KDa for monoclonal antibody (mAb) fragment analysis, peptide characterization, and biosimilars. (phenomenex.com.hk)
Quantification1
- Peptide level quantification of oxidation levels. (bioinfor.com)
Antibacterial2
- The device is effectively a micro-capacitor, with the antibacterial microbial peptides (AMPs) acting as the dielectric medium. (materialstoday.com)
- The team reconstructed near-complete genomes of hundreds of microorganisms from Northern California grasslands and identified more than a thousand biosynthetic gene clusters inferred to synthesize peptides, antibacterial toxins, and metabolites of unclear function. (genomeweb.com)
Antibodies2
- developed a screening method based on phage-display random-peptide libraries and identified a consensus motif - NXS/TDKS/T - that bound selectively to circulating antibodies from patients with prostate cancer. (the-scientist.com)
- In pre-existing sarcoidosis, elevated troponins, B-type natriuretic peptide (BNP), anti-heart, and anti-intercalated disk antibodies support CS diagnosis. (acc.org)
Synthetic2
- Thomas Carell, an organic chemist at Ludwig Maximilian University of Munich in Germany, and his colleagues created synthetic RNA molecules that could produce peptides up to 15 amino acids long. (the-scientist.com)
- Synthetic peptide corresponding to the sequence near the amino terminus of MKK7 (MAP2K7) conjugated to hemocyanin. (enzolifesciences.com)
Amino acids2
- The peptides (short chained amino acids) are much more robust, and are also sensitive to a much wider range of bacteria. (materialstoday.com)
- The fact that RNAs containing a couple of these nucleosides were able to bind amino acids and string them together to build peptides "is a very exciting finding," Martin tells Nature , "not only because it maps out a new route to RNA-based peptide formation, but because it also uncovers new evolutionary significance to the naturally occurring modified bases of RNA. (the-scientist.com)
Libraries2
- Identify single amino acid effects with maximally overlapping peptide libraries. (pepperprint.com)
- Using PEPperPRINT's unique laser printing technology, entire protein targets can be translated into highly overlapping peptide libraries in a convenient microarray format, allowing for both in-depth and high-throughput screening of immunogenic epitopes. (pepperprint.com)
Intact1
- Peptide mapping, subunit top/middle down analysis, and intact native and denatured analysis: The new Thermo Scientific™ Q Exactive™ BioPharma solution can do it all. (analyteguru.com)
Synthesis5
- However, it is possible to synthesis the peptides in the laboratory, meaning there is no similar threat to the frog population. (materialstoday.com)
- Molecular Hiving is a tag-assisted liquid-phase peptide synthesis technology developed by Professor Kazuhiro Chiba at Tokyo University of Technology and Agriculture. (prweb.com)
- This technology uses a hydrophobic tag, which is applied in the same way as the resin for solid-phase peptide synthesis (SPPS) processes. (prweb.com)
- In this webinar, the speaker will guide attendees through the individual steps for synthesis of peptides applying Molecular Hiving™ technology. (prweb.com)
- Molecular Hiving™ also allows the synthesis of peptides without the use of solvents and reagents which are carcinogenic, mutagenic, or toxic to reproduction (CMR substances). (prweb.com)
Lipid2
- OK-101 is a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor which is typically found on immune cells of the eye responsible for the inflammatory response. (tmcnet.com)
- We could clearly identify the location on the membrane when the peptide was external to the membrane (red dots on the peptide-membrane surface in Figure 2) versus when the peptide was directly interacting with the lipid bilayer atoms (blue dots on the peptide-membrane surface in Figure 2). (nvidia.com)
Protein sequence1
- Turn any protein sequence into a linear or conformational peptide librarie. (pepperprint.com)
Molecular4
- Therefore, intermediate isolation of the tag-bound peptide and excessive washing steps are not required for Molecular Hiving™ technology. (prweb.com)
- For more information or to register for this event, visit Cost-Efficient and Green Manufacturing of Peptides Thanks to Molecular Hiving Technology . (prweb.com)
- This is a 3D atomic scale map, or molecular structure, of the 2019-nCoV Spike protein. (drugtargetreview.com)
- See also David Thirumalai's Emerging Ideas on the Molecular Basis of Protein and Peptide Aggregation ' (.pdf). (alzforum.org)
Brain2
- A University of California, Irvine-led team of researchers working at the Center for Neural Circuit Mapping find links between brain disorders and dysfunction of newly identified inhibitory brain cell types. (news-medical.net)
- A team of UCI scientists led by Xiangmin Xu, PhD, professor of anatomy and neurobiology and director for the Center for Neural Circuit Mapping (CNCM) at the UCI School of Medicine, found that a distinct new class of brain inhibitory neurons when functioning abnormally may contribute to neurological and psychiatric conditions, including autism and schizophrenia. (news-medical.net)
Immune1
- Map T-cell epitopes and monitor cellular immune responses. (pepperprint.com)
Kinase1
- Members of the MAP kinase family of protein kinases (e.g. p38 and Jnk) are subject to dual phosphorylation of a conserved T-X-Y motif in their activation domain by upstream members of the MAP/ERK kinase (MEK/MKK) family. (enzolifesciences.com)
Epitopes2
- We offer a discovery service to academia, government and industry through the Serimmune universal serology platform that utilizes bacterial display peptide library technology and next generation sequencing to broadly profile antibody repertoires and identify antigens and epitopes associated with many diseases - all in a single assay. (serimmune.com)
- Such peptides are believed to be "promiscuous" T-cell epitopes that bind to the HLA supertypes on the surface of antigen-presenting cells that are broadly represented in the world's population. (genengnews.com)
Small4
- I will never forget the excitement of my collaborator Sandeep Patel when we were able to observe the exploration activity of small peptides on a large membrane surface. (nvidia.com)
- The number of drug development projects with biological drugs has been continuously increasing over the past decade, and therefore the expansion to serve this growing market was considered "a logical continuation" for Admescope's service development, after having previously built a strong and comprehensive service portfolio for the research of small molecules and peptides. (drugdiscoverynews.com)
- With the group of experienced protein scientists that we have recruited for our Biologics' team, we are able to serve the growing segment of biological drug development with the same high quality and expertise that our customers are used to with our services for small molecules and peptides. (drugdiscoverynews.com)
- Hi folks, Is there a screening system for Covid-19 to check the activity of small molecule/peptide? (drugtargetreview.com)
Technology4
- Webinar attendees will learn about the scalability and the substantial advantages of this technology regarding efficiency and towards greener manufacturing, as solvent consumption and material requirements are significantly reduced compared to conventional SPPS processes. (prweb.com)
- In this webinar, the benefits of integrating cutting-edge microfluidic technology with capillary electrophoresis (CE) and electrospray ionization (ESI) for enhanced mass spectrometry (MS) analysis is presented. (thermofisher.com)
- To fulfill this vision, we created a technology for building and interpreting a dynamic map of human immunity which continually evolves to map interactions between functional antibody repertoire and human disease. (serimmune.com)
- Abt Associates-a global company that conducts research, consulting, and technical services in health, environmental and social policy, technology, and international development-commits to pursuing opportunities within new and existing global projects to conduct antibiotic resistance mapping, landscaping, and trend analysis. (cdc.gov)
Analysis1
- In this GEN webinar, Dr. David Schriemer, University of Calgary, will present an innovative approach for applying HX-MS to protein analysis in biotherapeutics development. (diwou.com)
Researchers3
- Conducted by the University of Texas (UT) at Austin and the National Institutes of Health (NIH), both US, the study has produced a map of the Spike (S) protein, which may allow researchers to design and make vaccines and antiviral drugs. (drugtargetreview.com)
- The researchers produced a doubled haploid rose line from Rosa chinensis - one of the most influential genotypes in rose breeding - combining long and short reads, and anchoring to a high-density genetic map. (genomeweb.com)
- The researchers then used these variants and expressed transcripts from each patient to build a sample-specific database and identified 156,135 peptides, 28,944 phosphopeptides, and 4,376 N-glycopeptides from the global proteomes, phosphoproteomes, and N-glycoproteomes, respectively. (genomeweb.com)
Development2
- In addition, they showed a specific positive correlation between serum reactivity to the corresponding tumor peptide, development of metastatic androgen-independent disease, and shorter overall survival. (the-scientist.com)
- Using cryogenic electron microscopy, a team has mapped the Spike protein on COVID-19, which could be used in the development of vaccines. (drugtargetreview.com)
SERA1
- View our webinar walking through the use of SERA in Broad Serosurveillance and its use as a tool for research and diagnostic applications. (serimmune.com)
Short2
- Learn more about the research applications of PEPperCHIP ® Peptide Microarrays in this short video. (pepperprint.com)
- Peptides: are short chains of amino acid monomers linked by peptide (amide) bonds. (labroots.com)
Colleagues1
- Dr. Baker and his colleagues were successful in synthesizing a peptide containing two mutations, which provoked a greatly reduced T-cell reaction in healthy individuals. (genengnews.com)
Data2
- Most of the liquid state NMR data, obtained on monomeric Ab, indicate that the peptide by itself is dynamically flexible in solution. (alzforum.org)
- Understanding the data mining approach used to confirm peptide ID and authenticate, or even correct, MS1-based deuteration calculations. (diwou.com)
Target1
- Phage bearing specific antigenic determinants from a target gene can be purified in infectious form to generate a phage-display system that can used to map immunoglobulin binding sites. (the-scientist.com)
Library1
- Design your custom peptide library in minutes with the help of our project specialists. (pepperprint.com)
Highly1
- In the fibril state, the peptide becomes highly ordered (at least from residue 10 on). (alzforum.org)
Live1
- The goal of this live webinar is to present evidence-based approaches to addressing and managing the toxic burden of everyday life. (nanp.org)
Learn1
- Learn how to perform our assays in your own lab, or discover how other scientists have implemented PEPperCHIP® Peptide Microarrays in their research. (pepperprint.com)
Study1
- Figure 2: Study of peptide penetration and folding into membrane. (nvidia.com)
Submit1
- It took approximately 12 more days to reconstruct the 3D atomic scale map of the S protein and submit a manuscript. (drugtargetreview.com)
Found1
- The sensor exploits an antimicrobial peptide found on the skin of African clawed frogs. (materialstoday.com)
Surface1
- Within the realm of protein mapping, a significant interest of the group is surface mapping. (bioinfor.com)
Human1
- Scientists have announced a critical breakthrough in their research for a vaccine to comabt COVID-19 (coronavirus) by creating the first three-dimensional (3D) atomic-scale map of the section of the virus that attaches to and infects human cells. (drugtargetreview.com)
Life1
- The idea that RNAs and peptides could have interacted in the early days of life on Earth provides one way that life could have initially evolved without ribosomes. (the-scientist.com)