alpha 1-Antitrypsin Deficiencyalpha 1-AntitrypsinPulmonary EmphysemaEmphysemaPhenotypeLiver DiseasesPulmonary Disease, Chronic ObstructiveCell WallForced Expiratory VolumeTrypsin Inhibitorsalpha 1-AntichymotrypsinLung DiseasesAirway ObstructionLungPancreatic ElastaseAirway RemodelingHeterozygoteHomozygoteBronchiectasisProteostasis DeficienciesAirway ResistanceLiverAllelesHepatitisLiver CirrhosisSmokingMutationRespiratory Function TestsSpirometrySerpinsGenotypeBronchitisVital Capacity