• mutation
  • Conversely, degeneration is accelerated when potassium channel activity is decreased (by expressing a dominant-negative mutation of Shaker). (jneurosci.org)
  • On the congenic FVB/N background, mice that are homozygous for this mutation exhibit delayed Wallerian degeneration compared to wildtype controls. (jax.org)
  • membrane
  • Rather, a variety of lines of evidence suggest that the sodium and potassium channels manifest their effects upon degeneration through changes in the resting membrane potential, which in turn regulates the level of intracellular free calcium within the isolated distal axon. (jneurosci.org)
  • processes
  • Our findings help the understanding of the altered diffusion indices in the context of pathology and suggest that diffusion tensor imaging has the potential to monitor the processes of Wallerian degeneration in the central nervous system in vivo after acute damage. (pubmedcentralcanada.ca)
  • crush
  • We found that degeneration of the distal nerve stump after a nerve crush is greatly delayed when there is increased potassium channel activity (by overexpression of two different potassium channels, Kir2.1 and dORKΔ-C) or decreased voltage-gated sodium channel activity (using mutations in the para sodium channel). (jneurosci.org)