Axonal degenerationSlow wallerian degenerationDemyelinationDistalNervePeripheralAxonsSpinalSchwannChronicInflammationOccursInjuryRoleUndergo Wallerian degenerationNeuronal DegenerationPyramidal tractRetrograde degenerationRegenerationAxon degenerationDorsalLongitudinalNeuronsDiffusionSARM1MechanismShownWhite matterForm
Axonal degeneration9
- Axonal degeneration is followed by degradation of the myelin sheath and infiltration by macrophages. (wikipedia.org)
- Although most injury responses include a calcium influx signaling to promote resealing of severed parts, axonal injuries initially lead to acute axonal degeneration (AAD), which is rapid separation of the proximal (the part nearer the cell body) and distal ends within 30 minutes of injury. (wikipedia.org)
- The disintegration is dependent on Ubiquitin and Calpain proteases (caused by influx of calcium ion), suggesting that axonal degeneration is an active process and not a passive one as previously misunderstood. (wikipedia.org)
- Myelin clearance is the next step in Wallerian degeneration following axonal degeneration. (wikipedia.org)
- Focal infarction without distal axonal degeneration is demonstrated for the 1st month following onset of clinical symptoms. (nih.gov)
- Peripheral nerves respond to injury or disease in one or more of the following ways: segmental remyelination, Wallerian degeneration, and axonal degeneration. (uspharmacist.com)
- 5,6 Segmental demyelination and Wallerian degeneration are repair mechanisms that are relevant to traumatic nerve injury, whereas axonal degeneration is more characteristically seen in metabolic and toxic nerve disorders such as diabetes mellitus and renal failure. (uspharmacist.com)
- Axonal degeneration is a prediction of disability. (medscape.com)
- 2 - 5 In 1 study from a patient presenting with pure motor GBS, inflammatory demyelination with secondary axonal degeneration was restricted to ventral spinal roots. (ajnr.org)
Slow wallerian degeneration2
- Parson, SH , Mackintosh, CL & Ribchester, RR 1997, ' Elimination of motor nerve terminals in neonatal mice expressing a gene for slow wallerian degeneration (C57Bl/Wlds) ', European Journal of Neuroscience , vol. 9, no. 8, pp. 1586-1592. (elsevierpure.com)
- Using two mutant murine strains (the slow Wallerian degeneration mouse and a knockout for the chemokine receptors CCR2) we have found that prevention of macrophage accumulation in ganglia significantly inhibits the conditioning lesion response, suggesting that these macrophages play an important role in the response of neurons to injury. (case.edu)
Demyelination2
- Patients with primary Sjögren syndrome show loss of WM microstructural integrity, probably related to both Wallerian degeneration and demyelination. (ajnr.org)
- Precise inflammatory demyelination of these nerve trunks may imply an increase of endoneurial fluid nerve pressure potentially causing endoneurial ischemia and wallerian-like degeneration. (ajnr.org)
Distal5
- Wallerian degeneration is an active process of degeneration that results when a nerve fiber is cut or crushed and the part of the axon distal to the injury (which in most cases is farther from the neuron's cell body) degenerates. (wikipedia.org)
- Prior to degeneration, the distal section of the axon tends to remain electrically excitable. (wikipedia.org)
- A condition caused by degeneration, atrophy, and destruction of the distal part of a nerve fiber''s axon and myelin, when continuity with the neural cell nucleus has been severed due to injury. (nih.gov)
- In the absence of NGF, inhibition of glycolysis along distal axons results in axon degeneration independent of cell death. (jneurosci.org)
- 3,4 Axonotmesis leads to Wallerian degeneration , a process whereby the part of the axon that is separated from the neuronal cell body disintegrates distal to the injury. (uspharmacist.com)
Nerve7
- Degeneration of motor terminals after nerve section occurs much more slowly than normal in young adult mice of the C57Bl/Wlds strain. (elsevierpure.com)
- B) Nerve showing disruptive changes of axons (Wallerian degeneration) (black star). (cdc.gov)
- a) Peripheral nerve in longitudinal section stained with Luxol fast blue-periodic acid-Schiff (PAS) showing scattered wallerian degeneration (arrowheads). (medscape.com)
- In the late 1960s, neurophysiologic testing allowed the classification of CMT into 2 groups, one with slow nerve conduction velocities and histologic features of a hypertrophic demyelinating neuropathy (hereditary motor and sensory neuropathy type 1 or CMT1) and another with relatively normal velocities and axonal and neuronal degeneration (hereditary motor and sensory neuropathy type 2 or CMT2). (medscape.com)
- Sciatic nerve transection, early after birth, results in significant degeneration of spinal motoneurons as well as sensory neurons present in the dorsal root ganglia. (hindawi.com)
- I study the role of immune cells in nerve degeneration and regeneration, and compare nerve regeneration in different types of sensory neurons. (case.edu)
- Histograms evaluating large portions of tissue reveal significant increases in MD in individuals with Alzheimer's disease when compared with controls as well as a significant reduction in regional peak MD heights, which indicates nerve loss in gray matter and Wallerian degeneration in white matter. (diagnosticimaging.com)
Peripheral2
- Wallerian degeneration occurs after axonal injury in both the peripheral nervous system (PNS) and central nervous system (CNS). (wikipedia.org)
- We are primarily concerned with neurotoxicants that produce Wallerian-type degeneration of the axon and myelin of the central and peripheral nervous systems. (duke.edu)
Axons1
- We conclude (i) that the Wlds gene has no direct impact on the normal rate of postnatal synapse elimination, (ii) that Wallerian degeneration and synapse elimination must occur by distinct and different mechanisms, and (iii) that muscle fibres are able to sustain polyneuronal synaptic inputs even after motor axons have become disconnected from their cell bodies. (elsevierpure.com)
Spinal1
- Combined MBK and EPN exposure caused Wallerian type degeneration and paranodal axonal swelling in the spinal cord. (cdc.gov)
Schwann1
- The macrophages, accompanied by Schwann cells, serve to clear the debris from the degeneration. (wikipedia.org)
Chronic2
- The dynamic signal intensity changes at magnetic resonance (MR) imaging in active and chronic wallerian degeneration in the corticospinal tract were evaluated. (nih.gov)
- Chronic inflammation can result in edema, wallerian degeneration, and fibrotic changes to the neural tissues. (medscape.com)
Inflammation1
- In research and clinical settings, DTI has generated information on tissue infrastructure and indications of inflammation, tissue degeneration, and neurodevelopmental abnormalities, said Dr. Marco Bozzali from Don C. Gnocchi Foundation in Milan. (diagnosticimaging.com)
Occurs1
- A related process of dying back or retrograde degeneration known as 'Wallerian-like degeneration' occurs in many neurodegenerative diseases, especially those where axonal transport is impaired such as ALS and Alzheimer's disease. (wikipedia.org)
Injury1
- I. An analysis in tissue culture of proliferation during development, Wallerian degeneration, and direct injury. (rupress.org)
Role1
- This observation prompted us to re-examine the possible role of degeneration and intrinsic axon withdrawal during neonatal synapse elimination. (elsevierpure.com)
Undergo Wallerian degeneration1
- Specifically, YFP-labeled axons are present in regions beyond those with anterogradely labeled CST axons, most YFP-labeled axons beyond established CST locations do not undergo Wallerian degeneration following a large lesion of the sensorimotor cortex, some rubrospinal and reticulospinal neurons are labeled with YFP, and some YFP-labeled cells in the spinal gray matter have YFP-labeled projections into the spinal cord white matter. (nih.gov)
Neuronal Degeneration3
- 2015 ) Laser-Mediated Microlesions in Mouse Neocortex to Investigate Neuronal Degeneration and Regeneration. (neurotree.org)
- Axotomised neuromuscular junctions in Wld(S) mutant mice offer favourable experimental opportunities for examining developmental mechanisms of synaptic regression, that may also benefit our understanding of how degeneration in the synaptic compartment of a neuron is initiated, and its role in progressive, whole-cell neuronal degeneration. (ed.ac.uk)
- In this study, we hypothesized that higher Aß oligomerization in the blood are associated with the neuronal degeneration of the brain in the form of AD. (biomedcentral.com)
Pyramidal tract4
- 2. Longitudinal investigations on the anterograde and retrograde degeneration in the pyramidal tract following pontine infarction with diffusion tensor imaging. (nih.gov)
- 4. Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke. (nih.gov)
- An assessment of the correlation between early postinfarction pyramidal tract Wallerian degeneration and nerve function recovery using diffusion tensor imaging. (geneticsmr.com)
- This study aimed to evaluate the clinical significance of diffusion tensor imaging (DTI) in the early diagnosis of pyramidal tract Wallerian degeneration (WD) and assessment of neurological recovery following cerebral infarction. (geneticsmr.com)
Retrograde degeneration1
- A related process of dying back or retrograde degeneration known as 'Wallerian-like degeneration' occurs in many neurodegenerative diseases, especially those where axonal transport is impaired such as ALS and Alzheimer's disease. (wikipedia.org)
Regeneration1
- Degeneration and regeneration of nerve fiber BY PANDIAN MTHIS PPT ONLY FIOR. (slideshare.net)
Axon degeneration3
- shows axon degeneration with a typical "digestion chamber," containing axonal fragments (arrow). (nih.gov)
- SARM1 is now recognized as the primary axon killer through its NAD + -consuming enzymatic activity, and SARM1 inhibitors that protect against axon degeneration in pre-clinical studies are generating great excitement (2, 3). (genetex.com)
- GeneTex is expanding its inventory of antibodies for axon degeneration research with the addition of new recombinant rabbit antibodies against SARM1 (see below). (genetex.com)
Dorsal2
- Wallerian degeneration occurred in the dorsal funiculus where the white discoloration was observed on gross examination. (cdc.gov)
- Dorsal root ganglia neuronal cell bodies will be the principal target of proteasome inhibition, with peripheral nerve degeneration occurring later. (ack1inhibitor.com)
Longitudinal1
- dblp: Search for 'The acute phase of Wallerian degeneration: Longitudinal diffusion tensor imaging of the fornix following temporal lobe surgery. (dblp.org)
Neurons1
- When the neurons themselves die, Wallerian degeneration takes place, resulting in muscle weakness in those muscles once innervated by the now dead neurons. (cdc.gov)
Diffusion5
- 1. Retrograde Wallerian degeneration of cranial corticospinal tracts in cervical spinal cord injury patients using diffusion tensor imaging. (nih.gov)
- 5. Corticospinal tract degeneration and possible pathogenesis in ALS evaluated by MR diffusion tensor imaging. (nih.gov)
- 6. Wallerian degeneration in lateral cervical spinal cord detected with diffusion tensor imaging in four chronic stroke patients. (nih.gov)
- 14. [Diffusion tensor MRI of Wallerian degeneration: a case report]. (nih.gov)
- 18. Focal Wallerian degeneration of the corpus callosum in large middle cerebral artery stroke: serial diffusion tensor imaging. (nih.gov)
SARM12
- This work identified key players that dictate the fate of axons, including the pro-survival factors NMNAT2 and STMN2 and the degeneration-promoting factors DLK and SARM1 (1). (genetex.com)
- Next, I showed that Sarm1, a key effector of Wallerian degeneration, is not required for structural plasticity of Merkel cell-neurite complexes in young adulthood. (columbia.edu)
Mechanism1
- Research that began with investigations into the mechanism underlying Wallerian degeneration of damaged axons has revealed the crucial importance of NAD + metabolism in axon survival. (genetex.com)
Shown1
- Autopsy studies have shown Wallerian-like degeneration of motor fibers. (qxmd.com)
White matter1
- Adult lifespan maturation and degeneration patterns in gray and white matter: A mean apparent propagator (MAP) MRI study. (nih.gov)
Form1
- 2020 ) In vivo imaging of injured cortical axons reveals a rapid onset form of Wallerian degeneration. (neurotree.org)