• Glutamate levels were measured in the bilateral anterior cingulate cortex (ACC) using proton magnetic resonance spectroscopy, and GMV was assessed using voxel-based morphometry. (cambridge.org)
  • Glutamate concentrations and grey and white matter volume could be successfully determined at an ultra-high magnetic field strength. (amsterdamumc.org)
  • Effect of interferon-α on cortical glutamate in patients with hepatitis C: a proton magnetic resonance spectroscopy study. (ox.ac.uk)
  • The present study used magnetic resonance spectroscopy (MRS) to measure glutamate and its major metabolite glutamine in patients with hepatitis C who received treatment with pegylated IFN-α and ribavirin. (ox.ac.uk)
  • METHOD: MRS measurements of glutamate and glutamine were taken from a 25 × 20 × 20 mm voxel including the pregenual anterior cingulate cortex in 12 patients before and after 4-6 weeks of treatment with IFN. (ox.ac.uk)
  • The present pilot study examined changes in cortical glutamine/glutamate ratios in depressed adolescents receiving high-frequency repetitive transcranial magnetic stimulation. (elsevierpure.com)
  • Glutamate metabolites were quantified with 2 distinct proton magnetic resonance spectroscopy sequences in each brain region. (elsevierpure.com)
  • After repetitive transcranial magnetic stimulation and at 6 months of follow-up, glutamine/glutamate ratios increased in the anterior cingulate cortex and left dorsolateral prefrontal cortex with both measurements. (elsevierpure.com)
  • High-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex may modulate glutamate neurochemistry in depressed adolescents. (elsevierpure.com)
  • Single voxel magnetic resonance spectroscopy (MRS) was used to investigate creatine (Cre), total choline (t-Cho), glutamate + glutamine (Glx), N-acetylaspartate, and myo-inositol. (biomedcentral.com)
  • Magnetic resonance spectroscopy (MRS) studies have reported increased brain Glutamate (Glu) and Glx (Glu+Glutamine) in subjects with BD. (elsevierpure.com)
  • Forty-three healthy volunteers aged between 20 and 88 years were assessed for trait anxiety with the Subscale-2 of the State-Trait-Anxiety Inventory (STAI-Y2) and were studied with proton magnetic resonance spectroscopy ((1)H-MRS) to investigate GABA and Glx (glutamate+glutamine) contents within vmPFC. (unich.it)
  • Striatal dopamine synthesis capacity (Ki cer ) and anterior cingulate glutamate were measured using 18F-DOPA positron emission tomography and proton magnetic resonance spectroscopy respectively, before and after at least 5 weeks' naturalistic antipsychotic treatment in people with first episode psychosis ( n = 18) and matched healthy controls ( n = 20). (nature.com)
  • Striatal dopamine synthesis capacity (Ki cer ) can be measured in-vivo using positron emission tomography, and cortical glutamate can be measured using proton magnetic resonance spectroscopy (MRS). Effects on separate components of the dopamine and glutamate systems have been examined in few in-vivo studies [ 16 ] but not together in the same population. (nature.com)
  • 2012. " In Vivo Voxel Based Morphometry: Detection Of Increased Hippocampal Volume And Decreased Glutamate Levels In Exercising Mice " . (uni-heidelberg.de)
  • 2012. " Increase Of Hippocampal Glutamate After Electroconvulsive Treatment: A Quantitative Proton Mr Spectroscopy Study At 9.4 T In An Animal Model Of Depression " . (uni-heidelberg.de)
  • fMRS is based on the same principles as in vivo magnetic resonance spectroscopy (MRS). However, while conventional MRS records a single spectrum of metabolites from a region of interest, a key interest of fMRS is to detect multiple spectra and study metabolite concentration dynamics during brain function. (wikipedia.org)
  • In vivo single-voxel proton MRS provides a sensible and non-invasive characterization of canine brain lesions. (lacittadina.org)
  • Assignment of glial brain tumors in humans byin vivo 1H-magnetic resonance spectroscopy and multidimensional metabolic classification. (mpg.de)
  • In Vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification. (mpg.de)
  • This was verified by phantom measurements, where an SNR increase of 46% could be observed for localized 31 P spectroscopy in a voxel positioned comparable to an in vivo cardiac measurement scenario. (frontiersin.org)
  • A flexible 31 P/ 1 H RF coil array with improved SNR is presented, enabling localized in vivo cardiac 31 P spectroscopy at 7 T. (frontiersin.org)
  • 2009. " Hippocampal Alterations In Congenital Learned Helpless Rats After Electroconvulsive Seizures Detected With In Vivo 1H Mr-Spectroscopy At 9.4T " . In Proceedings 17Th Scientific Meeting, International Society For Magnetic Resonance In Medicine , 3289. (uni-heidelberg.de)
  • More than one-half of the variance in in vivo proton MR spectroscopy metabolite estimates is common to all metabolites. (musc.edu)
  • Proton MR spectroscopy provides possibility of noninvasive chemical analysis of the brain in vivo as well as it allows estimation of relative changes in brain metabolites, including N-acetylaspartate (NAA), choline-containing compounds, and total creatine [6]. (fortunepublish.com)
  • Voxel-based optimized morphometry (VBM) of gray and white matter in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis. (brain-knowledge-engine.org)
  • 2014. " Regional Cerebral Blood Volume (Rcbv) Bias Voxel-Based Morphometry (Vbm) In An Animal Study " . (uni-heidelberg.de)
  • Positron emission tomography (PET) and voxel-based morphometry have identified the posterior hypothalamic gray matter as the key area for the basic defect in CH. (medscape.com)
  • Cluster headache (CH): Voxel-based morphometry (VBM) structural imaging shows specific brain area of CH patients' (hypothalamus) being different to non-CH patients' brains. (medscape.com)
  • The data generated by fMRS usually shows spectra of resonances, instead of a brain image, as with MRI. (wikipedia.org)
  • 1 H-MRSI spectra from preoperative scanning on 15 patients with recurrent or newly diagnosed meningiomas were processed and analyzed, and specific voxels were selected based on their chemical contents. (karger.com)
  • Spectra obtained by single-voxel MRS examination were divided for each category. (lacittadina.org)
  • Here we investigated neurometabolites in brain regions that may underlie apathy in aMCI patients using proton magnetic resonance spectroscopy (H-1-MRS). Twenty-eight aMCI patients with varying degrees of apathy and 20 matched controls underwent H-1-MRS. Spectra were acquired from single voxels in the posterior cingulate cortex (PCC), dorsal anterior cingulate cortex (DACC), right dorsolateral prefrontal cortex (DLPFC), and right temporoparietal cortex (TPC). (uantwerpen.be)
  • A PRESS sequence (et 37 ms, rt 2000 ms) generated spectra in a 20 mm MRS cubic voxel in right-sided superior frontal white matter. (birmingham.ac.uk)
  • Together, these features enable acquisition of (31)P MRSI at high spatial resolutions (3.0 cm(3) voxel) in the occipital lobe of the human brain in clinically acceptable scan times (~15 min). (ox.ac.uk)
  • In fMRS, depending on the focus of the study, either single-voxel or multi-voxel spectroscopic technique can be used. (wikipedia.org)
  • We sought to develop a clinical workflow and uniquely capable custom software tool to integrate advanced 3-tesla 3D proton magnetic resonance spectroscopic imaging ( 1 H-MRSI) into industry standard image-guided neuronavigation systems, especially for use in brain tumor surgery. (karger.com)
  • Therefore, it is sometimes referred to as dynamic MRS, event-related MRS or time-resolved MRS. A novel variant of fMRS is functional diffusion-weighted spectroscopy (fDWS) which measures diffusion properties of brain metabolites upon brain activation. (wikipedia.org)
  • For the non-invasive detection of these neurometabolites, the SVS magnetic resonance spectroscopy (MRS) technique uses the nuclear magnetic resonance properties of protons to generate a frequency spectrum in which various metabolites can be identified and quantified by their chemical shift along the frequency axis [ 50 ]. (biomedcentral.com)
  • In single-voxel fMRS the selection of the volume of interest (VOI) is often done by running a functional magnetic resonance imaging (fMRI) study prior to fMRS to localize the brain region activated by the task. (wikipedia.org)
  • Baseline, posttreatment, and 6-month follow-up proton magnetic resonance spectroscopy scans of the anterior cingulate cortex and left dorsolateral prefrontal cortex were collected at 3 T with 8-cm 3 voxels. (elsevierpure.com)
  • Voxels were obtained from a test region within the anterior cingulate cortex, an area critical for a wide range of executive mechanisms as well as from a control volume in the posterior cingulate cortex. (edu.au)
  • Magnetic resonance imaging revealed extradural spinal cord compression at the ventral right aspect of the intervertebral disk space L3-4. (avma.org)
  • Investigators found that 3T magnetic resonance imaging (MRI) had better interobserver agreement, in a study comparing 3T with 1.5T phased array MRI in the presurgical workup of patients with epilepsy with complex focus localization. (medscape.com)
  • Focke et al explored the integrity of connecting networks using diffusion tensor imaging (DTI) and 2 whole-brain voxel-based methods: statistical parametric mapping (SPM) and tract-based spatial statistics (TBSS). (medscape.com)
  • Proton magnetic resonance spectroscopy ( 1 H-MRS) and brain imaging were performed at 7T in a 2×2×2cm 3 voxel in 33 participants between 18 and 31 years old. (amsterdamumc.org)
  • Abstract Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. (marbilab.it)
  • In adults, noninvasive chemical shift encoded Cartesian magnetic resonance imaging (MRI) and single-voxel magnetic resonance (MR) spectroscopy (SVS) accurately quantify hepatic steatosis but require breath-holding. (springer.com)
  • Proton chemical shift imaging, metabolic maps, and single voxel spectroscopy of glial brain tumors. (mpg.de)
  • IMCLs cannot be detected using conventional magnetic resonance imaging (MRI) because they appear as lipid droplets in the skeletal muscle cells that are in close contact with skeletal mitochondria [ 10 , 11 ]. (asianspinejournal.org)
  • In this study we examined the correlation between grey and white matter magnetization transfer ratio (MTR) parameters and the presence of IgM and IgG aCLs and lupus anticoagulant in 18 patients with systemic lupus erythematosus and a history of NPSLE but without cerebral infarcts on conventional magnetic resonance imaging. (biomedcentral.com)
  • In SLE patients with neuropsychiatric manifestations such as cognitive dysfunction, conventional magnetic resonance imaging (MRI) may be unremarkable or show only nonspecific abnormalities [ 4 ]. (biomedcentral.com)
  • Life After Mild Traumatic Brain Injury: Widespread Structural Brain Changes Associated With Psychological Distress Revealed With Multimodal Magnetic Resonance Imaging Biol Psychiatry Glob Open Sci. (usc.edu)
  • The design and construction of a dedicated RF coil setup for human brain imaging ((1)H) and spectroscopy ((31)P) at ultra-high magnetic field strength (7 T) is presented. (ox.ac.uk)
  • In this study, magnetic resonance imaging (MRI) was used to evaluate the relapse features of patients with Rolandic meningioma after the microsurgery. (hindawi.com)
  • According to the guidelines of the European Society of Neuro-Oncology, the main diagnostic method for meningioma is magnetic resonance imaging (MRI). (hindawi.com)
  • Magnetic resonance examination is characterized by multidirectional and external parametric imaging, which can clearly show the lesions of tumor soft tissue and microvessels [ 9 ]. (hindawi.com)
  • For the first time, we assessed 17 children with NS (9 females, mean age, 8.68±2.39) and 17 age- and sex-matched controls (9 female, mean age, 8.71±2.40) using diffusion brain imaging for white matter connectivity and structural magnetic resonance imaging to characterize brain morphology. (stanford.edu)
  • It is more sensitive than magnetic resonance imaging (MRI) in detection of changes related to decreased oxygen supply through the measurement of the metabolic changes that may occur before the morphologic changes. (fortunepublish.com)
  • On the seventh day of treatment, PRESS data were obtained from a 30×30×20 mm voxel placed in medial frontal cortex. (ox.ac.uk)
  • The part from the contemporaneous surge in GABA continues to be to be established.2 suggesting that ketamine focus on could be area of the pathogenesis of MDD also.16 brain proton magnetic resonance spectroscopy (1H MRS) research in healthy volunteers report increased glutamine17 and unchanged18 or increased glutamate19 amounts in response to ketamine administration. (siamtech.net)
  • This led to two subspectra (Shape 1C traces [a] and [b]) where the GABA C-4 resonance at 3.03 Glx and ppm C-2 at 3. (siamtech.net)
  • Subtracting both of these subspectra yielded a range consisting of just the edited GABA C-4 and Glx C-2 resonances with all overlapping resonances removed (Shape 1B). (siamtech.net)
  • The images produced by spectroscopy have also proved useful in the planning of radiotherapy treatment plans for brain and of course for the assessment of the potential damage caused by radiation therapy in the follow-up of patients who underwent a brain radiosurgery. (lacittadina.org)
  • Specifically, 3D MRSI-based overlays provide comprehensive, quantitative visual cues and location information during neurosurgery, enabling a progressive new form of online spectroscopy-guided neuronavigation. (karger.com)
  • Building a scalable pipeline for detection of blood vessels in the human brainstem using quantitative susceptibility MRI at ultrahigh magnetic fields (UHF). (mpg.de)
  • Recently, several studies have reported on the quantitative evaluation of Mm fatty degeneration with magnetic resonance spectroscopy (MRS) [ 9 - 16 ]. (asianspinejournal.org)
  • Using image segmentation and known creatine (Cre) concentrations for white and grey matter, metabolite concentrations were calculated for the excited MRS voxel. (elsevierpure.com)
  • Early increase in marker of neuronal integrity with antidepressant treatment of major depression: 1H-magnetic resonance spectroscopy of N-acetyl-aspartate. (ox.ac.uk)
  • This study used magnetic resonance spectroscopy to assess effects of short-term treatment with escitalopram on N-acetyl-aspartate (NAA), a marker of neuronal integrity. (ox.ac.uk)
  • Whilst previous neuroimaging studies have identified widespread volume loss across a number of cortical regions, to date no studies have utilised Proton Magnetic Resonance Spectroscopy (MRS) to provide insights into how neurometabolic changes may relate to such symptoms. (edu.au)
  • For the metabolic group all the patients affected from hepatic encephalopathy diagnosed by clinical examination, blood cell count, biochemical panel, AmmoniaCheck (Menarini) determination and optional hystopatology of the liver and, finally, a large group of patients who had normal spectroscopy. (lacittadina.org)
  • Proton MRS of Gadolinium-enhancing MS Plaques and Metabolic Changes in Normal-Appearing White Matter. (mpg.de)
  • Chernov et al found that single-voxel proton magnetic resonance spectroscopy (MRS)-detected reduction of N- acetylaspartate content and unilateral presence of lactate in the mesial temporal lobe structures may serve as diagnostic clues for lateralization of the epileptogenic zone in mesial temporal lobe epilepsy. (medscape.com)
  • The investigators conducted a retrospective study to evaluate the role of single-voxel proton MRS in preoperative investigation of patients with mesial temporal lobe epilepsy. (medscape.com)
  • Software package with sequences and protocols for single voxel proton spectroscopy. (siemens-healthineers.com)
  • We attempted to achieve reliable PRESS-localized single-voxel MRS at 3T of the isolated human amygdala by using anatomy to guide voxel size and location. (virginia.edu)
  • To balance the need for temporal resolution and sufficient SNR, fMRS requires a high magnetic field strength (1.5 T and above). (wikipedia.org)
  • Multi-voxel spectroscopy provides information about group of voxels and data can be presented in 2D or 3D images, but it requires longer acquisition times and therefore temporal resolution is decreased. (wikipedia.org)
  • Idiopathic generalised epilepsy: a pilot study of memory and neuronal dysfunction in the temporal lobes, assessed by magnetic resonance spectroscopy. (brain-knowledge-engine.org)
  • Images and hepatic proton-density fat fraction (PDFF) maps were scored for image quality. (springer.com)
  • Proton MRS was performed using the double-spin echo sequence with a voxel size of 20 cm 3 . (fortunepublish.com)
  • Applications in clinical medicine can benefit from fusion of spectroscopy data with anatomical imagery. (karger.com)
  • In Proceedings 20Th Scientific Meeting, International Society For Magnetic Resonance In Medicine , 799. (uni-heidelberg.de)
  • Magnetic Resonance in Medicine: MRM, 44 (1). (drcmr.dk)
  • The magnetic field homogeneity for many acquisitions was necessary to be GSK-3b significantly less than ≤20 Hz as evaluated by the entire width at half from the unsuppressed drinking water resonance. (siamtech.net)
  • Partial correlations assessed the association between metabolite levels and STAI-Y2 scores, removing the effect of possible nuisance factors including age, educational level, volumes of grey (GM) and white matter (WM) within MRS voxel. (unich.it)
  • These signals can be further enhanced by 30 ± 9% using the nuclear Overhauser effect by B1-shimmed low-power irradiation of water protons. (ox.ac.uk)
  • The simulation optimization and implementation of a flexible 31 P transmit/receive coil array, under the geometrical constraint of fitting into the housing of an already existing 12-channel proton array, to enable localized cardiac 31 P MRS at 7 T is presented. (frontiersin.org)
  • This study aimed to analyze the differences in the lipid contents in chronic low back pain (CLBP) patients with nociceptive pain (NocP) and neuropathic pain (NeP) using magnetic resonance spectroscopy (MRS) of the multifidus muscle (Mm). (asianspinejournal.org)
  • For example, new 3-dimensional (3D) spectroscopy techniques allow for improved correlation of metabolite profiles with specific regions of interest in anatomical tumor images, which can be useful in characterizing and treating heterogeneous tumors that appear structurally homogeneous. (karger.com)
  • McKnight TR, von dem Bussche MH, Vigneron DB, Lu Y, Berger MS, McDermott MW, Dillon WP, Graves EE, Pirzkall A, Nelson SJ: Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence. (karger.com)
  • Do NAA/CHO and NAA/CR ratios as measure by 1h MR spectroscopy differ between symptomatic and non-symptomatic concussed athletes in the early post injury period? (birmingham.ac.uk)
  • Frequency drift in MR spectroscopy at 3T. (musc.edu)