AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
DextransDextran SulfateBlood VolumeIron-Dextran ComplexPlasma VolumeColitisStroke VolumeLung Volume MeasurementsErythrocyte VolumeBlood Volume DeterminationFluorescein-5-isothiocyanateMagnetic Resonance ImagingDextranaseForced Expiratory VolumeDEAE-DextranPlasma SubstitutesOrgan SizeTime FactorsColonImaging, Three-DimensionalResidual VolumeImage Processing, Computer-AssistedHematocritDisease Models, AnimalCell SizeReproducibility of ResultsBrainCapillary PermeabilityHemodilutionIsotonic SolutionsMice, Inbred C57BLPermeabilityIntestinal MucosaPressureLeuconostocOsmotic PressureOsmolar ConcentrationLungFluorescent DyesHemodynamicsTomography, X-Ray ComputedDogsLaryngeal EdemaCardiac OutputDiffusionRats, Sprague-DawleyBlood PressureFluoresceinsMolecular WeightFluid TherapyLaryngismusSucroseAtrophyFicollModels, BiologicalSaline Solution, HypertonicErythrocyte AggregationHypovolemiaOsmosisRespiratory MechanicsWaterHeparinGlucansSodium ChlorideProspective StudiesReference ValuesTreatment OutcomeRabbitsImage Interpretation, Computer-AssistedViscositySensitivity and SpecificityKineticsAnalysis of VarianceHydrogen-Ion ConcentrationCell Membrane PermeabilityPolymersGlucosyltransferasesBlood ViscosityRats, Wistar
Sulfate SodiumFluoresceinSalineHydroxyethyl starchPolysaccharideIntravenousColitisNanoparticlesPolymerBiocompatibilityVascularBiocompatibleExpanderAlbuminElectrolyteAxonalMolecularAcetalEndosomesConcentrations2016ColloidISSNBehaviorInjectionFluorescentAnalyzeIntravascular volumeCarrier2000TissueSpeciesTraumaPlasma volumeHypovolemiaSignificantlyBloodFormulationsBondsTherapyApplying osmotic pressureTherapeuticIronEffectFluidSolutionsFunction
Sulfate Sodium2
  • In the present study we examined the protective potential of exogenously administered human umbilical cord derived mesenchymal stem cells (UCMSCs) against Dextran Sulfate Sodium (DSS) induced acute colitis in immunodeficient NOD.CB 17 - Prkdc scid /J mice with particular attention to endoplasmic reticulum (ER) stress. (biomedcentral.com)
  • Methods: The present study was conducted to determine the distinct role of the innate immune system in the development of a dextran sulfate sodium (DSS) colitis model in MyD88 -/- mice, because myeloid differentiation protein (MyD88) is a major adaptor molecule essential for signaling via Toll-like receptors (TLRs). (elsevierpure.com)
Fluorescein3
  • Dextran coupled with a fluorescent molecule such as fluorescein isothiocyanate can be used to create concentration gradients of diffusible molecules for imaging and allow subsequent characterization of gradient slope. (wikipedia.org)
  • The method consisted of a single intravenous injection of 12 mg of a large 150-kDa carboxy-methyl dextran conjugated to a fluorescent rhodamine-derived dye as the PV marker (PVM), and 35 mg of a small 5-kDa carboxy-methyl dextran conjugated to fluorescein, the renal clearance marker. (karger.com)
  • The size-selective permeability of different vascular beds to a group of fluorescein isothiocyanate dextrans of varying molecular weights was measured. (diabetesjournals.org)
Saline4
  • The changes in blood water concentration indicated a mean size of V of 5.9 1 (+/- 0.8, SEM) for Ringer's solution, 2.6 (+/- 0.3) 1 for dextran, and 1.2 (+/- 0.1) 1 for hypertonic saline. (silverchair.com)
  • In the present study, volunteers were given Ringer's solution, dextran, and hypertonic saline, and three markers of blood dilution were followed. (silverchair.com)
  • Crystalloid solutions for intravascular volume replenishment are typically isotonic (eg, 0.9% saline or Ringer's lactate). (merckmanuals.com)
  • If there is a glucose level less than 60 mg/dl, a bolus of 50% dextrose should be given at a volume of 0.5-1 ml/kg, diluted with and equal volume of saline, IV. (vin.com)
Hydroxyethyl starch1
  • Colloid solutions (eg, hydroxyethyl starch , albumin , dextrans) are also effective for volume replacement during major hemorrhage. (merckmanuals.com)
Polysaccharide3
  • Dextran is a complex branched glucan (polysaccharide derived from the condensation of glucose), originally derived from wine. (wikipedia.org)
  • Dextran, a biocompatible, water-soluble polysaccharide, was modified at its hydroxyls with acetal moieties such that it became insoluble in water but freely soluble in common organic solvents enabling its use in the facile preparation of acid-sensitive microparticles. (edu.sa)
  • Dextran is a complex, branched polymer or polysaccharide composed of glucose molecules. (pharmacy180.com)
Intravenous6
  • Still, no difference has been detected in antithrombotic effectiveness in comparison of intra-arterial and intravenous administration of dextran. (wikipedia.org)
  • Close to 70% of dextran-40 is excreted in urine within the first 24 hours after intravenous infusion, while the remaining 30% are retained for several more days. (wikipedia.org)
  • and in certain intravenous fluids to solubilize other factors, such as iron (in a solution known as Iron Dextran). (wikipedia.org)
  • Intravenous solutions with dextran function both as volume expanders and means of parenteral nutrition. (wikipedia.org)
  • 3 ] The purpose of fitting the data to a kinetic model is that this allows computer simulations to be made that predict the plasma volume expansion at any time during and after intravenous infusion of the fluid. (silverchair.com)
  • Patients and methods: A single 1000 mg intravenous (IV) [Am J Med Sci 31 (1999) 213] infusion of iron dextran was evaluated in an open-label study. (johnshopkins.edu)
Colitis3
  • Solutions of fluorescently-labelled dextran can be perfused through engineered vessels to analyze vascular permeability Dextran is used to make microcarriers for industrial cell culture Orally-administered dextran sodium sulphate is used to induce colitis in animal models of inflammatory bowel disease. (wikipedia.org)
  • Scholars@Duke publication: Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats. (duke.edu)
  • BACKGROUND AND AIMS: The role of sensory neurones in colitis was studied by chemical denervation of primary sensory neurones as well as antagonism of the vanilloid receptor-1 (VR-1) in rats prior to administration of dextran sulphate sodium (DSS) to induce colitis. (duke.edu)
Nanoparticles2
  • Dextran can be used as a stabilizing coating to protect metal nanoparticles from oxidation and improve biocompatibility. (wikipedia.org)
  • The dextran block copolymer was used to rapidly prepare nanoparticles encapsulating β-carotene through flash nanoprecipitation. (princeton.edu)
Polymer4
  • This characteristic branching distinguishes a dextran from a dextrin, which is a straight chain glucose polymer tethered by α-1,4 or α-1,6 linkages. (wikipedia.org)
  • In one embodiment, the nanocage is covalently attached to a polymer shell (e.g. a dextran shell). (justia.com)
  • A novel cationic polymer, dextran-spermine (D-SPM), has been found to mediate gene expression in a wide variety of cell lines and in vivo through systemic delivery. (biu.ac.il)
  • The analysis of these results, in terms of a statistical-mechanical model that incorporates polymer flexibility as well as the excluded volume of the protein, shows that the dramatic enhancement of bovine pancreatic trypsin inhibitor self-association can be quantitatively rationalized in terms of hard repulsive interactions. (lu.se)
Biocompatibility1
  • Owing to its ease of preparation, processability, pH-sensitivity, and biocompatibility, this type of modified dextran should find use in numerous drug delivery applications. (edu.sa)
Vascular1
  • The antithrombotic effect of dextran is mediated through its binding of erythrocytes, platelets, and vascular endothelium, increasing their electronegativity and thus reducing erythrocyte aggregation and platelet adhesiveness. (wikipedia.org)
Biocompatible1
  • Biocompatible amphiphilic block copolymer dextran-bpoly(L-lactide) was synthesized by the end-to-end coupling of amino-terminated dextran and acryloyl-terminated poly(L-lactide). (princeton.edu)
Expander3
  • Medicinally it is used as an antithrombotic (antiplatelet), to reduce blood viscosity, and as a volume expander in hypovolaemia. (wikipedia.org)
  • Dextran has traditionally been used in infusion fluid and volume expander products. (xawanlong.net)
  • Partially hydrolyzed dex-tran reduces blood viscosity and is used as a plasma substitute and a volume expander. (pharmacy180.com)
Albumin4
  • The authors infused 25 ml/kg of Ringer acetate solution, 5 ml/kg of 6% dextran 70 in 0.9% NaCl, and 3 ml/kg of 7.5% NaCl over 30 min in 8 male volunteers aged from 25 to 36 years (mean, 31 years) and measured the changes in total hemoglobin, serum albumin, and total blood water over time. (silverchair.com)
  • Serum albumin indicated a more pronounced dilution, which resulted in a larger expandable volume and a greater mean square error for the curvefitting. (silverchair.com)
  • The larger volume obtained for serum albumin can probably be explained by a loss of intravascular albumin into the tissues along with the infused fluid. (silverchair.com)
  • It often is taken as the change in distribution volume of radio-labeled or Evans blue-labeled albumin induced by volume loading. (silverchair.com)
Electrolyte1
  • Water and Sodium Balance Body fluid volume and electrolyte concentration are normally maintained within very narrow limits despite wide variations in dietary intake, metabolic activity, and environmental stresses. (merckmanuals.com)
Axonal1
  • In the present study spinal cord blood flow (SCBF), measured by the hydrogen clearance technique, and motor and somatosensory evoked potentials (MEP and SSEP) were recorded to evaluate whether the administration of nimodipine and dextran 40, alone or in combination, could increase posttraumatic SCBF and improve axonal function in the cord after acute SCI. (thejns.org)
Molecular2
Acetal1
  • In our nano-carrier, the amine groups are conjugated to the dextran platform through the acetal bonds, which are acid sensitive. (johnshopkins.edu)
Endosomes2
  • fluorescent-labelled dextran can be used to visualize these endosomes under a microscope. (wikipedia.org)
  • Therefore this siRNA carrier is stable in neutral and basic conditions, while the amine groups can be cleaved and released from dextran platform under weak acid conditions (such as in endosomes). (johnshopkins.edu)
Concentrations2
  • Cardiovascular effects of D-70 correlated with a dose-dependent increase in plasma dextran concentrations. (utmb.edu)
  • In the presence of high concentrations of inert macromolecules, the self-association of proteins is strongly enhanced through an entropic, excluded-volume effect variously called macromolecular crowding or depletion attraction. (lu.se)
20161
  • Chen, Z , Krishnamachary, B & Bhujwalla, ZM 2016, ' Degradable dextran nanopolymer as a carrier for choline kinase (Chok) siRNA cancer therapy ', Nanomaterials , vol. 6, no. 2. (johnshopkins.edu)
Colloid2
  • Thus, non-oxygen-carrying fluids (eg, crystalloid or colloid solutions) may be used to restore intravascular volume in mild to moderate blood loss. (merckmanuals.com)
  • If there is not adequate response to therapy, the remainder volume can be given as a colloid such as Haemacell, Dextran or Hetastarch (10-20 ml/kg/day). (vin.com)
ISSN1
  • Drought impact on pharmaceuticals in surface waters in Europe: Case study for the Rhine and Elbe basins, Science of The Total Environment, Volume 922, 2024, 171186, ISSN 0048-9697, https://doi.org/10.1016/j.scitotenv.2024.171186 . (janusinfo.se)
Behavior2
  • The miscibility behavior of dextran (Dx) with synthesized functional binary poly(citraconic anhydride-acrylamide) (poly(CA-alt-AAm) and ternary poly(citraconic anhydride-acrylamide-vinyl acetate) (poly(CA-co-AAm-co-VA) copolymers was investigated in dilute aqueous solutions by viscometry and in a solid state by Fourier transform infrared (FTIR) spectroscopy. (hacettepe.edu.tr)
  • Here, we investigated the effects of hypoxia and dextran-shelled OLNs on the pro-angiogenic phenotype and behavior of human dermal microvascular endothelium (HMEC-1 cell line), another cell population playing key roles during wound healing. (unito.it)
Injection2
Fluorescent1
  • To determine the performance of a rapid fluorescent indicator technique for measuring plasma volume (PV). (karger.com)
Analyze1
  • Therefore, a mathematical model was tested to analyze the volume kinetics of three types of fluids. (silverchair.com)
Intravascular volume5
  • states require large-volume IV fluid replacement, as does severe intravascular volume depletion (eg, due to diarrhea or heatstroke). (merckmanuals.com)
  • Intravascular volume deficiency is acutely compensated for by vasoconstriction, followed over hours by migration of fluid from the extravascular compartment to the intravascular compartment, maintaining circulating volume at the expense of total body water. (merckmanuals.com)
  • Intravascular volume deficiency. (merckmanuals.com)
  • Clinicians must carefully adjust intravascular volume and arterial blood pressure to effectively perfuse the graft, and the time course of volume expansion seems important for adequate hydration. (intechopen.com)
  • Key strategies that are used to achieve this goal involve the optimal management of the intravascular volume and achievement of early urine output. (intechopen.com)
Carrier1
  • We present a degradable dextran with amine groups as an siRNA nano-carrier. (johnshopkins.edu)
20001
  • Dextran chains are of varying lengths (from 3 to 2000 kilodaltons). (wikipedia.org)
Tissue2
Species1
  • The structure of dextran produced depends not only on the family and species of the bacterium but on the strain. (wikipedia.org)
Trauma1
Plasma volume1
Hypovolemia2
  • Outside of these features, larger dextrans, which do not pass out of the vessels, are potent osmotic agents, thus have been used urgently to treat hypovolemia[citation needed]. (wikipedia.org)
  • Despite the established efficacy of 7.5% NaCI/6% dextran-70 in the treatment of hypovolemia, the optimal formulation of a hyperosmotic/hyperoncotic small volume resuscitation solution has yet to be defined. (utmb.edu)
Significantly2
  • Diabetes did not significantly alter the BRB, but both statins decreased the volume of distribution of 70- and 40-kDa dextrans in the retina. (diabetesjournals.org)
  • A prior history of ID was associated with smaller total brain volumes, driven primarily by significantly less total gray matter (GM) and smaller GM volumes in several cortical regions. (frontiersin.org)
Blood7
  • The hemodilution caused by volume expansion with dextran use improves blood flow, thus further improving patency of microanastomoses and reducing thrombosis. (wikipedia.org)
  • The larger dextrans (>60,000 Da) are excreted poorly from the kidney, so remain in the blood for as long as weeks until they are metabolized. (wikipedia.org)
  • Dextran also increases blood sugar levels. (wikipedia.org)
  • 1,2 ] This approach has been used, for example, to show that Ringer solution increases the blood volume by 20-25% of the given amount of fluid. (silverchair.com)
  • Blood Products Whole blood can provide improved oxygen-carrying capacity, volume expansion, and replacement of clotting factors and was previously recommended for rapid massive blood loss. (merckmanuals.com)
  • Blood volumes (BV) were calculated based on PV and the subject's hematocrit. (karger.com)
  • The functionality of the matured microvasculature networks was demonstrated through the enhancement of cell-cell adhesion, angiogenesis process, and perfusion tests with microparticles, FITC-dextran, and whole mouse blood. (lu.se)
Formulations1
  • Recently, a new copolymer (Fisiograft®) , Ghimas SpA, Casalecchio di Reno, Italy) of 50% DL lactic acid and 50% glycolic acid (50 PLA: 50 PGA) mixed with dextran 125 as excipient, has been marketed in different formulations, such as sponge, gel, and powder. (bvsalud.org)
Bonds1
  • When the two reagents are combined, thiol groups on CD-Link form stable thioether bonds with thiol-reactive groups on SG-Dextran, which results in the formation of the gel. (ilexlife.com)
Therapy3
  • In this family, dextran-40 (MW: 40,000 Da), has been the most popular member for anticoagulation therapy. (wikipedia.org)
  • Transcranial Doppler-directed Dextran-40 therapy is a cost-effective method of preventing carotid thrombosis after carotid endarterectomy. (ox.ac.uk)
  • Postoperative thrombotic stroke may be reduced in incidence by the use of transcranial Doppler-directed Dextran-40 therapy. (ox.ac.uk)
Applying osmotic pressure1
  • citation needed] Dextran can be used in an ATPS for PEGylation Dextran is used in the osmotic stress technique for applying osmotic pressure to biological molecules. (wikipedia.org)
Therapeutic1
  • The volume expansion effect of the administered fluid is believed to be the therapeutic goal. (silverchair.com)
Iron1
  • 12 met clinical criteria for anemia and were administered iron dextran and B vitamins for 1-2 months. (frontiersin.org)
Effect2
  • This volume effect, however, is difficult to study. (silverchair.com)
  • At the macrostructual level, the effect on white matter volumes (WM) was not as overt. (frontiersin.org)
Fluid1
  • The curves were fitted to a one-volume and a two-volume model, which allowed an estimation of the size of the body fluid space expanded by the fluid (V) and the elimination rate constant (k(r) to be made. (silverchair.com)
Solutions1
  • Dextran is a complicating contaminant in the refining of sugar because it elevates the viscosity of sucrose solutions and fouls plumbing. (wikipedia.org)
Function1
  • Dextrans also reduce factor VIII-Ag Von Willebrand factor, thereby decreasing platelet function. (wikipedia.org)