Volume nucleic acid conformation. Medical search. Frequent questions

VLPs self-assembled into empty shells can be used safely as vaccines without the risk of replication or infection due to the lack of viral nucleic acid. (nature.com)
VLPs are highly immunogenic and can induce elevated titers of neutralizing antibodies, even without adjuvants, thanks to the maintenance of the native conformation of viral proteins presenting repetitive epitopes to the host immune system cells. (nature.com)

Cantor's laboratory at Boston University has developed methods for separating large DNA molecules, for studying structural relationships in complex proteins and nucleic acids, and for sensitive detection of proteins and nucleic acids in a variety of settings. (wikipedia.org)
Biochemical processes within the living cell occur in a highly crowded environment, where macromolecules, first of all proteins and nucleic acids, occupy up to 30% of the volume. (bvsalud.org)

Using reconstitution and knock-in models, we report that mutation of key amino acids involved in Z-DNA/RNA binding in ZBP1's ZBDs prevented necroptosis upon infection with mouse cytomegalovirus. (ox.ac.uk)

In post-doctoral work with Thomas Jukes he studied repetitive sequences in polypeptides, but most of his independent research has concerned nucleic acids, from his early work with nuclear magnetic resonance (NMR) and repetitive sequences in polydeoxyribonucleotides. (wikipedia.org)

The tecnique of SSCP analysis is based on the principle that changes in nucleic acid composition affect the conformation of single stranded DNA and thereby the mobility of the fragment when it is subjected to electrophoresis under non-denaturing conditions. (bmj.com)

Mutations that disrupted secondary RNA structure or the AAACA/G motif, without altering the amino acid sequence of 3D(pol), ablated replication of a subgenomic HAV replicon in transfected human hepatoma cells. (ox.ac.uk)

He is also a co-founder and Director of Retrotope, a US-based company using heavier isotopes of carbon (13C) and hydrogen (2H, deuterium) to stabilize essential compounds like amino acids, nucleic acids and lipids to target age-related diseases. (wikipedia.org)
It can be used to measure the intramolecular stability of a broad spectrum of biomolecules, including proteins, nucleic acids, lipids and detergent micellar systems. (lu.se)

Changes to the conformation of coding and non-coding RNAs form the basis of elements of genetic regulation and provide an important source of complexity, which drives many of the fundamental processes of life. (duke.edu)
Possibly combined with an excluded volume osmosis effect (EVO), hydrophobic catalysis may have important biological roles, e.g., in genetic recombination. (chalmers.se)

Nucleic acids are potent triggers for innate immunity. (ox.ac.uk)

The Chromosome Conformation Capture (3C) assay is a powerful technique to detect looping structures and assess the probability of interaction between distant genomic elements (1-3). (bath.ac.uk)
Different theoretical methods for the description of nucleic acid structures are reviewed. (ub.edu)
Firstly, we introduce the concept of classical force-field in the context of nucleic acid structures, discussing their accuracy. (ub.edu)
Special emphasis is made ion current state of the art molecular dynamics simulations of nucleic acids structures. (ub.edu)
As an integrative method, PyRy3D works with a wide variety of data, such as structures, distance restraints, information about solvent exposure and complex volume. (genesilico.pl)
8-Br-dG should prove useful as a chemical probe for the conformation about glycosidic bonds in unusual nucleic acid structures. (caltech.edu)
2021). Specifically, nanoporous electrode structures decreased Debye volume and reduced the effect of charge screening within nanopores to accelerate electron transfer between redox-tagged aptamer that mediates target recognition, and the surface of gold electrode. (stanford.edu)

Although the structure of RNA is highly flexible, the underlying dynamics of RNA are robust and are limited to transitions between the few conformations that preserve favourable base-pairing and stacking interactions. (duke.edu)
Chemical modifications are powerful tools to probe nucleic acid structure and protein-nucleic acid interactions. (caltech.edu)

Data mining of molecular dynamics trajectories of nucleic acids. (irbbarcelona.org)
Recent advances in the study of nucleic acid flexibility by molecular dynamics. (irbbarcelona.org)
We then examine theoretical approaches to the description of nucleic acids based on: i) a rigid or quasi-rigid description of the molecule, ii) molecular mechanics optimization, and iii) molecular dynamics. (ub.edu)

Cantor's three-volume book Biophysical Chemistry, co-authored with Paul Schimmel, was an influential textbook in the 1980s and 1990s. (wikipedia.org)
He is a consultant to more than 16 biotech firms, has published more than 400 peer reviewed articles, been granted 54 US patents, and co-authored a three-volume textbook on Biophysical Chemistry. (wikipedia.org)
Biophysical Chemistry: Part I: The Conformation of Biological Macromolecules. (wikipedia.org)

Exploring polymorphisms in B-DNA helical conformations. (irbbarcelona.org)
Double-stranded DNA and RNA adopt different helical conformations, including the unusual Z-conformation. (ox.ac.uk)

New approaches have been developed that take advantage of topological constraints in determining RNA backbone conformation based on secondary structure, and a limited set of other, easily accessible constraints. (duke.edu)
Geometrical and electronic structure variability of the sugar-phosphate backbone in nucleic acids. (irbbarcelona.org)

During the complex building procedure, PyRy3D changes conformations of these regions (or their shape) to mimic their dynamics. (genesilico.pl)
For example, all simulated regions are composed of pseudoatoms of a given radius (3.5A for proteins and 7.5A for nucleic acids). (genesilico.pl)

BIGNASim: a NoSQL database structure and analysis portal for nucleic acids simulation data. (irbbarcelona.org)

Scholars@Duke publication: Topological constraints: using RNA secondary structure to model 3D conformation, folding pathways, and dynamic adaptation. (duke.edu)

Complete L amino acid sequences were aligned by using ClustalW ( https://www.clustal.org ) and refined by using MUSCLE ( https://www.ebi.ac.uk/Tools/msa/muscle ) with default settings. (cdc.gov)

Macrocyclic scaffolds are particularly attractive for designing selective G-quadruplex ligands essentially because, on one hand, they show a poor affinity for the "standard" B-DNA conformation and, on the other hand, they fit nicely with the external G-quartets of quadruplexes. (hindawi.com)

The cDNA encodes a protein of 351 amino acids tentatively named FPR2, with a calculated molecular weight of 39 kDa. (unm.edu)
Steric pressure induced by membrane-tethered synthetic and protein crowders altered the sensors' conformation, causing increase in the intramolecular Förster's resonance energy transfer. (bvsalud.org)

The VP-DSC provides fast, accurate transition midpoint (Tm) determination, as well as a thermodynamic profile that can provide insight into the factors that affect conformation and stability. (lu.se)

Nucleic Acids Research , 17 (8), 3229-3245. (tmu.edu.tw)

Nanostructured electrodes have been shown to demonstrate superior sensing properties including better signal levels and faster diffusion of redox species to achieve high higher limit of detection for hybridization-based nucleic detection compared to their planar counterparts. (stanford.edu)
in 2009 which described an elegant way to tune the nanostructures for nucleic acid detection over a wide dynamic range. (stanford.edu)

Cantor's reviews include one on the physical chemistry of nucleic acids. (wikipedia.org)

However, target binding causes aptamer to adopt a folded conformation, bringing reporter tag into closer proximity to electrode surface to increase electron transfer to generate signals. (stanford.edu)

It is becoming increasingly apparent that chromatin is not randomly folded into the nucleus, but instead is highly organized into specific conformations within the nucleus. (bath.ac.uk)
To dissect the dynamic regulation of Runx1 in hematopoietic development, we analyzed its three-dimensional chromatin conformation in mouse embryonic stem cell (ESC) differentiation cultures. (ox.ac.uk)

16 this range (primarily cytochrome P-450 mediated oxidation to fatty acids and alcohols) is slow, while the aromatics are metabolized faster (oxidation of alkyl site and/or ring, sometimes with formation of reactive intermediates, and conjugation with glutathione, glucuronic acid, or glycine) (ATSDR 1999). (cdc.gov)

However, the flexibility modeling implemented in our method enables to fill the density map shape by adequate complex volume rather than building realistic full-atom models. (genesilico.pl)

Refinement of the AMBER force field for nucleic acids: improving the description of alpha/gamma conformers. (irbbarcelona.org)

Today the most frequently used methods for prescreening disease genes for mutations are single strand conformation polymorphism analysis (SSCP) and denaturing high performance liquid chromatography (DHPLC). (bmj.com)

The phylogenetic analysis was performed on MEGA X ( 23 ) by using the maximum-likelihood method and Le Gascuel matrix plus observed amino acid frequencies plus 5 discrete gamma categories distribution with parameter of 1.0728 plus invariant sites with 0.65% sites. (cdc.gov)

Researchers can access related articles from current and back volumes by purchasing access to these collections. (eurekaselect.com)

Nucleic acids can be modified either randomly by a variety of chemical reagents or site-specifically with synthetic base analog substitutions. (caltech.edu)

Anatomy4

Organisms8

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes91

Disciplines and Occupations8

Technology, Industry, Agriculture4

Information Science12

Health Care4

Viral2

Proteins and nucleic acids2

Mutation1

Nuclear magnetic1

Single stranded1

Amino Acid Seq1

Lipids2

Genetic2

Innate1

Structures7

Interactions2

Molecular dynamics3

Biophysical Chemistry3

Helical conformations2

Backbone2

Regions2

Simulation1

Publication1

Https1

Affinity1

Protein2

Stability1

Research1

Detection2

Chemistry1

Adopt1

Chromatin2

19991

Models1

Force field1

Methods1

Gamma1

Access1

Variety1