• genes
  • All these genes code for ion channels. (bmj.com)
  • Functionally important candidate genes upregulated in the VMN, including at time points corresponding to high natural vocal activity, encode ion channels and neurotransmitter receptors, hormone receptors and biosynthetic enzymes, neuromodulators, aerobic respiration enzymes, and antioxidants. (biomedcentral.com)
  • gene
  • Abnormalities of ion channel function are responsible for a variety of non-neurological disorders including Bartter syndrome, X linked nephrolithiasis, neonatal hyperinsulinism, long QT syndromes, and most notably defects in function of the CFTR chloride channel gene causing cystic fibrosis. (bmj.com)
  • Such genetic methods allowed the genetic identification of the "Shaker" K+ channel gene in Drosophila before ion channel gene sequences were well known. (wikipedia.org)
  • hERG
  • KCNE2 was originally discovered to regulate hERG channel function. (wikipedia.org)
  • New compounds such as the HERG channel activator (3 R ,4 R )-4-[3-(6-methoxy-quinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]-piperidine-3-carboxylic acid (RPR260243) will enable us to increase our understanding in cation channel modulation and to test the concept of channel activation as a clinically relevant principle in treatment of channelopathies. (aspetjournals.org)
  • cardiac
  • The condition may be life-threatening if weakness of the breathing muscles leads to respiratory failure , or if the low potassium levels lead to cardiac arrhythmias (irregularities in the heart rate). (wikipedia.org)
  • influx
  • In ventricular myocytes, excitation-contraction (EC) coupling occurs via a Ca 2+ induced Ca 2+ release mechanism such that the depolarization created by an action potential (AP) triggers Ca 2+ influx through voltage-dependent L-type Ca 2+ channels (i.e. (washington.edu)
  • Using electrophysiological, and optical approaches, we have found that an allosteric interaction between the C-terminal domains of voltage-gated Ca V 1.2 channels induces an increase in the open probability of the channels that amplifies Ca 2+ influx during the AP and contributes to reproducible EC-coupling. (washington.edu)
  • cation channel
  • Shortage in cation channel activators prevents testing of efficiency of activators in a variety of indications. (aspetjournals.org)
  • This shortage might result from the relative incapability of modern drug screening methods, but increasing knowledge about cation channel activator binding and action might enable us in the future to use in silico-guided drug design of channel modulators. (aspetjournals.org)
  • mechanism
  • The mechanism that permits coordinated opening of multiple Ca v 1.2 channels during EC-coupling, however, has not yet been elucidated. (washington.edu)
  • activation
  • In addition, the most common treatments for asthma, β-adrenergic agonists, apparently confer much of their effects through activation of large conductance Ca 2+ -activated (BK-type) K + channels ( Kotlikoff and Kamm, 1996 ). (frontiersin.org)
  • include
  • The fruits of these collaborations include recognition that diseases caused by ion channel dysfunction may have genetic and autoimmune aetiologies. (bmj.com)
  • current
  • The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and is activated by retigabine, a novel anti-convulsant drug. (bertin-bioreagent.com)
  • This charge transfer is measured as a transient capacitive current that precedes opening of the channel. (wikipedia.org)
  • regulation
  • In this study, we tested whether K V 1.5 channels are involved in the control of mesenteric arterial tone and its regulation by PVAT. (frontiersin.org)
  • Over the past decade, various potassium (K + ) channels have been implicated as important players in the regulation of arterial vascular tone and its control by perivascular adipose tissue (PVAT). (frontiersin.org)