Vivo magnetic resonance spectroscopy. Medical search. Frequent questions

Magnetic resonance spectroscopy (MRS), also known as nuclear magnetic resonance (NMR) spectroscopy, is a non-invasive, ionizing-radiation-free analytical technique that has been used to study metabolic changes in brain tumors, strokes, seizure disorders, Alzheimer's disease, depression, and other diseases affecting the brain. (wikipedia.org)
With the development and optimization of non-invasive techniques, such as nuclear magnetic resonance spectroscopy (MRS), several groups have worked on assessing cerebral metabolism in vivo . (frontiersin.org)
The primary methods used by investigators in this Branch are PET (positron emission tomography) and NMR (nuclear magnetic resonance). (nih.gov)
A great deal of my research involves MRI and in vivo nuclear magnetic resonance (NMR) spectroscopy. (mcmaster.ca)
Of particular importance is the use of 19F nuclear magnetic resonance spectroscopy to measure dissolved oxygen levels in vivo. (confex.com)
Analytical methods such as mass spectrometry and nuclear magnetic resonance spectroscopy allow our team to study metabolic consequences of altered energy and protein metabolism. (mayo.edu)
Commenting on the findings for Medscape Medical News , George M. Anderson, PhD, from Yale University, New Haven, Connecticut, called it "an important contribution to the now more than 20 studies that have used NMR [nuclear magnetic resonance] spectroscopy to measure in vivo levels of neurochemicals in brains of children and adults with autism. (medscape.com)
Dr. Grame F. Mason develops experimental models and methods for studies of brain metabolism using 1H and 13C Nuclear Magnetic Resonance (NMR) and Mass Spectrometry in conjunction with 13C isotopic labeling in vivo, in cell preparations, and other systems. (yale.edu)
Arai T, Nakao S, Mori K, Ishimori K, Morishima I, Miyazawa T, Fritz-Zieroth B (1990) Cerebral oxygen utilization analyzed by the use of oxygen-17 and its nuclear magnetic resonance. (springer.com)
Arai T, Mori K, Nakao S, Watanabe K, Kito K, Aoki M, Mori H, Morikawa S, Inubushi T (1991) In vivo oxygen-17 nuclear magnetic resonance for the estimation of cerebral blood flow and oxygen consumption. (springer.com)
Progress in Nuclear Magnetic Resonance Spectroscopy, 134-135, 52-64. (edu.au)
Molecular mobility in keratin-rich materials monitored by nuclear magnetic resonance: A tool for the evaluation of structure-giving properties. (lu.se)
Molecular dynamics simulations and solid-state nuclear magnetic resonance spectroscopy measurements of C-H bond order parameters and effective correlation times in a POPC-GM3 bilayer. (lu.se)

In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (MRS) provides non-invasive information about phospholipid metabolism. (westminster.ac.uk)

In vivo magnetic resonance spectroscopy (MRS) is a specialized technique associated with magnetic resonance imaging (MRI). (wikipedia.org)
Magnetic resonance spectroscopy is an analytical technique that can be used to complement the more common magnetic resonance imaging (MRI) in the characterization of tissue. (wikipedia.org)
Magnetic Resonance Spectroscopic Imaging (MRSI): a 2-dimensional (or 3-dimensional) MRS technique which uses two/three phase-encoding directions to create a two/three-dimensional map of spectra. (wikipedia.org)
This discovery formed the basis of a powerful technique used nowadays to study brain activity: blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI). (frontiersin.org)
Is the Subject Area "Magnetic resonance imaging" applicable to this article? (plos.org)
We sought to develop a clinical workflow and uniquely capable custom software tool to integrate advanced 3-tesla 3D proton magnetic resonance spectroscopic imaging ( 1 H-MRSI) into industry standard image-guided neuronavigation systems, especially for use in brain tumor surgery. (karger.com)
These two sections include a strong methodological orientation, with state-of-the-art facilities to develop, evaluate, and then apply new radiotracers for in vivo imaging. (nih.gov)
The Section on Magnetic Resonance Spectroscopy (MRS) develops and applies both high-resolution and in vivo MRS and imaging techniques. (nih.gov)
Working with high-field magnetic resonance spectrometers, this Section develops novel NMR methods and applies them to the study of neurotransmission and neurometabolism, with significant opportunities available for multi-modal collaborative imaging using MRS, MRI, and PET. (nih.gov)
Most MRI/fMRI studies are carried out on the 3 and 7 Tesla magnets at the Functional Magnetic Resonance Imaging Core Facility or Clinical Center Radiology Department. (nih.gov)
[ 1 ] Magnetic resonance imaging (MRI) of the brain is useful in the diagnosis and treatment of multiple sclerosis . (medscape.com)
Magnetic resonance imaging revealed extradural spinal cord compression at the ventral right aspect of the intervertebral disk space L3-4. (avma.org)
She specialises in understanding regulation of glucocorticoid action in metabolic and inflammatory diseases and has developed innovative tools to study steroid metabolism and flux in vivo, most recently by mass spectrometry imaging. (ed.ac.uk)
I am Director of the Centre for In Vivo Imaging , which represents Newcastle University's in vivo imaging portfolio. (ncl.ac.uk)
My interdisciplianry research team is focused on the development of innovative magnetic resonance imaging (MRI) and spectroscopy methods to characterise the structure, function and physiology of human tissues and organs through non-invasive and repeatable scans. (ncl.ac.uk)
Among these, Raman spectroscopy has attracted increasing attention as a highly sensitive molecular imaging technique for studying complex biological systems, including cells, tissues, and various biological materials [ 4 ]. (medsci.org)
Advances in radiologic imaging techniques, such as computed tomography (CT) scanning and magnetic resonance imaging (MRI), have improved the ability to predict the success for complete removal of the mass. (medscape.com)
Alonso BD, Lowe AS, Dear JP, Lee KC, Williams SC, Finnerty GT (2008) Sensory inputs from whisking movements modify cortical whisker maps visualized with functional magnetic resonance imaging. (springer.com)
the further development and commercialization of in vivo imaging technologies, 2. (nih.gov)
In addition, the property of Mn as Magnetic Resonance Imaging (MRI) contrast agent may be used to study Mn deposition in the human brain. (cdc.gov)
The wide range of related subjects covered, including basic Magnetic Resonance Imaging theory, practical applications and hands on experience, gives you a broad understanding of Magnetic Resonance Imaging. (abdn.ac.uk)
You will be in the advantageous position of learning in an environment that was pivotal in the early development of Magnetic Resonance Imaging and continues to contribute to its development. (abdn.ac.uk)
Dr. Yurgelun-Todd is an expert in the application of structural and functional magnetic resonance imaging, the administration and analysis of neurocognitive tests, and the integration of the results obtained by using multiple imaging modalities combined with clinical assessment. (va.gov)
Nonparametric 5D D-R2 distribution imaging with single-shot EPI at 21.1 T: Initial results for in vivo rat brain. (lu.se)
Multidimensional diffusion magnetic resonance imaging for characterization of tissue microstructure in breast cancer patients: A prospective pilot study. (lu.se)
For instance, functional magnetic resonance imaging monitors the blood oxygen level dependent (BOLD) contrast but is sensitive only to deoxygenated hemoglobin and the MRI machine is bulky. (lu.se)
Olsson E, Folkesson E, Peterson P, Önnerfjord P, Tjörnstrand J, Hughes HV, Englund M, Svensson J. Ultra-high field magnetic resonance imaging parameter mapping in the posterior horn of ex vivo human menisci. (lu.se)

In vitro spectra from CDR patients showed elevated PE and PC, mirroring the in vivo changes in PME, but reduced GPE and GPC concentrations were observed, at variance with the in vivo PDE findings. (westminster.ac.uk)
The algorithm for assessing radio protective potential of plant extracts and natural products was assessed via some target in vitro and in vivo tests and clinical trials. (europa.eu)
Preliminary In Vitro and In Vivo Evaluation of Antidiabetic Activity of Ducrosia anethifolia Boiss. (hindawi.com)
Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
Os estudos in vitro estão livres da complexidade e fatores de confusão próprios dos modelos in vivo e ensaios clínicos. (bvsalud.org)

Phosphorus magnetic resonance spectroscopy (31P-MRS) was used to study in vivo the energy metabolism of brain and skeletal muscle in two members of an Italian pedigree with NARP syndrome due to a point mutation at bp 8993 of mtDNA. (nih.gov)
Here, we review state-of-the-art MR methods to study brain function and metabolism in vivo , and their contribution to the current understanding of how astrocytic energy metabolism supports glutamatergic activity and cerebral function. (frontiersin.org)
Phosphorus ( 31 P) magnetic resonance spectroscopy (MRS) is known to be a powerful tool in the assessment of cell energy metabolism [ 1 - 3 ]. (frontiersin.org)

Existing technology, such as Positron Emission Tomography (PET), Magnetic Resonance Spectroscopy (MRS), and Single-photon emission computed tomography (SPECT), are currently optimal only for a limited range of molecules. (nih.gov)

Single Voxel Spectroscopy (SVS): has a minimum spatial resolution of approximately 1 cm3, and has the cleanest spectrum free from unwanted artifacts due to the small acquired volume leading to easy shim and less unwanted signals from outside the voxel. (wikipedia.org)
This was verified by phantom measurements, where an SNR increase of 46% could be observed for localized 31 P spectroscopy in a voxel positioned comparable to an in vivo cardiac measurement scenario. (frontiersin.org)

Several NMR methods are also studied to measure molecular targets (magnetic resonance spectroscopy (MRS)), local neuronal activity (functional MRI (fMRI)), and brain structure (structural MRI). (nih.gov)

By recording neuronal activity in vivo , Yizhar found that neurons in the medial prefrontal cortex of Cntnap2 homozygous mice have enhanced activity compared with wild-type littermates. (sfari.org)

Currently, the improvement of detection modalities (i.e., direct detection of 13 C isotopomers), the progress in building adequate mathematical models along with the increase in magnetic field strength now available render possible detailed compartmentalized metabolic flux characterization. (frontiersin.org)
Quantum sensors with nitrogen-vacancy (NV) diamonds have key potential in chemical analysis, NMR spectroscopy, and materials characterization. (researchandmarkets.com)

Applications in clinical medicine can benefit from fusion of spectroscopy data with anatomical imagery. (karger.com)
Our projects span the intersection of magnetic resonance physics, bioscience and clinical research, and aim to develop reliable and valuable quantitative measurements for implementation in clinical research and development into robust tools used in clinical practice. (ncl.ac.uk)

Assessment of brain metabolite correlates of adeno-associated virus-mediated over-expression of human alpha-synuclein in cortical neurons by in vivo (1) H-MR spectroscopy at 9.4 T. (lu.se)

Correlation of Serum Biomarkers and Magnetic Resonance Spectroscopy in Monitoring Disease Progression in Patients With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Due to mtDNA A3243G Mutation. (cdc.gov)

For example, new 3-dimensional (3D) spectroscopy techniques allow for improved correlation of metabolite profiles with specific regions of interest in anatomical tumor images, which can be useful in characterizing and treating heterogeneous tumors that appear structurally homogeneous. (karger.com)

The ability of magnetic resonance spectroscopy (MRS) to differentiate neoplastic brain cells and their metabolic and structural characteristics is evaluated. (nih.gov)
In vivo MRS is a method for non-invasive assessment of the homeostasis and dynamics of important endogenous, metabolically active compounds and neurotransmitters in the brain. (nih.gov)
http://nlamh.mclean.harvard.edu/ Dr. Silveri uses non-invasive magnetic resonance techniques to examine brain structure, function & neurochemistry, in healthy adolescents, emerging adults, and adults, and those with addictions and psychiatric illnesses. (researchgate.net)
Dr. Mason received further training at the University of Alabama at Birmingham, where he guided the group's 13C-labeling studies of the human brain in vivo in the 4.1T whole-body MR system. (yale.edu)
A continuing impediment to the understanding and diagnosis of brain disorders is our limited ability to non-invasively visualize viruses, proteins, metabolites, and other molecules in the brain in vivo. (nih.gov)

The effects of caloric restriction (CR) on in vivo muscle mitochondrial function in humans are controversial. (medscape.com)

A series of 1H NMR spectra were recorded in vivo at a short echo time of 35 ms using a 3 T GE magnetic resonance apparatus for two groups of five healthy voluntaries and five patients with endometrial cancer. (sogr.ro)

New PET radiotracers are synthesized for use as in vivo ligands to measure many different molecular targets, including membrane-bound receptors, proteins associated with intracellular signal transduction, and ones that reflect gene expression. (nih.gov)
Raman spectroscopy analyzes the biochemical components of a sample by measuring the inelastic scattering of light by different molecular species, producing a spectrum based on the chemical bonds present within the analyzed samples. (medsci.org)

MRI spectroscopy can be used to detect malignant meningiomas by comparing the metabolic and chemical contents of the healthy tissue with malignant tumor. (medscape.com)

A list of the metabolites with highest concentration (total choline, Alanine, lactate, intramyocellular lipids, N-acetyl aspartate, Glucose) was used together with water content, sum of a macromolecular resonances, sum of all other metabolites and age of volunteers/patients into an Principal Component Analysis (PCA). (sogr.ro)
Proton MRS (1 H-MRS) enables in vivo measurement of small molecules implicated in multiple sclerosis, but its application to key metabolites glutamate, γ-aminobutyric acid (GABA), and glutathione has been sparse. (lu.se)

In MRS, STEAM (Stimulated Echo Acquisition Method) and PRESS (Point Resolved Spectroscopy) are the two primary pulse sequence techniques used. (wikipedia.org)
Currently, the commonly used methods to quantify heavy water concentration include the density method, mass spectrometry, and spectroscopy techniques [ 3 ]. (medsci.org)
The system was validated in vivo against complementary techniques, including white light and diffuse reflectance spectroscopy. (lu.se)

We conducted an ancillary study to the CALERIE 2 randomized controlled trial to examine the effects of 12 months of 25% CR on in vivo skeletal muscle mitochondrial energetics, mitochondrial content, and markers of oxidative stress. (medscape.com)

Much of our work involves the use of stable isotope tracers to label proteins in vivo and study synthesis and accumulation of individual proteins. (mayo.edu)

Langendorff-mode isolated heart perfusion, in conjunction with 31 P NMR spectroscopy, combines the fields of biochemistry and physiology into one experiment. (jove.com)

In vivo mitochondrial function [maximal ATP synthesis rate (ATPmax), ATPflux/O 2 (P/O)] was determined by 31 P-magnetic resonance spectroscopy and optical spectroscopy, and body composition was determined by dual-energy X-ray absorptiometry. (medscape.com)

Magnetic resonance spectroscopy (MRS) studies have demonstrated neurochemical alterations in the frontal lobe of alcohol users, although most studies focused on older, alcohol-dependent s. (researchgate.net)

The low gyromagnetic ratio and in vivo concentration of 31 P results in a low intrinsic signal to noise ratio (SNR) ( 31 P-MRS has 100,000 × lower SNR than 1 H MRI [ 12 ]), which leads to low spatial and temporal resolution. (frontiersin.org)

Near infrared Spectroscopy (NIRS) and diffuse optical tomography (DOT) are spectroscopic methods that use light in the 690-nm to 850-nm range and can monitor changes in concentrations of oxygenated hemoglobin , deoxygenated hemoglobin, by using distinct absorption peaks at e.g. 850 nm and 760nm. (lu.se)

Edited Magnetic Resonance Spectroscopy (MRS) offers the unique possibility to measure gamma-aminobutyric acid (GABA) and other neurometabolites in vivo non-invasively in workers exposed to Mn. (cdc.gov)

Equipped with a Bruker Biospec 11.7T MRI the platform can proceed to a wide range of in vivo studies. (uclouvain.be)

Osprey is an all-in-one software suite for state-of-the art processing and quantitative analysis of in-vivo magnetic resonance spectroscopy (MRS) data. (nitrc.org)

These steps include: Shimming the magnetic field: this step is taken to correct for the inhomogeneity of the magnetic field by tuning different pulses in the x, y, and z directions. (wikipedia.org)
Wang X, Liu Nm, Zhao Yf, Yang F, Zhu Zj, Song D. Research Progress in the Medical Application of Heavy Water, Especially in the Field of D 2 O-Raman Spectroscopy. (medsci.org)

The in vivo activity was investigated by measuring some oxidative stress markers. (hindawi.com)

six patients with biliary duct strictures) were studied with in vivo 31P MRS. Peak area ratios of phosphomonoesters (PME) and phosphodiesters (PDE), relative to nucleotide triphosphates (NTP) were measured. (westminster.ac.uk)

Anatomy4

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