• In this study, the genotoxic effect of arsenic (As) and fluoride (F) in mice using comet, chromosomal aberration and lipid peroxidation assay was investigated. (ac.ir)
  • As a consequence, many sophisticated techniques including Ames Assay, in vitro and in vivo Toxicology Tests, and Comet Assay have been developed to assess the chemicals' potential to cause DNA damage that may lead to cancer. (wikipedia.org)
  • It is well known that there are in vitro and in vivo assay systems with different endpoints for evaluating chemical genotoxicity. (go.jp)
  • It is apparent that there are limitations of in vitro assay systems for chemical safety evaluation and risk assessment for human health, and in vivo assay systems are becoming more important from the viewpoint of weight of evidence. (go.jp)
  • There are several in vivo assay systems that have been developed and which are based on various endpoints. (go.jp)
  • Our genotoxicity testing services include the Ames test, chromosomal aberration test, in vitro micronucleus test, in vivo comet assay, and mouse lymphoma assay. (brfchennai.com)
  • In vitro mammalian chromosomal aberration assay (e.g. (brfchennai.com)
  • In vivo chromosomal aberration assay (e.g. (brfchennai.com)
  • In vivo Mammalian Alkaline Comet Assay (e.g. (brfchennai.com)
  • In vivo Pig-A Gene Mutation Assay (e.g. (brfchennai.com)
  • Do not donate of any health condition, or if the in vivo which is essential cell chromosome aberration test, and the prior to use. (autismcincy.org)
  • Among these, the rodent micronucleus test using hematopoietic cells has been most widely and frequently used to detect induction of chromosomal aberration. (go.jp)
  • It is evident that there are chemicals that gave a positive result in the in vitro chromosome aberration test but were negative in the rodent micronucleus test. (go.jp)
  • In the micronucleus test, development of the method using peripheral blood instead of bone marrow cells succeeded in reducing the total number of animals required for chromosomal aberration evaluation in vivo. (go.jp)
  • In-Vivo Micronucleus test using Mouse as Test System applying routine procedures and standard protocol. (sailife.com)
  • In vivo micronucleus test (e.g. (brfchennai.com)
  • In vivo Mammalian Erythrocyte Micronucleus Test (e.g. (brfchennai.com)
  • The effect of polymorphism of genes of xenobiotics detoxication on the frequencies of spontaneous and induced chromosome aberrations in human lymphocytes]. (cdc.gov)
  • It is well known that mammalian cells exposed to ionizing radiation can show different types of chromosome aberrations (CAs) including dicentrics, translocations, rings, deletions and complex exchanges. (unipv.it)
  • In vitro chromosome aberration test in mammalian cells (e.g. (brfchennai.com)
  • Genotoxicity tests comprise in vitro and in vivo assays to assess the effects on DNA and chromosomal structure and/or function. (nationalacademies.org)
  • The most extensive and important additions to the genotoxicity literature on fluoride since 1993 are in vivo assays in human populations and, to a lesser extent, in vitro assays using human cell lines and in vivo experiments with rodents. (nationalacademies.org)
  • Genotoxicity tests demonstrated that uf-TiO2 was negative in both the bacterial reverse mutation test and in an in vitro mammalian chromosome aberration test with Chinese hamster ovary cells. (rti.org)
  • This DNA damage can be in the form of single- and double-strand breaks, loss of excision repair, cross-linking, alkali-labile sites, point mutations, and structural and numerical chromosomal aberrations. (wikipedia.org)
  • The researchers concluded from testing that when metabolically activated, "PAs produce DNA adducts, DNA cross-linking, DNA breaks, sister chromatid exchange, micronuclei, chromosomal aberrations, gene mutations, and chromosome mutations in vivo and in vitro. (wikipedia.org)
  • Acrylamide has been shown to induce gene mutations in cultured animal cells and also in animals treated in vivo. (livsmedelsverket.se)
  • The most common mutations that cause Pelizaeus-Merzbacher disease are duplications of a region of the X chromosome that includes the entire PLP1 gene. (medscape.com)
  • In most cases, Pelizaeus-Merzbacher disease is caused by mutations of PLP1 on the long arm of the X chromosome (Xq22). (medscape.com)
  • With the newly developed in vitro and in vivo exposure systems specifically designed for extrapolation to human wireless phone usage, and the first epidemiology studies looking at health risks among cellular phone users, the WTR research added much needed perspective to the questions raised by previously published work. (medscape.com)
  • Chromosome aberrations as a measure of mutagenesis: comparisons in vitro and in vivo and in somatic and germ cells. (nih.gov)
  • The authors conclude that benzidine/DNA adducts are associated with chromosomal aberrations in- vivo, corroborating the findings on associations between in-vitro mutagenesis and transformation and levels of particular carcinogen DNA adducts. (cdc.gov)
  • Candidate gene association study of the radiosensitivity of human chromosomes with candidate gene polymorphisms upon exposure to gamma-irradiation in vitro and in vitro]. (cdc.gov)
  • Chromosomal aberrations in workers exposed to low levels of benzene: association with genetic polymorphisms. (cdc.gov)
  • The effect of genetic admixture in an association study: genetic polymorphisms and chromosome aberrations in a Colombian population exposed to organic solvents. (cdc.gov)
  • However, many of these studies have been conducted very recently, showing the in vivo hydroquinone toxicity exposure effects [ 16 - 20 ]. (hindawi.com)
  • In vivo pulmonary toxicity studies in rats demonstrated low inflammatory potential and lung tissue toxicity. (rti.org)
  • The existing methods for predicting long-term chemical toxicity-for example, analysis of structure-activity relationships (SAP,) and other correlational techniques, in vitro and in vivo short-term tests (STTs), and longer-term animal bioassays-all have valid, if different, uses at present and promise to become increasingly effective in the future, given appropriate research for their further development, validation, and integration. (nationalacademies.org)
  • The elevated level of chromosome aberrations for liquidators, as a whole, is observed for genotypes, which are characteristic of an elevated level of spontaneous aberrations, and it does not completely correspond to genotypes with the elevated radiosensitivity of chromosomes. (nih.gov)
  • It was shown that, for a group of liquidators heterozygote by site SOD2 C47T, the control level of the frequency of chromosome aberrations is not exceeded significantly. (nih.gov)
  • At the tendency level, the frequency of aberrations for liquidators was reduced for double homozygotes by deletions of genes GSTM1-GSTT1 and for homozygotes by the minor allele of site CYP1A1 T606G that is in an accordance with the results of experiments with the control sampling. (nih.gov)
  • The results revealed that VC efficiently ameliorates the genotoxic effect of As and F by increasing the frequency of chromosomal aberrations and primary DNA damage along with increased malondialdehyde (MDA) level. (ac.ir)
  • Allelic variants of polymorphic genes associated with a higher frequency of chromosome aberrations]. (cdc.gov)
  • Chromosome aberrations are a particularly relevant endpoint in radiobiology, because they play a fundamental role in the pathways leading either to cell death, or to cell conversion to malignancy. (unipv.it)
  • More than 180 in vitro and in vivo STTs for predicting mutagenicity and carcinogenicity have been developed, but few have been evaluated on a sufficiently broad spectrum of carcinogens and noncarcinogens to define their predictive value, and no single SST or combination of SSTs has been found to be adequately predictive of carcinogenicity. (nationalacademies.org)
  • Finally, two of the few available models of chromosome aberration induction by ionizing radiation (including heavy ions) will be described and compared, focusing on the different assumptions adopted by the authors and on how these models can deal with heavy ions. (unipv.it)
  • Bacterial gene mutation test and chromosomal aberrations test using mammalian cultured cells are representative examples. (go.jp)
  • This Test Guideline recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation. (qualiteklab.com)
  • Chromosomal effects of theophylline measured in mouse marrow cells in vivo. (nih.gov)
  • The third project is focused on identifying targets affecting leukemia stem cells and on providing in vivo proof of concept data for targeted therapies with a focus on antibody-based strategies. (lu.se)
  • In addition, the circular chromosome con- tains three marker genes (M1, M2, and M3), which when expressed, allow selection of the cells carrying the plasmid and sites 1 and 2, which allow specific restriction endonucleases (q.v.), to break the mole- cule. (damasgate.com)
  • The data on the variability of an elevated level of the frequencies of chromosome aberrations for a group of liquidators of the Chernobyl Nuclear Station accident depending on genotypes by candidate loci are presented. (nih.gov)
  • High doses of acrylamide have been applied in the toxicological studies, which is an accepted practice, but at the Swedish Food Agency studies in the laboratory have shown that chromosome aberrations are induced in mice at comparable low doses. (livsmedelsverket.se)
  • The aim of the present study was to evaluate Vitamin C (VC) as a potent natural antioxidant to mitigate the genotoxic effects of Arsenic trioxide and sodium fluoride in Swiss albino mice in vivo. (ac.ir)
  • Sodium fluoride-induced chromosome aberrations in different stages of the cell cycle: a proposed mechanism. (ac.ir)
  • After a brief introduction on the main general features of chromosome aberrations, in this work we will address key aspects of the current knowledge on chromosome aberration induction, both from an experimental and from a theoretical point of view. (unipv.it)
  • The correlation between DNA adducts and chromosomal aberrations in the target organ of benzidine exposed, partially-henatectomized mice. (cdc.gov)
  • The correlation between DNA adducts and chromosomal aberrations was studied in the liver of benzidine (92875) exposed male ICR-Sprague- Dawley-mice after partial hepatectomy. (cdc.gov)
  • In conclusion, VC mitigates the genotoxic effects of the two well-known water contaminants (As and F) effectively and efficiently at the given concentration in vivo. (ac.ir)
  • The pyrrolizidine alkaloids are mutagenic in vivo and in vitro and, therefore, responsible for the carcinogenesis prominently in the liver. (wikipedia.org)
  • Approximately 60-70% of cases of Pelizaeus-Merzbacher disease result from duplications of the region of the X chromosome that contains PLP1 (caused, it has been proposed, by defective deoxyribonucleic acid [DNA] replication). (medscape.com)
  • yeast artificial chromosomes (YACs) genetically engineered circular chromosomes that contain ele- ments from chromosomes contributed by Saccharo- myces and segments of foreign DNAs that can be much larger than those accepted by conventional cloning vectors (q.v.). As shown in the diagram on page 480, YACs are generated from synthetic mini- chromosomes that contain a yeast centromere (C), a replication orgin (RO), and fused telomeres (TR and Tr). (damasgate.com)
  • Nilotinib is a kinase inhibitor that is FDA approved for the treatment of newly diagnosed adult patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase and chronic phase (CP) and accelerated phase (AP) Ph+ CML in adult patients resistant to or intolerant to prior therapy that included imatinib . (wikidoc.org)
  • No chromosome type aberrations were observed. (cdc.gov)
  • Some available in vivo data on cancer patients and astronauts will be also reported, together with possible interpretation problems. (unipv.it)
  • Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
  • To achieve our objectives, we use start of the art next-generation sequencing technologies, in vitro and in vivo models of acute leukemia, cell sorting, single-cell sequencing and advanced bioinformatics. (lu.se)
  • a comparison between incorporation of the precursors of the a--t and g--c dna base pairs into the chromosomes of the chinese hamster]. (liverpool.ac.uk)
  • The results demonstrated a clastogenic effect for benzidine in-vivo. (cdc.gov)
  • Correlation between chromosomal aberration rate and net RAL was determined. (cdc.gov)
  • Our drug discovery services include in vitro and in vivo screening, target validation, and hit-to-lead optimization. (brfchennai.com)
  • Once these are ligated, an artificial chromosome is generated with a short and a long arm. (damasgate.com)
  • [ 5 ] In addition, some authors have reported the involvement of chromosomes 6 and 11 in a soft-tissue chondroma. (medscape.com)
  • Karyotypic aberration has been found to be associated with synovial chondroma (ie, trisomy 5). (medscape.com)
  • Its genome has been sequenced and found to consist of a 4.65 Mb chromosome and three plasmids of 96.2 kb, 70.3 kb, and 9.6 kb. (damasgate.com)
  • Inclusion of other genes in the duplicated region, or inclusion of aberrations of genes at the duplication endpoints, may potentially affect the phenotype. (medscape.com)