Vivo cellular ht29 cells. Medical search. Frequent questions

Additionally, it obviously suppresses the proliferation of MKN-1 and HT-29 cells with IC 50 values of 0.61±0.18 and 0.38±0.01 μM, respectively. (cancer-research-network.com)
While knockout circIFT80 in HT29 cell or SW480 cells, the proliferation, and migration of the cells were inhibited, the cell cycle was arrested in G2/M phase, and the cell apoptosis was increased. (hindawi.com)
For example, circRNA_000166 can function as an oncogene by promoting the proliferation of CRC cells and by limiting apoptosis. (hindawi.com)
β -Catenin is a transcription factor that plays an important role in cell proliferation, cellular differentiation, apoptosis, and metastasis [ 10 ]. (hindawi.com)
Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. (researchgate.net)
Amino acids are essential for cellular homeostasis, growth and proliferation via their contribution to a diverse range of cellular processes. (spandidos-publications.com)
We postulated that the role of AMPK as a central cellular energy sensor would result in opposite effects on glucose uptake and proliferation, suggesting different roles for 18F-FDG and 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) in assessing its effectiveness as an antineoplastic agent. (precisionimaging.center)
Glucose uptake and cell proliferation were measured by cell retention studies with either 18F-FDG or 18F-FLT. (precisionimaging.center)
MET, through activation of the AMPK pathway, produces a dose-dependent increase in tumor glucose uptake while decreasing cell proliferation in human and murine colon cancer cells. (precisionimaging.center)
Furthermore, silencing PrP c expression with si-PRNP amplified the fucoidan-induced changes in cell proliferation, apoptosis, and migration. (iiarjournals.org)
Effects of taspine on proliferation and apoptosis by regulating caspase-3 expression and the ratio of Bax/Bcl-2 in A431 cells. (rain-tree.com)
Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor-induced proliferation of the human hepatic stellate cell line LI90. (rain-tree.com)
We treated TMZ-resistant cells U251-TMZ and T98G-TMZ to normoxia or hypoxia and silenced NUPR1 in hypoxia-treated U251-TMZ and T98G-TMZ cells to assess cell viability, proliferation, apoptosis, LC3-II/LC3-I and p62 expressions, and autophagic flux under different concentrations of TMZ. (techscience.com)
Genetic ablation of TMEM9 inhibits colorectal cancer cell proliferation in vitro, ex vivo and in vivo mouse models. (nature.com)
Dichloroacetate (20 mM) did not reduce growth of non-cancerous cells but caused significant decrease in cancer cell proliferation ( P =0.009), which was associated with apoptosis and G 2 phase cell-cycle arrest. (dcaguide.org)
This study investigated the effect of acylated synthetic ghrelin (AG) on the survival and proliferation of human chemosensitive ovarian cancer cells (A2780) and explored some mechanisms of action with a focus on the p53 apoptotic pathway and PI3K/Akt and NF- κ B survival pathways. (hindawi.com)
However, while AG treatment had no effect on control cell viability, it significantly increased cell viability and proliferation and inhibited cell death in Cis-treated cells. (hindawi.com)
Among them and over decades of research, it was shown that the PI3K/Akt/mTOR pathway is one of the most frequently hyperactive pathways in OC as well as other types of solid tumors and is associated with increased cell growth, proliferation, migration, protein synthesis, survival, and chemotherapy resistance [ 7 - 9 ]. (hindawi.com)
Administration of insulin increased colon cancer cell proliferation and polyp formation in Azoxymethane (AOM)-induced cancer model ( 19 , 20 ). (amegroups.org)
The activation of PI3K/Akt pathway can increase cell survival, cell growth and proliferation ( 22-24 ). (amegroups.org)
In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical vein endothelial cells. (theinterstellarplan.com)

The addition of essential amino acids, but not non-essential amino acids to the cell culture medium resulted in the cancellation of this pronounced cytotoxicity. (spandidos-publications.com)

Consistent with the notion that fermentation leads to PPAR activation in vivo, feeding mice a diet rich in inulin induced PPAR target genes and pathways in the colon. (uea.ac.uk)
Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. (embl.de)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Western blot analysis was performed to study Boswellia sacra essential oil-regulated proteins involved in apoptosis, signaling pathways, and cell cycle regulation. (biomedcentral.com)
Consistently, the essential oil represses signaling pathways and cell cycle regulators that have been proposed as therapeutic targets for breast cancer. (biomedcentral.com)
It has been reported to reduce growth of these cancer cells mainly by reducing inhibitory phosphorylation of PDH, thereby promoting mitochondrial oxidative phosphorylation and inducing apoptosis through mitochondrial, NFAT-Kv 1.5, and p53 upregulated modulator of apoptosis (PUMA)-mediated pathways. (dcaguide.org)
EGCG is especially important and active in many essential cellular pathways including the cell cycle. (lumminary.com)
The use of in-vitro cell line allows the study of various molecular pathways. (sspc.ie)

These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
The extract also showed a dose dependent growth inhibition of all tested cell lines, IC 50 values against HCT-116, HUVEC, CCD-18CO and HT-29 were 14, 23, 50 and 52 μg mL -1 , respectively. (scialert.net)
Autophagic cell death was excluded as the inhibition of autophagy did not attenuate the cytotoxicity. (spandidos-publications.com)
Conclusion: Combination of fucoidan with silencing of PrP c has a synergic effect on the inhibition of HT29 colon cancer cell growth. (iiarjournals.org)
Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines. (rain-tree.com)
Treatment of CRC cells with MS-444 resulted in growth inhibition and increased apoptotic gene expression, while similar treatment doses in non-transformed intestinal cells had no appreciable effects. (oncotarget.com)
Pyruvate dehydrogenase kinase inhibition attenuates glycolysis and facilitates mitochondrial oxidative phosphorylation, leading to reduced growth of colorectal cancer cells but not of non-cancerous cells. (dcaguide.org)

To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
At 50 μg mL -1 , the extract had potently induced apoptotic cell death of HCT-116 colon cancer cell line by inducing caspases 3 and 7 activity. (scialert.net)

Relative cell viability was assessed using MTT assays. (wjgnet.com)
The migratory and invasive phenotypes of CRC cells were evaluated by in vitro transwell assays and in vivo metastatic models. (thno.org)
Subsequently, in-cell assays were performed to test the inhibitory potency of our compounds by evaluating their cytotoxicity in co-administration with the reference chemotherapeutic agents. (ebris.eu)

The largest apoptotic effect was evident in metastatic LoVo cells, in which DCA induced up to a ten-fold increase in apoptotic cell counts after 48 h. (dcaguide.org)

Results: While both methioninase alone (IC50=0.61 U/ml) and regorafenib alone (IC50=2.26 U/ml) inhibited the viability of HCT-116 cells, the combination of the two agents was more than twice as effective as either alone. (cancerdiagnosisprognosis.org)
On each model, a viability assay was performed after 3 days incubation time with inhibitors, followed by large-scale proteome profiling analysis on 2000 targets from each cell lysates. (tebubio.com)
Our customer needed to obtain in-vivo like responses to drug treatment, through monitoring parameters such as gene expression, biomarker analysis, cellular viability, invasion capability. (tebubio.com)
Boswellia sacra essential oil-mediated cell viability and death were studied in established human breast cancer cell lines (T47D, MCF7, MDA-MB-231) and an immortalized normal human breast cell line (MCF10-2A). (biomedcentral.com)
All three human breast cancer cell lines were sensitive to essential oil treatment with reduced cell viability and elevated cell death, whereas the immortalized normal human breast cell line was more resistant to essential oil treatment. (biomedcentral.com)

Expression is particularly high in the pancreas where it is thought to play a role in the differentiation of pancreatic beta cells. (embl.de)
Background: The putative functions of the cellular prion protein (PrP c ) are believed to be associated with cell signaling, differentiation, survival, and cancer progression. (iiarjournals.org)
2D cell culture : plating, amplification, differentiation. (tebubio.com)
In vitro differentiation of small intestinal epithelium that approaches physiologic functionality of the in vivo host may allow for the development of a pathogenesis model for norovirus. (cdc.gov)

Using animal models, in vivo and in vitro studies have suggested that green tea polyphenols interact with a number molecular targets that are active in cellular processes involved in a range of diseases such as certain cancer (further discussed in Role of green tea in preventing and fighting cancer). (lumminary.com)

Cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and Hoechst 33342 staining, and quantified by flow cytometry. (wjgnet.com)
EdU (ethynyl deoxyuridine, a thymidine analog) and annexin-propidium iodide flow cytometry was performed to determine cell cycle S-phase and apoptotic changes. (precisionimaging.center)

In this present study, we found that circIFT80 was abnormally overexpression in colorectal cancer tissues and tumor cells. (hindawi.com)
Although the LAT family plays important roles in the development and function of normal tissues, they are frequently increased in cancer cells ( 3 ). (spandidos-publications.com)
In addition to the realization of cell cultures in 3D, the collected tissues were fragmented and stored in cryogenic tubes in order to set up a bio-bank of tissues to be used both in view of the application of protocols to create organoid cultures from frozen tissues and through flash frozen technique, for genomic and proteomic sequencing. (ebris.eu)
Cells grown on porous collage-coated beads under fluid shear conditions in rotating wall vessel bioreactors differentiate into 3-D architectures resembling both the morphologic and physiologic function of in vivo tissues. (cdc.gov)
The design of the RWV bioreactor is based on the principle that organs and tissues function in a 3-D environment and that this spatial context is necessary for development of cultures that more realistically act like in vivo tissues and organs ( 25 ). (cdc.gov)

Methionine restriction was shown to increase the efficacy of chemotherapy drugs on cancer cells almost 40 years ago ( Cancer Diagn Progn 3(3) (2023)">2 , J Natl Cancer Inst 76(4) (1986)">3 ). (cancerdiagnosisprognosis.org)
Although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. (researchgate.net)
Insulin decreased drug efficacy of oxaliplatin in HT29 cells, which could be mediated by the activation of the PI3K/Akt pathway. (amegroups.org)
The project was a collaboration between DCU and Maynooth University and benefited from the combined expertise and infrastructure to support both in-vitro testing on skin and intestinal cell models and in-vivo testing on larvae to measure the toxicity of compounds and in vivo efficacy. (sspc.ie)

Materials and Methods: Firstly, we examined the half-maximal inhibitory concentration (IC50) of regorafenib alone and rMETase alone for the HCT-116 human colorectal-cancer cell line. (cancerdiagnosisprognosis.org)
Materials and Methods: PrP c expression was suppressed in HT29 human colon cancer cells by utilizing small-interfering RNA (si-PRNP), and cells were subsequently used to study the antiproliferative and anticancer effects of fucoidan treatment of HT29 human colon cancer cells. (iiarjournals.org)

The HT29-Red-FLuc Bioware® Brite Cell Line is a light-producing cell line derived from HT29-human colorectal adenocarcinoma. (novabio.lt)
Organism: Human · Tissue: Colon · Disease: Colorectal Adenocarcinoma · Optical Reporter: Red-FLuc This cell line has very bright bioluminescence, emitting at least 30,000 photons/cell/sec in vitro. (novabio.lt)
The aim of the present study was to determine if recombinant methioninase (rMETase) could lower the effective concentration of regorafenib in vitro against a colorectal-cancer cell line. (cancerdiagnosisprognosis.org)
To further confirm, the expression of candidate genes was investigated in exosomes derived from the parental HT-29 colorectal cancer cell line (HT-29-EXOs), and cancer stem cells (CSCs) -enriched spheroids (CSC-EXOs) derived thereof. (researchsquare.com)
BTC was initially described, purified and cloned from a mouse insulinoma cell line. (embl.de)
By means of a recently developed non-invasive ex vivo minimal model based on the interaction of the human enterocyte-like HT29 cell line and fecal slurries, we explored the enterocyte-associated microbiome of 21 Hadza hunter-gatherers and nine urban living Italians. (frontiersin.org)
A prostatic stromal myofibroblast cell line (WPMY-1) was co-incubated with testosterone (1 µM) and different concentrations of capsaicin (10-100 µM) for 24 and 48 h. (techscience.com)
To enable global accessibility, we generated a cell line that can enable production of thousands of vaccine doses per liter of cell culture and show that DCFHP-alum maintains potency for at least 14 days at temperatures exceeding standard room temperature. (stanford.edu)
Depending on the cell line, the cells were seeded as follows: 10 4 cells of A375 and SKMEL28, 2x10 4 cells of MNT1 and 1.5x10 4 cells of Me290 and SKMEL23. (ilexlife.com)

were used in the development of a human immunocompetent Organ-on-Chip - a human cell-based in vitro model of the choroid layer of the eye integrating melanocytes and microvascular endothelial cells, covered by a layer of retinal pigmented epithelial cells. (ilexlife.com)
Studies of viral attachment to cultured gastrointestinal epithelial cells (Caco-2) using recombinant virus-like particles or infectious noroviruses indicate that specific histo-blood group antigens play a key role in the attachment of the virus to the host cells ( 13 - 17 ). (cdc.gov)

In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)
were used to establish a 3D organotypic in vitro model containing microtumor spheroids, macrophages, neutrophils, fibroblasts and endothelial cells, allowing for the analysis of tumor-stroma interactions in a controlled and modifiable environment. (ilexlife.com)

By emitting intensified, longer wavelength light that is significantly brighter than other firefly luciferases, Perkin Elmer's bioluminescent oncology cell lines allow you to visualize and monitor the growth of deep tissue tumors in vivo. (novabio.lt)
In vivo treatment of MS-444 inhibited HuR cytoplasmic localization and decreased COX-2 expression in tumors. (oncotarget.com)

In particular, a protocol for the preparation of 3D cell cultures in micro-fluidics was developed in the laboratories of the Ebris Foundation, which induces the production of extracellular matrix (ECM) resulting from an active interaction between tumor cells and stromal cells, mimicking what happens in vivo. (ebris.eu)

A novel angiogenesis inhibitor impairs LoVo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation. (rain-tree.com)

Essential oil prepared by distillation of the gum resin traditionally used for aromatic therapy has also been shown to have tumor cell-specific anti-proliferative and pro-apoptotic activities. (biomedcentral.com)
The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells. (biomedcentral.com)
Total boswellic acids contents were not proportionally related to essential oil-induced tumor cell cytotoxicity among different fractions. (healthjade.net)
Although the active compound(s) in Boswellia sacra frankincense essential oil responsible for anti-tumor activity cannot be identified immediately due the complexity of frankincense essential oils, chemical compositions and/or ratios of these components present in the oil obtained at 100 °C (212 °F) would play significant roles in tumor cell-specific cytotoxicity. (healthjade.net)
Methanol extract and its fractions of Polyozellus multiplex inhibited the growth of several tumor cell lines and its water fraction showed a higher cytotoxicity effect of the human gastric carcinoma cell, SNU668 than on the other cell lines. (theinterstellarplan.com)

Perkin Elmer's bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies. (novabio.lt)

At concentrations required for PPARγ activation and ANGPTL4 induction in colon adenocarcinoma cells, SCFA do not stimulate PPARγ in mouse 3T3-L1 and human SGBS adipocytes, suggesting that SCFA act as selective PPARγ modulators (SPPARM), which is supported by coactivator peptide recruitment assay and structural modeling. (uea.ac.uk)
We established and implemented a physiologically relevant 3D Colorectal cancer cell-based assay. (tebubio.com)
Capsaicin (10-100 µM) significantly inhibited testosterone-treated WPMY-1 cell growth at 48 h by MTT assay. (techscience.com)
Chemopreventative - Assay of each fraction with MTT revealed significant tumoristatic effects of the water fraction of Polyozellus multiplex against human gastric and other cancer cells but not normal human lymphocytes. (theinterstellarplan.com)

We explored molecular markers shared between TDEs and circulating tumor cells (CTCs) in the blood of cancer patients to identify candidate genes involved in CRC metastasis. (researchsquare.com)
The glycolytic phenotype offers growth advantages to cancer cells by resisting apoptosis, and facilitating tumour spread and metastasis (Yeluri et al, 2009). (dcaguide.org)

In addition, xenograft tumor experiments showed that circIFT80 accelerated the tumorigenesis of CRC in vivo. (hindawi.com)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
More recently, cellular senescence has been considered as an additional cause of age-related tumorigenesis. (frontiersin.org)

Compounds isolated in freeze-dried açaí extract have been shown to enter human cells and neutralize free radicals at very low doses. (lifeextension.com)
Moreover, boswellic acids may not be the only compounds in frankincense essential oil for inducing pancreatic cancer cell death. (healthjade.net)
Some researchers also observed that frankincense essential oil enriched with high molecular weight compounds but lower boswellic acids contents frankincense essential oil was much more potent at inducing cytotoxicity in cultured pancreatic cancer cells. (healthjade.net)
Compounds 1-3 reduced the production of neurotoxic Aβ 1-42 production in APPswe-N2a cells in a concentration-dependent manner. (theinterstellarplan.com)

A novel taspine analog, HMQ1611, inhibits growth of non-small cell lung cancer by inhibiting angiogenesis. (rain-tree.com)

1. Equipped with HlyE, EcNe significantly caused tumor regression in mice xenografted with human colorectal cancer cells. (nature.com)
Our aim was to determine if switching metabolism from glycolysis towards mitochondrial respiration would reduce growth preferentially in colorectal cancer cells over normal cells, and to examine the underlying mechanisms. (dcaguide.org)

These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)
These results showed that n-hexane extract of S. koetjape possess both anti-angiogenic and apoptotic properties on colon cancer cell lines making it a good candidate for further studies. (scialert.net)
Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)
Under AAS culture conditions, the cell killing effect of GEF was synergistically pronounced in the EGFR-expressing cell lines, namely, CAL 27, Detroit 562, A549 and PANC-1 cells compared with those treated with either GEF or AAS alone. (spandidos-publications.com)
Colon cancer cell lines HT29 (human) and MC26 (murine) were treated for 24 or 72 h with a range of MET concentrations (0-10 mM). (precisionimaging.center)
After 24 h of MET incubation, phosphorylated AMPK levels increased severalfold in both cell lines, whereas total AMPK levels remained unchanged. (precisionimaging.center)
In cell retention studies, 18F-FDG uptake increased but 18F-FLT retention decreased significantly in both cell lines. (precisionimaging.center)
Impact of an anti-cancerous drug was investigated on colon cell lines (HT-29, HCT116 and LS174T) in conventional 2D monolayer and 3D spheroid cultures, in hypoxia or normoxia. (tebubio.com)
The expression of ELF4 in human CRC samples and CRC cell lines was determined by quantitative real-time PCR, immunohistochemistry and immunoblotting. (thno.org)
They therefore selected and synthesized, using our chemical and pharmaceutical skills, a series of molecules on which we performed proteomics experiments (DARTs) to confirm the selected target, choosing some cell lines resistant to chemotherapy such as mitoxantrone (including HepG2, MCF7-transfected and HT29). (ebris.eu)
Representative colorectal cancer and non-cancerous cell lines were treated with dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase. (dcaguide.org)
Dichloroacetate reduced lactate levels in growth media and induced dephosphorylation of E1 α subunit of pyruvate dehydrogenase complex in all cell lines, but the intrinsic mitochondrial membrane potential was reduced in only cancer cells ( P =0.04). (dcaguide.org)
As the activation of PI3K/Akt signal pathway increases the resistance of several cancer cell lines such ovarian, lung cancer to chemotherapeutic drugs ( 7 , 8 ), it is possible that PI3K/Akt may also play a role in the poor prognosis of obesity-associated colon cancer. (amegroups.org)
This study uses the established cell lines, Caco-2 and HT-29, as models of the intestinal epithelia. (sspc.ie)

Cellular ultrastructure was observed by transmission electron microscopy. (wjgnet.com)

Sangre de grado ( Croton palanostigma ) induces apoptosis in human gastrointestinal cancer cells. (rain-tree.com)

Antitumor activity of taspine by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo . (rain-tree.com)
This study tested insulin-caused resistance to oxaliplatin via activation of PI3K/Akt pathway in HT29 cells. (amegroups.org)

In conclusion, the findings of this study show that AG promotes cell survival of the OC cells and renders them resistat to Cis therapy, an effect that is mediated by the activation of PI3K/Akt/mTOR and activation of NF- κ B, and requires GHS-R1a. (hindawi.com)

Oral squamous cell carcinoma (OSCC) is a common malignant tumor. (techscience.com)
18 reported that components other than AKBA from solvent extracts of Boswellia serrata gum resins can induce cytotoxicity in malignant cells. (healthjade.net)

Results: Fucoidan treatment significantly inhibited growth and reduced cyclin and cyclin-dependent kinase (CDK) expression in HT29 colon cancer cells. (iiarjournals.org)
In both control and Cis-treated cells, AG treatment significantly increased PI3K/Akt/mTOR signaling and enhanced the nuclear accumulation of NF- κ B. Concomitantly, in both control and Cis-treated cells, AG significantly lowered the protein levels of p53, p-p53 (Ser16), PUMA, cytochrome C, and cleaved caspase-3. (hindawi.com)
These results suggested that blue chanterelle extracts inhibited the cell-surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells. (theinterstellarplan.com)

In summary, we introduce a highly potent and selective RIOK2 inhibitor in vitro and in vivo. (cancer-research-network.com)
Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. (rain-tree.com)
In some cases, cisplatin+AG-treated cells were pre-incubated either with [D-Lys3]-GHRP-6, a ghrelin receptor antagonist, or with LY294002, a PI3K inhibitor. (hindawi.com)

Here, we show that transcription and secretion of ANGPTL4 in human T84 and HT29 colon adenocarcinoma cells is highly induced by physiological concentrations of short-chain fatty acids (SCFA). (uea.ac.uk)
Age-related and metabolic diseases such as type 2 diabetes (T2D) represent a source of cellular stress due to their disruptive effect on normal physiological processes and, therefore, can induce premature senescence ( 10 ). (frontiersin.org)

In vivo 18F-FDG and 18F-FLT PET images were acquired before and 24 h after MET treatment of HT29 tumor-bearing mice. (precisionimaging.center)
0.05) in HT29 tumor-bearing mice. (precisionimaging.center)
Recently, the first in vitro norovirus cell culture model was reported for a virus that infects mice ( 18 , 19 ). (cdc.gov)

This study investigated the mechanism of NUPR1 in TMZ resistance in hypoxia-treated glioma cells and its mechanism in modulating autophagy. (techscience.com)
We found that hypoxia upregulated NUPR1 expression and autophagy while NUPR1 silencing suppressed hypoxia-induced TMZ resistance and autophagy in glioma cells. (techscience.com)
FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling. (cancerindex.org)

Representative models of differentiated human intestinal epithelium can be established by growing cells in 3 dimensions (3-D) on collagen-I-coated porous microcarrier beads in rotating-wall vessel (RWV) bioreactors that model the physiologic fluid-shear environment in their respective organs ( 21 - 24 ). (cdc.gov)

Our previous protocol to differentiate human induced pluripotent stem cells (iPSCs) into skin-derived precursor cells (SKPs) as a source of dermal stem cells employs mouse fibroblasts as feeder cells and is therefore unsuitable for clinical use. (bvsalud.org)

rMETase targets the methionine addiction of cancer ( Proc Natl Acad Sci USA 73(5) (1976)">1 - Biomolecules 10(4) (2020)">5 ), and selectively arrests cancer cells in late-S/G 2 phase at which many cytotoxic chemotherapy drugs are active ( Oncotarget 5(18) (2014)">6 - Proc Natl Acad Sci USA 77(12) (1980)">9 ). (cancerdiagnosisprognosis.org)

Boswellia sacra essential oil hydrodistilled at 100 o C was more potent than the essential oil prepared at 78 o C in inducing cancer cell death, preventing the cellular network formation (MDA-MB-231) cells on Matrigel, causing the breakdown of multicellular tumor spheroids (T47D cells), and regulating molecules involved in apoptosis, signal transduction, and cell cycle progression. (biomedcentral.com)

Here we evaluated whether polyozellin has the potential to ameliorate diseases characterized by mucosal inflammation in intestinal epithelial HT-29 cells. (theinterstellarplan.com)

Tas13D inhibits growth of SMMC-7721 cell via suppression VEGF and EGF expression. (rain-tree.com)
Tumor growth will be monitored and cellular system death due to drug action will be observed. (ebris.eu)
Acetyl-11-keto-β-boswellic acid (AKBA) is the most pronounced inhibitory effects among the 4 triterpene acids in suppressing human leukemia HL-60 cell growth as well as DNA, RNA, and protein synthesis 9 . (healthjade.net)
The cell cycle is an important cycle responsible for growth, replenishing of damaged cell and general cell division. (lumminary.com)
It is very important and is tightly regulated, accidental runaway cell growth/division leads to cancer, commonly defined as aberrant cell growth. (lumminary.com)
Our results demonstrate that the highly differentiated 3-D cell culture model can support the natural growth of human noroviruses, whereas previous attempts that used differentiated monolayer cultures failed. (cdc.gov)

Cells use a number of mechanisms to sense and maintain their homeostatic levels. (spandidos-publications.com)
In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)
In this study, polyozellin (PZ), a key constituent of PM, was applied to glutamate-treated HT22 cells to evaluate its neuroprotective mechanisms. (theinterstellarplan.com)

And it shows excellent selectivity to RIOK2 in both enzymatic and cellular studies. (cancer-research-network.com)
This study reported both in vitro cytotoxic and anti-angiogenic properties of S. koetjape indicating that S. koetjape is a good candidate for further in vivo studies targeting colorectal carcinoma. (scialert.net)

Vesicular acidification and trafficking are associated with various cellular processes. (nature.com)

BTC is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types. (embl.de)

Human A2780 ovarian cancer cells were cultured with or without AG treatment in the presence or absence of cisplatin. (hindawi.com)

Anatomy28

Organisms9

Diseases8

Chemicals and Drugs141

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Psychiatry and Psychology6

Phenomena and Processes22

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science1

Health Care1

Proliferation21

Pronounced cytotoxicity1

Pathways8

Inhibition7

Colon cancer cell line2

Assays3

Metastatic1

Viability5

Differentiation4

Vitro studies1

Flow cytometry2

Tissues5

Efficacy4

METHODS2

Line9

Epithelial cells2

Endothelial cells2

Tumors2

Stromal1

Phosphorylation1

Tumor cell5

Oncology1

Assay4

Metastasis2

Tumorigenesis3

Compounds4

Angiogenesis1

Colorectal cancer cells2

Lines14

Observed by transmission electron m1

Apoptosis in human1

Pathway2

Conclusion1

Malignant2

Significantly3

Inhibitor3

Physiological2

Mice3

Glioma cells3

Human intestinal1

Fibroblasts1

Chemotherapy1

Signal transduction1

Intestinal epithelial1

Growth6

Mechanisms3

Studies2

Processes1

Potent1

Ovarian1