Vivo ovariectomy. Medical search. Frequent questions

We employed in vitro cultures and two in vivo models to investigate whether androgens exert these effects directly on marrow lymphoid precursors or whether actions on marrow stromal elements are required. (jci.org)
Thus, we investigated the effects of Pu-erh tea extract (PTE) on ovariectomy-induced osteoporosis in rats and on osteoclastogenesis in vitro. (researchgate.net)
Conclusion: PTE can ameliorate ovariectomy-induced osteoporosis in rats and suppress osteoclastogenesis in vitro. (researchgate.net)
Numerous studies have been conducted on these effects, including in vivo, in vitro and clinical studies. (researchgate.net)
Esculetin, a phytoconstituent, known to inhibit osteoclast differentiation in vitro and increase bone density in vivo , could serve to cure osteoporosis. (niscair.res.in)
Here, we tested the hypothesis that female sex hormones alter vasocontractile responses after experimental stroke in vivo or after organ culture in vitro, a model of vasocontractile receptor upregulation. (lu.se)
Eliminating ROS elimination or inhibiting AKT blocked the effects of the laser therapy in vivo and in vitro. (google.com)
Loss of E2 increased mitochondrial membrane microviscosity and H 2 O 2 emitting potential, whereas E2 administration in vivo and in vitro restored membrane E2 content, microviscosity, complex I and I + III activities, H 2 O 2 emitting potential, and submaximal OXPHOS responsiveness. (umn.edu)
In vivo application of RESV was performed at 100 mg/kg intraperitoneally once every other day for 2 months, and in vitro application of RESV was performed at 10 μM. (thno.org)
The objective of the present study was to investigate the effects of MPA or Pg administration to ovariectomized (OVX) rats on in vivo and in vitro TSH release and pituitary TSH content. (scielo.org)

In vivo , SH491 could dramatically decrease the ovariectomy-induced osteoclast activity and relieve osteoporosis obviously. (zhihuiya.com)
HANCE extract exert protective effects against ovariectomy-induced osteoporosis in vivo," Osteoporosis International 22(2) (2011): 703-09. (supremenutritionproducts.com)
Several in vivo studies evaluated its role on osteoporosis and fracture healing, however, controversial results are seen in the literature. (syksignaling.com)
This systematic review clears the mechanisms of action of Simvastatin on bone metabolism and focuses on in vivo investigations that have evaluated its role on osteo- porosis and fracture repair to fi nd out (i) whether Simvas- tatin is effective on treatment of osteoporosis and fracture repair, and (ii) which of the many available protocols may have the ability to be translated in the clinical setting. (syksignaling.com)
On this basis, we are motivated to review all the important in vivo studies that have used Simvastatin to either treat osteoporosis or accelerate and enhance bone regeneration. (syksignaling.com)
Then, the different in vivo investi- gations that used Simvastatin in the fi eld of bone research were systematically compared and researched in order to find out (i) whether Simvastatin is effective in treatment of osteoporosis and fracture healing, and (ii) which of the many available protocols may have the ability to be translated in the clinical setting. (syksignaling.com)
Effect of Astragalus polysaccharides on ovariectomy-induced osteoporosis in mice. (geneticsmr.com)

However, it affected the alkaline phosphatase activity and mineralization effect in preosteoblastic cells in addition to its in vivo effect in ovariectomized rats. (niscair.res.in)

Combining the use of high-resolution synchrotron based micro-computed tomography (micro-CT), a powerful imaging tool capable of characterizing cortical porosity in three-dimensional (3D) space, with the appropriate animal model has the potential to directly track individual BMUs and assess their behaviours in vivo. (usask.ca)
The experiment described in this thesis is presented as one aspect of a larger study characterizing numerous rabbit-based models of cortical bone loss (ovariectomy and glucocorticoid induced), all of which are compared to a control. (usask.ca)
After one month of intermittent PTH administration, cortical bone microarchitectural changes in the distal tibiae of rabbits were assessed ex vivo using micro-CT at a resolution of 10 μm and dynamic histomorphometry. (usask.ca)

Furthermore, specifically knock out 11β-HSD1 in osteoclasts, by crossing cathepsin-cre mice with 11β-HSD1 flox/flox mice, presented significant protecting effect of skeleton when they underwent ovariectomy surgery. (ijbs.com)
In young C57BL/6N mice, short-term ovariectomy decreased-whereas E2 therapy restored-mitochondrial respiratory function, cellular redox state (GSH/GSSG), and insulin sensitivity in skeletal muscle. (umn.edu)

Intragastrical administration of platinum nanoparticle reduced ovariectomy (OVX)-induced bone loss with lowered level of in vivo bone resorption. (endocrine-abstracts.org)
however, none of the treadmill training regimens prevented ovariectomy induced bone loss. (frontiersin.org)

Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. (nature.com)

Various manifestations nantly male, cohorts to investigate potential tion, was made between the two by assuming of Pb toxicity have been uncovered through sex hormone-driven differences in the long- that only hysterectomies with ovariectomies epidemiologic investigations [World Health term skeletal accumulation of lead. (cdc.gov)

The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)

The cellular cause for in vivo effect was sought by studying its effect on the pre-osteoblastic cell line. (niscair.res.in)

Contro- versial results between the in vivo studies are mostly due to the differences in the route of administration, dose, dosage and carrier type. (syksignaling.com)

Here he also utilizes mesenchymal stem cells or their products incorporated in a biodegradable scaffold that undergoes substantial in vivo remodeling to develop a native-like blood vessel. (pitt.edu)

Recently potential neuroprotective effects of maca have been studied in both in vitro and in vivo experimental models. (hindawi.com)
We examined the effects of human umbilical cord-derived mesenchymal stem cells (HUMSCs) in Wharton's jelly on ovariectomy (OVX)-induced osteoporosis by using in vitro and in vivo experiments. (nycu.edu.tw)
In this paper we report findings from in vitro and in vivo (uterotrophic) studies which confirm that a range of alkyl hydroxy benzoate preservatives (parabens) are weakly estrogenic. (researchgate.net)

16. Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo. (nih.gov)

In an in vivo model of murine ovariectomy-induced osteoporosis, pharmacological inhibition or acute genetic knockdown of Nox4 mitigated loss of trabecular bone. (jci.org)
The role of these pathways in mechanical disuse is also studied, using several in vivo models of disuse osteoporosis. (iu.edu)
Osteoporosis - The objective of this study was to evaluate the preventive effects of Red clover total isoflavones on the progression of bone loss induced by estrogens deficiency (ovariectomy) in rats. (theinterstellarplan.com)

To examine the effects of estrogen withdrawal and replacement on amyloid β (Aβ) levels and amyloid β-protein precursor (AβPP) processing in vivo , Swedish mutant AβPP transgenic mice were ovariectomized or sham ovariectomized at four weeks of age and treated with placebo or 17β- or 17α-estradiol pellets, the latter being a weak estrogen receptor agonist. (nih.gov)
Ovariectomy suppressed Tag expression, and thereby, blocked tumorigenesis in the transgenic mice. (elsevierpure.com)
Insulin resistance is a major cause of type 2 diabetes, and my research program has largely explored the molecular link between inflammation and insulin resistance using transgenic mice with elegant in vivo metabolic experiments and molecular approaches. (umassmed.edu)
This study aimed to evaluate the impact of FGFR3 signaling on bone regeneration and bone mineralization during menopause by developing a distraction osteogenesis (DO) mouse model after ovariectomy (OVX) using transgenic mice with activated FGFR3 driven by Col2a1 promoter ( Fgfr3 mice). (biomedcentral.com)

Selected compounds from this class demonstrated very potent in vivo antagonism of estradiol in an immature rat uterine weight assay, effectively inhibited ovariectomy-induced bone resorption in a 42 days treatment paradigm, and lowered serum cholesterol levels in ovx'd adult rat models. (rcsb.org)
These findings suggest that Red clover isoflavones are effective in reducing bone loss induced by ovariectomy, probably by reducing of the bone turnover via inhibition of bone resorption. (theinterstellarplan.com)

The combination of Src and EGFR inhibition with Gemcitabine treatment method in STAT3 mediated therapy resistant pancreatic tu mors was also successful at inhibiting the development of xenografts of each therapy delicate and resistant pancreatic cancer cells in vivo without the need of expanding tox icity. (gp120-inhibitors.com)

Methods: Three-month-old C57BL/6J mice were fed a phytoestrogen-free diet and subjected to either ovariectomy or sham operation. (edu.hk)
In skeletal muscles of C57BL/6 mice that were E 2 deficient via ovariectomy (OVX), pRLC was lower than that from ovary-intact, sham-operated mice (Sham). (arizona.edu)

Principal scientist for multiple chronic in vivo rodent carcinogenicity/toxicity studies on persistent organic pollutants, conducted according to GLP by extramural testing facilities for the NTP. (nih.gov)

The objective of this study was the evaluation of the antiangiogenic effect of a red clover extract (RCE) used in food supplements for menopausal complaints as well as of its main isoflavones in an i n vivo system, the chorioallantoic membrane assay of fertilized hen's eggs. (theinterstellarplan.com)

This knowledge suggests that reveromycin A is a potent inhibitor for osteoclasts in vivo. (fortuneonline.org)

However, subcutaneous administration of butylparaben produced a positive uterotrophic response in vivo, although it was approximately 100,000 times less potent than 17 beta-estradiol. (researchgate.net)

In addition, a recent study also demonstrated that STA-21, a STAT3 inhibitor, suppressed osteoclastogenesis in vivo [6]. (pdgfreceptor.com)

Ovariectomy markedly diminished MaSC number and outgrowth potential in vivo, whereas MaSC activity increased in mice treated with oestrogen plus progesterone. (nih.gov)
The laboratory is specialized in conducting in vivo studies in mice treated with PTH or subjected to ovariectomy. (gatech.edu)

SWH suppressed the ovariectomy-induced expression of Cbfa1 mRNA and cathepsin K mRNA and enhanced the ratio of OPG/RANKL mRNA expression in the tibia. (edu.hk)

In vivo assessment of neuroinflammation by 18-kDa translocator protein positron-emission-tomography (TSPO-PET) ligands receives growing interest in preclinical and clinical research of neurodegenerative disorders. (biomedcentral.com)

We use genetic models, retroviral transduction, bone marrow transplantation, T cell transfer and in vivo treatments with hormones, cytokines and antibodies. (gatech.edu)

The In-Vivo Biology department houses a state of the art laboratory animal facility based on clean and dirty corridor concept. (patanjali.res.in)

Estrogen response elements present in the promoter region were functional in vivo. (elsevierpure.com)
i) varying estrogen levels in female mice, or (ii) the inflammatory effects of ovariectomy. (rafinhibitors.com)

Hence, there is no in vivo model available to study the spontaneous progression and genomic evolution from early BM infiltration to manifestation of bone metastasis. (nature.com)

In this in vivo study, they provide the first functional characterization of two distinct neuropeptide-defined (corticotropin-releasing factor, and cholecystokinin) GABAergic BNST (bed nuclei of stria terminalis) subpopulations. (inscopix.com)
PREFACE TO THE THIRD EDITION The scepticism with which many medical men formerly held off from the study of the internal secretions has been gradually replaced by the opposite tendency which, in many students of endocrinology, is exhibited as an en- deavor to interpret every change in the living human organism as a disturbance of the endocrine balance. (nih.gov)

This project dissects the molecular mechanisms through which Src inhibits bone formation using in vivo and in vitro approaches with the long term goal of better understanding the clinical and translational potential of Src inhibitors to enhance bone density and fracture susceptibility. (iu.edu)
We examined the effects of tumor necrosis factor-α (TNFα) and interleukin-6 (IL6) gene knockout in preserving the bone loss induced by ovariectomy (OVX) and the mechanisms involved in bone metabolism. (endocrinology-journals.org)

Previous studies have also shown that maca could improve learning and memory in some experimental animal models such as ethanol-, scopolamine-, or ovariectomy-induced memory impairment [ 9 - 11 ]. (hindawi.com)

Using antibiotics, fecal microbiota transplant, and ovariectomy, we are investigating the underlying mechanism of gender-selective effects of altered gut microbiota on energy homeostasis and metabolism. (umassmed.edu)
The inhibitory effects of reveromycin A administered immediately after ovariectomy was the most effective at the early phase of bone loss than at the later stage. (fortuneonline.org)

They include several resource-oriented papers like simultaneous optogenetics and calcium imaging during free behavior, genetically-encoded fluorescent indicators for dopamine, and new calcium sensors, etc., all validated during in vivo behaviors. (inscopix.com)

The reduced pRLC in OVX muscle was reversed by in vivo E 2 treatment. (arizona.edu)
The results showed that treatment of EECS after ovariectomy has not been able to increase bone density compared to the control group OVX. (chemoprev.org)

In order to assess the biological potential of 'Giza 1' seeds in vivo , the extraction procedure was reproduced here. (frontiersin.org)

Hence, naive T cells from 7- to 11-week-old male C57BL/6 mice were collected by FACS and stimulated for 4 days ex vivo, supplemented with combinations of TGF-β, IL-6 and IL-23. (rafinhibitors.com)

Anatomy15

Organisms8

Diseases9

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes23

Information Science1

Health Care1

Vitro10

Osteoporosis7

Rats1

Cortical3

Mice2

Bone loss2

Differentiation1

Investigations1

Experiments1

Cellular1

Results1

Blood1

Vitro and in vivo3

Prevents ovariectomy-induced bone loss1

Osteoporosis3

Transgenic mice4

Bone Resorption2

Inhibition1

Sham2

Toxicity studies1

Assay1

Osteoclasts1

Potent1

Inhibitor1

Mice treated2

MRNA1

Assessment1

Genetic1

Biology1

Estrogen2

Model1

Study2

Mechanisms2

Studies1

Effects2

Calcium1

Treatment2

Potential1

Days1