• In addition, a deeper characterization of immune infiltrates, including the presence of a high number of cytotoxic (CD8 + ) TILs or a high CD8 + /FOXP3 + ratio, is able to define TNBC patients with a better prognosis following neoadjuvant chemotherapy [ 6 ]. (biomedcentral.com)
  • These cellular components can include cells of the innate immune system, such as myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and eosinophils, as well as cells of the adaptive immune system, including CD4⁺ T regulatory cells (Tregs) and cytotoxic CD8⁺ T cells. (ubc.ca)
  • Intraperitoneal administration of IL-15cx results in a moderate inhibition of breast cancer growth that is associated with an increase in the frequency of cytotoxic CD8 T cells and the improvement of their function. (frontiersin.org)
  • IL-15 is considered superior to IL-2 for cancer immunotherapy due to its strong bioactivity in improving CD8 + T and natural killer (NK) cell survival, proliferation and cytotoxic function ( 8 ). (frontiersin.org)
  • Preclinical models predict that blockade of the coinhibitory molecule cytotoxic T lymphocyte-associated antigen 4 (CTLA4) on lymphocytes results in the release of a cell cycle inhibitory checkpoint, allowing lymphocyte proliferation, tumor targeting, and regression. (snmjournals.org)
  • The cytotoxic T lymphocyte-associated antigen 4 (CTLA4) is a coinhibitory activation-induced surface receptor on T cells that functions as a major negative regulator of anti-self-immune responses. (snmjournals.org)
  • Immunotherapy is emerging as a new form to treat cancer by harnessing the activity of cytotoxic CD8 + T lymphocytes (CTLs) that specifically recognize tumor-associated antigens. (lifeboat.com)
  • Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. (frontiersin.org)
  • Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for regulating immune responses, with changes in numbers sufficient to break immune tolerance. (frontiersin.org)
  • We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). (lu.se)
  • Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1. (southernbiotech.com)
  • Studies to antigen uptake, processing and presentation to T cells, the biology of dendritic cells and the regulation of immunity are aimed to raise our understanding of the immune reactions to tumor cells and improve immunotherapy of cancer. (universiteitleiden.nl)
  • Dendritic cells (DC) are responsible for initiating all antigen-specific immune responses. (aacrjournals.org)
  • Upon completion of this activity, the participant should understand the critical roles of dendritic cells in guiding host immune responses, and the details of how they mature, process, and present antigens. (aacrjournals.org)
  • In this study, we tested whether preventative and therapeutic vaccination could be achieved by direct injection of antigen-expressing lentiviral vector, obviating the need for ex vivo transduction of dendritic cells. (jci.org)
  • Specifically, CD8 and CD4 immune response is required for T cell activation by dendritic cells. (pdx.edu)
  • Lentiviral vectors encoding antigens are promising vaccine candidates because they transduce dendritic cells (DC) in vivo and prime CTL responses. (elsevierpure.com)
  • We explored the antigen-presenting cell requirement during primary L. major infection using a mouse model in which MHC II, I-A β b , expression is restricted to CD11b + and CD8α + dendritic cells (DCs). (silverchair.com)
  • This propensity for tolerance could be attributed to the paucity of professional antigen-presenting cells and the expression of transforming growth factor (TGF)-?2. (ox.ac.uk)
  • In this study, we have used tetrameric major histocompatibility complex-peptide complexes to directly visualize antigen-specific cluster of differentration (CD)8+ T cells during the primary immune response to Epstein-Barr virus (EBV) infection in humans. (jenner.ac.uk)
  • We show that massive expansion of activated, antigen-specific T cells occurs during the primary response to this virus. (jenner.ac.uk)
  • The majority of the antigen-specific cells had an activated/memory phenotype, with expression of human histocompatibility leukocyte antigen (HLA) DR, CD38, and CD45RO, downregulation of CD62 leukocyte (CD62L), and low levels of expression of CD45RA. (jenner.ac.uk)
  • After recovery from AIM, the frequency of antigen-specific T cells fell in most donors studied, although populations of antigen-specific cells continued to be easily detectable for at least 3 yr. (jenner.ac.uk)
  • Human CD8+CD28- suppressor T cells (Ts) are a subset of T cells generated in the course of in vitro and in vivo immunizations. (nih.gov)
  • Ts recognize MHC class I:peptide complexes and inhibit the reactivity of T helper cells (Th) with cognate antigen specificity. (nih.gov)
  • We have demonstrated for the first time that CD8+CD28- Ts represent a unique subset of regulatory cells that induces the differentiation of tolerogenic antigen-presenting cells, initiating a suppressive loop which results in the induction and spreading of Th unresponsiveness. (nih.gov)
  • These data indicate that koff rate measurements can improve the predictability of adoptive immunotherapy and provide diagnostic information on the in vivo quality of T cells. (mdc-berlin.de)
  • Functionally, cDC1 cross-present exogenous antigens to activate CD8 + T cells and can promote IL-12 dependent Th1 responses ( 1 , 5 - 7 ). (frontiersin.org)
  • We review the literature express CD8 and induce apoptosis of cells on which they on the role of CD4+ and CD8+ T cell-mediated immunity in recognize foreign antigens presented by MHC class I mol- influenza infection and the available data on the role of ecules, providing a defense against intracellular pathogens these responses in protection from highly pathogenic such as viruses. (cdc.gov)
  • Influenza-specific CD8+ T cells recognize multiple of reagents and genetically modified mouse models has viral epitopes on target cells and antigen-presenting cells. (cdc.gov)
  • Upon i.m. injection of DNA vectors expressing Nef mut -derivatives, nanovesicles containing antigens fused with Nef mut are released by muscle cells, can freely circulate into the body, and can be internalized by antigen-presenting cells (APCs). (nature.com)
  • Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system. (lu.se)
  • Reprogramming restored the expression of antigen presentation complexes and costimulatory molecules on the surfaces of tumor cells, allowing the. (lu.se)
  • Human primary tumor cells could also be reprogrammed to increase their capability to present antigen and to activate patient-specific tumor-infiltrating lymphocytes. (lu.se)
  • Our approach serves as a platform for the development of immunotherapies that endow cancer cells with the capability to process and present endogenous tumor antigens. (lu.se)
  • Reprogramming cancer cells to antigen-presenting cells. (lu.se)
  • Rapamycin enhanced expansion of peripheral antigen-specific CD8 T cells and IFNγ production following ex vivo antigen stimulation. (aacrjournals.org)
  • More CD8 T cells infiltrated and were activated after PD-L1 mAb treatment in mice with immunogenic MOC1 tumors, which were stable or increased by the addition of rapamycin, but suppressed when PD901 was added. (aacrjournals.org)
  • Rapamycin increased IFNγ production capacity in peripheral and tumor-infiltrating CD8 T cells. (aacrjournals.org)
  • I demonstrated that using glucose restriction of CD8⁺ T cells in vitro led to improved tumor regression in vivo. (ubc.ca)
  • The goal of this study was to examine the activity of IL-15/IL-15Rα complex (IL-15cx) to CD8 + T cells and evaluate its potential efficacy in murine breast cancer models. (frontiersin.org)
  • IL-15cx shows superior in vivo bioactivity to expand CD8 T cells in comparison to an equimolar single chain IL-15. (frontiersin.org)
  • By means of in vivo fate mapping, we found a striking variability of immune responses derived from individual CD8(+) T cells and show that robust acute and recall immunity requires the initial recruitment of multiple precursors. (nih.gov)
  • Here, we show that even expression of minor histocompatibility (mH) antigens is sufficient to provoke acute rejection of tissues differentiated from ES cells. (ox.ac.uk)
  • They are exceptionally efficient at antigen presentation and also adept at generating just the right type of T cells in response to a given pathogen. (aacrjournals.org)
  • Background Post-translational modification of proteins has the potential to alter the ability of T cells to recognize major histocompatibility complex (MHC) class -I and class-II restricted antigens, thereby resulting in altered immune responses. (bmj.com)
  • Modified peptides showed enhanced binding to HLA-A2 compared with the native sequences and immunization of HLA-A2 transgenic mice generated high avidity modification specific CD8 responses that killed peptide expressing target cells. (bmj.com)
  • however, the challenge for T cells is to recognize tumour antigens whilst minimizing cross-reactivity with antigens associated with healthy tissue. (scancell.co.uk)
  • Some tumour cells, including those associated with viral infections, have clear, tumour-specific antigens that can be targeted by T cells. (scancell.co.uk)
  • It provides a dominant negative signaling to T cells on binding to the costimulatory molecules CD80 (B7.1) and CD86 (B7.2) expressed on the surface of antigen-presenting cells ( 1 ). (snmjournals.org)
  • Cell surface CTLA4 has 100-1,000 times higher affinity for the costimulatory molecules expressed by antigen-presenting cells, thereby efficiently competing with the positive costimulatory receptor CD28 ( 1 ). (snmjournals.org)
  • Despite occasional cases of expansion of melanoma-specific T cells ( 14 , 15 ), the bulk of the data suggest that there is no detectable expansion of tumor antigen-specific lymphocytes, in particular when focusing on CD8+ T-cell responses. (snmjournals.org)
  • In a phase I/II trial in patients with metastatic melanoma, direct intra-dermal injection of mRNA coding for relevant tumor-associated antigens was well tolerated and influenced the frequency of vaccine-antigen directed CD4 and CD8 T cells as well as regulatory T cells (T Regs). (biomedcentral.com)
  • Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
  • We hypothesized lysosome-associated membrane glycoprotein 1 (LAMP1, CD107a) to be a marker for fratricide in TCR transgenic CD8 + T cells. (oncotarget.com)
  • Here, we demonstrated that intradermal administration of clinically relevant vaccines efficiently induces Trm cells specific for tumor-specific and self-antigens that accumulate in vaccinated and non-vaccinated skin. (lifeboat.com)
  • Interestingly, vaccination-induced Trm cells strongly suppress the growth of melanoma, independently of circulating CD8 T cells, and were able to infiltrate melanoma tumors. (lifeboat.com)
  • Resident memory CD8 + T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens. (lifeboat.com)
  • Vaccination-induced Trm cells were largely resistant to in vivo intravascular staining and antibody-dependent depletion. (lifeboat.com)
  • 8-10 Long-lasting protective immunity relies on the efficient establishment of long-lived memory CD8 + T cells, which have the potential to eradicate primary and disseminated tumors. (lifeboat.com)
  • 11 They have been typically classified in two subsets: effector-memory (Tem) and central-memory (Tcm) CD8 + T cells. (lifeboat.com)
  • Here we examine their stimulation of antigen-specific CD4 + T cells, critical for protective immunity against tumors or infectious disease. (elsevierpure.com)
  • Murine DC infected with the various lentivectors could stimulate OT-I (CD8 + , OVA TCR transgenic) T cells and all except OVAcyt could also stimulate OT-II (CD4 + , OVA TCR transgenic) T cells in vitro. (elsevierpure.com)
  • The Ii-OVA vector was the most potent inducer of IFN-γ-secreting CD4 + and CD8 + T cells and was the only vector to protect mice completely from challenge with OVA-expressing tumor cells. (elsevierpure.com)
  • MHC II-positive macrophages are a primary target of infection and a crucial effector cell controlling parasite growth, yet their function as antigen-presenting cells remains controversial. (silverchair.com)
  • MHC II + DCs prime CD4 + Th1 cells to nominal antigens ( 5 ) and could fulfill this role during L. major infection ( 1 ). (silverchair.com)
  • transferred labeled TCR-transgenic CD8 + P14 T cells that recognized the gp33-41 CD8 + epitope from LCMV into naive mice. (acir.org)
  • Decreasing the dose of the virus increased IFNγ production by TP cells, suggesting that higher antigen loads led to the generation of TP cells with repressed effector functions. (acir.org)
  • A proprietary tool developed by Genocea called ATLAS™ (Antigen Lead Acquisition System) will be used to identify true immunogenic neoantigens from each patient's tumor that are recognized by their own CD4 and/or CD8 T cells. (uchicagomedicine.org)
  • ATLAS-identified neoantigens will be used to stimulate and select autologous T cells collected by apheresis to generate an adoptive cell product ex vivo. (uchicagomedicine.org)
  • TIGIT and PD-1 impair tumor antigen-specific CD8(+) T cells in melanoma patients[J]. The Journal of Clinical Investigation, 2015, 125(5): 2046-2058. (ijsciences.com)
  • We observed a significant increase in IFN-γ-producing CD8 + T cells in bronchoalveolar lavage fluid (BALF) of immunocompetent mice that repeatedly aspirated A. fumigatus conidia in contrast to mice challenged with A. versicolor , a species that is not typically associated with invasive, disseminated disease. (cdc.gov)
  • Airway IFN-γ + CD8 + T-cells were decreased and lung germination was eliminated in mice that aspirated A. fumigatus conidia that were formaldehyde-fixed or heat-inactivated. (cdc.gov)
  • Furthermore, A. fumigatus particles exhibited greater persistence in the lungs of recipient mice when compared to non-viable A. fumigatus or A. versicolor , and this correlated with increased maintenance of airway memory-phenotype CD8 + T cells. (cdc.gov)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • Vaccination with messenger RNA (mRNA) encoding full-length tumor antigens is a novel option for immunotherapy. (biomedcentral.com)
  • In addition to acquiring improved antigen presentation, tumor-APCs had impaired tumorigenicity in vitro and in vivo. (lu.se)
  • My work involving the depletion of PTPα in TNBC reveals PTPα as a regulator of ECM degradation and invasion in vitro and in vivo. (ubc.ca)
  • Focusing on the early onset of TNBC, neoadjuvant trials could represent excellent in vivo platforms to test immunotherapy agents and their potential combinations, allowing the performance of translational studies for biomarker implementation and improved patient selection. (biomedcentral.com)
  • However, nothing is known about the ability of the N-specific CD8 + T cell immunity in controlling viral replication in the lungs, a major pathogenic signature of severe disease in humans. (nature.com)
  • To fill the gap, we investigated the immunity generated in the lungs by N-engineered EVs in terms of induction of N-specific effectors and resident memory CD8 + T lymphocytes before and after virus challenge carried out three weeks and three months after boosting. (nature.com)
  • The adaptive immune system, discovered by Paul Ehrlich, involves the production of circulating antibodies that can provide long lasting, systemic immunity that is specific to antigens expressed by a given pathogen. (aacrjournals.org)
  • The impaired viral replication matched with a reduced induction of Spike-specific CD8 + T lymphocytes. (nature.com)
  • The antiviral effect appeared similarly strong when the viral challenge was carried out 3 months after boosting, and associated with the persistence of N-specific CD8 + T-resident memory lymphocytes. (nature.com)
  • Distinct subsets of DCs exist in vivo , broadly divided into conventional (cDC) and plasmacytoid (pDC) subsets. (frontiersin.org)
  • In mice, cDCs (CD11c + MHCII + ) are sub-divided into functionally distinct phenotypes defined as cDC1 (CD8 + IRF8 + XCR1 + Clec9a + CD24 + ) and cDC2 (IRF4 + CD11b + SIRPα + ) whilst in humans the equivalent DC subsets are defined by expression of CD8 + IRF8 + XCR1 + Clec9a + CD141 + (cDC1) and IRF4 + CD1c + (cDC2) ( 1 - 4 ). (frontiersin.org)
  • I identified several potentially suppressive myeloid cell subsets, including TAMs and arginase-1ʰⁱ monocytic-MDSCs (M-MDSCs) that expand during CD8⁺ T cell-mediated tumor regression and subsequent recurrence, which may play a role in tumor regrowth. (ubc.ca)
  • A core feature of protective T cell responses to infection is the robust expansion and diversification of naïve antigen-specific T cell populations into short-lived effector and long-lived memory subsets. (nih.gov)
  • We demonstrate that antigen presentation by these DC subsets is sufficient to control a subcutaneous L. major infection. (silverchair.com)
  • The DC subsets that initiate Th1 priming in vivo have not been delineated clearly. (silverchair.com)
  • This study provides the first evidence that homocitrullinated proteins in tumors can also be targets for CD8 T-cell responses. (bmj.com)
  • This research suggests that post-translational modification of proteins provide efficient targets in tumors for both CD4 and CD8 T-cell-mediated therapies. (bmj.com)
  • Cross-presentation initiates immune responses against tumors and viral infections by presenting extracellular antigen on MHC I to activate CD8 + T cell-mediated cytotoxicity. (elsevierpure.com)
  • Immune staining of CD8 in anti-PD-L1-treated tumors from Col1a2 CreERT2 IL-17RC f/f mice of the DMBA/TPA skin cancer model. (rupress.org)
  • Entrez Gene: MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E)". Takahashi K, Shichijo S, Noguchi M, et al. (wikipedia.org)
  • Current vaccine strategies against influenza focus on Antigen-specific ligation of T-cell receptors induces generating robust antibody responses. (cdc.gov)
  • We developed a CD8 + T-cell-based vaccine platform based on intramuscular (i.m.) injection of a DNA vector coding for antigens of interest fused at the C-terminus of a biologically inactive Human Immunodeficiency Virus (HIV)-Type 1 Nef protein (Nef mut ) having an unusually high efficiency of incorporation into EVs. (nature.com)
  • CV9103 is a prostate-cancer vaccine containing self-adjuvanted mRNA (RNActive®) encoding the antigens PSA, PSCA, PSMA, and STEAP1. (biomedcentral.com)
  • The follow-up vaccine CV9104 including the additional antigens prostatic acid phosphatase (PAP) and Muc1 is currently being tested in a randomized phase IIb trial to assess the clinical benefit induced by this new vaccination approach. (biomedcentral.com)
  • The cell-based therapeutic vaccine Sipuleucel T targeting the antigen PAP has been approved by the US Food and Drug Administration in 2010 and recently by the European Medicines Agency for the treatment of asymptomatic - minimally symptomatic metastatic CRPC based on a median prolongation in overall survival by 4.1 months compared to placebo controls [ 4 ]. (biomedcentral.com)
  • Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene. (wikipedia.org)
  • Importantly, DCs also help guide the immune system to respond to foreign antigens while avoiding the generation of autoimmune responses to self. (aacrjournals.org)
  • The mRNA vaccines can encode multiple antigens, strengthening the immune response against pathogens and enabling the targeting of multiple microbial variants [19] . (researchgate.net)
  • A total of 26/33 evaluable patients treated at 1280 μg developed an immune response, directed against multiple antigens in 15 out of 33 patients. (biomedcentral.com)
  • Nanovaccines can improve antigen presentation, targeted delivery, stimulation of the body's innate immune system, and a strong T-cell response without putting people at risk. (researchgate.net)
  • Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. (lifeboat.com)
  • For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
  • The primary endpoint was safety and tolerability, the secondary endpoint was induction of antigen specific immune responses monitored at baseline and at weeks 5, 9 and 17. (biomedcentral.com)
  • In vivo antibody depletion revealed a CD8 T-cell-dependent, and not NK cell-dependent mechanism of tumor growth inhibition after treatment with rapamycin and PD-L1 mAb, ruling out significant effects from NK cell-mediated antibody-dependent cellular cytotoxicity. (aacrjournals.org)
  • CD8 responses were assessed in vitro for cytotoxicity and in vivo tumor therapy. (bmj.com)
  • Fig. 4: Anti-CD80 TKMG48 augments PD-1-binding capacities of DCs and suppresses antigen-specific T cell responses in vivo. (nature.com)
  • Results Homocitrullinated peptides from aldolase and cytokeratin were identified, that stimulated CD8-mediated responses in vivo. (bmj.com)
  • Methods Homocitrullinated peptides were identified and assessed in vitro for HLA-A2 binding and in vivo in human leukocyte antigen (HLA) transgenic mouse models for immunogenicity. (bmj.com)
  • Injection of a lentiviral vector encoding an MHC class I-restricted T cell epitope of lymphocytic choriomeningitis virus (LCMV) and CD40 ligand induced an antigen-specific cytolytic CD8 + T lymphocyte response that protected the mice from infection. (jci.org)
  • Therefore, CD11b + and CD8α + DCs are not only key initiators of the primary response but also provide all the necessary cognate interactions for CD4 + T cell Th1 effectors to control this protozoan infection. (silverchair.com)
  • this was found to be the direct result of higher viral loads, and thus higher antigen burden in the chronic infection model. (acir.org)
  • Thus, the guidelines presented below are intended for the evaluation and management of persons who may have tuberculous infection and HIV-induced anergy to delayed-type hypersen- sitivity (DTH) skin test antigens, including PPD-tuberculin. (cdc.gov)
  • Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
  • This review explores evolving knowledge of the immunopathogenic mechanisms, pharmacogenomic associations, in vivo and ex vivo diagnostics for causality assessment, and medication cross-reactivity data related to SCAR syndromes. (medscape.com)
  • [ 4 ] The aim of this article is to provide a complementary review of emerging immunopathogenic mechanisms, established pharmacogenomic associations, in vivo and ex vivo causality assessment tools and medication cross-reactivity data related to SCAR syndromes. (medscape.com)
  • The ability to divorce these events may allow the deletion of antigen-specific and pathological CTL populations without the deleterious effects induced by full CTL activation. (ox.ac.uk)
  • These findings suggest that recombinant vaccines rather than vaccines with higher egg-based antigen doses may provide improved antibody responses in highly vaccinated populations. (cdc.gov)
  • In the presence of CD8 coreceptor binding, there is a good correlation between TCR signaling, killing of the targets, and FasL-mediated CTL apoptosis. (ox.ac.uk)
  • Endogenous synthesis of antigen results in efficient proteolytic peptide processing and presentation of peptide antigen on MHC class I proteins. (jci.org)
  • The time delay tial expression of CD4 and CD8 coreceptors. (cdc.gov)
  • Nevertheless, despite their immunogenicity in vivo, transplantation tolerance may be readily established by using minimal host conditioning with nondepleting monoclonal antibodies specific for the T cell coreceptors, CD4 and CD8. (ox.ac.uk)
  • Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones. (unil.ch)
  • The magnitude of the antigen-specific component versus the bystander component of a primary T cell response remains controversial. (jenner.ac.uk)
  • In Chapter 4, I profiled the dynamic myeloid compartment following antigen specific CD8⁺ T cell-mediated tumor regression and recurrence. (ubc.ca)
  • T-bet is partially involved in CD8 T cell expansion ex vivo and in vivo due to IL-15 or IL-15cx. (frontiersin.org)
  • 5. Arnaboldi PM, Roth-Walter F, Mayer L. Suppression of Th1 and Th17, but not Th2, responses in a CD8 + T cell mediated model of oral tolerance. (southernbiotech.com)
  • Thus, Hcit-specific CD8 T-cell responses have potential in the development of future anticancer therapy. (bmj.com)
  • Memory CD8 + T cell responses have the potential to mediate long-lasting protection against cancers. (lifeboat.com)
  • CD8α + and CD11b + DCs can be infected in vitro ( 6 ), and T cell priming to an immunodominant L. major peptide is mediated by CD11b + DCs ( 7 ). (silverchair.com)
  • In this study, we have compared the effector functions and fate of a number of human CTL clones in vitro or ex vivo following contact with variant peptides presented either on the cell surface or in a soluble multimeric format. (ox.ac.uk)
  • May participate in antigen-induced T-cell activation. (lu.se)
  • Therefore, murine airway CD8 + T cell-responses to aspiration of Aspergillus conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. (cdc.gov)
  • Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
  • Several features of lentiviral vectors have made them advantageous for the expression of therapeutic proteins in vivo. (jci.org)
  • BACKGROUND: Emerging data suggest that second-generation influenza vaccines with higher hemagglutinin (HA) antigen content and/or different production methods may induce stronger antibody responses to HA than standard-dose egg-based influenza vaccines in adults. (cdc.gov)
  • Importantly, in vivo the homocitrullinated aldolase specific response was associated with efficient CD8 dependent antitumor therapy of the aggressive murine B16 tumor model indicating that this epitope is naturally presented in the tumor. (bmj.com)
  • However, the in vivo contribution of SEC22B to cross-presentation has not been tested. (elsevierpure.com)
  • Syngeneic models of oral cancer were used to determine if blocking oncogenic signaling improved in vivo responses to PD-L1 monoclonal antibody (mAb). (aacrjournals.org)
  • Vaccination strategies eliciting CTL responses specific for tumor-specific and self-antigens have shown promising results in recent clinical trials. (lifeboat.com)
  • A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex. (ox.ac.uk)
  • The Food and Drug Administration has licensed for the evaluation of cellular hypersensitivity a multiple puncture device (MULTITEST CMI(R)) that delivers seven DTH antigens percutaneously. (cdc.gov)
  • In contrast, responses to antigens administered by a Mantoux-type procedure, in which a known quantity of a known concentration of a standardized antigen is deposited in the skin, may be more accurate indicators of a waning or increasing cellular hypersensitivity. (cdc.gov)