SusceptibilityMeropenemAntibacterialIsolatesCeftazidimeSusceptible to piperacillinCefepimeTigecyclineAmpicillinPlus an aminoglycosideAntibioticParenteralAntimicrobialBeta-lactamStrainsAmikacinBactericidalPseudomonasEfficacyActivityBacteriaAmoxicillinConcentrationsPenicillinIntravenousVivoOrganismsInfectionsDosageTreatmentDataProductModelActiveHoursBody
Susceptibility8
- Objectives: The objectives of this study were to compare the antibiotic susceptibility of Pseudomonas aeruginosa strains with increased efflux pump expression in vitro and in vivo and to use these same strains to evaluate the efficacy of combinations of antibiotics with putative efflux pump inhibitors in vivo. (st-andrews.ac.uk)
- The efficacy of levofloxacin, piperacillin and meropenem against larvae infected with the efflux pump mutants reflected susceptibility to the same drugs in vitro. (st-andrews.ac.uk)
- Other macrolides, including azithromycin, clarithromycin, and telithromycin (in order of decreasing susceptibility), retain in vitro activity against most Pasteurella strains. (medscape.com)
- None of the antibacterials exerted a significant effect on the in vitro susceptibility of the yeasts to the antifungal agents or on their ability to form biofilms. (bvsalud.org)
- The results of in vitro susceptibility testing of ESBL producers indicate that the activity of non-β-lactam agents (amikacin and ciprofloxacin) significantly decreased during the time period of the study. (cmac-journal.ru)
- Our strategy was based on in vitro data showing that PTZ/AMK combination covered 92.8% of extended spectrum β-lactamase-producing Escherichia coli isolates.3 Since aminoglycosides were rarely used in our hospital, amikacin susceptibility was also relatively well preserved in clinical isolates of Pseudomonas and Acinetobacter spp. (datexis.com)
- VITEK 2 Gram Negative Susceptibility Card, AST-N107, REF 22 265, For In Vitro Diagnostic Use, 20 cards/box. (fda.gov)
- Cards that are intended for use with the Vitek 2 Systems in clinical laboratories as an in vitro test to determine the susceptibility of clinically significant aerobic/anaerobic gram-negative bacilli to antimicrobial agents. (fda.gov)
Meropenem5
- In vitro activity of meropenem, imipenem, piperacillin/tazobactam, ciprofloxacin, amikacin, and cefepime against P. aeruginosa and A. baumannii Isolated from Brazilian intensive care units: MYSTIC Study Group (Brazil 2001). (jmilabs.com)
- Candida albicans, C. tropicalis, C. glabrata, C. parapsilosis and C. guilhermondii were seeded into antibacterial (cefepime, meropenem, vancomycin, and piperacillin- tazobactam) gradient plates produced in Mueller-Hinton Agar. (bvsalud.org)
- Piperacillin/tazobactam, imipenem or meropenem, tigecycline, and eravacycline are recommended for complicated intra-abdominal infections when enterococci are known or presumed to be involved. (msdmanuals.com)
- A generic meropenem product has recently become available in South Africa and we aimed to compare the generic product with the innovator product using established in vitro microbiological testing methods.Method: Comparative minimum inhibitory concentrations (MICs) were determined for 115 clinically relevant isolates using the broth microdilution reference method. (bvsalud.org)
- the MBC was only twice the MIC.Conclusion: Reference method MIC and MBC testing of a large sample of clinically relevant microorganisms against meropenem has demonstrated comparable in vitro activity between the innovator and generic products. (bvsalud.org)
Antibacterial3
- In vitro antibacterial effect of tea polyphenols combined with common antibiotics on multidrug-resistant Klebsiella pneumoniae. (supp.ai)
- Piperacillin / tazobactam are antibacterial combination for intravenous administration which consists of semi synthetic antibiotic piperacillin sodium and a ß-lactamase inhibitor tazobactam sodium. (cathaydrug.com)
- Alpit is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a β-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below. (sdrugs.com)
Isolates7
- This study was therefore designed to investigate the in vitro therapeutic outcome of combining an aminoglycoside (gentamicin) and some floroquinolones including ciprofloxacin, ofloxacin, perfloxacin and gatifloxacin at different ratios against E. coli isolates expressing ESBL enzymes. (scialert.net)
- Antimicrobial activity of tigecycline and comparator agents was assessed in vitro against 27857 isolates source from blood samples collected between 2012 and 2016 as part of the Tigecycline Evaluation and Surveillance Trial (TEST). (biomedcentral.com)
- Nosocomial pneumonia (moderate to severe) caused by β-lactamase producing isolates of Staphylococcus aureus and by piperacillin/tazobactam-susceptible Acinetobacter baumannii , Haemophilus influenzae , Klebsiella pneumoniae , and Pseudomonas aeruginosa (Nosocomial pneumonia caused by P. aeruginosa should be treated in combination with an aminoglycoside) [ see Dosage and Administration (2) ]. (sdrugs.com)
- Ulifloxacin is generally more active in vitro than other fluoroquinolones against a variety of clinical isolates of Gram-negative bacteria, including community and nosocomial isolates of Escherichia coli, Klebsiella spp. (ncats.io)
- The focus of this report is to examine changes in antimicrobial resistance epidemiology among clinical isolates of Enterobacterales and Pseudomonas aeruginosa collected in six Latin American countries as part of the Antimicrobial Testing Leadership and Surveillance (ATLAS) program from 2015 to 2020, with a focus on the in vitro activity of ceftazidime-avibactam against Multidrug-Resistant (MDR) isolates. (scielo.br)
- In-vitro activity of five beta-lactam/beta-lactamase inhibitor combinations against consecutive isolates of the Enterobacteriaceae and Pseudomonas aeruginosa. (cmac-journal.ru)
- and to compare the MICs with isolates from the same site upon the South African launch of piperacillin-tazobactam. (bvsalud.org)
Ceftazidime1
- It is usually susceptible to piperacillin and ceftazidime. (wikipedia.org)
Susceptible to piperacillin2
- Therefore, the treatment of mixed infections caused by piperacillin-susceptible organisms and piperacillin-resistant, --lactamase producing organisms susceptible to piperacillin and tazobactam should not require the addition of another antibiotic. (popular-pharma.com)
- †These are not --lactamase producing bacteria and, therefore, are susceptible to piperacillin alone. (popular-pharma.com)
Cefepime1
- 8. Thomson K.S., Moland E.S. Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase-producing Enterobacteriaceae. (cmac-journal.ru)
Tigecycline1
- The new tetracycline-derivative tigecycline also has excellent in vitro activity against P multocida and other pathogens encountered in animal and bite injuries. (medscape.com)
Ampicillin2
- Enterococci associated with endocarditis are difficult to eradicate unless a combination of certain cell wall-active antibiotics (eg, penicillin, ampicillin, amoxicillin, piperacillin, vancomycin) plus an aminoglycoside (eg, gentamicin, streptomycin) is used to achieve bactericidal activity. (msdmanuals.com)
- Tazobactam-piperacillin compared with sulbactam-ampicillin, clavulanic acid-ticarcillin, sulbactam-cefoperazone, and piperacillin for activity against beta-lactamase-producing bacteria isolated from patients with complicated urinary tract infections. (cmac-journal.ru)
Plus an aminoglycoside1
- Initial presumptive treatment of patients with nosocomial pneumonia should start with Alpit at a dosage of 4.5 g every six hours plus an aminoglycoside, totaling 18.0 g (16.0 g piperacillin/2.0 g tazobactam). (sdrugs.com)
Antibiotic1
- Purpose: The objective of this study was to model the killing effect of a β-lactam antibiotic, piperacillin (PIP), in neutropenic and E. coli ATCC 25922 infected rats after different dosing regimens using a modified Emax PK-PD model. (ufrgs.br)
Parenteral2
- Piperacillin / tazobactam parenteral combination (VIGOCID), is a white powder consisting of piperacillin and tazobactam as their sodium salts. (cathaydrug.com)
- 6. Burgess D.S., Hall R.G. In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae. (cmac-journal.ru)
Antimicrobial2
- Although many antimicrobial agents display good in vitro activity against the pathogens frequently implicated in diabetic foot infections, effective treatment can be complicated by reduced tissue penetration in this population secondary to peripheral arterial disease and emerging antimicrobial resistance, which can result in clinical failure. (japmaonline.org)
- Piperacillin-tazobactam remains a valuable antimicrobial agent whose continued longevity will depend on appropriate optimisation of pharmacodynamic parameters. (bvsalud.org)
Beta-lactam2
- Resistance may develop during therapy if treated with cephalosporins or beta-lactam/beta-lactamase inhibitors, even if susceptible in vitro. (firstline.org)
- 1. Finegold S.M. In vitro efficacy of beta-lactam/ beta-lactamase inhibitor combinations against bacteria involved in mixed infections. (cmac-journal.ru)
Strains6
- Appendicitis (complicated by rupture or abscess) and peritonitis caused by piperacillin-resistant, --lactamase producing strains of Escherichia coli or the following members of the Bacteroides fragilis group: B. fragilis, B. ovatus, B. thetaiotaomicron, or B. vulgatus. (popular-pharma.com)
- Postpartum endometritis or pelvic inflammatory disease caused by piperacillin-resistant, --lactamase producing strains of Escherichia coli . (popular-pharma.com)
- Community-acquired pneumonia (moderate severity only) caused by piperacillin-resistant, --lactamase producing strains of Haemophilus influenzae. (popular-pharma.com)
- Piperacillin/tazobactam has been shown to be active against most strains of the following microorganisms both in vitro and in clinical infections. (popular-pharma.com)
- 10. Edelstein M., Edelstein I., Semchenkova D., Stratchounski L. The effect of large inoculaon in vitro activities of penicillin-inhibitor combinations and cefoperazone-sulbactam against ESBL-producing Escherichia coli and Klebsiella pneumoniae strains. (cmac-journal.ru)
- In this study, a novel A. baumannii lytic phage, the YMC 13/03/R2096 ABA BP (phage Βϕ-R2096), which specifically causes the lysis of CRAB strains, was characterized in detail in vitro and in silico, and the in vivo effectiveness of phage therapy was evaluated using Galleria mellonella and a mouse model of acute pneumonia. (biomedcentral.com)
Amikacin1
- From 2013, we implemented a carbapenem-saving strategy using an empirical combination of piperacillin-tazobactam and amikacin (PTZ/AMK) as a bridging regimen before using Gr2C. (datexis.com)
Bactericidal2
- Piperacillin sodium is bactericidal in action by inhibiting septum formulation and cell wall synthesis of susceptible bacteria. (cathaydrug.com)
- Piperacillin exerts bactericidal activity by inhibiting septum formation and cell wall synthesis of susceptible bacteria. (popular-pharma.com)
Pseudomonas1
- Combinations of piperacillin and aminoglycosides shown to be synergistic in vitro against Pseudomonas aeruginosa and Enterobacteriaceae. (cathaydrug.com)
Efficacy1
- The inhibitory effect of combinations of putative efflux pump inhibitors (trimethoprim and sertraline) with antibiotics on the strain overexpressing MexAB-OprM was also measured in vitro and compared with their efficacy in vivo in terms of larval survival and bacterial burden. (st-andrews.ac.uk)
Activity4
- activity vs. Enterobacteriaceae less than ticarcillin/clavulanate and piperacillin/tazobactam. (hopkinsguides.com)
- In vitro, piperacillin is active against a variety of gram-positive and gram-negative aerobic and anaerobic bacteria with an extended spectrum of activity against gram-negative bacteria. (cathaydrug.com)
- It has little clinically relevant in vitro activity against bacteria due to its reduced affinity to penicillin-binding proteins. (cathaydrug.com)
- The tazobactam component of this combination product does not decrease the activity of the piperacillin component against piperacillin-susceptible organisms. (popular-pharma.com)
Bacteria2
- The bacteria designated by the acronym SERMOR-PROVENF (SER = Serratia, MOR = Morganella, PROV = Providencia, EN = Enterobacter, F = freundii for Citrobacter freundii ) have similar, although not identical, chromosomal beta-lactamase genes that are inducible. (medscape.com)
- In vitro, piperacillin is active against a variety of gram-positive and gram-negative aerobic and anaerobic bacteria. (popular-pharma.com)
Amoxicillin1
- Good to strong responses were also generated to haptenic compounds (amoxicillin, piperacillin and Bandrowski's base) that are not associated with an HLA risk allele. (liverpool.ac.uk)
Concentrations1
- Piperacillin and tazobactam are also secreted into the bile, high concentrations are also found and about 20% of a dose may be excreted by this route. (cathaydrug.com)
Penicillin1
- Piperacillin sodium a ureidopenicillin, derived from D(-)-a-aminobenzyl-penicillin. (cathaydrug.com)
Intravenous1
- Piperacillin and tazobactam should be administered by intravenous infusion over 30 minutes. (popular-pharma.com)
Vivo2
- thus, resistance is readily documented in vitro and may emerge rapidly in vivo. (medscape.com)
- Os valores dos parâmetros da modelagem PK-PD obtidos in vivo diferiram dos descritos na literatura para o mesmo antibiótico e bactéria quando simulados in vitro. (ufrgs.br)
Organisms1
- Infections caused by piperacillin-susceptible organisms, for which piperacillin has been shown to be effective, are also amenable to Megacilin treatment due to its piperacillin content. (popular-pharma.com)
Infections1
- Des infections microbiennes ont été observées chez 30% (155/519) de l'ensemble des malades admis au service de soins intensifs pour adultes de l'Hôpital universitaire de Jordanie à Amman en 1993. (who.int)
Dosage2
- For children with appendicitis and/or peritonitis the recommended Alpit dosage is 100 mg piperacillin/12.5 mg tazobactam per kilogram of body weight, every 8 hours in pediatric patients 9 months of age and older. (sdrugs.com)
- For pediatric patients 2 to 9 months of age, the recommended dosage is 80 mg piperacillin/10 mg tazobactam per kilogram of body weight, every 8 hours. (sdrugs.com)
Treatment1
- Polymyxin B may be effective treatment, at least in vitro, though not without frequent adverse effects. (wikipedia.org)
Data4
- Absolute Markets Insights announced the addition of a statistical data titled as, Piperacillin Acid (CAS 61477-96-1) Market to its massive repository. (bloggersbaba.com)
- Strategier baseret på farmakokinetik og -dynamik (PK/PD)-data er foreslået som en metode til optimering af eksponeringen af antibiotika hos kritisk syge. (ugeskriftet.dk)
- The intention was to use the MIC data to evaluate and contextualise contemporary dosing strategies of piperacillin-tazobactam in South Africa. (bvsalud.org)
- The MIC data were then used to evaluate current dosing strategies based on current evidence-based pharmacodynamic parameters for piperacillin-tazobactam. (bvsalud.org)
Product1
- As a result the recalling firm issued a letter dated 3/30/11 via Fed Ex on 4/4/11 flagged "URGENT PRODUCT CORRECTION NOTICE (EXPANDED RECALL), VITEK 2 Piperacillin/Tazobactam Test, Document #9300786. (fda.gov)
Model2
- Pharmacokinetics-pharmacodynamics of tazobactam in combination with piperacillin in an in vitro infection model. (jmilabs.com)
- Thus, SMX-NO can be used as a model reagent for in vitro T cell activation. (liverpool.ac.uk)
Active1
- Piperacillin is metabolized to a minor microbiologically active desethyl metabolite. (cathaydrug.com)
Hours1
- The usual total daily dose of Alpit for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam). (sdrugs.com)
Body1
- Piperacillin and tazobactam are widely distributed in body tissues and fluids. (cathaydrug.com)