[ 1 ] Identifying candidate precursors or enabling genes may pave the way for cancer screening, as with the ret proto-oncogene and medullary thyroid carcinoma . (medscape.com)
Gene ontology (GO) analysis suggested platelet-derived growth factor A (PDGFA) and proto-oncogene, Serine/Threonine kinase Raf-1 (RAF1) as new CRC candidate markers in CTCs and TDEs. (researchsquare.com)
Scholars@Duke publication: The proto-oncogene bcl-3 encodes an I kappa B protein. (duke.edu)
Vivo7
Antisense mixed-backbone oligonucleotides (MBO) specifically inhibit MDM2 expression in a dose- and time-dependent manner, resulting in significant anti-tumor activity in vitro and in vivo. (nih.gov)
Intron A has been shown to have intracellular, antiviral immunomodulatory, and antiproliferative effects, in-vitro and in-vivo. (centerwatch.com)
MUKHERJEE,A,B. "Cells in vivo and in vitro from osteopetrotic mice homozygous for c-src disruption show suppression of synthesis of osteopontin, a multifunctional extracellular matrix protein. (osu.edu)
Vemurafenib inhibited the growth of B-Raf V600E-positive melanomas in vitro and in vivo. (lclabs.com)
The goal of our study is to investigate the genome's ability to express the HPV-16 oncogenes in vitro and to cause tumors in vivo . (iupui.edu)
Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
In this review, we discuss the various factors of BNNT production that can influence its toxicity followed by summarizing the toxicity findings from in vitro and in vivo studies conducted to date, including a review of particle clearance observed with various exposure routes. (cdc.gov)
Assays5
Thermal stability assays show that ERKi do not destabilise ERK2 (or ERK1) in vitro, suggesting that ERK2 turnover is a cellular consequence of ERKi binding. (babraham.ac.uk)
To evaluate the leukemogenic role of RUNX1-MT in ASXL1 -mutated cells, we co-expressed RUNX1 -MT (R135T) and ASXL1 -MT (R693X) in different cell lines and performed immunoblot, co-immunoprecipitation, gene expression microarray, quantitative RT-PCR, cell proliferation, differentiation, and clonogenic assays for in vitro functional analyses. (biomedcentral.com)
2017). Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing. (who.int)
The effects of PIP5K1α and its inhibitor on growth and invasion of BC were confirmed by using in vitro assays including. (lu.se)
The material from each step isscreened using acellular and in vitro assays for evaluating general toxicity, mechanisms of toxicity, and macrophage function. (cdc.gov)
Tumor5
Moreover, it was revealed that miRNAs can act as tumor suppressors or oncogenes. (nature.com)
In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Línea celular eucariótica obtenida en una fase estacionaria o de quiescencia que experimenta, en cultivo, una transformación hacia un estado de crecimiento descontrolado semejante a un tumor in vitro. (bvsalud.org)
Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. (bvsalud.org)
Pathway3
In summary, in the present study data suggested that black currant concentrates, Ben Gairn and Ben Hope, activated eNOS via Akt/PI3 kinase pathway in vitro in HUVECs and that the effect was not dependent on vitamin C. (nih.gov)
The role of the mTOR pathway in estrogen-driven proliferation and effects of combining RAD001 and letrozole were examined in vitro in two breast cancer models. (aacrjournals.org)
We have made stable Gli1 and Gli2 expressing cell lines as well as PTCH knockdowns (in both N/TERT-1 and NEB-1) keratinocytes and these are being used as in vitro models to investigate the HH pathway in skin cancer and in conjunction with BCC derived stromal cells to develop novel in vitro models of BCC as alternatives to animals. (qmul.ac.uk)
Homolog3
Genetic alterations of BCL2 (B-cell CLL/lymphoma 2), MYC [v-myc myelocytomatosis viral oncogene homolog (avian)] and CCND1 (cyclin D1) are the most frequently found alterations in human B-cell lymphomas. (haematologica.org)
Western blotting was performed to detect the protein levels of cyclin‑dependent kinase inhibitor P21 (P21), B‑cell lymphoma‑2 (Bcl‑2), matrix metalloproteinase 9 (MMP9) and E26 oncogene homolog 1 (ETS1). (spandidos-publications.com)
A BRAF mutation favored but did not guarantee a sensitive response, while cells bearing a neuroblastoma RAS viral oncogene homolog mutation or wild-type BRAF were resistant. (lclabs.com)
Genes4
7 Importantly, it is believed that other hitherto unknown genes also play important roles in lymphomagenesis in addition to the synergistic effects of the aforementioned two oncogenes since human B-cell lymphomas often show a variety of genes subject to alterations and/or deregulated expression. (haematologica.org)
The existence of G-quadruplex DNA is also heavily implied in the promoter region of genes and oncogenes, and is thus assumed to play an important regulatory role in their transcription [ 26 ]. (hindawi.com)
To increase selective pressure in vitro , we replaced the MmuPV1 L1 and L2 genes with a neomycin cassette (MmuPV1-16E6E7neo). (iupui.edu)
Through large-scale analysis of 897 patients with gastro-oesophageal adenocarcinomas (GOAs) coupled with in vitro models, we find KCNQ family genes are mutated in â ¼30% of patients, and play therapeutically targetable roles in GOA cancer growth. (bvsalud.org)
BRAF1
Since the identification of somatic mutations in the BRAF oncogene, targeted therapies directed toward mutated tumors have emerged and demonstrated dramatic clinical effect. (lu.se)
Viral1
HPV-16 is a high-risk type that causes ~ 50% of cervical cancers and ~ 70% of oropharyngeal cancers by expressing viral oncogenes E6 and E7 in replicating keratinocytes. (iupui.edu)
Cells3
These include effects on intracellular oncogene expression, stimulation of natural killer and cytotoxic T-cells, microphage activation, and induction of cytokine production. (centerwatch.com)
Our previous study found that chronic in vitro exposure to dispersed single (D-SWCNT) and multi wall CNT (D-MWCNT) resulted in neoplastic transformation in human small airway epithelial cells (SAEC). (cdc.gov)
Comparison of tryptic peptide maps of the bcl-3 protein synthesized in vitro, and p56 and p38 from HeLa cells, shows that they are all structurally related. (duke.edu)
Investigate1
To investigate the in vitro effects of suicide gene therapy system of herpes simplex virus thymidine kinase gene (HSV-TK) in combination with the treatment of nucleotide analog-ganciclovir (GCV) on human pancreatic cancer, and to provide a novel clinical therapeutic method for human pancreatic cancer. (wjgnet.com)
Tumors1
This study demonstrates in vitro that certain cell types from pleomorphic adenoma are able to clone and survive over a long term and develop subcutaneous tumors in nude mice. (biomedcentral.com)
Mechanisms1
Genome profiling identified oncogene signaling mechanisms in CNT SAECs that were quite different from asbestos-exposed (ASB) SAEC. (cdc.gov)
Human3
SV40 Transfected Human Anterior Cruciate Ligament Derived Ligamentocytes-Suitable as a Human in Vitro Model for Ligament Reconstruction? (mdpi.com)
In vitro models of human skin and in vitro modelling of skin carcinogenesis, alternatives to animal models in skin. (qmul.ac.uk)
These in vitro, and their expression in these human tumour virus. (who.int)
Protein1
Furthermore, bcl-3 antisera immunoprecipitates an in vitro-radiolabeled 37-kD (I kappa B alpha) protein. (duke.edu)
Functional1
Next, we developed a synergism-based functional screening method for the identification of other oncogene(s) that act with Bcl2 and Myc . (haematologica.org)
Marker1
Here, we present robust SWCNT, MWCNT, ASB and UFCB specific gene marker sets for in vitro chronically exposed SAEC. (cdc.gov)
Cancer2
In conclusion, toxicogenomic profiling in a chronic in vitro exposure model identified particle-specific gene markers and known lung cancer markers which can potentially aid in assessing CNT exposure and detection of early disease markers. (cdc.gov)
RÉSUMÉ Des données de plus en plus nombreuses indiquent que les antioxydants alimentaires ont des effets favorables sur la réduction du risque de cancer. (who.int)
Model2
A deep understanding of schizophrenia at such an intimate level has been hampered by a single technical bottleneck: the lack of a robust in vitro disease model. (psychiatrictimes.com)
In Basal Cell Carcinoma we are investigating the role of paracrine Hedgehog (HH) signalling between the stroma and epithelium and the role of oncogene induced senescence (OIS). (qmul.ac.uk)
Cell2
An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
Esto ocurre espontáneamente o mediante la interacción con virus, oncogenes, radiaciones o drogas/productos químicos. (bvsalud.org)
Studies1
MITF-low Proliferative, MITF-high Pigmentation and High-immune response are the dominant ones suggesting two distinct lineages of melanoma (MITF-high and low), which is also supported by in vitro studies. (lu.se)