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  • secrete
  • Looking at gene expression profiling I was able to find that the cancer cells that have the capacity to live within this environment secrete a factor called complement C3. (ecancer.org)
  • phagocytosis
  • Hyperglycemic inhibition of complement-mediated opsonization resulted in decreased phagocytosis efficiency by euglycemic neutrophils, such that neutrophil function was not directly inhibited by excess glucose. (hindawi.com)
  • severity
  • Systemically neutralizing C5 abrogated the development of OB, reduced acute rejection severity, lowered systemic and local levels of C3a and C5a, recovered CRP expression, and diminished systemic IL-17 and IL-6 levels. (iupui.edu)
  • specific
  • The B, T and NK T cells among IHIC isolated employing mechanical disruption were found to be immunocompetent, i.e. they proliferated in vitro in response to their specific stimuli (lipopolysaccharide, concanavalin A and alpha-galactosylceramide respectively) and produced immunoglobulin M and interferon-gamma. (diva-portal.org)
  • Ehrlich believed that each antigen-specific amboceptor has its own specific complement, whereas Bordet believed that there is only one type of complement. (wikipedia.org)
  • cells
  • We recently demonstrated the roles of complement C3a and extracellular matrix (ECM) turnover in an in vitro model for deposit formation in inherited macular degeneration using primary mouse RPE cells. (arvojournals.org)
  • IL-6 was elevated while the MMP-2 activity was diminished in a dose-dependent manner in media from the C3a treated RPE cells. (arvojournals.org)
  • IL-17 differentially suppressed Crry expression in airway epithelial cells in vitro. (iupui.edu)
  • C3a in neural crest cells), that stimulates other cells in the group that have the receptors to that chemo-attractant. (wikipedia.org)
  • Wound healing is commonly studied in vitro using cell lines such as Madin-Darby Canine Kidney cells. (wikipedia.org)
  • found
  • Complement factor C3, recently found to contain covalently bound phosphate, was phosphorylated in vitro by cyclic AMP-dependent protein kinase (protein kinase A) and Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). Both protein kinases phosphorylated the same serine residue(s) located in the C3a portion of the alpha-chain. (diva-portal.org)
  • While initially found to have in vitro activity suggesting that they might act as pro-inflammatory agents, Serhan and colleagues and other groups found that the lipoxins as well as a large number of newly discovered metabolites of other PUFA possess primarily if not exclusively anti-inflammatory activities and therefore may be crucial for causing the resolution of inflammation. (wikipedia.org)
  • infection
  • Rats were euthanized and had peritoneal lavage at 2 or 24 hours after infection to evaluate early and late complement-mediated effects. (hindawi.com)
  • known
  • It has been shown to be a chemoattractant for eosinophils, and the form C3a desArg is also known as ASP (Acylation Stimulating Protein), a peptide that participates in fatty acid metabolism. (nationaljewish.org)
  • Results
  • At Advanced Diagnostic Laboratories, the C3a RIA technique is the default method for patient diagnostics, preferred in order to maintain continuity of results for our customers who follow patients over time. (nationaljewish.org)
  • Our results were consistent with prior reporting that diabetic patients have a decreased ability to fix complement by IgG [ 17 ]. (hindawi.com)
  • local
  • Neutralizing IL-17 recovered CRP expression in murine lung allografts and decreased local C3a production. (iupui.edu)
  • data
  • These data indicated that OB induction is in part complement dependent due to IL-17 mediated down regulation of CRPs on airway epithelium. (iupui.edu)
  • serum
  • By 1884, several laboratories had demonstrated that serum from guinea pigs that had recovered from cholera killed the cholera bacterium in vitro. (wikipedia.org)
  • inflammatory
  • While initially found to have in vitro activity suggesting that they might act as pro-inflammatory agents, Serhan and colleagues and other groups found that the lipoxins as well as a large number of newly discovered metabolites of other PUFA possess primarily if not exclusively anti-inflammatory activities and therefore may be crucial for causing the resolution of inflammation. (wikipedia.org)
  • autoimmune
  • Complement is implicated in several disease states, including various autoimmune diseases, and has been found to contribute to other clinical conditions such as adult respiratory syndrome, heart attack, rejection following xenotransplantation and burn injuries. (justia.com)
  • study
  • During early remyelination oligodendrocytes migrated to the corpus callosum in higher numbers in C3a and C5a transgenic mice, thus enabling these mice to remyelinate as effectively as WT mice by the end of the ten week study. (uiowa.edu)
  • In an in vitro study, chondroitin sulfate reduced the IL-1β-induced nuclear factor-kB (NF-κB) translocation in chondrocytes. (wikipedia.org)
  • cell
  • Wound healing is commonly studied in vitro using cell lines such as Madin-Darby Canine Kidney cells. (wikipedia.org)
  • found
  • Complement-mediated tissue injury has also been found to result from bioincompatibility situations such as those encountered in patients undergoing dialysis or cardiopulmonary bypass. (justia.com)
  • cells
  • IL-17 differentially suppressed Crry expression in airway epithelial cells in vitro. (iupui.edu)
  • However
  • However, C3a and C5a transgenic mice had exacerbated demyelination and slightly delayed remyelination in the corpus callosum compared to WT mice. (uiowa.edu)
  • type
  • Exogenous C3a enhanced IL-17 production from alloantigen or autoantigen (type V collagen) reactive lymphocytes. (iupui.edu)
  • Ehrlich believed that each antigen-specific amboceptor has its own specific complement, whereas Bordet believed that there is only one type of complement. (wikipedia.org)
  • specific
  • In the early 20th century, this controversy was resolved when it became understood that complement can act in combination with specific antibodies, or on its own in a non-specific way. (wikipedia.org)