• until recently, they were the only two members of the polyomavirus family known to express the middle tumor antigen protein, which is uniquely efficient at inducing neoplastic transformation in infected cells, resulting in transformation in in vitro cell culture and in the formation of tumors in vivo. (wikipedia.org)
  • The p53 protein regulates Brca1 transcription both in vitro and in vivo, and Brca1 participates in p53 accumulation after gamma-irradiation through regulation of its phosphorylation and Mdm2 expression. (nih.gov)
  • 107] demonstrated that IL-1 production and signaling from the IL-1 receptor are necessary components of Raf-induced transformation of NIH 3 T3 cells, which exclude other factors involvement in the vivo model [85]. (mayabouchenaki.com)
  • TRA was visualized in vivo by nitroxide-enhanced MRI on anesthetized animals or in vitro by electron paramagnetic resonance spectroscopy on isolated tissue specimens. (nih.gov)
  • Design and Methods Growth in culture, colony formation and oncogenicity in vivo were assessed in mouse primary B cells exogenously expressing various combinations of Bcl2 , Myc and Ccnd1 . (haematologica.org)
  • BMSCs can also be engineered to secrete a variety of different proteins in vitro and in vivo that could potentially treat a variety of serum protein deficiencies and other genetic or acquired diseases [ 13 ]. (hindawi.com)
  • quantitative correlations between in vivo and in vitro results were highly significant. (elsevierpure.com)
  • evaluated the protective effects of the natural molecule Evodiamine (EV) extracted from Evodia rutaecarpa in osteoarthritis through in vitro and in vivo experiments. (researchgate.net)
  • Several natural and synthetic HDAC inhibitors have been shown to affect the growth and survival of tumor cells in vitro and in vivo. (oregonstate.edu)
  • Subsequent in vitro and in vivo studies have demonstrated the initial steps of cancer cell invasion and dissemination by disrupting the integrity of the myoepithelial belt that encircles the LECs [ 7 , 8 , 9 , 10 , 11 ]. (biomedcentral.com)
  • In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
  • Conclusion: In conclusion, fluoro-edenite regulates the expression of pRb to trigger a network of signals strictly connected with cell proliferation and neoplastic cell transformation. (unict.it)
  • LCH is characterized by the proliferation of CD1a-positive activated Langerhans (not atypical Langerhans cell, morphologically)-like cells (LCH cells) generating inflammatory granuloma. (mayabouchenaki.com)
  • We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)
  • Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. (spandidos-publications.com)
  • Therefore, various biologically active peptides such as angiotensin, affecting cell proliferation, have become a new area of study in endometrial cancer research. (spandidos-publications.com)
  • Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
  • In various other research, a chimeric protein comprising an anti-IL-6 Ab fused to exotoxin was discovered to inhibit proliferation of prostate carcinoma cell lines [20]. (healthandwellnesssource.org)
  • More in detail, both conditions have been widely associated with the accumulation of genetic and epigenetic alterations responsible for the alteration of cell proliferation and apoptosis responsible for the neoplastic transformation of cells and the development of tumors (Candido et al. (researchgate.net)
  • The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES. (lookformedical.com)
  • Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation in human colon cancer cells. (jefferson.edu)
  • Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
  • Cellular senescence is a multifaceted process that arrests the proliferation of cells that are at risk of neoplastic transformation. (nature.com)
  • Many mechanisms have been proposed for the inhibition of carcinogenesis by tea, including the modulation of signal transduction pathways that leads to the inhibition of cell proliferation and transformation, induction of apoptosis of preneoplastic and neoplastic cells, as well as inhibition of tumor invasion and angiogenesis. (indexindex.com)
  • Heterozygous mutation of Trp53 decreases p53 and results in attenuated apoptosis and G1-S checkpoint control, allowing Brca1Delta11/Delta11 cells to proliferate. (nih.gov)
  • These results demonstrate a functional role for PMS2 to protect against PCa progression by enhancing apoptosis of PCa cells. (oncotarget.com)
  • inhibition of iASPP by RNA-mediated interference or antisense RNA in C. elegans or human cells, respectively, induces p53-dependent apoptosis. (ox.ac.uk)
  • Treatment using the JAK2 inhibitor AG490 induced apoptosis in NRP-152, however, not NRP-154 cells. (healthandwellnesssource.org)
  • Histone deacetylase (HDAC) inhibitors may be useful for cancer prevention and therapy by virtue of their ability to 'reactivate' the expression of epigenetically silenced genes, including those involved in differentiation, cell cycle regulation, apoptosis, angiogenesis, invasion, and metastasis. (oregonstate.edu)
  • Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
  • Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)
  • After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)
  • Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)
  • Results Primary B cells exogenously expressing Bcl2 , Myc and Ccnd1 showed factor-independent growth ability, enhanced colony-forming capability and aggressive oncogenicity, unlike the cases observed with the expression of any combination of only two of the genes. (haematologica.org)
  • These genes are transcriptionally deregulated as the partner genes of IgH translocation, and are thus thought to perform crucial roles in human B-cell lymphomagenesis. (haematologica.org)
  • 2 A synergistic effect resulting from a combination of two genes from BCL2 , MYC and CCND1 has been implicated in human B-cell lymphomagenesis. (haematologica.org)
  • 7 Importantly, it is believed that other hitherto unknown genes also play important roles in lymphomagenesis in addition to the synergistic effects of the aforementioned two oncogenes since human B-cell lymphomas often show a variety of genes subject to alterations and/or deregulated expression. (haematologica.org)
  • The now-activated JAK2 phosphorylates STAT3, which forms homodimers, can combination the nuclear membrane and work as a transcription aspect, inducing several genes including genes mixed up in cellular transformation procedure [15]. (healthandwellnesssource.org)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
  • That is, "foreign" genes can be purposefully introduced into the germ line (reproductive) cells of the patient by means of such vectors, the reason being to genetically "enhance" or engineer the future progeny of the patient. (lifeissues.net)
  • A single exposure or multiple exposures of these cells to MNU was effective in inducing tumorigenic cells that produced palpable tumors as early as 6 weeks after transplantation. (eurekamag.com)
  • Two treatments with MNU (100 micrograms/ml) were optimal for neoplastic transformation and produced tumors in 79% of the injected fat pads. (eurekamag.com)
  • Transplanted cells in nude mice formed subcutaneous tumors, which had histological features of squamous cell carcinoma with apparent keratinizing tendencies. (biomedcentral.com)
  • This study demonstrates in vitro that certain cell types from pleomorphic adenoma are able to clone and survive over a long term and develop subcutaneous tumors in nude mice. (biomedcentral.com)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained perturbation of thyroid hormone homeostasis. (cdc.gov)
  • SM-AP1-3 cells were immunopositive for keratin only, indicating their duct-epithelial or squamous cell differentiation, while SM-AP4/5 cells were positive for both keratin and S-100 protein, indicating their myoepithelial cell differentiation. (biomedcentral.com)
  • In the woman's breast, this process of cell differentiation is directed by hormones produced in the later stages of pregnancy. (ewtn.com)
  • Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation. (spandidos-publications.com)
  • In this issue of Cancer Discovery , Dominguez and colleagues report that TET2 function is critical for germinal center exit and plasma cell differentiation, and its deficiency can lead to B-cell lymphoma phenotypes. (aacrjournals.org)
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
  • High-efficiency neoplastic transformation of mouse mammary epithelial cells in primary collagen gel culture was induced by N-methyl-N-nitrosourea (MNU). (eurekamag.com)
  • Mammary epithelial cells, isolated from virgin BALB/c mice, were embedded within collagen gels and grown in a serum-free medium containing prolactin, progesterone, and linoleic acid. (eurekamag.com)
  • Eleven to 14 days after the final carcinogen treatment, the cells were removed from the collagen gels and injected into the cleared mammary fat pads of syngeneic hosts to assay for transformed cell populations. (eurekamag.com)
  • Control cells cultured for the same periods of time as MNU-treated cells produced only ductal outgrowths that were morphologically similar to those found in the mammary glands of adult virgin hosts. (eurekamag.com)
  • This system provides a distinct means to study the mechanism of mammary neoplastic transformation at cellular and molecular levels. (eurekamag.com)
  • We have previously reported a mouse model in which Brca1 exon 11 is eliminated in mammary epithelial cells through Cre-mediated excision. (nih.gov)
  • This mutation is often accompanied by alterations in transformation-related protein 53 (Trp53, encoding p53), which substantially accelerates mammary tumor formation. (nih.gov)
  • Recognition of the effective involvement of the myoepithelial cells in mammary gland development and in hampering tumorigenesis has renewed the interest in investigating the biological roles of this second main mammary lineage. (biomedcentral.com)
  • In the 5% strength, it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. (nih.gov)
  • The diagnosis should be established prior to treatment, since this method has not been proven effective in other types of basal cell carcinomas. (nih.gov)
  • In our previous study, we proposed a concept of focal carcinomas in pleomorphic adenoma which is an advanced stage of accumulated atypical cells with P53 over-expressions as an initial stage or a latent form of apparent carcinomas secondarily arising in pleomorphic adenoma [ 3 ]. (biomedcentral.com)
  • various biopsies from different european malignant lymphomas, two biopsies from nasopharyngeal carcinomas, and material from non-neoplastic lymph nodes were assayed for the presence of epstein-barr virus (ebv) dna by nucleic acid hybridization. (liverpool.ac.uk)
  • They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
  • A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
  • A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
  • Genomic studies have uncovered silencing TET2 mutations in B-cell and T-cell lymphomas ( 6-8 ), indicating a tumor suppressor role for TET2 in lymphoid malignancies. (aacrjournals.org)
  • Although human HSCs as vehicles to treat metachromatic leukodystrophy (MLD) has been used to treat patients with early onset MLD in a phase I/II trial, the HSCs give rise to all different blood cell lineages, such as the myeloid and lymphoid cell lineages [ 11 ]. (hindawi.com)
  • Splenic marginal zone lymphoma with circulating villous lymphoid cells (SMZL) is a distinct and very different pathological entity since the WHO 2008 classification: it is characterized by an expansion of the splenic white pulp with the infiltration of the red pulp. (fortuneonline.org)
  • Hairy cells are small to medium-sized lymphoid cells with an oval or indented nucleus with homogeneous and spongy chromatin. (fortuneonline.org)
  • Lymphoid neoplasms are cancers of the immune system, which afflict both adults and children, and account for 6-10% of all neoplastic diseases. (univ-mrs.fr)
  • However, this approach requires prior in-depth understanding of the mechanisms by which lymphoid cells undergo neoplastic initiation and progression. (univ-mrs.fr)
  • Lymphoid cells concerned with humoral immunity. (lookformedical.com)
  • A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • When the virus is injected into juvenile hamsters from naive populations, it induces leukemias and lymphomas which are free of virus particles but whose cells contain extra-chromosomal viral DNA. (wikipedia.org)
  • Background A synergistic effect resulting from a combination of BCL2 and MYC or MYC and CCND1 has been implicated in human B-cell lymphomas. (haematologica.org)
  • Genetic alterations of BCL2 (B-cell CLL/lymphoma 2), MYC [v-myc myelocytomatosis viral oncogene homolog (avian)] and CCND1 (cyclin D1) are the most frequently found alterations in human B-cell lymphomas. (haematologica.org)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1. (ox.ac.uk)
  • Cancer is a multi-factorial process involving genetic and epigenetic events which result in neoplastic transformation. (oregonstate.edu)
  • DNA mismatch repair (MMR) enzymes act as proofreading complexes that maintains genomic integrity and MMR-deficient cells show an increased mutation rate. (oncotarget.com)
  • In this issue of Cancer Discovery , Dominguez and colleagues report their findings on the mechanistic link between TET2 mutation and germinal center (GC) B-cell transformation (3). (aacrjournals.org)
  • This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
  • Her experience includes the use of in vitro systems to investigate cytotoxicity, morphological neoplastic transformation, genotoxicity and intracellular fate of nanomaterials. (europa.eu)
  • However, biological and molecular mechanisms linked to cancer development after mineral fibres exposure were not fully investigated.Methods: In the present study, mesothelial (MeT-5A) and human bronchoalveolar alveolar epithelial (A549) cell lines were incubated with rising concentrations of fluoro-edenite to evaluate the expression of retinoblastoma (Rb) protein, which has been demonstrated to play an important role in cell cycle control and tumour progression. (unict.it)
  • Murakami I, Gogusev J, Fournet JC, Glorion C, Jaubert F. Detection of molecular cytogenetic aberrations in langerhans cell histiocytosis of bone. (mayabouchenaki.com)
  • In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
  • Molecular studies are usually needed, particularly in complex cases, including cases with transformation and/or progression. (fortuneonline.org)
  • 2019). In the last decades, it was widely demonstrated how these two pivotal determinants of human pathologies are strongly associated with each other in a dual relationship where aging induces a pro-inflammatory state in the organism and inflammation, in turn, leads to the activation of cellular and molecular pathways involved in cell senescence and aging (Chung et al. (researchgate.net)
  • In this review, we provided an overview of the myoepithelial cells' histogenesis, molecular and biological markers, and physiological commitments. (biomedcentral.com)
  • Ceramide generated in late endosomal compartments is recognized as a potent regulator of cell signaling, but its molecular interactions with late endosomal transmembrane proteins have not been studied in depth. (sphingolipidclub.com)
  • To test this hypothesis, we used an occupationally relevant low dose/long term exposure in vitro model system which utilized a normal human bronchial epithelial cell line (Beas2B). (cdc.gov)
  • Over the past decades, luminal epithelial cell lineage has gained considerable attraction as the functionally milk-secreting units and as the most fruitful acreage for breast cancer launching. (biomedcentral.com)
  • Collectively, our study reveals that the BET inhibitor JQ-1 exerts potent anti-cancer and anti-inflammatory effects by interfering with the core transcriptional program of neoplastic transformation. (ox.ac.uk)
  • We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • In the 1970s, somatic cell genetic techniques were developed to allow the quantification and characterization of specific gene mutations arising in irradiated cultures of somatic cells. (nationalacademies.org)
  • Their development is a complex multistep process of genetic alterations and cellular transformations, which can take decades to progress into invasive and metastatic tumor. (univ-mrs.fr)
  • A deoxyribonucleotide polymer that is the primary genetic material of all cells. (lookformedical.com)
  • This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
  • Guanylyl cyclase C (GCC), the intestinal receptor for the paracrine hormones guanylin and uroguanylin whose early loss characterizes transformation, has emerged as a component of developmental programs organizing spatiotemporal patterning along the crypt-surface axis whose loss promotes tumorigenesis through hyperproliferation and genetic instability. (jefferson.edu)
  • Of even more concern would be the use of somatic cell gene therapies that are purposefully and deceptively used to change the genetic makeup of the patient's future progeny who would continue to carry the "foreign" gene - all done under the guise of treating the somatic cells of a particular patient to "cure" his/her disease. (lifeissues.net)
  • Second, the same genetic engineering process can be used with germ line cells of the patient as the specific target. (lifeissues.net)
  • Disruption of DNA damage response pathways results in an accumulation of genetic mutations, gene amplifications and chromosome alterations, which are key initiating factors in cellular transformation and oncogenesis. (unife.it)
  • This bacterium induces the neoplastic growth of plant cells that differentiate to form "hairy roots. (bioone.org)
  • While HCV induces glutaminolysis to create an environment favorable for viral replication, it predisposes the cell to transformation. (unibe.ch)
  • nFe2O3 transformed cells also possess a pro-inflammatory phenotype, including increased oxidative stress, EMT marker proteins, and changes in select inflammatory cytokines. (cdc.gov)
  • Hence, an inhibitory form of ASPP resembling 53BP2 could allow cells to bypass the tumor-suppressor functions of p53 and the ASPP proteins. (ox.ac.uk)
  • 2021). Similarly, cell senescence due to aging has been widely associated with the impairment of mitochondrial as well as proteosome and lysosome functions responsible for the accumulation of aberrant or misfolded proteins often observed in different neurodegenerative disorders (Sikora et al. (researchgate.net)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Studies have increasingly focused on the potential therapeutic effects of stem cell transplantation for neurological diseases [ 10 ]. (hindawi.com)
  • Bone marrow stem cells, including the pluripotent hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs), are being considered as potential targets for cell and gene therapy-based approaches against a variety of different diseases. (hindawi.com)
  • 2021). Besides these well-known pathogenetic mechanisms related to inflammaging, other processes are involved in age-related and inflammatory-related diseases including enzyme dysfunctions, cell death, impaired tissue renewal and tissue degeneration (Li, 2013). (researchgate.net)
  • Studies in animals and human tissue cultures indicate that cells in this state face exceptionally high risks of becoming cancerous. (ewtn.com)
  • Before a woman first conceives, her breasts consist mostly of connective tissue surrounding a branching network of ducts, with relatively few milk producing cells. (ewtn.com)
  • However, obtaining primary neuronal cells from adult tissue is difficult and faces major ethical issues in clinical practice. (hindawi.com)
  • Cells grown in vitro from neoplastic tissue. (lookformedical.com)
  • Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. (lookformedical.com)
  • Epithelial cells derived from 46 human breast tissue samples of patients suffering from breast cancer have been cultivated. (shengsci.com)
  • A computer-based scanning and image-processing system has been developed to quantitate the relative level of expression of each of 4000 cloned complementary DNA sequences in small biopsies routinely removed from the mucosa of normal and neoplastic human large intestine. (elsevierpure.com)
  • Here we used HCV-infected cells and liver biopsies to study how HCV modulates the glutaminolysis pathway, which is known to play an important role in cellular energetics, stress defense and neoplastic transformation. (unibe.ch)
  • Transcript levels of glutaminolytic factors were quantified in Huh7.5 cells or primary human hepatocytes infected with the JFH1 HCV strain as well as in biopsies of chronic HCV patients. (unibe.ch)
  • We show that HCV modulates the transcript levels of key enzymes of the glutamine metabolism in vitro and in liver biopsies of chronic HCV patients. (unibe.ch)
  • PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
  • The histological features of squamous cell carcinoma from the transplanted cell systems in nude mice might suggest a secondary onset of malignancy from a pre-existing benign adenoma. (biomedcentral.com)
  • A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
  • An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
  • Head and neck squamous cell carcinoma in vitro (cell culture). (medscape.com)
  • HPV infections have received particular attention in recent years, as high-risk strains have been linked to some cases of oral squamous cell carcinoma. (medscape.com)
  • On the contrary, LCH is a reactive disorder with underlying neoplastic potential. (mayabouchenaki.com)
  • Exogenous IL-6 turned on androgen reactive gene appearance in the lack of androgens in individual LNCaP cells [21]. (healthandwellnesssource.org)
  • Since DNA and RNA are essential for cell division and growth, the effect of fluorouracil may be to create a thymine deficiency which provokes unbalanced growth and death of the cell. (nih.gov)
  • Overexpression of human epidermal growth factor receptor 2 (HER2) causes cell transformation and development of various types of malignancies. (iranpath.org)
  • Among several markers that have been defined for EOC, DNA damage and repair system factors, molecules involved in the G1 cell cycle, PI3K pathway, MAPK pathway, and also growth factors attracted more attention for targeted therapy (3). (iranpath.org)
  • In prostate, the functional role of this gene has never been reported and in this study, our aim was to investigate the effect of PMS2 on growth properties of prostate cancer (PCa) cells. (oncotarget.com)
  • Under the influence of these hormones, her breast cells undergo massive growth. (ewtn.com)
  • This period of rapid growth towards maturity is when breast cells arc most likely to be affected by certain cancer causing agents, or "carcinogens. (ewtn.com)
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
  • Cancer is characterized by uncontrolled growth and division of a cell, with extension beyond the normally limiting basement membrane and through the boundaries of normal cells. (medscape.com)
  • Because of its mutated aggressive genetics, this cell has a selective growth advantage over its neighbors. (medscape.com)
  • [ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)
  • Oncogenic expression of PBF in endocrine cancers would thus confer a survival and proliferative advantage following DNA damage, facilitating neoplastic growth and tumourigenesis. (unife.it)
  • Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. (bvsalud.org)
  • Additionally, MECs contributed effectively to maintaining the right luminal cells' polarization and further separating them from the adjacent stroma by making an integrated fence. (biomedcentral.com)
  • Indeed, disruption of the MECs layer was reported to facilitate the invasion of the cancer cells to the surrounding stroma. (biomedcentral.com)
  • Therefore, damaging the MECs layer resulted in the release of various factors (such as SDF1/CXCL12, CXCL14, MMP, and tenascin) [ 11 , 12 ] with a potential to modify the tumour microenvironment and facilitate the paracrine communication between the tumour epithelial cells and the enclosed stroma enhancing the tumour aggressiveness [ 11 , 13 ]. (biomedcentral.com)
  • more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (lookformedical.com)
  • Mutations have also been found in the blood of elderly patients without hematopoietic cancers, indicating that TET2 loss alone is not sufficient to trigger leukemic transformation (reviewed in ref. 5 ). (aacrjournals.org)
  • letters to the editor: bone marrow transplantation and leukemic transformation of transplanted cells]. (liverpool.ac.uk)
  • The importance of choice IL-6 signaling pathways in the various phenotypes of the two 2 cell lines is normally discussed. (healthandwellnesssource.org)
  • Although pathologists in their daily services of surgical pathology had recognized such singular atypical cells in pleomorphic adenomas, these atypical cells were not always regarded as evidence or the source for malignant transformation [ 4 - 6 ]. (biomedcentral.com)
  • Nutrient deprivation, biochemical analysis and metabolite quantification were performed with JFH1 infected Huh7.5 cells. (unibe.ch)
  • 1. Biochemistry of viral replication and in vitro transformation -- pt. (who.int)
  • In HHV-1 and HHV-2 oral infections, viral replication within the oral epithelium may cause lysis of epithelial cells, with vesicle formation. (medscape.com)
  • Introduction: In this study we addressed the expression of Rb and pRb protein in human lung epithelial A549 and MeT-5A cell cultures treated with three concentrations of fluoro-edenite fibres to gain insights into the biomolecular mechanisms underlying the interaction between these environmental particulates/fibres and human respiratory epithelium. (unict.it)
  • Although estrogens have been shown to play a central role in breast cancer development, their carcinogenicity on human breast epithelial cells (HBECs) has not yet been clearly demonstrated. (eurekamag.com)
  • Clonal integration of a polyomavirus in human Merkel cell carcinoma. (mayabouchenaki.com)
  • The aim of the present study was to evaluate the influence of angiotensin II (Ang II) on human EC cells. (spandidos-publications.com)
  • Biological assays were performed on well-[Ishikawa (ISH)] moderately (MFE-296) and poorly (MFE-280) differentiated human adenocarcinoma cancer cell lines, representing the G1, G2 and G3 stage of EC. (spandidos-publications.com)
  • The objective of this study was to identify additional cooperative gene(s) associated with BCL2 and MYC or MYC and CCND1 in human B-cell lymphomagenesis. (haematologica.org)
  • Importantly, human B-cell lymphoma cases with concurrent multiple translocations including BCL2 , MYC and CCND1 have been reported. (haematologica.org)
  • The use of human telomerase reverse transcriptase-immortalized bone marrow mesenchymal stromal cells (hTERT-BMSCs) as vehicles to deliver antinociceptive galanin (GAL) molecules into pain-processing centers represents a novel cell therapy strategy for pain management. (hindawi.com)
  • this limitation has been overcome via ectopic expression of human telomerase reverse transcriptase (hTERT), the catalytic component of telomerase, to produce large quantities of these cells as an attractive source for cellular transplantation [ 16 - 18 ]. (hindawi.com)
  • This technologic and biologic revolution continued through the 1960s to today, and the explosion in technology has fueled the current expansion of knowledge into the working of the human cell. (medscape.com)
  • establishment of ebna-expressing cell lines by infection of epstein-barr virus (ebv)-genome-negative human lymphoma cells with different ebv strains. (liverpool.ac.uk)
  • cells of two ebna (epstein-barr virus nuclear antigen)-negative human lymphoma cell lines, bjab and ramos, were infected with two strains of epstein-barr virus (ebv). (liverpool.ac.uk)
  • clonal transformation of human leukocytes by epstein-barr virus in soft agar. (liverpool.ac.uk)
  • Hayflick, L. The limited in vitro lifetime of human diploid cell strains. (nature.com)
  • A classic paper that describes the limited replicative lifespan of normal human cells. (nature.com)
  • Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells. (shengsci.com)
  • No tumor-specific expression levels of protein kinase C isoenzymes and of c-fos in human breast cancer cell cultures. (shengsci.com)
  • The comet assay was used to measure the DNA damage induced in vitro by nicotine in human leukocytes as the extent of DNA migration in the comet head area, tail length, percent DNA in the tail, and Olive tail moment. (who.int)
  • Our results show an nFe2O3 induced time dependent cellular transformation, evaluated by colony formation assay, beginning at about 3 months post exposure. (cdc.gov)
  • Treatment with JQ-1 effectively impaired TPA-induced colony formation in vitro. (ox.ac.uk)
  • This goal, however, cannot be accomplished until the specific agent(s) or mechanisms that initiate the neoplastic process are identified. (eurekamag.com)
  • 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
  • Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. (nature.com)
  • By mechanisms still barely understood by man, these basic cells are directed to become different from one another. (ewtn.com)
  • To time, the mechanisms root the pathogenesis of the disease, including how regular prostate cells become neoplastic, unidentified remain. (healthandwellnesssource.org)
  • One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
  • In this lecture, I will focus on several new roles of SphKs and Spns2 in regulation of immune cell trafficking, cancer progression, and pulmonary metastasis. (sphingolipidclub.com)
  • Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing. (nature.com)
  • Conclusions We conclude from these tests that STAT3 activity is important in the phenotype of NRP-154 cell, however, not NRP-152 cells. (healthandwellnesssource.org)
  • For instance, early investigators noticed that transfection of untransformed B cells using a plasmid for constitutive appearance of IL-6 conferred the tumorigenic phenotype over the cells [2]. (healthandwellnesssource.org)
  • The transformation in prostate cell phenotype from paracrine IL-6-activated to autocrine IL-6-activated is thought to be a adding element in the development from harmless hyperplasia to neoplasia [17]. (healthandwellnesssource.org)
  • Work in knockout mouse models has shown that TET2 loss enhances hematopoietic stem cell (HSC) self-renewal, expanding the HSC pool (reviewed in refs. (aacrjournals.org)
  • We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
  • We found that these compounds exhibit potent anticancer effects through the reaction with microtubules, causing cell cycle arrest. (shengsci.com)
  • In this study, we investigated the effect of the BET inhibitor JQ-1 on malignant transformation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin epidermal JB6 P+ cells. (ox.ac.uk)
  • We hypothesized that an amorphous silica coating (SiO2-nFe2O3) would ablate iron homeostasis disruption induced by an uncoated but otherwise identical particle (nFe2O3), and would therefore reduce nFe2O3-induced subsequent neoplastic-like cellular transformation and oxidative stress. (cdc.gov)
  • Here, an hTERT-BMSCs/Tet-on/GAL cell line was constructed using a single Tet-on-inducible lentivirus system, and subsequent experiments demonstrated that the secretion of rat GAL from hTERT-BMSCs/Tet-on/GAL was switched on and off under the control of an inducer in a dose-dependent manner. (hindawi.com)
  • 3 - 7 The synergistic effect of BCL2 and MYC has also been implicated in the histological and clinical transformation of indolent follicular lymphoma into a more aggressive lymphoma. (haematologica.org)
  • Indeed, the potent pathotropic migratory properties of BMSCs and ability to circumvent both the complications associated with immune rejection of allogenic cells and many of the moral reasons associated with embryonic stem cell use suggest that BMSCs are most promising stem cells as a potential target for the clinical use of genetically engineered stem cells [ 14 , 15 ]. (hindawi.com)
  • The HCL-Japanese variant form (jpHCL) is rare and less well defined: there are common points with vHCL but several aspects are different in terms of morphology of hairy cells, degree of leukocytosis or clinical course. (fortuneonline.org)
  • An accurate diagnosis is necessary given that different clinical management is required: the first step in a definitive diagnosis is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and a specific Flow Cytometric Analysis (FCA). (fortuneonline.org)
  • clinical applications of cell surface markers. (liverpool.ac.uk)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • This, in turn, creates a clonal population of a single abnormal cell. (medscape.com)
  • An "in vitro"study on lung cells exposed to fluoro-edenite fibres. (unict.it)
  • In the current study, we assessed the cytotoxic effects of idarubicin-Z HER2 affibody conjugate on the positive-HER2 cancer cell lines. (iranpath.org)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • PBF is a multifunctional proto-oncogene which is overexpressed in thyroid, pituitary and breast cancers, with roles in cell transformation, invasion and transporter regulation. (unife.it)
  • Individuals have been studied from well-defined population groups in which colonic epithelial cells have progressed to increasingly advanced stages of neoplastic transformation. (elsevierpure.com)
  • One of the key cellular components with functional roles in both innate and adaptive arms of the immune response are Langerhans cells (LCs) (2). (mayabouchenaki.com)
  • Classical Hairy Cell Leukemia (HCL) and HCL-like disorders are a very heterogeneous group of mature B-cell Chronic Lympho proliferative Disorders (B-CLPD). (fortuneonline.org)
  • S1P is generated intracellularly by two sphingosine kinases (SphK1, SphK2) and is exported out of cells by Spinster 2 (Spns2) to exert its effects through activation of five specific cell surface S1PRs in autocrine or paracrine manners. (sphingolipidclub.com)
  • This is called "recombinant-DNA somatic cell gene transfer" or therapy, the point being that the targets are the diseased somatic cells of the patient. (lifeissues.net)
  • Second, there have been scientific studies documenting the fact that not only the somatic cells but also the germ line cells of the patient can be accidentally infected in the process of using somatic cell gene therapies. (lifeissues.net)