• We present a patient who developed severe hypocalcaemia after administration of denosumab in the context of severe vitamin D deficiency and a normal kidney function. (bmj.com)
  • Yamamoto M, Kawanobe Y, Takahashi H, Shimazawa E, Kimura S, Ogata E. Vitamin D deficiency and renal calcium transport in the rat. (medscape.com)
  • while the odds of symptomatic hypocalcaemia for patients with severe vitamin D deficiency was 10.18 times (95% CI: 1.14-90.86, P = 0.04) greater than for those with vitamin D sufficiency. (biomedcentral.com)
  • Despite an increasing number of studies investigating predictors of postoperative hypocalcaemia, there have been conflicting results regarding the impact of preoperative vitamin D deficiency. (biomedcentral.com)
  • A meta-analysis of risk factors for hypocalcaemia after total thyroidectomy pooling the results of eight studies indicated that the incidence of hypocalcaemia was significantly increased in patients with vitamin D deficiency [ 4 ]. (biomedcentral.com)
  • Vitamin D deficiency, hypocalcemia, and hearing loss in children. (llu.edu)
  • As the world's attention has been riveted upon the growing COVID-19 pandemic, many researchers have written brief reports supporting the hypothesis that vitamin D deficiency is related to the incidence and severity of COVID-19. (frontiersin.org)
  • The clear common thread among the top risk groups-vitamin D deficiency-may be being overlooked because of previous overstated claims of vitamin D benefits. (frontiersin.org)
  • Firstly, the innate immune system is impaired by vitamin D deficiency, which would predispose sufferers to viral infections such as COVID-19. (frontiersin.org)
  • Vitamin D deficiency also increases the activity of the X-chromosome-linked "Renin-Angiotensin" System, making vitamin D deficient individuals (especially men) more susceptible to COVID-19's deadly "cytokine storm" (dramatic immune system overreaction). (frontiersin.org)
  • Secondly, the groups who are at highest risk for severe COVID-19 match those who are at highest risk for severe vitamin D deficiency. (frontiersin.org)
  • And thirdly, the pattern of geographical spread of COVID-19 reflects higher population vitamin D deficiency. (frontiersin.org)
  • Both within the USA and throughout the world, COVID-19 fatality rates parallel vitamin D deficiency rates. (frontiersin.org)
  • Although randomized controlled trial results may be available eventually, the correlational and causal study evidence supporting a link between vitamin D deficiency and COVID-19 risks is already so strong that it supports action. (frontiersin.org)
  • The 141 author groups writing primarily about biological plausibility detailed how vitamin D deficiency can explain every risk factor and every complication of COVID-19, but agreed that other factors are undoubtedly at work. (frontiersin.org)
  • Two causal modeling studies and several analyses of variance strongly supported the hypothesis that vitamin D deficiency is a causal, rather than a bystander, factor in COVID-19 outcomes. (frontiersin.org)
  • The literature review also found that prophylactically correcting possible vitamin D deficiency during the COVID-19 pandemic is extremely safe. (frontiersin.org)
  • The objective of this longitudinal study was to determine whether serum vitamin D deficiency at baseline could predict the onset of non-Alzheimer dementias (NAD) within 7 years among older women. (karger.com)
  • More NAD were observed in women with vitamin D deficiency (p = 0.023). (karger.com)
  • We found an association between vitamin D deficiency at baseline and the onset of NAD (adjusted odds ratio = 19.57, p = 0.042). (karger.com)
  • Conversely, vitamin D deficiency was not associated with AD (p = 0.222). (karger.com)
  • Baseline vitamin D deficiency predicted the onset of NAD within 7 years among older women. (karger.com)
  • Vitamin D deficiency and insufficiency as well as low serum calcium levels can trigger negative health outcomes in women of childbearing age. (ucl.ac.uk)
  • We found a high prevalence of vitamin D deficiency and insufficiency in women of childbearing age, with insufficiency affecting more than half of these women. (ucl.ac.uk)
  • The highest prevalence of vitamin D deficiency and insufficiency was observed in the South region. (ucl.ac.uk)
  • D deficiency and hypocalcemia due to hypo- or hyperparathyroid disorders. (e-lactancia.org)
  • Neil is recognised nationally and internationally for his work in metabolic bone diseases including osteoporosis, vitamin D deficiency and disorders of calcium homeostasis. (birmingham.ac.uk)
  • Ten children with vitamin D deficiency (59%) had abnormalities on histologic studies of the growth plate, but only 3 had abnormal radiographs. (contemporarypediatrics.com)
  • In addition, adverse event reports submitted to FDA showed severe and symptomatic hypocalcemia, including hospitalization and death, is occurring in patients with advanced kidney disease treated with Prolia. (medlineplus.gov)
  • Preliminary results from a separate internal FDA study investigating the risk of hypocalcemia suggest that patients on dialysis treated with Prolia are at substantial risk for severe and symptomatic hypocalcemia, including hospitalization and death. (medlineplus.gov)
  • Symptoms of hypocalcemia include numbness in fingers and toes, muscle cramps, irritability, impaired mental capacity and muscle twitching. (wikipedia.org)
  • Advise patients on dialysis to immediately seek help if they experience symptoms of hypocalcemia. (medlineplus.gov)
  • Diagnosis and management of hypocalcaemia. (bmj.com)
  • As hypocalcemia progresses, muscle cramps are common, and people may become confused, depressed, and forgetful and have tingling in their lips, fingers, and feet as well as stiff, achy muscles. (msdmanuals.com)
  • Acute hypocalcemia can lead to paresthesia, tetany, and seizures (characteristic physical signs may be observed, including Chvostek sign, which is poorly sensitive and specific of hypocalcemia, and Trousseau sign). (bmj.com)
  • Total calcium of less than 8.0 mg/dL is hypocalcaemia, with levels below 1.59 mmol/L (6 mg/dL) generally fatal. (wikipedia.org)
  • Sodium 146 mmol/LL, potassium 4.9 mmol/L, urea 26.7 mmol/L, and creatinine 236 µmol/L, eGFR 23 ml/minute, adjusted calcium 1.6 mmol/L and phosphate 1.34 mmol/L). He did not have any signs and symptoms of hypocalcaemia. (endocrine-abstracts.org)
  • [ 5 ] Vitamin D stimulates intestinal absorption of calcium, regulates PTH release by the chief cells, and mediates PTH-stimulated bone reabsorption. (medscape.com)
  • Use of calcitonin-salmon injection is recommended in conjunction with adequate calcium and vitamin D intake to prevent the progressive loss of bone mass. (medscape.com)
  • The lack of the biologically active vitamin D3 causes impaired bone mineralization. (wisdompanel.com)
  • The body needs vitamin D to promote bone growth. (epnet.com)
  • Low vitamin D may be a significant risk factor in bone fractures in children and various diseases including infections and asthma , the researchers say. (contemporarypediatrics.com)
  • [ 1 ] Symptomatic patients with classic clinical findings of acute hypocalcemia require immediate resuscitation and evaluation. (medscape.com)
  • Intravenous calcium infusion is essential to raise calcium levels and resolve or minimize symptoms in the setting of acute hypocalcemia. (springer.com)
  • SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Emergency management of acute hypocalcaemia in adult patients. (bmj.com)
  • The presentation of hypocalcemia varies widely, from asymptomatic to life-threatening. (medscape.com)
  • Hypocalcemia varies from a mild asymptomatic biochemical abnormality to a life-threatening disorder. (bmj.com)
  • Sixteen treated chronically with vitamin D2 and 14 with calcitriol. (medscape.com)
  • No participants in the D2 group were hospitalized or went to the emergency department for hypocalcemia compared with four in the calcitriol group, (p=0.03), three of whom had multiple ED visits. (medscape.com)
  • Vitamin D influences these levels after its dihydroxylation into calcitriol. (medscape.com)
  • Vitamin D influences these levels after its dihydroxylation into calcitriol (at the 25 position in the liver and the 1 position in the kidney). (medscape.com)
  • Calcitriol and other vitamin D metabolites are used in the treatment and prevention of Vit. (e-lactancia.org)
  • The aim of this clinical narrative review is to summarize and critically appraise the literature on the differential diagnosis of hypocalcemia and to provide its correct management. (springer.com)
  • The clinical features of hypocalcemia largely manifest through neuromuscular excitability. (bmj.com)
  • he works with NICE and was Clinical Lead for NICE Guideline on Primary Hyperparathyroidism (NG132) and instigated Rapid Evidence Summary for vitamin D in COVID-19 (ES28). (birmingham.ac.uk)
  • The initial step in the metabolic activation process is the introduction of a hydroxyl group at the side chain at C-25 by the hepatic enzyme, CYP 27 (a vitamin D-25-hydroxylase). (medscape.com)
  • 1] In both cases, hypocalcaemia was associated with renal failure and hepatic impairment. (endocrine-abstracts.org)
  • Linnebur SA, Vondracek SF, Vande Griend JP, Ruscin JM, McDermott MT. Prevalence of vitamin D insufficiency in elderly ambulatory outpatients in Denver, Colorado. (medscape.com)
  • Eight infants with vitamin D insufficiency (33%) had abnormal growth plate histology but normal radiology. (contemporarypediatrics.com)
  • This new therapy has the advantage of being effective for correcting serum calcium levels and significantly reducing the daily requirements of calcium and active vitamin D supplements. (springer.com)
  • During dose titration, serum calcium levels should be monitored frequently and if levels decrease below the normal range, appropriate steps should be taken to increase serum calcium levels, such as by providing supplemental calcium, initiating or increasing the dose of calcium-based phosphate binder, initiating or increasing the dose of vitamin D sterols, or temporarily withholding treatment with Sensipar [see Monitoring For Hypocalcemia and WARNINGS AND PRECAUTIONS ]. (globalrph.com)
  • The latter were randomized to oral calcium (3 g/day) plus vitamin D (1 mg/day) (Group A, n=49), calcium alone (Group B, n=49), or no supplements (Group C, n=50). (nih.gov)
  • COVID-19 was compared with dengue fever, for which oral vitamin D supplements of 4,000 IU for 10 days were significantly more effective than 1,000 IU in reducing virus replication and controlling the "cytokine storm" (dramatic immune system over-reaction) responsible for fatalities. (frontiersin.org)
  • Despite treatment with intravenous calcium and oral vitamin D tablets, his calcium level did not normalize. (endocrine-abstracts.org)
  • In a 2 x 2 factorial design, patients were randomized to receive either chelation or placebo infusions, and oral vitamins or placebo. (acc.org)
  • Hypocalcemia may worsen during treatment. (nih.gov)
  • Hypocalcemia can worsen and must be corrected prior to use. (nih.gov)
  • On occasion, severe hypocalcemia may result in seizures, tetany, refractory hypotension, or arrhythmias that require a more aggressive approach, including intravenous infusions of calcium. (medscape.com)
  • Exclusion criteria: Patients with attacks induced by definite cause, such as hypotension, hypocalcemia, excessive ultrafiltration or fast ultrafiltration (UFR of >13 mL/hr/kg). (who.int)
  • Quantitatively severe hypocalcemia can sometimes present with few symptoms, if onset has been protracted and chronic. (bmj.com)
  • Preliminary results from a separate internal FDA study further investigating hypocalcemia in dialysis patients treated with Prolia show a substantial risk with serious outcomes, including hospitalization and death. (medlineplus.gov)
  • Hypocalcemia may occur subsequent to failure of any of the mechanisms by which serum calcium concentration is maintained. (bmj.com)
  • Hypocalcemia is common and can occur unnoticed with no symptoms or, in severe cases, can have dramatic symptoms and be life-threatening. (wikipedia.org)
  • This case report emphasises the importance of screening and ongoing monitoring of risk factors for iatrogenic hypocalcaemia with denosumab treatment. (bmj.com)
  • Hypocalcemia is a state of electrolyte imbalance in which the circulating serum calcium level is low. (bmj.com)
  • Your doctor will tell you to take supplements of calcium and vitamin D while you are being treated with ibandronate injection. (medlineplus.gov)
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. (medlineplus.gov)
  • Calcium and vitamin D supplements may be used to treat hypocalcemia. (msdmanuals.com)
  • He was managed conservatively and started on calcium carbonate and vitamin D supplements with a favorable evolution. (bvsalud.org)
  • You instruct the parents to increase caloric feedings, which should include vitamin and mineral supplements. (cdc.gov)
  • While effective in the treatment of fracture reduction, hypocalcaemia is a known potential adverse effect. (bmj.com)
  • Multivariate logistic regression was performed to analyse the association of vitamin D levels with the risk of hypocalcaemia after controlling for potential confounding factors. (biomedcentral.com)
  • The U.S. Food and Drug Administration (FDA) is investigating the risk of severe hypocalcemia with serious outcomes, including hospitalization and death, in patients with advanced kidney disease on dialysis treated with the osteoporosis medicine Prolia (denosumab). (medlineplus.gov)
  • Our review of interim results from an ongoing safety study of Prolia suggests an increased risk of hypocalcemia, or low calcium levels in the blood, in patients with advanced kidney disease. (medlineplus.gov)
  • Our review of the interim results from this ongoing safety study suggests an increased risk of hypocalcemia with Prolia in patients with advanced kidney disease. (medlineplus.gov)
  • Sensipar is not indicated for use in adult patients with CKD who are not on dialysis because of an increased risk of hypocalcemia [see WARNINGS AND PRECAUTIONS ]. (globalrph.com)
  • Therefore, we aimed to estimate the prevalence of serum vitamin D and calcium deficiencies and insufficiencies and associated risk factors in Brazilian women of childbearing age and to assess whether there are differences in prevalence according to regions of the country and the presence or absence of pregnancy. (ucl.ac.uk)
  • This fear of complications was based on studies from the 1970s that used very high doses of vitamin D2 (over 150,000 units per day), much higher than used today (50,000-100,000 units per day). (medscape.com)
  • Profound hypocalcaemia after high doses of intravenous fusidic acid. (endocrine-abstracts.org)
  • Diseases associated with hypocalcemia, increased cell membrane permeability, impaired transmission of nerve impulses in muscles. (arterium.ua)