• Dive into the research topics of 'Hantaan virus nucleocapsid protein binds to importin α proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B'. Together they form a unique fingerprint. (mssm.edu)
  • Background It has been suggested that acute infantile bronchiolitis associated with respiratory syncytial virus (RSV) may share some pathogenic features with atopic asthma in that virus-specific IgE is produced and cysteinyl leukotrienes (cLTs) and eosinophil cationic protein (ECP) have been detected in airway secretions. (elsevierpure.com)
  • Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008. (cdc.gov)
  • Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children. (cdc.gov)
  • Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis. (cdc.gov)
  • Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. (cdc.gov)
  • Dowd JB , Palermo T , Brite J , McDade TW , Aiello A . Seroprevalence of Epstein-Barr virus infection in U.S. children ages 6-19, 2003-2010. (cdc.gov)
  • VSV infection triggered rapid differentiation of blood monocytes into immature dendritic cells as well as their apoptosis, which depended on caspase 3/7 activation. (karger.com)
  • Some viruses, including those that cause HIV/AIDS, HPV infection, and viral hepatitis, evade these immune responses and result in chronic infections. (wikipedia.org)
  • A VACV lacking the C4L gene (vΔC4) showed no significant differences from wild-type virus in growth kinetics or spread in cell culture, but had reduced virulence in a murine intranasal model of infection. (ox.ac.uk)
  • Furthermore, bronchoalveolar lavage fluid from vΔC4-infected mice had increased cell numbers at day 5 post-infection, which correlated with reduced lung virus titres from this time onward. (ox.ac.uk)
  • Natural symptomatic and experimental influenza infections resulted in a rise in antibody dependent NK cell activation post-infection to the hemagglutinin of the infecting strain, but changes in NK cell activation to M1 and NP were variable. (edu.au)
  • Although antibody dependent killing of target cells infected with vaccinia viruses expressing internal influenza proteins was not detected, opsonising antibodies to NP and M1 likely contribute to an antiviral microenvironment by stimulating innate immune cells to secrete cytokines early in infection. (edu.au)
  • refeeding activation of virus infection following famine? (umn.edu)
  • Activation of p38 MAPK (but not of JNK) was demonstrated in mouse fibroblasts in response to infection with encephalomyocarditis virus (ECMV), a picornavirus that replicates through a dsRNA intermediate. (elsevierpure.com)
  • Upregulation of PD-1 and its ligands PD-L1 and PD-L2 is observed during acute virus infection and after infection with persistent viruses including important human pathogens such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV). (frontiersin.org)
  • Questions are limited to clinicians who would like information related to Zika virus infection. (cdc.gov)
  • In addition to the samples from the 55 pediatric patients, people less than 21 years of age, who had laboratory-confirmed Ebola virus disease, we selected samples from 50 adult patients, more than 21 years of age, who had laboratory-confirmed infection. (cdc.gov)
  • Severe acute respiratory syndrome (SARS) is a serious, potentially life-threatening viral infection caused by a previously unrecognized virus from the Coronaviridae family, the SARS-associated coronavirus (SARS-CoV). (medscape.com)
  • Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain infections and cancers. (msdmanuals.com)
  • Human Immunodeficiency Virus (HIV) Infection in Infants and Children Human immunodeficiency virus (HIV) infection is caused by the retrovirus HIV-1 (and less commonly by the related retrovirus HIV-2). (msdmanuals.com)
  • Macrophage activation syndrome (MAS) is a potentially fatal complication caused by excessive activation and expansion of macrophages and T lymphocytes. (manipal.edu)
  • Jayashree, K , Rao, S & Kamath, N 2017, ' Influenza B virus triggering macrophage activation syndrome in an infant ', Indian Journal of Critical Care Medicine , vol. 21, no. 11, pp. 802-803. (manipal.edu)
  • van der Ven AJ , Netea MG , van der Meer JW , de Mast Q . Ebola virus disease has features of hemophagocytic lymphohistiocytosis syndrome. (cdc.gov)
  • Outbreaks of Ebola virus disease occur sporadically in sub-Saharan Africa and are associated with exceptionally high case-fatality rates. (cdc.gov)
  • Pediatric patients have been underrepresented in Ebola virus disease studies because total numbers of affected children in any given Ebola virus disease outbreak, whether associated with Ebola virus or Sudan virus or Bundibugyo virus are usually low because of outbreak dynamics and societal structure. (cdc.gov)
  • For example, nosocomial Ebola virus disease infections mostly occur in adults working on hospital wards, and children are not usually caregivers for Ebola virus disease patients. (cdc.gov)
  • The relatively large number of pediatric cases in this outbreak enabled closer investigation of factors associated with increased survival of pediatric patients with Ebola virus disease. (cdc.gov)
  • Samples collected during the Gulu outbreak have been invaluable for advancing understanding of Ebola virus disease pathophysiology. (cdc.gov)
  • During the 2000-2001 Gulu Ebola virus disease outbreak, an international response team, including representatives from the US Centers for Disease Control and Prevention, or CDC, provided clinical and technical assistance. (cdc.gov)
  • Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. (cdc.gov)
  • The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (wakehealth.edu)
  • We find that modulation of autophagy using this recombinant SINV negatively regulated production of infectious viruses . (bvsalud.org)
  • A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. (wikipedia.org)
  • A meaning of 'agent that causes infectious disease' is first recorded in 1728, long before the discovery of viruses by Dmitri Ivanovsky in 1892. (wikipedia.org)
  • In this work, we have revealed that early viral protein UBCv1, the only known conjugating enzyme encoded by a virus, modulates innate immune and inflammatory signaling. (mdpi.com)
  • Lerner, M. R., Andrews, N. C., Miller, G. & Steitz, J. A. Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. (nature.com)
  • C-reactive protein (CRP, not shown) leads to classic pathway activation analogous to lectin pathway activation by MBL and ficolins. (medscape.com)
  • Vaccinia virus (VACV) strain Western Reserve protein C4 has been characterized and its function and contribution to virus virulence assessed. (ox.ac.uk)
  • C4 represents the ninth VACV protein to inhibit NF-κB activation and remarkably, in every case examined, loss of each protein individually caused an alteration in virus virulence, despite the presence of other NF-κB inhibitors. (ox.ac.uk)
  • We report here that the nucleocapsid (N) protein of HTNV was able to inhibit TNF-α-induced activation of NF-κB, as measured by a reporter assay, and the activation of endogenous p65, an NF-κB subunit. (mssm.edu)
  • In contrast, activation of both MKK4 and JNK by dsRNA was greatly reduced in cells lacking RNase L (or lacking both RNase L and PKR) but was restored in these cells when introduction of dsRNA was followed by inhibition of ongoing protein synthesis or transcription. (elsevierpure.com)
  • These results are consistent with the notion that the role of RNase L and PKR in the activation of MKK4 and JNK is the elimination, via inhibition of protein synthesis, of a labile negative regulator(s) of the signaling to JNK acting upstream of SEK1/MKK4. (elsevierpure.com)
  • We propose that p38 MAPK is a general participant in dsRNA-triggered cellular responses, whereas the activation of JNK might be restricted to cells with reduced rates of protein synthesis. (elsevierpure.com)
  • These observations provide a mechanistic molecular link between M81 virus replication-a central viral function and a cancer risk factor-and the production of a chemokine involved in inflammation and carcinogenesis. (nature.com)
  • Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas. (nature.com)
  • We also show that a nanobody (a single-domain antibody) that interferes with FluPol A dimerization inhibits the synthesis of vRNA and, consequently, inhibits virus replication in infected cells. (nature.com)
  • Fig. 4: Nb8205, which binds FluPol A at the dimer interface, inhibits cRNA to vRNA replication and virus growth. (nature.com)
  • Retroviruses are enveloped RNA viruses defined by their mechanism of replication via reverse transcription to produce DNA copies that integrate into the host cell's genome. (msdmanuals.com)
  • Functional assays using a firefly luciferase reporter plasmid under the control of a nuclear factor kappa B (NF-κB)-dependent promoter demonstrated that C4 inhibits NF-κB activation at, or downstream of, the inhibitor of kappa kinase (IKK) complex. (ox.ac.uk)
  • Cytokine and chemokine expression in humans infected with Sudan Ebola virus. (cdc.gov)
  • Researchers at University of California, San Diego, suggest that the ancestors of modern humans may have caught herpes virus from chimpanzees before going their separate ways on the evolution path. (medindia.net)
  • According to the study, the ancestors of modern humans were infected by the Herpes Simplex Virus-1 from chimpanzees more than 6 million years ago, before the evolutionary split, while Herpes Simplex Virus-2, which causes genital warts, jumped from chimpanzees to Homo erectus 1.6 million years ago, long before the rise of early modern humans. (medindia.net)
  • The results help us to better understand how these viruses evolved and found their way into humans. (medindia.net)
  • Understanding where our viruses come from will help guide us in preventing future viruses from making the jump into humans", lead researcher Joel Wertheim said. (medindia.net)
  • Emergence of a novel swine-origin influenza A (H1N1) virus in humans. (cdc.gov)
  • HIV-1 originated in Central Africa in the first half of the 20th century, when a closely related chimpanzee virus first infected humans. (msdmanuals.com)
  • The app goes beyond standard virus protection to secure you against potentially hazardous malware such as spyware, rootkits, security exploits, and ransomware. (procrackserial.com)
  • Providing comprehensive, multi-layered protection for your PC, Mac, smartphone, and tablet, Norton 360 Deluxe from Norton by Symantec is an all-in-one security solution that helps defend against malware, ransomware, viruses, and other online threats. (easeus.com)
  • This pathway is activated by viruses, fungi, bacteria, parasites, cobra venom, immunoglobulin A, and polysaccharides and forms an important part of the defense mechanism independent of the immune response. (medscape.com)
  • Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. (wikipedia.org)
  • Most virus species have virions too small to be seen with an optical microscope and are one-hundredth the size of most bacteria. (wikipedia.org)
  • The origins of viruses in the evolutionary history of life are unclear: some may have evolved from plasmids-pieces of DNA that can move between cells-while others may have evolved from bacteria. (wikipedia.org)
  • Kaspersky Anti-Virus Crack is the backbone of your PC's internet security system, delivering essential, real-time protection from the latest malware. (procrackserial.com)
  • Kaspersky Anti-Virus uses intelligent scanning and minor, frequent updates to deliver real-time, efficient protection from the latest malware threats across the Internet. (procrackserial.com)
  • Kaspersky Anti-Virus License Key runs upon cloud-based technology to continuously update the database from all its users globally, thus assuring up-to-day virus signatures and promptly reacting to new breeds of threatening viruses and malware before the actual damage is about to take place. (procrackserial.com)
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  • The software should be effective at detecting and removing viruses, Trojans, spyware, and other malware. (easeus.com)
  • This provides an invaluable source of information for paleovirologists to trace back ancient viruses that existed as far back as millions of years ago. (wikipedia.org)
  • Exposure to a 50 Hz electromagnetic field induces activation of the Epstein-Barr virus genome in latently infected human lymphoid cells. (healthkeys.uk)
  • Researchers from Lund Stem Cell Center highlight the importance of controlling viral elements that reside in the genome and how their activation during development may contribute t. (lu.se)
  • African swine fever virus (ASFV) is an acute and persistent swine virus with a high economic burden that encodes multiple genes to evade host immune response. (mdpi.com)
  • We found that the strongest similarity between all these conditions is the activation of common P53 downstream genes. (pasteur.fr)
  • We're happy to present our most recent publication 'Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors' published on July 18. (lu.se)
  • Interestingly, increased P53 activation and apoptosis are induced not only in cells expressing high levels of viral antigens but also in cells showing low or undetectable levels of the same proteins. (pasteur.fr)
  • Transient overexpression of UBCv1 impaired activation of NF-κB and AP-1 transcription factors induced by several agonists of these pathways. (mdpi.com)
  • Activation of the complement pathways. (medscape.com)
  • Double-stranded RNA (dsRNA) accumulates in virus-infected mammalian cells and signals the activation of host defense pathways of the interferon system. (elsevierpure.com)
  • The Epstein-Barr virus M81 strain, isolated from a nasopharyngeal carcinoma, induces potent spontaneous virus production in infected B cells. (nature.com)
  • Viral infections in animals provoke an immune response that usually eliminates the infecting virus. (wikipedia.org)
  • We propose that refeeding may be an important mechanism for activation of certain viral infections previously suppressed by famine. (umn.edu)
  • Observations of infections with and illness due to parainfluenza, mumps and respiratory syncytial viruses and Mycoplasma pneumoniae. (cdc.gov)
  • The Ebolavirus genus includes 5 different viruses that result in different case-fatality rates: Ebola virus, Sudan virus, and Bundibugyo virus cause fatal infections, but neither Tai Forest virus nor Reston virus has been associated with human fatalities. (cdc.gov)
  • Epidemiological evidence from the current outbreak of Zika virus (ZIKV) and recent studies in animal models indicate a strong causal link between ZIKV and microcephaly. (pasteur.fr)
  • Also, at the end of today's session, participants will be able to apply CDC Zika laboratory testing algorithms when determining which patients with relevant travel history, possible Zika virus exposure, or Zika symptoms, should receive testing. (cdc.gov)
  • Here, using crystallography and cryo-electron microscopy, we determine the structures of FluPol A from human influenza A/NT/60/1968 (H3N2) and avian influenza A/duck/Fujian/01/2002 (H5N1) viruses at a resolution of 3.0-4.3 Å, in the presence or absence of a cRNA or vRNA template. (nature.com)
  • Rota PA, Wallis TR, Harmon MW, Rota JS, Kendal AP, Nerome K. Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983. (cdc.gov)
  • The evolutionary dynamics of human influenza B virus. (cdc.gov)
  • Objective To test the association between eosinophil activation and cysteinyl leukotriene production in the upper airway secretions of infants with RSV positive (RSV+ve) bronchiolitis. (elsevierpure.com)
  • In evolution, viruses are an important means of horizontal gene transfer, which increases genetic diversity in a way analogous to sexual reproduction. (wikipedia.org)
  • Inflammatory responses in Ebola virus-infected patients. (cdc.gov)
  • Multiple viruses have developed evasion strategies to circumvent the host cell inflammatory process, with one of the most prevalent being the disruption of nuclear factor kappa B (NF-κB) activation. (mssm.edu)
  • HIV is one of several viruses transmitted through sexual contact and by exposure to infected blood. (wikipedia.org)
  • The disease onset is nonspecific and is characterized by abrupt onset of fever, fatigue, headache, myalgia, and gastrointestinal distress 3 to 13 days after exposure to the virus. (cdc.gov)
  • Another published paper shows that mobile phone radiation can also activate Epstein-Bar virus in human lymph cells. (healthkeys.uk)
  • The protease of adenovirus serotype 2 requires cysteine residues for both activation and catalysis. (microbiologyresearch.org)
  • C1q can also be activated by mycoplasmal organisms, RNA viruses, bacterial endotoxins, and cell membranes of some organelles without the presence of antibody. (medscape.com)
  • Because they possess some but not all such qualities, viruses have been described as "organisms at the edge of life" and as replicators. (wikipedia.org)
  • What the researchers mean by "activate" is to cause the virus to be excreted, or expressed, by the living cell. (healthkeys.uk)
  • Oncolytic vesicular stomatitis virus (VSV) can be delivered intravenously to target primary and metastatic lesions, but the interaction between human peripheral blood leukocytes (PBLs) and VSV remains poorly understood. (karger.com)
  • Hantaviruses such as Hantaan virus (HTNV) and Andes virus cause two human diseases, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome, respectively. (mssm.edu)
  • Human immunodeficiency virus (HIV) is a retrovirus. (msdmanuals.com)
  • To address this gap, we use a genetic approach to activate macroautophagy / autophagy in the yellow fever mosquito ( Aedes aegypti ), infected with a recombinant Sindbis virus (SINV) expressing an autophagy activator. (bvsalud.org)
  • As pVI is also required for activation of the adenovirus-coded protease, the same pVI derivatives were assessed for their ability to activate recombinant adenovirus-coded 23K protease. (microbiologyresearch.org)
  • Less well appreciated is the fact that the PD-1/PD-L1 axis also regulates antiviral immune responses and is therefore modulated by a number of viruses. (frontiersin.org)
  • In the course of these studies, we identified a long- sought site of RNase L-mediated cleavage in the 28S rRNA, which could cause inhibition of translation, thus allowing the activation of JNK by dsRNA. (elsevierpure.com)
  • Binding of factor H to C3b increases its inactivation by factor I. Properdin stabilizes it, preventing its inactivation by factors H and I. The alternate pathway does not result in a truly nonspecific activation of complement because it requires specific types of compounds for activation. (medscape.com)
  • Thus, M81 induced chronic inflammation in its target cells and this resulted in increased virus production. (nature.com)
  • Viruses are considered by some biologists to be a life form, because they carry genetic material, reproduce, and evolve through natural selection, although they lack the key characteristics, such as cell structure, that are generally considered necessary criteria for defining life. (wikipedia.org)
  • In contrast, activation of IRF3 and ISRE signaling upon stimulation with TRIFΔRIP, cGAS/STING or RIG-I-CARD remained unaltered. (mdpi.com)
  • Kaspersky Anti-Virus Full Crack is a background of four different output ports: full, quick, custom, and removable drive-mode. (procrackserial.com)
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