Virulence gene expression regulation bacterial. Medical search. Frequent questions

100 types on the basis of immunogenic differences in their surface M proteins and polymorphisms in the emm gene ( 1 ). (cdc.gov)
In addition to the PrfA regulon, the Clp stress proteins have an impact on Listeria virulence. (ed.ac.uk)
In this sense, we aim to characterize the behaviour of different promoters of genes involved in biofilm regulation under different conditions and to search for possible new DNAbinding proteins associated with their promoter regions. (usp.br)
Analysis of virulence related gene expression and computational simulations of pivotal proteins involved in pathogenesis demonstrate that myricetin downregulates the saeR global regulator and interacts with sortase A and α-hemolysin. (nature.com)
I enjoyed working with yeast RNA mechanisms and the involved proteins, but I was also very happy to collaborate with groups working on other organisms and mechanisms, such as bacterial mechanisms of virulence. (cosminribo.eu)
CBP and p300 are two highly similar proteins that play critical roles as "super-organizers" of transcription of genes. (atlasofscience.org)
BioID screen for bacterial virulence proteins: new tools for… The discovery of penicillin in the 1920s revolutionized our ability to treat bacterial infection. (atlasofscience.org)
These thermosensors are part of a regulatory network, such as the production of heat shock proteins mediated by sigma factor 32 (RpoH) in Escherichia coli or the transcriptional repressor of heat-shock genes HrcA in Bacillus subtilis (Hecker et al. (springer.com)
Launch For all microorganisms well-timed and temporal legislation of gene appearance and its own translation to proteins level is essential for cell proliferation. (immune-source.com)
The observed inhibition of fibronectin binding was confirmed by a reduction in the expression of genes encoding two major fibronectin-binding streptococcal surface proteins, Sof and SfbI. (microbiologyresearch.org)
Two genes encoding putative internalin proteins were chosen for further study. (omictools.com)
Interestingly, several alkali induced genes/proteins can provide a cross protective overlap to other types of stresses. (essex.ac.uk)
Co-immunoprecipitation, bacterial two-hybrid and pull-down analyses showed that PilH and PilG were able to interact with district subsets of proteins that potentially account for their regulatory impact. (biomedcentral.com)
Taken together, we demonstrate that for the conditions tested PilG and PilH have inverse regulatory effects on flagellum-dependent and pili-dependent motility in Xcc and that this regulatory impact depends on these proteins influences on genes/proteins involved in flagellar biosynthesis and pilus assembly. (biomedcentral.com)

In bacteria, cyclic di-AMP has been implicated in the control of growth, cell wall homeostasis, bacterial biofilm formation and virulence gene expression, heat and osmotic stress regulation and responses, sporulation, potassium transport, lysis, and antibiotic resistance. (wikipedia.org)
Mapping transcriptional regulation of biofilm-related genes promoters in Pseudomonas. (usp.br)
Knockout mutants of rna01 and a double knockout mutant of rna01 and hfq, both had decreased biofilm formation and hemolytic activity, attenuation for virulence in Galleria mellonella, altered stress susceptibility, and an altered outer membrane protein profile. (bvsalud.org)
Differential gene expression analysis indicated that this isolate formed excessive biofilm by reducing flagellar formation (7.4 to 1,624.1 folds) and overproducing extracellular matrix components including CdrA (4.4 folds), alginate (5.2 to 29.1 folds) and Pel (4.8-5.5 folds). (frontiersin.org)
QS is a process of bacterial cell-cell communication that controls virulence and biofilm formation in many bacterial species. (wadsworth.org)
This organism produces a diverse array of virulence factors, including toxins, adhesins, colonization and biofilm factors. (biomedcentral.com)
We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. (nature.com)
Subramani (2019) said that Quorum sensing (QS) is a process of intercellular signaling or cell-cell communication and a vital regulatory mechanism for coordinating biofilm formation including common activities and physiological processes such as symbiosis, formation of spores or fruiting bodies, antibiotics synthesis, genetic competence, apoptosis, and virulence in many bacterial species using extracellular QS signaling molecules, which is often referred to as autoinducers. (learnlifescience.com)
It is a second messenger that modulates a variety of bacterial growth phenotypes including biofilm formation. (learnlifescience.com)

S. aureus has a vast array of virulence determinants whose expression is modulated by an intricate regulatory network, where transcriptional factors (TFs) are the primary elements. (biomedcentral.com)
These data define the transcriptional changes induced during growth in low iron conditions and illustrate the potential of this dataset in the identification of putative virulence determinants for future study. (omictools.com)
CsrRS (or CovRS) is a two-component system implicated in the control of multiple virulence determinants in the important human pathogen, group A Streptococcus (GAS). (lu.se)

Microscopic analysis of cell and colony structure indicates that CmrRST promotes the formation of elongated bacteria arranged in bundled chains, which may contribute to bacterial migration on surfaces. (nih.gov)
DNA supercoiling and environmental regulation of gene expression in pathogenic bacteria. (microbiologyresearch.org)
As in all pathogenic bacteria, virulence of the facultative intracellular Listeria species is a multifactorial trait. (ed.ac.uk)
An important factor of bacterial virulence is the formation of biofilms which are aggregates of microorganisms incorporated into an extracellular matrix that protects bacteria from hostile environments. (usp.br)
Bacterial regulatory small RNAs (sRNAs) play important roles in gene regulation and are frequently connected to the expression of virulence factors in diverse bacteria. (bvsalud.org)
The research in the Division of Microbiology & Parasitology comprises a wide range of topics including: bacterial motility and flagellar biogenesis, mechanisms of entry of bacteria into mammalian cells, bacterial toxin export and multi-drug efflux, regulation of gene expression during host-pathogen interaction, transmission, cell-cycle dynamics and virulence mechanisms in malaria parasites, host modulation by parasitic organisms and dynamics of parasitic worm infection in human populations. (cam.ac.uk)
Research in the Paczkowski laboratory focuses on the mechanisms of regulation of quorum sensing (QS) in Gram-negative bacteria, such as Pseudomonas aeruginosa , Vibrio cholerae , Aeromonas hydrophila , and Chromobacterium violaceum . (wadsworth.org)
QS allows bacteria to synchronously alter gene expression patterns that underpin collective behaviors. (wadsworth.org)
Learning how bacteria correctly interpret these blends of AIs and elicit appropriate gene expression responses is essential to understand how bacteria communicate, and, more globally, to understand how all organisms decode environmental stimuli. (wadsworth.org)
We use a combination of bacterial genetics, biochemistry, structural biology, and chemical biology to understand how bacteria respond appropriately to signals in a complex environment. (wadsworth.org)
Given the high number of virulence factors present in these bacteria, and the niche-specific role many of them play during different stages of the infectious process, gene expression must be finely tuned in order to efficiently coordinate their expression, and also continue to preserve energy pools. (biomedcentral.com)
ppGpp is an intracellular sensor that, in response to different types of stress, coordinates the rearrangement of the gene expression pattern of bacteria to promote adaptation and survival to new environmental conditions. (ibecbarcelona.eu)
Consequently, bacteria have developed different systems to sense changes in environmental conditions such as temperature and induce an adaptation of metabolism and gene expression. (springer.com)
Bacteria with variant cagY alleles that reduced T4SS function showed comparable reduction in binding to a5ß1 integrin, although CagY was still expressed on the bacterial surface. (pacb.com)
Bacteria respond to changing environments by altering gene expression. (mechanobio.info)
Two-component regulatory systems (TCRS) are important mediators of signal transduction that enable bacteria to detect physical and/or chemical changes and then relay this signal through the cytoplasm to the bacterial nucleoid, where modulation of gene expression occurs. (mechanobio.info)
Most c-di-GMP-dependent signaling pathways control the ability of bacteria to interact with abiotic surfaces or with other bacterial and eukaryotic cells (Romling et al, 2013). (learnlifescience.com)
Inversely, high ID50 values are associated with motile and fast-growing bacteria that use quorum-sensing based regulation of virulence factors expression. (pasteur.fr)
However, despite the numerous studies on bacterial motility in other Gram-negative bacteria, only limited work has been carried out examining the motility regulation in Xcc . (biomedcentral.com)
We observed CsrS-dependent regulation of 72 of the 73 genes whose expression changed in response to elevated extracellular Mg(2+) in wild-type bacteria, a result that identifies CsrS as the principal, if not exclusive, sensor for extracellular Mg(2+) in GAS. (lu.se)

Fermentable carbon sources seem to have a particular role in virulence gene regulation. (ed.ac.uk)
Finally, we examine the conservation of 135 USA300 TFs amongst 11 other S. aureus strains, identifying a key group of regulators that display a high degree of conservation, including many that have previously been demonstrated to play a role in virulence gene regulation. (biomedcentral.com)

The analysis of virulence gene expression in vivo, i.e. in infected host cells, indicates that yet uncharacterized bacterial factors other than PrfA, and possibly also host factors, modulate the expression of the PrfA regulon. (ed.ac.uk)
It is quite resistant to antimicrobials and has several virulence factors that contribute to its high pathogenicity. (usp.br)
Most of this regulation is carried out directly by transcription factors that modulate the activity of promoters aimed at expressing virulence factors. (usp.br)
In this context, DNA-binding transcription factors (TFs) play an important regulatory role by either repressing or activating genes in response to environmental and physiological conditions. (biomedcentral.com)
In Escherichia coli, ppGpp regulates the expression of cellular factors that are important during urinary tract infections. (ibecbarcelona.eu)
Our data further support the role of ppGpp participating in the coordinated regulation of the expression of bacterial factors required during infection. (ibecbarcelona.eu)
Some MTases undeniably are virulence factors that specifically hijack the host defense mechanism. (ac.ir)
Bacterial ribonucleotide reductases (RNRs) play a significant role in the formation of dNTPs and their expression is normally regulated with the transcription factors NrdR and Hair. (immune-source.com)
Genome-wide transcript analysis showed that B. anthracis undergoes considerable changes in gene expression during growth in iron-depleted media, including the regulation of known and candidate virulence factors. (omictools.com)
Infectious dose is not associated with genome size and shows insignificant phylogenetic inertia, in line with frequent virulence shifts associated with the horizontal gene transfer of a small number of virulence factors. (pasteur.fr)
. campestris ( Xcc ) involves the coordinate expression of many virulence factors, including surface appendages flagellum and type IV pili, which are required for pathogenesis and the colonization of host tissues. (biomedcentral.com)

Cloned structural genes for the osmotically regulated binding-protein-dependent glycine betaine transport system (ProU) of Escherichia coli K-12. (microbiologyresearch.org)
The aims of this research work were to determine the patterns of antibiotic resistance in Escherichia coli isolates from the meat of wild or domestically reared pigeons from Spain, to detect the presence of virulence and antibiotic resistance genes, and to carry out a phylogenetic classification of the isolates. (mdpi.com)

While many two-component systems control basic cellular processes such as motility, nutrient uptake and cell division, bacterial pathogens use two-component systems to control virulence. (mechanobio.info)
One pathogenic factor of Xcc that is gaining more notoriety in virulence is motility. (biomedcentral.com)

SPI-2 virulence is induced upon entry into macrophages, but the mechanisms of SPI-2 gene control in vivo remain unclear, particularly with regard to negative regulators that control the contextual activation of SPI-2. (mcmaster.ca)
I am a scientist working at the Pasteur Institute and interested in the molecular mechanisms that shape gene expression. (cosminribo.eu)
Although CSS systems regulate bacterial processes as crucial as stress response, iron scavenging and virulence, the exact mechanisms that drive CSS are still not completely understood. (vu.nl)
Filipowicz, W., Bhattacharyya, S. N. & Sonenberg, N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (nature.com)
Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. (nature.com)
These mechanisms are very diverse in the detail, but share commonalities whose quantification should enlighten the evolution of virulence from both a molecular and an ecological perspective. (pasteur.fr)
Streptococcal pathogens continue to evade concerted efforts to decipher clear-cut virulence mechanisms, although numerous genes have been implicated in pathogenesis. (cdc.gov)

For example, in chronic skin wounds, Pseudomonas aeruginosa virulence is activated by Gram-positive organisms, such as Staphylococcus aureus . (asmblog.org)
The bacterial plant pathogen Pseudomonas syringae causes economically important diseases of a wide variety of plant species and is used as a model organism to understand the molecular basis of plant disease. (ox.ac.uk)
Pseudomonas aeruginosa is an adaptable bacterial pathogen that infects a variety of organs, including the respiratory tract, vascular system, urinary tract, and central nervous system, causing significant morbidity and mortality. (biomedcentral.com)

Our findings indicate that C. difficile employs phase variation of the CmrRST signal transduction system to generate phenotypic heterogeneity during infection, with concomitant effects on bacterial physiology and pathogenesis. (nih.gov)
Regulation of c-di-AMP is critical because high c-di-AMP levels lead to abnormal physiology, growth defects, and reduced virulence in infection. (wikipedia.org)
Whereas host genetic susceptibility plays a key role in modulating disease manifestation, variations in bacterial virulence properties contribute to infection severity. (cdc.gov)
Here, we characterize the role of this alarmone in the regulation of the hlyCABD(II) operon of the UPEC isolate J96, encoding the toxin alpha-hemolysin that induces cytotoxicity during infection of bladder epithelial cells. (ibecbarcelona.eu)
Here, we identified and characterized YdgT as a negative modulator of the SPI-2 pathogenicity island and established that this negative regulation is central to systemic pathogenesis because ydgT mutants overexpressing typhoid virulence genes were ultimately attenuated during infection. (mcmaster.ca)
ydgT mutants displayed a biphasic virulence phenotype during in vivo competitive infections that consisted of an early "gain-of-virulence" dependent on SPI-2 activation, followed by attenuation later in infection indicating that proper contextual regulation of SPI-2 by YdgT is necessary for full virulence during systemic colonization. (mcmaster.ca)
The major H. pylori virulence factor that determines whether infection causes disease or asymptomatic colonization is the type IV secretion system (T4SS), a sort of molecular syringe that injects bacterial products into gastric epithelial cells and alters host cell physiology. (pacb.com)
Deletion of either gene (GBAA0552 or GBAA1340) resulted in attenuation in a murine model of infection. (omictools.com)
Our results show the key role of immune subversion in effective human infection by small bacterial populations. (pasteur.fr)

Studies have shown that bacterial mutant strains with low c-di-AMP levels lysed significantly faster than their parent strains. (wikipedia.org)
Among these strains is a highly virulent subclone of serotype M1T1 that has exhibited unusual epidemiologic features and virulence, unlike all other streptococcal strains. (cdc.gov)
The T3SS imposes a significant cost on the bacterium, and strains which have lost the plasmid and/or genes encoding the T3SS grow faster than wild-type strains in the laboratory, and fail to bind the indicator dye Congo Red (CR). (ox.ac.uk)
Actinobacillus pleuropneumoniae hfq mutants strains are attenuated for virulence in pigs, impaired in the ability to form biofilms, and more susceptible to stress, but knowledge of the extent of sRNA involvement is limited. (bvsalud.org)
Additionally, exploring the regulatory differences between CA-MRSA and other MRSA strains may aid our understanding of the increase in virulence observed amongst community-associated isolates. (biomedcentral.com)
Even though diverse strains of S. aureus have been extensively studied, and subjected to genome sequencing, the function of a large proportion of their genes remains unidentified. (biomedcentral.com)
These genes were identified using a comparative genome analysis of 215 strains belonging to ten human-related Haemophilus (sub)species (training dataset). (biomedcentral.com)
In particular, H. influenzae serotype b (Hib) strains were one of the major causes of bacterial meningitis in children worldwide until the introduction of an effective conjugate vaccine [ 6 , 7 ]. (biomedcentral.com)
PCR-sequencing and qRT-PCR were performed to compare mutations and expression levels of MTases in different strains. (ac.ir)
We found a correlation between mycobacterial MTases expression and resistance to antibiotics in M.tb strains. (ac.ir)

To search for sRNAs in A. pleuropneumoniae, we developed a strategy for the computational analysis of the bacterial genome by using four algorithms with different approaches, followed by experimental validation. (bvsalud.org)
Natural competence is a mode of horizontal gene transfer, which is based on the ability of a bacterium to take up free DNA from the environment and recombine it with the bacterial genome resulting in natural transformation. (biomedcentral.com)
Therefore, we established an accurate and rapid whole genome sequencing (WGS) based classification and serotyping algorithm and combined it with the detection of resistance genes. (biomedcentral.com)
Genome regulation encompasses all facets of gene expression, from the biochemical modifications of DNA, to the physical arrangement of chromosomes and the activity of the transcription machinery. (mechanobio.info)
Summary: Comparative genomics remains a pivotal strategy to study the evolution of gene organization, and this primacy is reinforced by the growing number of full genome sequences available in public repositories. (omictools.com)

Cyclic di-AMP has been linked to fatty acid synthesis regulation in Mycobacterium smegmatis, the growth of S. aureus in conditions of low potassium, the sensing of DNA integrity in B. subtilis, and cell wall homeostasis in multiple species. (wikipedia.org)
The expression of retS over time was also evaluated by western blot when co-cultivated with Staphylococcus aureus and Candida albicans in artificial sputum media and we noticed that there was no change in the expression of this gene when compared to the axenically cultured PAO1. (usp.br)
A comparison of the TF repertoire of S. aureus against 1209 sequenced bacterial genomes was carried out allowing us to identify a core set of orthologous TFs for the Staphylococacceae , and also allowing us to assign potential functions to previously uncharacterized TFs. (biomedcentral.com)
As virulence determinant production is very tightly regulated in S. aureus , a thorough understanding of its regulatory network is necessary to fully comprehend the pathogenic processes of this bacterium. (biomedcentral.com)

Epigenetic analysis revealed a specific N 6 -methyl adenine (m 6 A) methylating pattern including methylation of alginate, flagellar and quorum sensing associated genes. (frontiersin.org)

In addition, the presence of antibiotic resistance genes within the German dataset was evaluated with SRST2 and correlated with results of traditional phenotyping assays. (biomedcentral.com)

We mined the literature for experimental data on infectious dose of bacterial pathogens in humans (ID50) and also for traits with which ID50 might be associated. (pasteur.fr)

The RNA chaperone Hfq promotes the association of small RNAs (sRNAs) with cognate mRNAs, controlling the expression of bacterial phenotype. (bvsalud.org)
This MHC phenotype is dominantly enhanced by removal of rok or of other members of the PCP effector gene family. (uni-wuerzburg.de)

These findings demonstrate that BP regulatory gene(s) exist within the differential chromosome segment trapped in the SHR-Lx congenic strain and that this region of chromosome 8 plays a major role in the hypertension of SHR vs. BN-Lx rats. (jci.org)
Essentially nothing is known about the signal transduction pathways involved in the observed differential expression of virulence genes. (ed.ac.uk)
In order to gain a more comprehensive perspective on the physiology and regulation of the AlTR, we compared differential gene expression and protein content of cells adapted at pH 9.5 and un-adapted cells (pH 7.0) using complementary DNA (cDNA) microarray and two-dimensional (2D) gel electrophoresis, (combined with mass spectrometry) respectively. (essex.ac.uk)

Researching the interplay of host and pathogen gene regulation. (cam.ac.uk)
A prominent example is the gram-negative pathogen Salmonella Typhimurium , which is a frequent cause of bacterial gastroenteritis. (mechanobio.info)
We observed a downregulation in the expression of genes involved in host response, such as TNF signaling, IL-1β production, and phagosome formation in Mφ, and phosphatidylinositol signaling and TNF signaling in PMNs, being in line with the ability of the pathogen to survive within phagocytes. (frontiersin.org)

Using QS as a model will allow us to understand long-standing questions in the field related to signal recognition preferences in single species and multi-species environments and the regulation of the interrelated signaling cascade that exists to coordinate behavior. (wadsworth.org)
tracrRNA-mediated crRNA maturation is conserved among different bacterial species. (nature.com)
It is caused by various species of the bacterial genus Brucella , which mainly infect domestic animals, especially goats, sheep, and cows, and use them as natural reservoirs. (frontiersin.org)

Genomic characterization predicted specific genomic islands highly associated with virulence, transcriptional regulation, and DNA restriction-modification systems. (frontiersin.org)

We identified previously unrecognized putative CRP-S sites upstream of both genes. (biomedcentral.com)
Seven putative mycobacterial MTase genes ( Rv0645c , Rv2966c , Rv1988 , Rv1694 , Rv3919c , Rv2756c , and Rv3263 ) and Rv1392 as SAM synthase were selected for analysis. (ac.ir)

It is possible that in addition to enzymatic regulation, intracellular c-di-AMP levels can be regulated by active transport via multidrug resistance transporters that secrete c-di-AMP from the cytoplasm. (wikipedia.org)
The expression of the bacterial genes involved in the different steps of the infectious process--invasion, intracellular multiplication and spreading--is temporally and spatially controlled, thus ensuring the presence of the respective gene products at the right moment and place. (ed.ac.uk)
Adaptive intracellular gene expression involved genes that are associated with virulence, the general stress response, cell division, and changes in cell wall structure and included many genes with unknown functions. (essex.ac.uk)

These findings reveal epigenetic contributions to chronic painful TMD through methylation of the genes FMOD, PM20D1, ZNF718, ZFP57, and RNF39, following the development of acute painful TMD. (iasp-pain.org)
2007. Epigenetic memory at malaria virulence genes. . (cornell.edu)

Right here we profile bacterial destiny under circumstances of overexpression and deletion of NrdR in appearance causes a substantial decrease in bacterial development and fitness also at normal temperature ranges and causes lethality at raised temperature ranges. (immune-source.com)
In parallel research on complementary appearance of downregulated important genes and demonstrated partial rescue from the fitness defect due to NrdR overexpression. (immune-source.com)
Deletion of downregulated nonessential genes and upon NrdR overexpression led to diminished bacterial development and fitness recommending an additional function for NrdR in regulating various other genes. (immune-source.com)

Functional characterization of the identified regions found relationships between methylation at these loci and nearby genetic variation contributing to chronic painful TMD and with gene expression of proximal genes. (iasp-pain.org)

The Rv1392 expression level also decreased in INH R isolate. (ac.ir)

Current antibiotics work by interfering with bacterial growth, which is a fine game plan… until it stops working. (wadsworth.org)

Within the research in Molecular Biology, one important field along the years has been the analyses on how prokaryotes regulate the expression of their genes and what the consequences of these activities are. (ibecbarcelona.eu)
Moreover, we present strong evidence that Mg(2+) signals through CsrS to regulate an extensive and previously undefined repertoire of GAS genes. (lu.se)

Post-genomic analysis techniques such as next-generation sequencing have produced vast amounts of data about micro organisms including genetic sequences, their functional annotations and gene regulatory interactions. (uni-bielefeld.de)
The effect of Mg(2+) on regulation of global gene expression was evaluated using genomic microarrays in an M-type 3 strain of GAS and in an isogenic csrS mutant. (lu.se)

The latter group has several potential mRNA targets, many of which are involved with virulence, stress resistance, or metabolism, and connect the sRNAs in a complex gene regulatory network. (bvsalud.org)
CoryneRegNet is the reference database and analysis platform for corynebacterial gene regulatory networks. (uni-bielefeld.de)
In this article we introduce the updated version 6.0 of CoryneRegNet and describe the updated database content which includes, 6352 corynebacterial regulatory interactions compared with 4928 interactions in release 5.0 and 3235 regulations in release 4.0, respectively. (uni-bielefeld.de)
We also demonstrate how we support the community by integrating analysis and visualization features for transiently imported custom data, such as gene regulatory interactions. (uni-bielefeld.de)

The plasmid encodes a Type III secretion system (T3SS) on a 30 kb pathogenicity island (PAI), and is maintained in a bacterial population through a series of toxin:antitoxin (TA) systems which mediate post-segregational killing (PSK). (ox.ac.uk)

For this purpose, the non-pathogenic production host P. putida KT2440 containing the rhlAB genes with the native P. aeruginosa 5′-UTR region was used. (springer.com)

Our research has demonstrated that the correlation of bacterial pigments on their susceptibility to antimicrobial agents. (biomedcentral.com)

Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences. (ox.ac.uk)

By transcriptome analyses (RNA-seq and RT-PCR) we confirm these observations as PilG is shown to upregulate many genes involved chemotaxis and flagellar biosynthesis but these similar genes were downregulated by PilH. (biomedcentral.com)

Salmonella typhimurium proP gene encodes a transport system for the osmo- protectant glycine betaine. (microbiologyresearch.org)
Osmoregulation of gene expression in Salmonella typhimurium: proU encodes an osmotically-induced glycine betaine transport system. (microbiologyresearch.org)

This altered gene expression also correlated directly with protein levels, bacterial capacity for DNA uptake, and natural transformability. (biomedcentral.com)
This gene encodes a protein that is the master regulator of transformation and a homolog of Sxy, which was first described in Haemophilus influenzae [ 7 ],[ 8 ]. (biomedcentral.com)
2005. A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP. . (cornell.edu)
Creating sequence-expression-activity maps accelerates the optimization of many protein systems and allows previous measurements to quantitatively inform future designs. (omictools.com)
Sjöberg A., Trouw L., McGrath F., Hack E. C. and Blom A. M. (2006) Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein. (lu.se)

These outcomes suggest that raised appearance of NrdR is actually a suitable methods to retard bacterial development and virulence as its raised expression decreases bacterial fitness and impairs web host cell adhesion. (immune-source.com)

Linkage and comparative mapping studies indicate that the transferred chromosome segment contains a number of candidate genes for hypertension, including genes encoding a brain dopamine receptor and a renal epithelial potassium channel. (jci.org)
Moreover in comparison to NrdR deletion cells overexpressing NrdR demonstrated significantly reduced adherence to individual epithelial cells reflecting reduced bacterial Fesoterodine fumarate (Toviaz) virulence. (immune-source.com)

22 ]. The transcriptional regulator QstR, which might require a cofactor for its full activity (indicated by the triangle), positively regulates the comEA gene potentially by binding to a QstR-specific binding motif (indicated by the dashed box and so far unidentified). (biomedcentral.com)

Prototrophy suppressor mutations in a ppGpp-deficient strain restore the alpha-hemolysin expression from this operon to wild-type levels, confirming the requirement of ppGpp for its expression. (ibecbarcelona.eu)
Only two mutations were found in isoniazid resistance (INH R ) strain for Rv3919c (T to G in codon 341) and Rv1392 (G to A in codon 97) genes. (ac.ir)

5'-pApA is also involved in a feedback inhibition loop that limits GdpP gene-dependent c-di-AMP hydrolysis, leading to elevated c-di-AMP levels. (wikipedia.org)
Cyclic di-AMP has also been linked to bacterial RNA synthesis inhibition. (wikipedia.org)
Unlike antibacterials that aim to inhibit cell growth, antivirulence therapies are based on the inhibition of bacterial virulence. (nature.com)

He identified periodic acid-Schiff (PAS)-staining granules, most likely representing degenerating bacterial forms, within macrophages isolated from the small bowel as well as other tissue and fluid specimens (eg, pericardium, endocardium, lymph nodes, synovia, lung, brain, meninges) obtained from patients in whom Whipple disease was suspected. (medscape.com)

Since cyclic di-AMP is a signaling nucleotide, it is presumed to adhere to the same regulation pathways, where environmental changes are sensed by synthesis or degradation enzymes, which modulate enzyme concentration. (wikipedia.org)
First described to modulate metabolic adaptive responses, ppGpp modulates the expression of genes belonging to very diverse functional categories. (ibecbarcelona.eu)

Here, we discovered a temporal modulation of ubKDM1A and KDM1A+2a during human and mice fetal cardiac development and evaluated their impact on the regulation of cardiac differentiation. (ibecbarcelona.eu)
Contributing to the interest of the present topic is the fact that modulation of gene activity involves the sensing of intra- and inter-cellular conditions, DNA binding and DNA dynamics, and interaction with the replication/transcription machinery of the cell. (ibecbarcelona.eu)

To investigate the response of LuxS01 and wild type strain to exogenously added AI-2, cells from Venetoclax in vitro experiments A and B were harvested in late exponential phase for RNA extraction and microarray gene expression analysis. (hsdpathway.com)
Here, using A. pleuropneumoniae strain MIDG2331 (serovar 8), 14 sRNAs were identified by co-immunoprecipitation with Hfq and the expression of eight, identified as trans-acting sRNAs, were confirmed by Northern blotting. (bvsalud.org)

This work increases our understanding of the multilayered and complex nature of the influence of Hfq-dependent sRNAs on the physiology and virulence of A. pleuropneumoniae. (bvsalud.org)

Bacterial small RNAs (sRNAs) are known regulators in many physiological processes. (learnlifescience.com)

These systems are composed of an outer membrane receptor that senses the inducing signal, an extracytoplasmic function sigma factor (σECF) that targets the cytosolic response by modifying gene expression and a cytoplasmic membrane anti-sigma factor that keeps the σECF in an inactive state in the absence of the signal and transduces its presence from the outer membrane to the cytosol. (vu.nl)

Using model predictions, we designed and characterized 47 additional pathway variants to navigate its activity space, find optimal expression regions with desired activity response curves, and relieve rate-limiting steps in metabolism. (omictools.com)

To our knowledge, this study is the first to characterize global gene regulation by a GAS two-component system in response to a specific environmental stimulus. (lu.se)

Studies in both commensal and UPEC isolates demonstrate that no UPEC specific factor is strictly required for the ppGpp-mediated regulation described. (ibecbarcelona.eu)

Rapid recombination among transfected plasmids, chimeric episome formation and trans gene expression in Plasmodium falciparum. (cornell.edu)

Integration leads to reduced PAI gene expression and impaired secretion through the T3SS, while excision of pINV from the chromosome restores T3SS function. (ox.ac.uk)
For this, the upstream regions of the gacA, gacS, ladS, retS, rsmA, rsmZ and PA1611 genes were cloned separately into a miniTn7 vector and inserted into the PAO1 chromosome. (usp.br)

PRODORIC2: the bacterial gene regulation database in 2018. (uni-bielefeld.de)

Anatomy15

Organisms43

Diseases18

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes86

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science7

Health Care5

Proteins14

Biofilm9

Determinants3

Bacteria20

Role in virulence gene regulation2

Factors11

Escherichia2

Motility2

Mechanisms7

Pseudomonas3

Infection9

Strains10

Genome5

Aureus4

Quorum1

Antibiotic resistance genes1

Pathogens1

Phenotype2

Differential3

Pathogen3

Species3

Transcriptional regulation1

Putative2

Intracellular3

Epigenetic2

Overexpression3

Methylation1

Isolate1

Antibiotics1

Regulate2

Genomic2

Regulatory4

Pathogenicity1

Pathogenic1

Susceptibility1

Molecular1

Flagellar1

Salmonella typhimurium2

Protein5

Decreases1

Epithelial2

Regulates1

Mutations2

Inhibition3

Macrophages1

Modulate2

Modulation2

Strain2

Physiology1

Physiological1

Outer membrane1

Metabolism1

Characterize1

Isolates1

Formation1

Chromosome2

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