Viral ribavirin. Medical search. Frequent questions

We compared the efficacy and safety of peginterferon alfa-2a plus ribavirin, interferon alfa-2b plus ribavirin, and peginterferon alfa-2a alone in the initial treatment of chronic hepatitis C. (nih.gov)
the incidence of influenza-like symptoms and depression was lower in the groups receiving peginterferon alfa-2a than in the group receiving interferon alfa-2b plus ribavirin. (nih.gov)
In patients with chronic hepatitis C, once-weekly peginterferon alfa-2a plus ribavirin was tolerated as well as interferon alfa-2b plus ribavirin and produced significant improvements in the rate of sustained virologic response, as compared with interferon alfa-2b plus ribavirin or peginterferon alfa-2a alone. (nih.gov)
The treatment of insulin resistance by decreasing hyperinsulinemia could improve sustained response rates in patients with chronic hepatitis C treated with peginterferon plus ribavirin. (isciii.es)
Besides, virus C infection may induce insulin resistance by blocking intracellular signaling, and lastly, insulin resistance has been associated with a decreased rate of sustained response to peginterferon alpha plus ribavirin in patients with chronic hepatitis C. (isciii.es)
A new direct acting antiviral (DAA) combination for hepatitis c virus (HCV) infection is more effective than sofosbuvir and peg-interferon plus ribavirin, according to a recent study. (pharmacytimes.com)
Telaprevir, a first generation orally bioavailable inhibitor of the nonstructural 3/4A HCV protease, shows significantly higher rates of SVR than standard care of PEG-IFN α and ribavirin in patients with HCV G1 disease when given for 12 weeks in combination with regimens of PEG-IFN α plus ribavirin lasting 12, 24, or 48 weeks [ 4 - 6 ]. (hindawi.com)
Although the SVR rates in patients receiving telaprevir with PEG-IFN α and ribavirin (triple therapy) were higher than those in PEG-IFN α plus ribavirin (combination therapy) patients, drop-out rates due to increased side effects were also higher in the triple therapy patients [ 4 - 6 ]. (hindawi.com)
For example, treatment of hepatitis C, a common viral infection and a cause of liver cirrhosis, with pegylated interferon plus ribavirin is complicated by hemolytic anemia induced by ribavirin. (cdc.gov)

Hepatitis E virus (HEV), an important agent of viral hepatitis worldwide, can cause severe courses of infection in pregnant women and immunosuppressed patients. (mdpi.com)
Ribavirin, also known as tribavirin, is an antiviral medication used to treat RSV infection, hepatitis C and some viral hemorrhagic fevers. (wikipedia.org)
Among the viral hemorrhagic fevers it is used for Lassa fever, Crimean-Congo hemorrhagic fever, and Hantavirus infection but should not be used for Ebola or Marburg infections. (wikipedia.org)
Statins may improve this combination's efficacy in treating hepatitis C. Ribavirin is the only known treatment for a variety of viral hemorrhagic fevers, including Lassa fever, Crimean-Congo hemorrhagic fever, Venezuelan hemorrhagic fever, and Hantavirus infection, although data regarding these infections are scarce and the drug might be effective only in early stages. (wikipedia.org)
It is not known if treatment that includes ribavirin and another medication cures hepatitis C infection, prevents liver damage that may be caused by hepatitis C, or prevents the spread of hepatitis C to other people. (medlineplus.gov)
Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory tract infection in infants and children and the second most common viral cause of pneumonia in adults. (medscape.com)
One states that recurrent wheezing and subsequent airway dysfunction are caused by damage to the lung during an infant s viral infection. (rtmagazine.com)
These guidelines recommended the use of ribavirin for all patients requiring mechanical ventilation for RSV infection and for infants with complicating factors (including underlying cardiovascular or pulmonary disease) placing them at high risk for severe disease. (rtmagazine.com)
The use of anti-viral therapies, such as pegylated-interferon and ribavirin, has been found to efficaciously treat HEV infection. (unboundmedicine.com)
Anyone who has chronic hepatitis B is also susceptible to infection with another strain of viral hepatitis known as hepatitis D (formerly called delta virus). (adam.com)
designed to protect against viral infection. (absp.org.uk)
Viral encephalitis, complicated with pulmonary infection, was suspected as a potential diagnosis. (cdc.gov)
She had been sick for two weeks with shooting fevers, bad throat and mouth, aching, not responding to antibiotics-a viral infection. (gavi.org)
What should I know about hepatitis E (hep E) viral infection? (medicinenet.com)
Hepatitis E is a viral infection , which is caused by the hepatitis E virus that usually comes from dirty water. (medicinenet.com)
Hepatitis E viral infection causes symptoms and signs, for example, soreness and swelling of the liver (hepatitis) and yellow eyes ( jaundice ). (medicinenet.com)
Hepatitis E viral infection symptoms and signs include yellow eyes and skin, nausea and vomiting , pain in the right side of the abdomen, dark or brown urine, and light-colored stool . (medicinenet.com)
What is hepatitis E (hep E) viral infection? (medicinenet.com)
Ribavirin BioPartners As a standard treatment, Ribavirin is indicated for use in combination with Interferon Alpha to treat chronic Hepatitis C (HCV) infection. (pharmaceutical-business-review.com)
Chronic hepatitis C virus (HCV) infection was generally treated with pegylated interferon (PEG-IFN) and ribavirin combination therapy. (hindawi.com)
Ribavirin (36791045) has been used to treat severe respiratory syncitial virus pneumonia in infants and children, while pentamidine-isethionate (140647) has been used for the prevention and treatment of Pneumocystis-carinii pneumonia in immunocompromised patients, including those with human immunodeficiency virus infection. (cdc.gov)
Impact of erythropoietin on sustained virological response to peginterferon and ribavirin therapy for HCV infection: a systematic review and meta-analysis. (bvsalud.org)

To date, HEV infections can only be treated with ribavirin (RBV). (mdpi.com)
The recommended treatment for LCMV infections obtained through organ transplantation includes reduced immunosuppression and ribavirin. (cdc.gov)
Although a number of other febrile viral infections may produce hemorrhage, only the agents of Lassa, Marburg, Ebola, and Crimean-Congo hemorrhagic fevers are known to have caused significant outbreaks of disease with person-to-person transmission. (cdc.gov)
The combination is given with ribavirin, a nonspecific drug that modifies host factors in viral infections. (medpagetoday.com)
Examples of misuse include when antibiotics are taken by people with viral infections like colds and flu, and when they are given as growth promoters in animals and fish. (who.int)
Most commonly, it is the result of infections (bacterial, viral, or fungal), but it can occur as a result of chemical injury (gastric acid/aspiration of food/hydrocarbon and lipoid pneumonia/radiation-induced pneumonia). (pediatriconcall.com)
Lymphocytic predominance may be seen in viral pneumonia, pertussis, and atypical infections. (pediatriconcall.com)
An important defense mechanism against viral infections in our body are special proteins, the antibodies. (sflorg.com)
During viral infections, the complex and dynamic distributions of variants, termed viral quasispecies, play a key role in the adaptability of viruses to changing environments and the fate of the population as a whole. (springer.com)
The efficacy of ribavirin in other viral infections is being evaluated. (medscape.com)
Ribavirin is used clinically in combination with interferon for hepatitis C, in aerosol form for respiratory syncytial virus (RSV), and as potential prophylaxis and/or treatment of Congo-Crimean hemorrhagic fever, hantavirus infections, and arenavirus hemorrhagic fevers. (medscape.com)

The reported incidence of viral pneumonia (see the image below) has increased during the past decade. (medscape.com)
Depending on the virulence of the organism, as well as the age and comorbidities of the patient, viral pneumonia can vary from a mild, self-limited illness to a life-threatening disease. (medscape.com)
The influenza viruses are the most common viral cause of pneumonia. (medscape.com)
Their efficacy in patients with influenza viral pneumonia or severe influenza is unknown. (medscape.com)
PIV pneumonia: Treatment is mainly supportive, but aerosolized and oral ribavirin have been associated with reduction in PIV shedding and clinical improvement in immunocompromised patients. (medscape.com)
Viral pneumonia decreases in frequency in healthy young and middle-aged adults, but it then increases substantially among the elderly. (medscape.com)
Because of the difficulty in distinguishing between the various etiologic agents, both viral and bacterial, causing pneumonia, the workup for symptomatic patients with an infiltrate on chest radiograph should include laboratory studies. (medscape.com)
Viral pneumonia can be diagnosed by isolation and identification of the pathogen through viral culture. (medscape.com)
5 SARS-CoV-2 was isolated from the airway epithelial cells of patients with viral pneumonia in Wuhan. (medsci.org)
Some forms of viral pneumonia, particularly adenoviral disease, tend to cause bronchiolitis obliterans and hyperlucent lung syndrome. (pediatriconcall.com)

The addition of the anti-viral drug telaprevir to a standard treatment for hepatitis C can shorten the duration of therapy and increase the number of patients who can be cured of their disease, according to the results of study coordinated by investigators from the Duke Clinical Research Institute. (sciencedaily.com)
Our study found that by combining the standard therapy with the direct anti-viral drug telaprevir, we could reduce the duration of treatment by 50 percent, to 24 weeks, and, at the same time, improve the cure rate by 50 percent. (sciencedaily.com)
Status: Approved by EMA Ribavirin is a chemically-derived synthetic analogue of guanosine that has a broad spectrum anti-viral effect by inhibiting RNA polymerase of various RNA viruses. (pharmaceutical-business-review.com)
The types of pharmaceuticals being developed and tested can be divided into several categories: anti-viral medications, immune-enhancing therapies for severe disease, cytokine-storm therapies for severe disease, and ACE2-directed therapies. (city-journal.org)
Anti-viral pharmaceuticals disrupt the ability of the virus to replicate. (city-journal.org)

Estimated effects of ribavirin compared with no treatment on mortality outcomes from the McCormick ( 11 ) and IND 16666 (Birch & Davis Associates and Sherikon Inc., US Army Medical Research and Development Command, unpub. (cdc.gov)

OBJECTIVE: We sought to determine whether viral transcripts were present within the skin of patients with HCV and LP, and if systemic virologic response to interferon alfa and ribavirin correlated with response of the LP.Materials and methods A total of 4 men and 1 woman all presented with cutaneous eruptions of LP, and 1 had oral LP lesions. (thedoctorsdoctor.com)

For instance, patients infected with hepatitis C virus are usually treated with peginterferon and ribavirin to prevent progressive hepatic fibrosis, cirrhosis, and hepatocellular carcinoma. (cdc.gov)

In this form, it interferes with RNA metabolism required for viral replication. (wikipedia.org)
For this reason, when ribavirin is incorporated into RNA, as a base analog of either adenine or guanine, it pairs equally well with either uracil or cytosine, inducing mutations in RNA-dependent replication in RNA viruses. (wikipedia.org)
Ribavirin, which is taken orally, may work by preventing the virus from reproducing (viral replication). (infectioncontroltoday.com)
Ribavirin is a synthetic guanosine analogue (1-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide) that inhibits viral replication by inhibiting DNA and RNA synthesis. (medscape.com)
It is an acyclic nucleoside analogue of 2'-deoxyguanosine that inhibits viral replication in vitro and in vivo by competing with deoxyguanosine triphosphate for viral DNA polymerase, inhibiting DNA synthesis. (medscape.com)
Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits viral replication in vitro. (medscape.com)

The enzyme inosine triphosphate pyrophosphatase (ITPase) dephosphorylates ribavirin triphosphate in vitro to ribavirin monophosphate, and ITPase reduced enzymatic activity present in 30% of humans potentiates mutagenesis in hepatitis C virus. (wikipedia.org)
The purpose of this paper is to raise awareness regarding the burden of disease related to viral hepatitis and the need for urgent action to prevent hepatitis B virus and hepatitis C virus transmission in the Eastern Mediterranean Region. (who.int)
Viral Entry The envelope proteins of HCV form a heterodimer which helps binding the hepatitis C virus to the receptors present on the hepatocytes membrane. (bartleby.com)
Patients and Methods: A descriptive retrospective study from January 2012 to November 2013 on a cohort of patients chronic carriers of hepatitis B virus (n = 11) treated with Pegylated Interferon to 180 mcg per week and hepatitis C virus (n = 30) treated with a combination therapy associating pegylated Interferon to 180 mcg per week and Ribavirin assayed according to the genotype. (scirp.org)
The researchers measured rates of sustained viral response - or SVR - defined as 24 weeks during which the hepatitis C virus remains undetectable in the body after the completion of therapy. (sciencedaily.com)
Lichen planus associated with hepatitis C virus: No viral transcripts are found in the lichen planus, and effective therapy for hepatitis C virus does not clear lichen planus. (thedoctorsdoctor.com)
BACKGROUND: Although hepatitis C virus (HCV) was not discovered until 1989, it was recognized for many years that a viral agent was responsible for many cases of posttransfusion or parenterally transmitted hepatitis. (thedoctorsdoctor.com)

Arias A, Agudo R, Ferrer-Orta C, Pérez-Luque R, Airaksinen A, Brocchi E, Domingo E, Verdaguer N, Escarmis C (2005) Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding. (springer.com)

For HCV, there was 52.94% of cases of sustained viral response (SVR) including 44.44% of genotype 1, 83.33% of genotype 2 and 100% of genotype 4. (scirp.org)
Patients administered Zepatier did better in terms of having fewer side effects, but achieved the same sustained viral response. (pharmacytimes.com)
The group that received standard therapy for up to 48 weeks had a sustained viral response rate of 41 percent, McHutchison said. (sciencedaily.com)

Treatment with oral ribavirin was commenced for patient B on May 2. (cdc.gov)
Patients A and C were started on intravenous ribavirin treatment on May 3, with patient C having received oral ribavirin for 2 days prior. (cdc.gov)

Structural proteins are all encoded by the 3' terminus of the viral genome. (medsci.org)
First, a full-length functional ZIKV cDNA clone was engineered as a bacterial artificial chromosome, with each reporter gene under the cap-independent translational control of a cardiovirus-derived internal ribosome entry site inserted downstream of the single open reading frame of the viral genome. (mdpi.com)
Genetic changes in the viral genome may have enabled the virus to adapt to humans. (bvsalud.org)

RNA viruses replicate as mutant distributions termed viral quasispecies. (biomedcentral.com)

Chronic liver disease related to viral hepa titis has emerged as a leading public health problem in the Eastern Mediterranean Region. (who.int)
Objectives: To assess the efficacy of Pegylated Interferon in clinical practice in patients with chronic viral hepatitis B and C and determine the hematologic side effects. (scirp.org)
Conclusion: The free antiviral treatment program helped treat 10% of chronic viral hepatitis B and C. Our results are not different from those of the literature. (scirp.org)
Following "the Dakar Appeal" [3] , the Ivorian government, through the National Program of the Fight against Viral Hepatitis (NPFVH) has made freely available to patients of the 3 Teaching Hospitals of Abidjan, Pegylated Interferon (PEG-IFN) from February 2012 to November 2013 for the treatment of chronic hepatitis B and C. The pre, per and post therapeutic biological, radiological and histological tests remain the responsibility of patients. (scirp.org)
The aims of our work were to assess the effectiveness of treatment with PEG-INF alone or in combination with Ribavirin (RBV) in clinical practice in patients with chronic hepatitis B or C and to determine the hematologic side effects. (scirp.org)
The FDA has approved two different treatment regimens for chronic hepatitis C: monotherapy (using a single drug, interferon) and combination therapy (using two drugs, interferon and ribavirin). (infectioncontroltoday.com)
Chronic viral hepatitis E can cause cirrhosis (liver scarring) over time that leads to liver failure. (medicinenet.com)

The treatment of HCV with IFN + ribavirin in Benin is effective for genotype 2. (scirp.org)
Mean age of the study participants was 44 years, 60% were male, 56% were infected with genotype 1 hepatitis C, mean baseline viral RNA load was 6.9 log IU/mL, and median length of treatment was 12 weeks. (medscape.com)

It is a guanosine (ribonucleic) analog used to stop viral RNA synthesis and viral mRNA capping, thus, it is a nucleoside analog. (wikipedia.org)
Reversal of the in vitro antiviral activity by guanosine or xanthosine suggests ribavirin may act as an analogue of these cellular metabolites. (nih.gov)

Administration of ribavirin is accomplished using a small-particle aerosol generator. (rtmagazine.com)

Sustained virological response (SVR) was defined as undetectable viral load C 6 months after stopping treatment. (scirp.org)
However, most of these RVAs have been identified via dsRNA viral genomes and not from infectious viruses, and their virological properties, such as cell/host tropisms, transmissibility, and pathogenicity, are unclear and remain to be clarified. (bvsalud.org)

Results: Respiratory syncytial virus (RSV) is the most common viral bronchiolitis in young children. (benthamscience.com)

it works in conjunction with a drug called ribavirin, a nucleoside analogue, to suppress the viral activity of hepatitis C. Side effects can include severe flu-like symptoms, depression, fatigue, insomnia and anemia. (sciencedaily.com)

It is noted by the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) that "Ribavirin has poor in vitro and in vivo activity against the filoviruses (Ebola and Marburg) and the flaviviruses (dengue, yellow fever, Omsk hemorrhagic fever, and Kyasanur forest disease)" The aerosol form has been used in the past to treat respiratory syncytial virus-related diseases in children, although the evidence to support this is rather weak. (wikipedia.org)
The term viral hemorrhagic fever (VHF) refers to the illness associated with a number of geographically restricted viruses. (cdc.gov)
Lassa fever, a viral hemorrhagic fever caused by the Lassa virus (LASV), is endemic in West Africa and is associated with high morbidity and mortality. (bvsalud.org)

2019 March 4, https://media.tghn.org/medialibrary/2019/03/Dr._Ludwig_memo.pdf ) studies in a systematic review of published and unpublished studies for evidence for ribavirin treatment of Lassa fever. (cdc.gov)
A total of 1121 patients were randomly assigned to treatment and received at least one dose of study medication, consisting of 180 microg of peginterferon alfa-2a once weekly plus daily ribavirin (1000 or 1200 mg, depending on body weight), weekly peginterferon alfa-2a plus daily placebo, or 3 million units of interferon alfa-2b thrice weekly plus daily ribavirin for 48 weeks. (nih.gov)
Ribavirin has also been used as a treatment for herpes simplex virus. (wikipedia.org)
One small study found that ribavirin treatment reduced the severity of herpes outbreaks and promoted recovery, as compared with placebo treatment. (wikipedia.org)
Your doctor will order blood tests before you start taking ribavirin and often during your treatment. (medlineplus.gov)
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ribavirin and each time you refill your prescription. (medlineplus.gov)
The objectives of this work were twofold: 1) to evaluate the effectiveness and safety of treatment with classic dual interferon pegylated alpha-2a (IFN) and ribavirin therapy in Benin, and 2) to present problems related to financial accessibility to this treatment. (scirp.org)
Although treatment for viral hepatitis C (VHC) has been around for many years and is widely used in developed countries, the high cost of pharmaceuticals (pegylated interferon and ribavirin) and pre-, per-, and post-treatment assessment has long been a brake on its implementation in developing countries, including Benin. (scirp.org)
Two treatment regimens are available: traditional dual therapy (interferon + ribavirin) used since 2010 and direct-acting antivirals (DAAs) since the end of 2015. (scirp.org)
Among the studies carried out in this country on viral hepatitis, very few have focused on treatment. (scirp.org)
Seven patients reduced the dose of ribavirin during therapy owing to reduced hemoglobin or anemia -- a known effect of ribavirin -- but the change did not affect treatment success. (medpagetoday.com)
Indeed, Cohen noted, the recently reported PEARL studies showed that ribavirin can be dropped entirely without affecting treatment success rates, but that data wasn't available when this trial was designed. (medpagetoday.com)
Objective: This article provides readers with an update on the evaluation, diagnosis, and treatment of viral bronchiolitis, primarily due to RSV. (benthamscience.com)
Cochrane evidence-based reviews have been performed on most treatment modalities for RSV and viral bronchiolitis. (benthamscience.com)
Treatment for viral bronchiolitis is mainly symptomatic support. (benthamscience.com)
Ribavirin was approved in 1986 as a treatment for RSV, and RSVIG intravenous (RSV-IGIV) was approved by the US Food and Drug Administration in 1996 for RSV prophylaxis in susceptible patients. (rtmagazine.com)
Those getting Zepatier were either treatment-naive or had failed the sofosbuvir/peg-interferon/ribavirin regimen. (pharmacytimes.com)
Standard treatment for the most common type of hepatitis C is 48 weeks of a combination of two drugs, peginterferon alfa-2a and ribavirin, which cures less than half of patients and has significant side effects that make it very difficult for some patients to continue their treatment," said John McHutchison, M.D., a hepatologist and gastroenterologist and researcher at the DCRI, and lead investigator on this study. (sciencedaily.com)
For unclear reasons, African Americans have been known to be less responsive to treatment, independent of other host and viral factors. (cdc.gov)
This multicenter study involved 150 Asian treatment-naïve patients infected with HCV G1b who received 12 weeks of telaprevir in combination with 24 weeks of peginterferon- α -2b and ribavirin. (hindawi.com)
In the present study, the SVR rate was examined in treatment-naïve patients with HCV G1b who were treated with a regimen consisting of 12 weeks of telaprevir, combined with PEG-IFN α and ribavirin, followed by 12 weeks of the PEG-IFN and ribavirin. (hindawi.com)
A GWAS of change in hemoglobin levels during ribavirin treatment identified inosine triphosphatase (ITPA) variants that can protect against ribavirin-induced anemia. (cdc.gov)
In addition, a viral RNA load below 25 IU/mL was achieved by 98% of 642 patients at the end of treatment. (medscape.com)

In this former indication the oral (capsule or tablet) form of ribavirin is used in combination with pegylated interferon alfa, including in people coinfected with hepatitis B, HIV and in the pediatric population. (wikipedia.org)
All patients were treated with interferon alfa and ribavirin. (thedoctorsdoctor.com)

Epidemic Intelligence Service (EIS) Officer, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases (ext. 1344). (cdc.gov)
Chief, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases: Joseph B. McCormick, M.D. (ext. 3308). (cdc.gov)
Senior Medical Officer, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases: Susan P. Fisher-Hoch, M.D. (ext. 3308). (cdc.gov)
Director, Division of Viral Diseases, Center for Infectious Diseases (ext. 3574). (cdc.gov)

The hepatitis E virus (HEV) is the main cause of acute viral hepatitis. (sflorg.com)
Most cases of acute viral hepatitis. (msdmanuals.com)
Overview of Acute Viral Hepatitis Acute viral hepatitis is diffuse liver inflammation caused by specific hepatotropic viruses that have diverse modes of transmission and epidemiologies. (msdmanuals.com)
All can cause acute viral hepatitis. (msdmanuals.com)

In addition to the above, ribavirin has been shown to have in vitro activity against influenza A and B viruses and herpes simplex virus, but the clinical significance of these data is unknown. (nih.gov)
Ribavirin is active against RSV and several other types of viruses. (rtmagazine.com)
On the contrary, current evidence indicates that mutant spectra contribute to viral pathogenesis, can modulate the expression of phenotypic traits by subpopulations of viruses, can include memory genomes that reflect the past evolutionary history of the viral lineage, and, furthermore, can participate in viral extinction through lethal mutagenesis. (springer.com)

Ribavirin has demonstrated antiviral activity against RSV in vitro 1 and in experimentally infected cotton rats. (nih.gov)

The subjects were administered either 12 weeks of Zepatier or sofosbuvir/peg-interferon and ribavirin. (pharmacytimes.com)
The Zepatier group had an SVR12 of 99.2%, compared with 90.5% in the group taking the sofosbuvir/peg-interferon/ribavirin combination. (pharmacytimes.com)

Ribavirin is used primarily to treat hepatitis C and viral hemorrhagic fevers (which is an orphan indication in most countries). (wikipedia.org)
Ribavirin will not treat hepatitis C (a virus that infects the liver and may cause severe liver damage or liver cancer) unless it is taken with another medication. (medlineplus.gov)
Ribavirin is used with an interferon medication such as peginterferon alfa-2a [Pegasys] or peginterferon alpha-2b [PEG-Intron]) to treat hepatitis C in people who have not been treated with an interferon before. (medlineplus.gov)

Phylogenetic and PAQ analysis provide adequate procedures to describe the evolution of viral sequences subjected to lethal mutagenesis. (biomedcentral.com)

A nonspecific viral prodrome is followed. (msdmanuals.com)

Here, too, as with all the other anti-virals being tested-including lopinavir/retonovir, ribavirin, umifenovir, and favipiravir-the results of clinical trials are needed before we can draw any conclusions. (city-journal.org)

Unlike other forms of viral hepatitis, the virus does not stay in your body once you recover. (adam.com)

Hepatitis E is caused by an enterically transmitted RNA virus and causes typical symptoms of viral hepatitis, including anorexia, malaise, and jaundice. (msdmanuals.com)
Hepatitis A Hepatitis A is caused by an enterically transmitted RNA virus that, in older children and adults, causes typical symptoms of viral hepatitis, including anorexia, malaise, and jaundice. (msdmanuals.com)

Charpentier C, Dwyer DE, Mammano F, Lecossier D, Clavel F, Hance AJ (2004) Role of minority populations of human immunodeficiency virus type 1 in the evolution of viral resistance to protease inhibitors. (springer.com)

Ribavirin targeted eIF4E in AML patients in monotherapy and combination studies and this corresponded to objective clinical responses including complete remissions. (wikipedia.org)
2 Several clinical isolates of RSV were evaluated for ribavirin susceptibility by plaque reduction in tissue culture. (nih.gov)
On the basis of successful clinical trials, the American Academy of Pediatrics (AAP) issued recommendations14 for ribavirin use in 1993. (rtmagazine.com)
Viral resistance should be considered in patients with poor clinical response or persistent viral excretion. (medscape.com)

Taken alone, ribavirin does not effectively suppress levels of the virus in the bloodstream. (infectioncontroltoday.com)

Ribavirin resistance in AML patients arose leading to loss of eIF4E targeting and relapse. (wikipedia.org)
Resistance was caused by deactivation of ribavirin through its glucuronidation in AML cells or impaired drug entry/retention in the AML cells. (wikipedia.org)
There may be additional forms of ribavirin resistance displayed by cancer cells. (wikipedia.org)
Ribavirin, a broad-spectrum antiviral, was added to increase the potential for synergistic effects and also to prevent viral drug resistance, Mynarek explained. (medscape.com)

ribavirin decreases effects of stavudine by Other (see comment). (medscape.com)

Hepatitis A is a viral disease that affects the liver. (jonbarron.org)

Ribavirin was patented in 1971 and approved for medical use in 1986. (wikipedia.org)

HAMBURG, Germany - A combination of the antiviral drugs pleconaril and ribavirin slowed the decline of pancreatic insulin production compared with placebo in children and adolescents with newly diagnosed type 1 diabetes, new phase 2 data show. (medscape.com)
But studies have shown that the interferon and ribavirin combination, approved in 1998, is more effective than interferon alone. (infectioncontroltoday.com)
In a randomized, Phase IIb, double-blinded, 37-center study of telaprevir in combination with peginterferon alfa-2a and ribavirin, the researchers examined the responses of 250 patients on four trial arms. (sciencedaily.com)

It is phosphorylated in vivo, and the active form may interfere with viral genomic synthesis. (medscape.com)

Therefore, there is a need to develop methods to describe the relationship among components of mutant spectra in viral populations. (biomedcentral.com)

Assay for Ribavirin for Inhalation Solution, USP in human materials is by a radioimmunoassay which detects ribavirin and at least one metabolite. (nih.gov)

The antiviral agent ribavirin, which many chronically infected people receive, can even increase the formation of such viral variants. (sflorg.com)
The research team took a closer look at eight such virus variants from samples of chronically infected patients treated with ribavirin in the laboratory. (sflorg.com)

Tissue from the upper or lower respiratory tract, sputum samples, and samples obtained by nasopharyngeal washing, bronchoalveolar lavage, and biopsy may be submitted for viral culture. (medscape.com)
In cell cultures the inhibitory activity of ribavirin for respiratory syncytial virus (RSV) is selective. (nih.gov)

We included all patients treated with IFN + ribavirin for hepatitis C at CNHU/HKM. (scirp.org)
3 One study also showed that RSV-specific IgE antibody in bronchial secretions was decreased in patients treated with aerosolized Ribavirin for Inhalation Solution, USP. (nih.gov)

Ribavirin may cause anemia (condition in which there is a decrease in the number of red blood cells) that can worsen any heart problems you have and can cause you to have a heart attack that can be life-threatening. (medlineplus.gov)

Ribavirin is a synthetic nucleoside with antiviral activity. (nih.gov)

One of the proposed modes of action of RBV is a direct mutagenic effect on viral genomes, inducing mismatches and subsequent nucleotide substitutions. (mdpi.com)
Anderson JP, Daifuku R, Loeb LA (2004) Viral error catastrophe by mutagenic nucleosides. (springer.com)

The mechanism of action of ribavirin is not entirely clear. (wikipedia.org)

However, the detection of viral pathogens does not always indicate active disease. (medscape.com)
Viral cultures are still the criterion standard for most viral pathogens, but they take a long time to complete. (medscape.com)

Background: Viral bronchiolitis is a common condition and a leading cause of hospitalization in young children. (benthamscience.com)
Children with viral bronchiolitis in early life are at increased risk of developing asthma later in childhood. (benthamscience.com)
Conclusion: Viral bronchiolitis is common. (benthamscience.com)
Viral bronchiolitis in early life predisposes asthma development later in childhood. (benthamscience.com)

Neutralizing antibody responses to RSV were decreased in aerosolized Ribavirin for Inhalation Solution, USP-treated infants compared to placebo-treated infants. (nih.gov)

Ribavirin comes as a tablet, a capsule and an oral solution (liquid) to take by mouth. (medlineplus.gov)

Organisms7

Diseases15

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Health Care2

Geographicals1

Plus ribavirin9

Infection22

Infections11

Pneumonia10

Anti-viral5

Effects of Ribavirin1

Virologic response1

Treated with peginterferon1

Replication6

Hepatitis C vir7

Polymerase1

Sustained viral response3

Oral ribavirin2

Genome3

Termed viral quasispecies1

Chronic7

Genotype2

Guanosine2

Small Particle Aerosol Generator1

Virological2

Common viral1

Nucleoside analogue1

Hemorrhagic Fever3

Treatment23

Interferon alfa2

Infectious Diseases4

Acute viral hepatitis4

Viruses3

Vitro1

Sofosbuvir2

Treat hepatitis3

Lethal mutagenesis1

Nonspecific1

Lopinavir1

Forms of viral1

Symptoms of viral2

Evolution of viral1

Clinical4

Suppress1

Resistance4

Decreases1

Liver1

19861

Combination3

Genomic1

Mutant spectra1

Assay1

Variants2

Respiratory2

Patients treated2

Anemia1

Synthetic1

Mutagenic2

Mechanism of act1

Pathogens2

Bronchiolitis4

Responses1

Tablet1