• OBJECTIVES: We sought to determine vaccine antibody titres and the prevalence of hepatitis B surface antigen (HBsAg) in both HIV-positive and HIV-negative infants born to HIV-positive mothers in Botswana. (bvsalud.org)
  • 17 Jan 2018 - Expert meeting on adeno-associated viral vectors, 06 September 2017, EMA, London. (pdfkul.com)
  • This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
  • Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. (lookformedical.com)
  • as of December 2013 there are 456 different HLA-A*02 proteins. (wikipedia.org)
  • Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
  • Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
  • CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
  • The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. (wikipedia.org)
  • In summation, HLA-A*02 appears to be somewhat less effective than other HLA-As at protecting against HIV infections. (wikipedia.org)
  • Since 1996, she established a molecular virology laboratory in Chang Gung University and the Research Center for Emerging Viral Infections in 2008. (cgu.edu.tw)
  • Vaccines, therefore, provide alternate preventative techniques for the spread of viral infection. (ijpsr.com)
  • HLA-A*02 appears to stimulate peripheral blood mononuclear cells in a manner that inhibits HIV replication. (wikipedia.org)
  • They subsequently focused on viral-host interactions, in which molecular targets for drug discovery were identified, and series of compounds were developed that inhibit EV71 replication. (cgu.edu.tw)
  • however, its hindrance for viral replication is a large hassle for vaccine development. (ijpsr.com)
  • For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. (wikipedia.org)
  • HLA-A*02 (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. (wikipedia.org)
  • Our identification of the first non-human primate-specific minor histocompatibility antigen now published at Frontiers in Immunology. (wisc.edu)
  • Therefore, we modeled allo-HSCT in ART-suppressed simian-human immunodeficiency virus (SHIV)-infected Mauritian cynomolgus macaques (MCMs) to illuminate factors contributing to transplant-induced viral reservoir decay. (wisc.edu)
  • Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. (mdpi.com)
  • we demonstrate that human milk can inhibit the dc-sign-mediated transfer of hiv-1 to cd4+ t lymphocytes as well as viral transfer by both immature and mature dcs. (liverpool.ac.uk)
  • In 2010 the World Health Organization Naming Committee for Factors of the HLA System revised the nomenclature for HLAs. (wikipedia.org)
  • In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)
  • In addition, there are several HLA-A*02 haplotypes that appear to contribute heavily to higher or lower viral loads in HIV patients. (wikipedia.org)
  • Among patients with EBV+ HL, only 35.5% of people expressed HLA-A*02 compared to 50.9% in the EBV-HL group and 53% in the control group. (wikipedia.org)
  • This high affinity increases the probability of CD8+ t-cell recognition of EBV peptides held by HLA-A*02 complexes. (wikipedia.org)
  • There was neither correlation of CD4 + CCR5 + , CD1a + cell numbers, or claudin-1 expression with tissue-bound drug metabolites, nor with p24 production after ex-vivo viral challenge. (bvsalud.org)
  • Viral pathogenesis can be caused by cellular malfunction and or cell death. (ijpsr.com)
  • Increased foam cell formation results from lack of VDR-SERCA2b interaction, causing SERCA dysfunction, activation of ER stress-CaMKII-JNKp-PPARγ signaling, and induction of the scavenger receptors CD36 and SR-A1. (regenerativemedicine.net)
  • As of December 2013, there are 456 alleles identified (mostly by sequence homology) as being A2, of those 27 are nulls, and a large majority have unknown serotypes, although it is highly probable that they will all return A2 serotypes. (wikipedia.org)
  • This is a significant decrease and is almost certainly a result of the abnormally efficient binding of HLA-A*02 to peptides originating from EBV. (wikipedia.org)
  • HLA-A*02 is globally common, but particular variants of the allele can be separated by geographic prominence. (wikipedia.org)
  • Two-point haplotype analysis between TNFB(B*01 allele) and HLA show that the allele is in linkage disequilibrium with HLA-A1, Cw7, B8, C4A(Null), DR3, DQ2.5. (wikipedia.org)
  • High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD). (nih.gov)
  • Association between the HLA-DQA1 rs1391371 risk allele and chronic rhinosinusitis. (nih.gov)
  • HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy. (nih.gov)
  • hence, a normal HBV serology profile is characterized by HBV surface antigen (HBsAg) and anti-HBc positivity. (bvsalud.org)
  • Isolated fractions were examined for their capacity to bind [125I]C1q as a measure of immune complex levels, and for their ability to bind soluble tumour-specific antigen as well as to react with antigens expressed at the surface of viable hepatoma cells. (nih.gov)
  • Eleven participants were highly viremic with high HBV viral load while on a lamivudine- or tenofovir-containing regimen. (bvsalud.org)
  • While type 1 diabetes shows an extended association on the HLA A1-B8-DR3-DQ2 haplotype, the association appears not to extend beyond the HLA-B locus. (wikipedia.org)
  • In the mid-1980s the association with A1-B8-DR3 and HIV progression appeared shortly after the discover of the virus. (wikipedia.org)
  • An association was seen between viral hepatitis and HLA-A1. (wikipedia.org)
  • Association of HLA-DQ Heterodimer Residues -18β and β57 With Progression From Islet Autoimmunity to Diabetes in the Diabetes Prevention Trial-Type 1. (nih.gov)
  • A1-B8 associated with more rapid progression to seropositivity, and was strongly associated with a rapid decline in T4 cells and development of HIV-related symptoms within four years of infection. (wikipedia.org)
  • Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). (nih.gov)
  • A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
  • This disequilibrium made it appear that A1 and other class I gene-alleles were disease factors, when these alleles were only attached to a long segment of conserved DNA that had disease associated genes on the other end. (wikipedia.org)
  • HLA-DQA1 belongs to the HLA class II alpha chain paralogues. (nih.gov)