CleanroomHemorrhagic FeverVectorsAutoimmune diseasesGene therapyContainmentInfectious diseasesEnrollmentInfectionsInfectionSamplesVialFormulationAircraftTherapies for PatientsEbolaIsolationProteinAirflowCancerPopulationsTumorAdditionTransportTeamProductionEnvironmentProductIntegrityResistanceSystemManufacturingCellSuccessfullyPositiveRenalSystemsCareTreatmentsInvasiveDoseTreatmentMaterialTotalStudyTestEnterTransferMedicalHigh-risk
Cleanroom3
- In this case, this is a sterility testing facility (a cleanroom containing two isolators). (ejpps.online)
- These plates are often used to monitor cleanroom, isolators, and other surfaces. (curissystem.com)
- Ansell™ Gammex™ offers cleanroom operatives, surgeons, nurses and patients the highest level of protection against external aggression, allergic skin reactions, and bacterial and viral contamination. (cleanroomsuppliesltd.com)
Hemorrhagic Fever3
- Since 2012, the DAIT, a joint Department of Health and Ministry of Defence asset, has successfully transferred 1 case-patient with Crimean-Congo hemorrhagic fever, 5 case-patients with Ebola virus disease, and 5 case-patients with high-risk Ebola virus exposure. (cdc.gov)
- Since 2012, this team has successfully transferred 1 patient with advanced Crimean-Congo hemorrhagic fever ( 2 ) and 5 patients with Ebola virus disease (EVD) ( 3 - 5 ), 2 with recrudescence or late neurologic complications ( 6 , 7 ). (cdc.gov)
- The term viral hemorrhagic fever (VHF) refers to the illness associated with a number of geographically restricted viruses. (cdc.gov)
Vectors2
- ATMPs differ from traditional products on several major contamination control points: the potential lifesaving nature, the risk of migration of viral vectors from the intended step, patient to patient contamination, and the reduced ability to remove contaminants. (bioprocessonline.com)
- Sectors of the CDMO market - sterile injectables, prefilled syringes, biologics APIs, and viral vectors - are expected to expand quickly, driven by an accelerating shift in the pharmaceutical market toward innovative biologic and cell and gene therapy products. (drug-dev.com)
Autoimmune diseases2
- Cell and gene therapy has been used to treat various types of diseases, including cancer, neurological disorders, autoimmune diseases, genetic disorders, and viral infections. (ispe.org)
- Headquartered in China Clover Biopharmaceuticals is a global, clinical-stage research-based biotech company dedicated to the discovery, development and commercialization of transformative biologic therapies in the fields of oncology, autoimmune diseases, and viral vaccines. (pharma-industry-review.com)
Gene therapy1
- Our viral vector experts are dedicated to helping your advance your viral gene therapy from pre-clinical through commercial production, backed by a superior regulatory track record. (sigmaaldrich.com)
Containment5
- End-to-end maximal patient containment from overseas to the receiving hospital and subsequent discharge is achieved through the T-ATI ( Figure 1 ), which is designed to interface with the Trexler isolator. (cdc.gov)
- There are 2 basic designs of Air Transport Isolator systems, closed and open, both of which offer maximum containment of highly infectious biologic agents. (cdc.gov)
- The Aeromedical Isolation Team (AIT, or SMART-AIT) of the US Army Medical Research Institute of Infectious Diseases (USAMRIID) at Fort Detrick, Maryland was a military rapid response team with worldwide airlift capability designed to safely evacuate and manage contagious patients under high-level (BSL-4) bio-containment conditions. (wikipedia.org)
- Created in 1978, during its final years the AIT was one of MEDCOM's Special Medical Augmentation Response Teams (SMART teams) comprising a portable containment laboratory along with its transit isolators for patient transport. (wikipedia.org)
- Throughout its existence the AIT was associated with a BSL-4 Medical Containment Suite (MCS, called "the Slammer") at USAMRIID for ICU-level patient care under biocontainment. (wikipedia.org)
Infectious diseases8
- 40 years, the British Royal Air Force has maintained an aeromedical evacuation facility, the Deployable Air Isolator Team (DAIT), to transport patients with possible or confirmed highly infectious diseases to the United Kingdom. (cdc.gov)
- In the 1970s, the British Royal Air Force (RAF) was tasked with developing a portable isolation facility that could retrieve patients with infectious diseases. (cdc.gov)
- The Trexler Air Transport Isolator, a portable isolation facility used to transfer patients with serious infectious diseases. (cdc.gov)
- Epidemic Intelligence Service (EIS) Officer, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases (ext. 1344). (cdc.gov)
- Chief, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases: Joseph B. McCormick, M.D. (ext. 3308). (cdc.gov)
- Senior Medical Officer, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases: Susan P. Fisher-Hoch, M.D. (ext. 3308). (cdc.gov)
- Director, Division of Viral Diseases, Center for Infectious Diseases (ext. 3574). (cdc.gov)
- Patients and healthcare workers can encounter a variety of infectious diseases that are easily spread throughout the facility from all surfaces including hard-to-clean contaminated equipment and high touch surfaces. (steramist.com)
Enrollment1
- 25 articles of error realization was your enrollment isolator on a marginal list. (wheaty.net)
Infections2
- Although a number of other febrile viral infections may produce hemorrhage, only the agents of Lassa, Marburg, Ebola, and Crimean-Congo hemorrhagic fevers are known to have caused significant outbreaks of disease with person-to-person transmission. (cdc.gov)
- Microbes can contaminate medical devices and lead to dangerous infections if vulnerable and immunocompromised patients. (curissystem.com)
Infection5
- Here, we demonstrate antibody-mediated enhancement of CHIKV attachment and infection in primary human monocytes and B cells and a relevant murine cell line in the presence of sub-neutralizing levels of anti-CHIKV antibodies obtained from CHIKV-infected patients or animals. (datexis.com)
- To investigate if sub-neutralizing concentrations of CHIKV-specific antibodies enhance CHIKV infection, diluted CHIKV-specific patients' plasma obtained from a CHIKV cohort8,34,35 were mixed with CHIKV before being used to infect human primary monocytes and B cells. (datexis.com)
- It was observed that infection in the presence of patients' plasma (total IgG concentrations of 1.8 ± 1.45 µg/ml) led to an increase in the numbers of Zs-Green positive monocytes. (datexis.com)
- Once again, the viral RNA load did not concur with enhanced infection (Fig. S1b). (datexis.com)
- It came about following a viral infection he contracted after an accident damaged his pancreas and its insulin-producing beta cells. (elpostrebodas.es)
Samples3
- The positive rate and viral loads of air samples were 26.1% and 3.14-5.72 log 10 copies/m 3 air, respectively. (biomedcentral.com)
- The seven viral isolates were obtained from the nasopharyngeal swab samples, including three strains of H1N1 and four strains of H3N2. (biomedcentral.com)
- Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)
Vial1
- Alcami provides an isolator manufacturing environment for liquid and lyophilized vial and syringe manufacturing. (ncbiotech.org)
Formulation2
- Catalent offered a tablet formulation through its OptiForm ® Total Supply solution, incorporating formulation development, clinical trial material manufacturing, and supply and distribution to patients. (drug-dev.com)
- High government and non-government organizations investments in the research and development projects worldwide as well as major players are developing products with various formulation to increasing patient compliance and acceptability, which are major factors for the development of pharmaceutical manufacturing industry in coming future. (growthmarketreports.com)
Aircraft3
- A single Trexler Air Transport Isolator patient transport system ready for use on a Boeing C-17 Globemaster transport aircraft. (cdc.gov)
- Demarcation of clean and dirty zones during use of the Trexler Air Transportable Isolator patient transport system on a Boeing C-17 Globemaster transport aircraft. (cdc.gov)
- At the core of AIT operations was its specialized equipment, notably the Aircraft Transit Isolator (ATI). (wikipedia.org)
Therapies for Patients1
- Philadelphia-based clinical-stage biotech Cabaletta Bio focuses on developing and launching the first curative targeted cell therapies for patients. (european-biotechnology.com)
Ebola1
- In addition, 5 patients with Ebola exposures, including 2 high-risk and 2 intermediate-risk exposures, have been transferred ( 4 , 8 - 10 ) ( Table 1 ). (cdc.gov)
Isolation4
- In the United Kingdom, 2 high-level isolation units (HLIU) are primarily responsible for the care of patients with viral hemorrhagic fevers (VHFs): the Royal Free Hospital, London, and the Royal Victoria Infirmary, Newcastle. (cdc.gov)
- Both units use the Trexler patient isolator, in which patient care is provided within an isolation tent. (cdc.gov)
- During 2008-2010, the AIT began preliminary training with, and testing of, a new transit isolator product - the Patient Isolation Unit (PIU) - developed by the Gentex Corporation under a contract with the U.S. Air Force. (wikipedia.org)
- The Air Force's capabilities, however, do not meet the standard of biocontainment (BSL-4) facilities, but rather represent enhanced patient isolation. (wikipedia.org)
Protein3
- We show that ApoBDs generated from IAV-infected monocytes contained IAV mRNA, protein and virions and consequently, could facilitate viral propagation in vitro and in vivo, and induce a robust antiviral immune response. (nature.com)
- SARS-CoV-2 is an RNA virus that has a trimeric spike (S) protein in its viral membrane resembling other enveloped RNA viruses such as HIV, RSV and Influenza. (pharma-industry-review.com)
- The S-Trimer simulates the native trimeric viral spike (S) protein. (pharma-industry-review.com)
Airflow1
- Under the respiratory airflow, it still has a barrier effect against viral aerosols, virus-containing liquids, etc., and the outer surface of the mask does not come into contact with the human body when it is removed. (in.ua)
Cancer4
- Additionally, sensitive o2 kinds were elevated in hippocampal cells associated with new organizations compared to the charade manage, 447.3 within high dose team aImmunotherapy offers changed cancer treatment method, nonetheless, not every tumor types along with patients are fully understanding of this approach. (tyrosinekinases.com)
- Evaluative Study of Patients with Acute Leukemia under Gnotobiotic Conditions by the Gnotobiotic Project Group of the European Organization for Research on Treatment of Cancer (E.O.R.T.C. (elsevier.com)
- Combined with in-vitro proliferation assays using CRISPR-Cas9/RNAi and patient survival analysis, MEK inhibitors PD19830 and BRD-K12244279, pilocarpine, and tremorine were discovered as potential new drug options for treating breast cancer. (cdc.gov)
- This signature provided significant prognostic stratification in The Cancer Genome Atlas breast cancer patients (n = 1100), as well as basal-like and luminal A subtypes, and was associated with distinct immune infiltration and activities. (cdc.gov)
Populations4
- Modular and podular laboratory and manufacturing allow rapid reconfiguration to support development of drugs for diverse patient populations. (pharmtech.com)
- The need for flexibility in product development and manufacturing to support drugs for smaller patient populations seems to be increasing. (pharmtech.com)
- We are enabling a 'scale-out' approach to address the increasing demands to treat diverse patient populations. (pharmtech.com)
- Growing geriatric population in the world poses an opportunity for the pharmaceutical market growth due to increase in number of patient populations. (growthmarketreports.com)
Tumor1
- Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)
Addition1
- Clarification around plasmid vs. viral vector manufacturing and the addition of example processes in Figures 1 to 3 (see below) were changes made to the draft guidance to help address the scope. (bioprocessonline.com)
Transport2
- The Trexler Air Transport Isolator (T-ATI) system has since undergone modifications and improvements. (cdc.gov)
- Dedicated road transport that can accommodate the Air Transport Isolator patient transport system, such as the Jumbulance shown, enables seamless end-to-end transfer from patient pickup to the destination facility. (cdc.gov)
Team2
- Separate T-ATIs are owned by the Ministry of Defence (MOD) and the Department of Health, and both capabilities are operated by a dedicated MOD team that includes the medical operations directorate, the RAF Aeromedical Evacuation Coordination Cell (AECC), and the Deployable Air Isolator Team (DAIT). (cdc.gov)
- While moving the isolator, team members wore protective suits and positive-pressure, HEPA-filtered Racal hoods (manufactured by Racal Health & Safety, Inc, Frederick, Maryland). (wikipedia.org)
Production4
- Millipore ® CTDMO Services delivers expertise and flexible solutions for viral vector development and manufacturing to advance cell and gene therapies from preclinical through commercial production. (sigmaaldrich.com)
- Our viral vector experts work with our clients to identify and evaluate improvements to current processes in order to streamline therapeutic production, address risk, and accelerate cell and gene therapies to the clinic. (sigmaaldrich.com)
- The joint production platform will significantly increase our and our partners' manufacturing capabilities in the cell therapy space reinforcing our claim to offer treatment to potentially thousands of patients from one donated liver," said Dr. John Tchelingerian, CEO of Promethera Biosciences. (european-biotechnology.com)
- Depletion of UBR4 resulted in a significant decrease in RVFV titers and a reduction in viral RNA production. (morulaivf.com)
Environment3
- The interior of the isolator was maintained at a pressure negative to the external environment by a high-efficiency particulate air (HEPA) filtered blower. (wikipedia.org)
- The isolator could be attached directly to a transfer port, situated on the external wall of the main USAMRIID building, to allow movement of the patient into a BSL-4 medical care suite without exposing the environment to the patient. (wikipedia.org)
- Topics discussed include gnotobiotic environment on isolated patients and in dentistry and parasitology, as well as carcinogenesis in and physiological effects of gnotobiotic environments. (elsevier.com)
Product1
- The pharmaceutical manufacturing is controlled by guidelines issued by regulatory bodies which look after the proper conduct of procedures so that the product remains harmless to patients and demonstrate positive effect. (growthmarketreports.com)
Integrity1
- We are committed to the highest standards of scientific excellence and integrity for the benefit of patients, the medical community, our partners, shareholders and employees. (innomedics.net)
Resistance2
- Effects of icodextrin on insulin resistance and adipocytokine profiles in patients on peritoneal dialysis. (farkindia.in)
- Especially high levels of resistance to tear, alcohol-based hand disinfectants, and viral penetration. (cleanroomsuppliesltd.com)
System1
- After the successful start of the new travel-by clinic at Truman Bodden Sporting activities Advanced parking lot earlier this week, we have determined that this website satisfies the requires of this each day testing clinic and makes it possible for for improved group handle, a more streamlined system for patients as they will be analyzed from the convenience of their car or truck. (haftpflichtversicherungg.com)
Manufacturing3
- Discover how we leverage our over 25 years of experience, knowledge and expertise in viral vector development and manufacturing to provide a de-risked, reproducible and streamlined path to clinical and commercial manufacturing through our viral vector platforms. (sigmaaldrich.com)
- For the last eight years, I've been working in a variety of technical marketing leadership positions and I really have a passion for developing and bringing new products to market to help drive manufacturing efficiencies and flexibility, ultimately trying to speed up the time to market for life saving and life enhancing drugs for patients. (on24.com)
- As a result, viral vector manufacturing now clearly lies within the scope of GMP manufacture (dark gray background in figures), while plasmids are on a sliding scale of applicability to the GMPs (white to light gray background in figures), with construct preparation outside of GMP and increasing level of controls as the plasmid nears drug substance. (bioprocessonline.com)
Cell2
- Shibuya has manufactured and installed a variety of aseptic systems and equipment for hospitals and universities which includes cell culture isolators, robotic cell culture isolators and 3D bio printers. (european-biotechnology.com)
- We also identified an antipsychotic, Haloperidol, as an unexpected inhibitor of monocyte cell disassembly which could impair ApoBD-mediated viral propagation under in vitro conditions. (nature.com)
Successfully2
- The first clinical trial kits were successfully delivered to MGB's patients within six months. (drug-dev.com)
- CpG 1018's ability to enhance the immune response, as successfully demonstrated in HEPLISAV-B, is expected to reduce the dose of antigen needed, helping ensure broader availability to patients. (pharma-industry-review.com)
Positive1
- Let me warn everybody who has carried out this that you are in violation of the Community Health Regulation and you may perhaps nevertheless be positive, carrying a higher viral load, and you are placing the public and yourself at great threat and you are just outright egocentric. (haftpflichtversicherungg.com)
Renal2
- Use of less iodinated contrast is particularly crucial in patients with pre-existing renal dysfunction, as CM is concentrated in renal tubules, having a direct toxic effect, modulating tubular regulatory mechanisms, and producing renal vasoactive substances. (edu.au)
- Risk of contrast induced nephropathy is considered low in human patients with no history or symptoms of renal disease. (edu.au)
Systems1
- A serious risk assessment looking at the HVAC air classifications, manipulation processes with/without single-use systems, and the transfer systems must be made and contrasted with Annex 1, developing the risk to the patient. (bioprocessonline.com)
Care1
- Developed by Vickers in the U.K. in the 1970s - and manufactured in later years by Elwyn Roberts Isolators, Shropshire, UK, until 2007 - the ATI was a self-contained unit capable of transporting a patient with a highly virulent disease and at the same time providing maximum microbiological security while full nursing care and treatment are rendered. (wikipedia.org)
Treatments1
- CCMI is part of an established supply chain for ATMP products and has delivered several clinical programs aimed at offering patients alternative treatments through advanced therapies. (ispe.org)
Invasive2
- It is suitable for wearing by clinical medical personnel during the invasive operation, providing protection for the patients undergoing treatment and medical personnel performing invasive operations, and preventing the spread of blood, body fluids and splashes. (in.ua)
- This study sought to identify biomarkers for selecting patients with a high potential for developing invasive carcinoma in the breast with normal histology, benign lesions, or premalignant lesions. (cdc.gov)
Dose1
- Lean body weight (LBW) has been considered in particularly obese human patients when prescribing a dose of CM, as body fat is not metabolically active and contributes little to dispersing or diluting the CM in the blood. (edu.au)
Treatment2
- Cidofovir is indicated only for the treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS). (medilib.ir)
- Company Description Alcon discovers, develops and commercializes first-in-class therapies for the treatment of patients with glaucoma, dry eye, retinal diseases and other diseases of the eye. (ncbiotech.org)
Material1
- Thus, in the absence of Nef, the decreased quantity of viral material transferred to targets could be a unequivocal consequence of the reduced amount of Gag proteins at the plasma membrane of donor cells. (centralparkcarriagesofficial.org)
Total3
- An individualized plan of progressive exercise initiated as soon as possible in the recovery process is the best way to ensure the total recovery of the patient in the least amount of time and with fewest complications (4). (forex-consultant.com)
- The first case was a patient with a total of 11 follicles and 6 oocytes retrieved. (svbww.eu)
- A total of 118 (15%) patients had "suspected ischemic" STDmaxV1-4, of whom 106 (90%) had an acute culprit lesion, 99 (84%) had OMI, and 95 (81%) underwent percutaneous coronary intervention. (morulaivf.com)
Study2
- The case study is a sterility testing isolator. (ejpps.online)
- Chapter 2 is a retrospective study performed to determine the variability of major abdominal vessel and organ contrast enhancement and to establish any relationship with abdominal fat percentage in contrast enhanced CT studies, performed on 62 clinical patients at U-Vet Werribee Animal Hospital between February 2014 and February 2019. (edu.au)
Test1
- They are also resistant to viral penetration, and verified by extensive bacteriophage test results. (cleanroomsuppliesltd.com)
Enter1
- View real-time graphs, quickly, enter patient data, and easily navigate with the high-resolution color touch screen. (a-msystems.com)
Transfer1
- Currently, no UK-published guidelines exist on how to transfer such patients. (cdc.gov)
Medical2
- It is worn on the face of personnel in contact with viral materials in medical institutions to prevent the spread of the virus from patients to medical personnel. (in.ua)
- It is used in the mouth and nose of medical staff in the operating room to prevent the spread of dandruff and respiratory microorganisms to open surgical wounds, and to prevent the body fluids of surgical patients from spreading to medical staff, which plays a role of two-way biological protection. (in.ua)
High-risk1
- Conclusions Among patients with high-risk acute coronary syndrome, the specificity of ischemic STDmaxV1-4 was 97% for OMI and 96% for OMI requiring emergent percutaneous coronary intervention. (morulaivf.com)