• protein
  • Block the processing of viral protein and assembly of the virion. (brainscape.com)
  • NS5A inhibitors have been developed to target the NS5A protein. (wikipedia.org)
  • In early 1990s, the determination of biological crystal structure of influenza virus surface protein led to the discovery of the active site and provided the opportunities to discover and design new and specific inhibitors. (wikipedia.org)
  • The conformational-change mechanism confers certain advantages, but it also has drawbacks: serpins are vulnerable to mutations that can result in serpinopathies such as protein misfolding and the formation of inactive long-chain polymers. (wikipedia.org)
  • The origin of the spring-loaded mechanism lies within the exposed gp41, which contains two consecutive heptad repeats (HR1 and HR2) following the fusion peptide at the N terminus of the protein. (wikipedia.org)
  • broad-spectrum
  • The aim of the present study was to investigate the interactions of these two active compounds and an inactive analogue used as a negative control, LJ025, with biological membrane models, in order to clarify the mechanism of action at the molecular level of these new broad-spectrum enveloped virus entry inhibitors. (jpt.com)
  • fusion
  • It was reported recently that a new aryl methyldiene rhodanine derivative, LJ001, and oxazolidine-2,4-dithione, JL103, act on the viral membrane, inhibiting its fusion with a target cell membrane. (jpt.com)
  • It acts as an inhibitor which blocks viral entry into host cells at a step after virus binding but before virus-cell fusion, and also irreversibly inactivates the virions themselves by generating reactive singlet oxygen molecules which damage the viral membrane. (wikipedia.org)
  • The gp120 will bind CD4 and the CCR5co receptor molecule, and this triggers gp41-mediated fusion of the viral and cellular membranes. (wikipedia.org)
  • sialic acid
  • Viral neuraminidase cleaves terminal neuraminic acid (also called sialic acid) residues from glycan structures on the surface of the infected cell. (wikipedia.org)
  • In general, mammalian sialic acid residues are at terminal positions (non-reducing end) in complex glycans, and so viral neuraminidases - which are exo-glycosidase enzymes - use these terminal residues as their substrates. (wikipedia.org)
  • machinery
  • In light of its important role within the MHC I antigen processing pathway, TAP is a prime target for viral immune evasion strategies, and we summarize how this antigen translocation machinery is sabotaged by viral factors. (surrey.ac.uk)
  • Some pathogens, such as human cytomegalovirus, express caspase inhibitors that arrest the apoptotic machinery of the host cell. (wikipedia.org)
  • mRNA
  • We report here the identification of inhibitors of pyrimidine biosynthesis, which reveals a novel requirement for pyrimidines in NS1-mediated block of mRNA nuclear export. (rupress.org)
  • substrate
  • Ribonuclease H (abbreviated RNase H or RNH) is a family of non-sequence-specific endonuclease enzymes that catalyze the cleavage of RNA in an RNA/DNA substrate via a hydrolytic mechanism. (wikipedia.org)
  • genes
  • In the lytic phase, the viral genes are being actively transcribed and many times ultimately lead to cell death. (wikipedia.org)
  • This means that these genes are controlled through a mechanism affecting the chromatin structure that allows them to be expressed in the latent phase. (wikipedia.org)
  • molecules
  • Antigenic peptides are guided to major histocompatibility complex class I (MHC I) molecules and are finally displayed on the cell surface, where they mount an adaptive immune response against viral infected or malignantly transformed cells. (surrey.ac.uk)
  • receptor
  • Viral entry into CD4-positive cells commences when three subunits of a glycoprotein 120 (gp120) bind to CD4 receptor and a coreceptor. (wikipedia.org)
  • cells
  • Necrotic cells are cleared from the immune system by a mechanism called pinocytosis, or cellular drinking, which is mediated by macropinosomes, a subcellular component of macrophages. (wikipedia.org)
  • isolates
  • Individual isolates consist of closely related, yet heterologous populations of viral genomes. (google.com)
  • Bind
  • Recently, inhibitors derived from HR2 such as Fuzeon (DP178, T-20) bind to the HR1 region on gp41 have been developed. (wikipedia.org)
  • synthesize
  • they are analogues of the naturally occurring deoxynucleotides needed to synthesize the viral DNA and they compete with the natural deoxynucleotides for incorporation into the growing viral DNA chain. (wikipedia.org)
  • host
  • Other studies propose an alteration of host cell factors as a possible third mechanism. (wikipedia.org)
  • The viral DNA is then integrated into the host chromosomal DNA, which then allows host cellular processes, such as transcription and translation, to reproduce the virus. (wikipedia.org)
  • structural
  • Here, we review the structural organization and the molecular mechanism of this specialized antigen translocon. (surrey.ac.uk)
  • Favorable characteristics have been introduced through varied structural changes, and structural similarities between NS5A inhibitors that are clinically approved are readily apparent. (wikipedia.org)
  • The structures indicated that the inhibitory mechanism involved an unusual conformational change and prompted the subsequent structural focus of serpin studies. (wikipedia.org)