AlkaloidsAlkaloidVinorelbineOncovinRoseaSulfateLiposomeChemotherapyIsolated in 1961IntravenousCatharanthusDoxorubicin2019TubulinApoptosisInhibitsToxicityInjectionConstipationCancerEfficacyPeripheral neuropathyDoseSide effectsLeukemiaDerivativesTreatmentTreatmentsSymptomsNumbnessMildVeinDrugEffective
Alkaloids15
- Accidental injection of vinca alkaloids into the spinal canal (intrathecal administration) is highly dangerous, with a mortality rate approaching 100 percent. (wikipedia.org)
- Vincristine is created through the semi-synthesis coupling of indole alkaloids vindoline and catharanthine in the vinca plant. (wikipedia.org)
- Vincristine lipid complex is in a class of medications called vinca alkaloids. (medlineplus.gov)
- Vinca alkaloids, such as vinblastine and vincristine, have also been shown to have antifungal activity. (selfgrowth.com)
- Vincristine (and other vinca alkaloids) should only be given intravenously via a minibag. (ahrq.gov)
- Co-administration of anthracyclines and vinca alkaloids on the same day is a standard of care for hematopoietic malignancies. (uni-muenchen.de)
- The chemo drugs vincristine and vinblastine, vinca alkaloids, although they come from a different plant, Catharanthus roseus, aka the Madagascan Periwinkle, work in the same manner - inhibiting cell division. (acsh.org)
- Quinidine, theophylline, or vinca alkaloids (eg, vincristine) because their effectiveness may be decreased by Procardia. (canadianpharm.org)
- Vincristine belongs to a group of drugs called vinca alkaloids. (medicap.com)
- Plant alkaloids are mitotic spindle poisons active in G2 and M phases of cell division (vinca alkaloids, taxanes) or are topoisomerase interactive agents (etoposide and teniposide). (vin.com)
- The quest for hostile to cancerous growth compounds from plant sources began vigorously during the 1950s with the disclosure and advancement of the different regular mixtures like vinca alkaloids, vinblastine, vincristine and cytotoxic podophyllotoxins. (researchsquare.com)
- Vincristine sulphate belongs to a group of medications known as vinca alkaloids and is obtained from the plant Vinca rosea Linn. (vin.com)
- Vinca alkaloids act as antimicrotubule agents that block mitosis by arresting cells in the metaphase. (vin.com)
- Taxol - paclitaxel, Taxotere - docetaxel, and Abraxane - albumin-bound paclitaxel) and vinca alkaloids (e.g. (shu.edu)
- Vinca alkaloids (vincristine, vinblastine, etc.) bind to microtubule plus ends and the outer surface of microtubules, inhibiting microtubule lengthening (polymerization) as well as shortening (depolymerization) (Figure 2B). (shu.edu)
Alkaloid2
- It is a vinca alkaloid that can be obtained from the Madagascar periwinkle Catharanthus roseus. (wikipedia.org)
- It is a type of vinca alkaloid and a type of antimitotic agent. (news-medical.net)
Vinorelbine1
- Vincristine and vinblastine are most commonly used, and new drugs such as etoposide, teniposide, and vinorelbine are being used in human medicine but have not yet received widespread use in veterinary oncology. (vin.com)
Oncovin2
- Vincristine, also known as leurocristine and marketed under the brand name Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. (wikipedia.org)
- Vinblastine and Oncovin - vincristine) have been reported to be highly effective against breast cancer as well as many other types of cancer. (shu.edu)
Rosea2
- They are derived from periwinkle ( Vinca rosea ) and mayapple ( Podophyllum peltatum ) plants. (vin.com)
- A pan tubulin inhibitor, isolated from Catharanthus roseus (the Madagascar periwinkle, formerly Vinca rosea ). (guidetoimmunopharmacology.org)
Sulfate2
- The U.S. Food and Drug Administration today approved Marqibo (vincristine sulfate liposome injection) to treat adults with a rare type of leukemia called Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL). (news-medical.net)
- Marketed formulations contain vincristine sulfate ( PubChem CID 249332 ). (guidetoimmunopharmacology.org)
Liposome1
- The liposome encapsulation of vincristine enhances the efficacy of the vincristine drug while simultaneously decreasing the neurotoxicity associated with it. (wikipedia.org)
Chemotherapy4
- Vincristine is delivered via intravenous infusion for use in various types of chemotherapy regimens. (wikipedia.org)
- The main side effects of vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. (wikipedia.org)
- Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine. (wikipedia.org)
- Vincristine lipid complex should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. (medlineplus.gov)
Isolated in 19611
- Vincristine was first isolated in 1961. (wikipedia.org)
Intravenous1
- It is extremely important that the intravenous needle delivering vincristine be properly positioned in the vein. (medicap.com)
Catharanthus1
- Left top) Catharanthus roseus, aka the Madagascan Periwinkle, a member of the Vinca plant family, is the source of the cancer drug vincristine (Right top) Nice structure, huh? (acsh.org)
Doxorubicin3
- If both drugs are applied simultaneously, doxorubicin inhibits apoptosis induction of vincristine. (uni-muenchen.de)
- While it is well understood that doxorubicin activates p53 and induces cell-cycle arrest, we observed that cell-cycle arrest disabled inactivation of anti-apoptotic Bcl-2-family members by vincristine. (uni-muenchen.de)
- One dog died after the third dose of vincristine, and in one case the tumor was vincristine resistant, and the doxorubicin treatment was required. (vin.com)
20191
- New York, NY -- ( SBWIRE ) -- 02/02/2019 -- Global Vincristine market size will increase to Million US$ by 2025, from Million US$ in 2017, at a CAGR of during the forecast period. (sbwire.com)
Tubulin1
- Vincristine works partly by binding to the tubulin protein, stopping the tubulin dimers from polymerizing to form microtubules, causing the cell to be unable to separate its chromosomes during the metaphase. (wikipedia.org)
Apoptosis1
- Therefore, it follows that vincristine was unable to activate downstream apoptosis signaling. (uni-muenchen.de)
Inhibits1
- The vincristine molecule inhibits leukocyte production and maturation. (wikipedia.org)
Toxicity1
Injection2
- tell your doctor and pharmacist if you are allergic to vincristine, any other medications, or any of the ingredients in vincristine lipid complex injection. (medlineplus.gov)
- Your doctor may not want you to receive vincristine lipid complex or may need to change your dose of vincristine lipid complex injection. (medlineplus.gov)
Constipation1
- Your doctor may tell you to take a stool softener or laxative to help prevent constipation during your treatment with vincristine lipid complex. (medlineplus.gov)
Cancer6
- A downside, however, to Vincristine is that it does not only affect the division of cancer cells. (wikipedia.org)
- Vincristine is also being studied in the treatment of other types of cancer. (news-medical.net)
- Cycling cells are required for vincristine to kill cancer cells efficiently. (uni-muenchen.de)
- Vincristine treats certain types of cancer. (medicap.com)
- Vincristine has been use in combination with other medicines to treat certain types of cancer. (medicap.com)
- Vincristine has been use in combination with other medicines to treat the following cancers: non-Hodgkin's lymphoma, Hodgkin's lymphoma, acute lymphoblastic leukemia (ALL), Wilms' tumor (a form of pediatric kidney cancer), rhabdomyosarcoma, and neuroblastoma. (medicap.com)
Efficacy1
- The purpose of this work was to document the efficacy and side effects of vincristine sulphate treatment on TVTc. (vin.com)
Peripheral neuropathy2
- One of the first symptoms of peripheral neuropathy is foot drop: A person with a family history of foot drop and/or Charcot-Marie-Tooth disease (CMT) should avoid vincristine. (wikipedia.org)
- With repeated doses of vincristine, you may feel symptoms of peripheral neuropathy (tingling sensation and numbness in the fingers and toes). (medicap.com)
Dose3
- Vincristine-induced neuropathy is the main dose-limiting side effect. (wikipedia.org)
- The vincristine administrations, at the dose of 0.5 mg/m 2 of body surface (IV), were done considering all the manufacturers' warnings recommendations. (vin.com)
- Vincristine sulphate, at the dose of 0.5 mg/m 2 of body surface (IV), on 7-14 days intervals, reveal high efficiency (86.6%) for TVTc treatment. (vin.com)
Side effects4
- Most people experience some side effects from vincristine treatment. (wikipedia.org)
- Vincristine lipid complex may cause side effects. (medlineplus.gov)
- Vincristine is safe for most patients, but potential side effects can occur, as gastrointestinal alterations, myelosuppression and extravasation injury. (vin.com)
- Before the therapy sections it is necessary to execute the clinical evaluation, the cytological exam and the complete blood count for monitoring the side effects related to vincristine. (vin.com)
Leukemia1
- Vincristine is the active ingredient in a drug used to treat acute leukemia. (news-medical.net)
Derivatives1
- There is an attempt to overcome resistance by the addition of derivatives and substituents to the vincristine molecule. (wikipedia.org)
Treatment2
- It is important for you to tell your doctor how you are feeling during your treatment with vincristine lipid complex. (medlineplus.gov)
- One tumor (6.6%) was refractory to vincristine, while at the treatment beginning we observed a mass reduction. (vin.com)
Treatments1
- Use a reliable method of birth control while receiving vincristine treatments. (medicap.com)
Symptoms1
- Vincristine has been proven hazardous and should be avoided by all CMT patients, including those with no symptoms. (asociatiacmt.ro)
Numbness1
- Vincristine can cause tingling sensation and numbness in the fingers and toes. (medicap.com)
Mild1
- Toxicities associated with vincristine are mild, but perivascular reaction can be a problem. (vin.com)
Vein3
- Vincristine lipid complex should be administered only into a vein. (medlineplus.gov)
- Vincristine lipid complex comes as a liquid to be injected intravenously (into a vein) over 1 hour by a doctor or nurse in a medical facility. (medlineplus.gov)
- [3] If vincristine is used alone, it is given once a week strictly into a vein. (mdwiki.org)
Drug3
- The overuse of vincristine may also lead to drug resistance by overexpression of the p-glycoprotein pump (Pgp). (wikipedia.org)
- This is not a complete list of vincristine drug interactions. (medicap.com)
- www.drugguide.com/ddo/view/Davis-Drug-Guide/51789/all/vinCRIStine. (drugguide.com)
Effective1
- Vincristine was an effective chemotherapeutic agent for genital TVTc, showing tumours totally regression in 13 dogs, among them the therapy was also efficient for one case of diffuse cutaneous TVTc. (vin.com)