• Here, we describe a novel, high-affinity binding site for I-TevI endonuclease, encoded within the group I td intron of phage T4. (rcsb.org)
  • Specific lesions of the tryptaminergic system by stereotaxic injections of 5 6-dibydroxytryptamine within raphe and anterior ventricles did not significantly modify binding of either ligand. (erowid.org)
  • Catecholamines inhibited ligand binding in the potency order adrenaline NA isoprenaline, corresponding to peripheral a-receptor activation. (erowid.org)
  • 6-OHDA reduced NA levels by 80%, NA uptake by 67% and reduced ligand binding. (erowid.org)
  • exposed side chains, and weak ligand binding. (lu.se)
  • The location of the receptor binding site (blue circle) includes the 120-loop and the 180-helix. (cdc.gov)
  • On the surface model (right), only amino acid substitutions adjacent to the antigenic sites and receptor binding site are labeled. (cdc.gov)
  • The other PDB files used for analysis and comparison in this work were downloaded from the RCSB PDB website ( http://www.rcsb.org/ ), including the structures of A. thaliana Toc75 POTRA domains ( 5UAY ), the NMR structure of the C. reinhardtii preFdx1 transit peptide ( 1FCT ) and the crystal structure of RopP2 from Ralstonia solanacearum ( 5W3X ). (nature.com)
  • Using structural, biochemical, and cell-based assays, we show that GR binding sequences, differing by as little as a single base pair, differentially affect GR conformation and regulatory activity. (rcsb.org)
  • This generally yields a large library of DNA sequences, including some that were bound by the transcription factor directly, some that were bound indirectly via interactions with other molecules, and some false positives (such as cases of nonspecific binding). (ucsc.edu)
  • Failing the matrices I could calculate them myself in R if I knew the sequences they bind to. (biostars.org)
  • If anyone knows of somewhere I could download a whole bunch on known binding sequences for these factors it would be very easy to calculate the motifs and matrices. (biostars.org)
  • Vitamin D is an important modulator of cellular proliferation through the vitamin D receptor (VDR) that binds to DNA in the regulatory sequences of target genes. (oncotarget.com)
  • We present a model in which the flexibility in protein-DNA interactions allows I-TevI to bind variant intronless alleles to promote intron mobility while facilitating its function in autorepression, and thereby persistence in its host. (rcsb.org)
  • This method is illustrated for the Ribosome Binding Site Problem, which is to identify the short mRNA 50 untranslated sequence that is recognized by the ribosome during initiation of protein synthesis. (aaai.org)
  • The liver of a sexually mature female brown trout contains more than twice as many binding sites as that of the male (168 ± 15 fmol/mg protein cf. 69 ± 4 fmol/mg protein), and no difference in kD is observed between males and females (2.6 ± 0.2 nM and 2.9 ± 0.3 nM, respectively). (nerc.ac.uk)
  • Plasma from both male and female brown trout was also found to bind [3H]estradiol, but with lower affinity (kD in 10−8 M range) and higher capacity (4000 - 11,000 fmol/mg protein) and with less specificity. (nerc.ac.uk)
  • It is concluded that cytosol and plasma binding of estradiol in brown trout are distinct, and indicative of the presence of an intracellular hepatic estrogen receptor and a plasma sex-steroid-binding protein. (nerc.ac.uk)
  • A key characteristic of each transcription factor protein is its DNA binding domain. (ucsc.edu)
  • The results show a requirement for an as yet unidentified protein to capacitate vinculin binding to focal contact sites and suggest that this protein is peripheral and interacts directly with the binding site. (rupress.org)
  • On the cartoon view (left), all amino acid changes in the HA protein are labeled. (cdc.gov)
  • Disulfiram is highly lipid soluble (accumulates in adipose tissue, crosses blood-brain barrier), highly protein-bound, and has 80% bioavailability after an oral dose of 350 mg. (medscape.com)
  • Today, 90% of all protein crystal therefore be viewed as a continuous temperature-jump relax- structures are determined from diffraction data recorded at ation experiment, where different degrees of freedom partici- temperatures of 90-120 K (3). (lu.se)
  • To understand how cholesterol interacts with M2 to generate membrane curvature, we have determined the cholesterol-binding site of M2 by measuring protein-cholesterol distances and cholesterol orientation in the membrane. (lu.se)
  • The data represent the first direct determination of the cholesterol-binding structure of a membrane protein in lipid bilayers, and moreover indicate a specific mechanism by which cholesterol concentration gradients in the membrane drive the M2 protein to the neck of the budding virus to conduct membrane scission. (lu.se)
  • Due to renewed interest in covalent drugs and the plethora of potential drug targets, these represent prototypes for the design of kinase inhibitory compounds that achieve high specificity through covalent interaction and yet still bind reversibly to the ATP cleft, a strategy that could be applied to avoid issues with conventional covalent binders. (nottingham.ac.uk)
  • Receptor binding specificity of A/New York/108/2016 (H7N2) influenza virus isolated from a human who experienced influenza-like illness after exposure to sick domestic cats at an animal shelter in New York, NY, USA, 2016. (cdc.gov)
  • Customary binding sites of intron-encoded homing endonucleases lie within cognate intronless alleles, at the so-called homing sites. (rcsb.org)
  • Crystallographic studies showed that the overall interactions of the DNA-binding domain with the operator and homing sites are similar, but have some different hydrogen-bonding contacts. (rcsb.org)
  • Over the course of the COVID-19 pandemic, he has made significant contributions to our understanding of antibody-spike interactions through in-depth structural analysis that detail the specificities and mechanisms of how monoclonal neutralizing antibodies bind spike to prevent infection. (stanford.edu)
  • Chemical Interactions Some drugs produce effects without altering cellular function and without binding to a receptor. (msdmanuals.com)
  • Pharmacodynamic drug-drug interactions result in competition for receptor binding sites or alter postreceptor response. (msdmanuals.com)
  • LSD binds to the human 5-HT 2B receptor (one in a large family of serotonin receptors ) in a peculiar way that prolongs its signaling kinetics. (blogspot.com)
  • The binding characteristics of agonists and antagonists to CNS n-noradrenergic membrane receptors were studied. (erowid.org)
  • Naturally occurring hormone that crosses cell membranes to bind to cytoplasmic receptors. (medscape.com)
  • Binding sites with characteristics conforming to those of a putative estrogen receptor have been identified in the liver of sexually mature male and female brown trout. (nerc.ac.uk)
  • Some repeats contain putative calcium-binding sites. (embl.de)
  • Each DNA binding domain recognizes and interacts with DNA that matches a specific nucleotide pattern, or motif. (ucsc.edu)
  • These motifs tend to be short and degenerate, so even when the DNA binding motif is known, one cannot generally predict where a given transcription factor may bind. (ucsc.edu)
  • associated Gene Ontology annotation of this binding site. (ugent.be)
  • Transcription is regulated through the binding of transcription factor proteins to specific cis -level regulatory sites in the DNA. (ucsc.edu)
  • These disorders can change receptor binding, alter the level of binding proteins, or decrease receptor sensitivity. (msdmanuals.com)
  • We hypothesized that single nucleotide polymorphisms (SNPs) in VDR-binding sites might affect target gene expression and influence the progression of prostate cancer. (oncotarget.com)
  • It provides unique identifiers, names and synonyms, list of complex members with their unique identifiers (UniProt, ChEBI, RNAcentral), function, binding and stoichiometry annotations, descriptions of their topology, assembly structure, ligands and associated diseases as well as cross-references to the same complex in other databases (e.g. (stanford.edu)
  • This site is an operator that overlaps the T4 late promoter, which drives I-TevI expression from within the td intron. (rcsb.org)
  • TFBSs are typically located upstream of target genes, within a few thousand base pairs of the transcription start site. (bvsalud.org)
  • Remarkably, all inhibitors bind to a common lipid-exposed pocket formed by the partially open lateral gate and plug domain of the channel. (biorxiv.org)
  • Therefore, the local lipid composition of the membrane is a key regulator of the site of virus-cell fusion. (lu.se)
  • LSD Binding corresponded to a saturable reversible high affinity site with a corresponding dissociation constant similar to that of 5-HT (KD = 2 x 10-q M) and a second, saturable and reversible site of less affinity with a corresponding ED close to 2 to 3 x 10-5 M. Various plotting systems of the binding curve indicated for the second site a positive cooperativity, the Hill coefficient being 3.7. (erowid.org)
  • Binding of 3H-ligands was saturable with KD values of 5.8 nM and 0.48 nM for 3H-CD and 3H-WB-4101, respectively. (erowid.org)
  • Black Fox Bound is an amateur bondage website from UK. (freeones.com)
  • Content looks a bit like it's from early 2000s, but if bondage is your kick, you will enjoy photos and videos from that site. (freeones.com)
  • If you like damsel-in-distress style bondage, this website is for you. (freeones.com)
  • Located in the former headquarters of the largest domestic slave trading company in the United States, the Freedom House Museum shares the painful stories of thousands of men, women, and children who passed through the site on their way to lives of hard labor and bondage on the large plantations of the Deep South. (virginia.org)
  • In an arbitration case that even the judge noted had "very unique" facts, Jennifer Jo Smith was awarded $35,544 in a suit against Paige White, a legendary performer and director in the bondage community, after Smith was injured during a San Francisco photo shoot while bound and hanging from ropes. (law.com)
  • Neuraminidase inhibitors block the release of progeny virions from a host cell by selectively binding to the active site of the neuraminidase enzyme. (who.int)
  • View the legally binding agreement that all host sites enter into with CDC in order to host an associate. (cdc.gov)
  • It was an intimate wedding with legally binding ceremony on site. (tuscandream.com)
  • Binding is highly specific, only estradiol and estrone displace specifically bound [3H]estradiol. (nerc.ac.uk)
  • Find support for a specific problem in the support section of our website. (mdpi.com)
  • Online management features for Standing Orders include the option for the Library to assign a specific order code to track and view Standing Orders spending. (librarybound.com)
  • The binding of TFs to TFBSs influences the recruitment of the transcriptional machinery, thereby regulating gene transcription in a precise and specific manner. (bvsalud.org)
  • Contributors that provided submissions made several general comments on the draft code as a whole and gave their views on specific sections of the instrument. (who.int)
  • IIIF provides researchers rich metadata and media viewing options for comparison of works across cultural heritage collections. (si.edu)
  • We also use third-party cookies that help us analyze and understand how you use this website. (aaai.org)
  • These webinars include information about the history of the program, funding for associates, an overview of the program itself, guidance on the characteristics of a quality PHAP training experience, and steps on how to apply to be a host site. (cdc.gov)
  • Structure-guided discovery of a new class of inhibitors of Polo-like kinase 1 (PLK1) catalytic activity that interact with Cys67 of the ATP binding site is described. (nottingham.ac.uk)
  • 10-12), sometimes in the catalytic site of enzymes. (lu.se)
  • Compounds containing the benzothiazole N-oxide scaffold not only bind covalently to this residue, but are reversible inhibitors through the formation of Meisenheimer complexes. (nottingham.ac.uk)
  • Mutations conferring resistance to the inhibitors are clustered at this binding pocket. (biorxiv.org)
  • This mutation is located in a highly conserved region of the promoter and disrupts the binding site for the transcription factor HNF-4α, mutations in the gene encoding HNF-4α being another cause of MODY (MODY1). (diabetesjournals.org)
  • Mutants of residues in the transition-metal ion-binding site severely affect transport, whereas a mutation of a conserved histidine located near this site results in metal ion transport that appears uncoupled to proton transport. (nature.com)
  • It may not display this or other websites correctly. (gbatemp.net)
  • Update your browser to view this website correctly. (lu.se)
  • Some mechanisms of action in CIDP are altering mediator function at site of inflammation and suppressing immune response. (medscape.com)
  • Some comments expressed the view that the data gathering, information exchange, and monitoring and institutional mechanisms recommended under Articles 7, 8 and 10 are important components of the draft code that may strengthen health systems. (who.int)
  • Talc crystal viewed along the [100] axis, looking along the layers of the crystal Talc is a common metamorphic mineral in metamorphic belts that contain ultramafic rocks, such as soapstone (a high-talc rock), and within whiteschist and blueschist metamorphic terranes. (wikipedia.org)
  • The authors created a crystal structure of 5-HT 2B bound to LSD and found an "unexpected binding configuration in the orthosteric site. (blogspot.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Structural basis of transcription: RNA Polymerase II substrate binding and metal coordination at 3.0 A using a free-electron laser. (stanford.edu)
  • This mechanism of kinase inhibition results in compounds that can target PLK1 with high selectivity, while avoiding issues with irreversible covalent binding and interaction with other thiol-containing molecules in the cell. (nottingham.ac.uk)
  • Vinculin interaction with permeabilized cells: disruption and reconstitution of a binding site. (rupress.org)
  • In this study we have examined the interaction of vinculin with these sites in permeabilized L6 myoblasts to define conditions that perturb the binding and subsequently to reconstitute it. (rupress.org)
  • Dose-Response Relationships Regardless of how a drug's effect occurs-through binding or chemical interaction-the concentration of the drug at the site of action controls the effect. (msdmanuals.com)
  • This process involves fragmenting DNA, selecting the fragments of DNA that are bound by a certain transcription factor, and sequencing those DNA fragments. (ucsc.edu)
  • The concentration of the drug at the receptor site influences the drug's effect. (msdmanuals.com)
  • A special eclipse-viewing offer, St. Louis Solar Eclipse Escape includes a one-night stay in Arch-view accommodations and two pairs of solar viewing glasses. (fourseasons.com)
  • Our social media channels are external sites and have their own binding terms and conditions. (health.gov.au)
  • As used in this Terms of Service and Privacy Policy, "We" and "abcteach" and "Site" refer to all websites and services, whether public or membership, operated or offered by abcteach. (abcteach.com)
  • By using the Site, you accept and agree to be bound by the following terms. (abcteach.com)
  • We may, solely at our discretion, modify or revise these terms and conditions at any time by updating this web page, and you agree to be bound by these modifications or revisions. (abcteach.com)
  • Use of this Site is subject to express terms of use. (godaddy.com)
  • If you access the Materials on this website, you agree to be bound by the terms and conditions below. (telefonica.com)
  • If you do not agree to the terms and conditions, do not access this website or view any of the Materials. (telefonica.com)
  • Please be aware that Facebook's recent changes to the page experience mean if you are blocked from Health's Facebook page you will be unable to view our page content. (health.gov.au)
  • For example, instead of linking to the home page of a newspaper, a deep link might take the user directly to a newspaper article within the site. (abcteach.com)
  • page, you can view and edit each order separately. (godaddy.com)
  • Competition for binding was stereospecific ((-)phenylethanolamines (+)isomers). (erowid.org)
  • Necessary cookies are absolutely essential for the website to function properly. (aaai.org)
  • Keep in mind those results (as with the smaller binding site studies) will be context-dependent. (biostars.org)
  • Rather, we found that phosphorylated activation loop Y842 serves as a binding site of SHP2, which is required for FLT3-induced activation of RAS/ERK pathway. (lu.se)
  • In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. (nature.com)
  • You need JavaScript enabled to view it. (librarybound.com)
  • Craig recently shared a new essay that talks about the process he went through in putting out Koya Bound - as with all of his essays, it's as informative as it is entertaining to read. (jeansnow.net)
  • You'll of course remember Koya Bound , the beautiful photography book that Craig Mod and Dan Rubin recently Kickstarted, covering one of the annual (or is it bi-annual) walks that Craig likes to do. (jeansnow.net)
  • It's been great following Craig 's work on the Koya Bound book, from Kickstarter campaign , to getting the thing printed , to the massive task of signing and stamping all those books , to finally properly launching it this week at an event held at the Leica Salon in Ginza. (jeansnow.net)
  • Last month I mentioned Craig Mod and Dan Rubin 's upcoming photography book, Koya Bound , while pointing out a great interview with them that was published in The Japan Times - a talk about the walk that inspired the book. (jeansnow.net)
  • The Japan Times has a great photo essay and interview up with Craig Mod and Dan Rubin , who earlier this year walked the Kumano Kodo route in Wakayama, and are about to launch a photo book based on the experience ( Koya Bound , out in September). (jeansnow.net)
  • The pharmacologic response depends on the drug binding to its target. (msdmanuals.com)
  • exposed_validate(&$form, &$form_state) in /var/alternc/html/f/ftm/drupal-6.9/sites/all/modules/views/handlers/views_handler_filter_date.inc on line 0. (dominionpaper.ca)
  • Fluorescently labeled vinculin binds to focal contact areas in permeabilized cells independent of actin (Avnur, Z., J. V. Small, and B. Geiger, 1983, J. Cell Biol. (rupress.org)
  • For example, Kennedy et al (2011) report on 2362 TGFB-induced SMAD4 binding sites in an ovarian cancer cell line. (biostars.org)
  • 96:1622-1630), but the nature of the binding site is unknown. (rupress.org)