Loss of viable myocardiumPresence of viable myocardiumRight ventricular myocardiumIschemic myocardiumCardiacRevascularizationInfarctSilent ischemiaCoronary arteryDobutamine stressSPECTMyocardial tissueViabilityUptakeMismatchDetectionHibernatingTissuePerfusion defectsNecrosisSegmentsHibernationContractilityScarSeverelyReversibleMetabolicIdentifyExtentContractile functionRevascularisationBypassContrastBloodFunctionAreaLeftStressHeart muscleApproachStudiesCell
Loss of viable myocardium1
- Imaging evidence of new loss of viable myocardium or regional wall motion abnormality in a pattern consistent with an ischemic etiology. (who.int)
Presence of viable myocardium4
- p=0.001] were associated with the presence of viable myocardium. (wits.ac.za)
- Myocardial uptake of thallium-201 chloride is directly proportional to the regional myocardial blood flow and is dependent on the presence of viable myocardium. (wikidoc.org)
- Myocardial uptake of thallium-201 chloride is proportional to regional myocardial blood flow and is dependent on the presence of viable myocardium. (wikidoc.org)
- Therefore, the perfusion defects during stress images are not observed in the rest images, and these reversible perfusion defects indicate the presence of viable myocardium. (wikidoc.org)
Right ventricular myocardium3
- We measured epigenome-wide DNA methylation at 866,895 5'-cytosine-phosphate-guanine-3' (CpG) sites in blood (n=3), buccal cells (n=3), and right ventricular myocardium (n=4) collected from infants with TOF and compared the percent of differentially methylated CpG sites across tissue types. (nih.gov)
- A novel constitutive model for passive right ventricular myocardium: evidence for myofiber-collagen fiber mechanical coupling. (tamu.edu)
- Given the strong link between tissue structure and mechanical behavior, there remains a need for a myocardial constitutive model that accurately accounts for right ventricular myocardium architecture. (tamu.edu)
Ischemic myocardium3
- The bypass restores blood flow to the ischemic myocardium which, in turn, restores function, viability, and relieves anginal symptoms. (statpearls.com)
- Due to heterogeneous distribution of blood flow, the relative extraction of thallium by non-ischemic myocardium is greater than that by ischemic myocardium. (wikidoc.org)
- These images reveal a decreased uptake by the ischemic myocardium, creating a perfusion defect. (wikidoc.org)
Cardiac5
- February 13, 2012 (London, United Kingdom) - Authors of a small study using cardiac-derived stem cells in "convalescent" MI patients say they've uncovered some of the first true evidence that the heart can regenerate, describing a new method that, they say, led to "unprecedented" improvements in viable heart muscle [1]. (medscape.com)
- By contrast, viable myocardial mass increased by 13 g from baseline by six months in patients who received the cardiac-derived cells (p=0.001) with a nonsignificant 0.9-g increase seen in the control group (p=0.01 between groups). (medscape.com)
- Cardiac magnetic resonance: The most frequently used MR contrast agents based on Gd-chelates accumulate in the extracellular space which is increased in scarred myocardium. (wikipedia.org)
- Cardiac tissue engineering, which combines the use of cells and biomaterials, has been proposed as an alternative therapy for myocardial infarction (MI) 1 , with the goals of repairing the damaged myocardium, recovering heart function, and preventing ventricular remodeling in end-stage heart failure. (nature.com)
- Continued depression of the myocardium with beta-blocking agents over a period of time can, in some cases, lead to cardiac failure. (nih.gov)
Revascularization3
- Segments of the myocardium demonstrating reduced perfusion and increased or preserved 18FFluorodeoxyglucose (18F-FDG) uptake are considered to be viable and thus suitable for revascularization. (wits.ac.za)
- While areas which do not hyperenhance from the gadolinium injection are viable and do recover and contraction improves after revascularization. (rjmatthewsmd.com)
- Detection of viable myocardium prior to revascularization. (uniklinik-freiburg.de)
Infarct3
- Blockages in any of the coronary arteries cause a corresponding defect in myocardial perfusion, ischemia and if unrepaired can lead to permanent infarct or damage to the myocardium. (statpearls.com)
- Ideal would be to subject ypu to a pet scan for viability of myocardium in the infarct area. (doctorspring.com)
- However practically speaking most doctors do not follow this protocol and assuming that more than 10 percent of the are is viable in the infarct area the revascularisation of the 100 percent occluded artery is advised. (doctorspring.com)
Silent ischemia2
- The clinical situations where one can expect hibernating myocardium are:[citation needed] chronic stable angina unstable angina silent ischemia after AMI Stunned myocardium Myocardial scarring Wijns W, Vatner SF, Camici PG (July 1998). (wikipedia.org)
- Clinically, discerning the etiology of depressed myocardial contractile function is difficult, whether due to stunned myocardium, silent ischemia, or hibernating myocardium. (medscape.com)
Coronary artery2
- Differentiation between viable myocardium and scar tissue in segments with abnormal contraction has important consequences in the clinical management of patients with coronary artery disease. (amsterdamumc.org)
- The total amount of myocardium in jeopardy predicts risk, and prolonged persistence of systolic wall thickening abnormality may also identify severe coronary artery disease (CAD). (ecrjournal.com)
Dobutamine stress2
- Echocardiography: A wall motion abnormality at rest which improves during a low-dose dobutamine stress test is classified as "hibernating myocardium. (wikipedia.org)
- 11. Low-dose dobutamine electrocardiograph-gated myocardial SPECT for identifying viable myocardium: comparison with dobutamine stress echocardiography and PET. (nih.gov)
SPECT3
- 1. Comparison of microsphere-equivalent blood flow (15O-water PET) and relative perfusion (99mTc-tetrofosmin SPECT) in myocardium showing metabolism-perfusion mismatch. (nih.gov)
- 6. Assessment of absolute Tc-99m tetrofosmin retention in the myocardium as an index of myocardial blood flow and coronary flow reserve by gated-SPECT/CT: a feasibility study. (nih.gov)
- Viable Myocardium Detected by Hybrid PET/MR and SPECT for the Prediction of the Efficacy of PCI in Patients With CTO. (ichgcp.net)
Myocardial tissue1
- Due to the use of viable myocardial tissue, the contribution of myofibers was significant at all strains with the predicted tensile modulus of [Formula: see text]32kPa. (tamu.edu)
Viability1
- 3. Assessment of myocardial viability in dysfunctional myocardium by resting myocardial blood flow determined with oxygen 15 water PET. (nih.gov)
Uptake1
- Eight 201 Tl defects showed concordantly decreased FDG uptake (metabolism-perfusion matches) indicating scarred tissue, whereas six regions of hypoperfusion demonstrated a relatively increased FDG uptake (mismatches), suggesting viable myocardium. (amsterdamumc.org)
Mismatch1
- Perfusion-metabolism mismatch (viable myocardium) was observed in 586 (31.5%) out of 1862 perfusion defects. (wits.ac.za)
Detection1
- These advantages of 2D-STE are useful for the detection of subclinical recovery of dysfunctional but viable myocardium after CTO-PCI [5]. (scirp.org)
Hibernating9
- In cardiology, hibernating myocardium is a state when some segments of the myocardium exhibit abnormalities of contractile function. (wikipedia.org)
- The term hibernating myocardium is also used to indicate chronic myocardial contractile dysfunction due to ischemia, in which there is reduced coronary blood flow at rest and increased myocardial demand results in impaired contractility. (medscape.com)
- In hibernating myocardium, contractile function can be partially or totally restored by improving coronary blood flow or by reducing oxygen demand of the myocardium. (medscape.com)
- Rahimtoola suggested that hibernating myocardium is characterized by a state of persistently impaired myocardial and LV function at rest due to reduced coronary blood flow that can be partially or completely restored to normal by improving blood flow or by reducing oxygen demand (see the image below). (medscape.com)
- Schematic representation of infarction (cell death), chronic ischemia with contractile dysfunction (hibernating myocardium), and transient ischemia (stunned myocardium) with restored blood flow with transient contractile dysfunction. (medscape.com)
- The recanalization of a chronic total coronary occlusion is the possible way to improve left ventricular (LV) function through the recovery of hibernating myocardium. (scirp.org)
- Metabolic adaptions are considered to play a vital role in the recovery of salvageable myocardium in the context of stunned and hibernating myocardium. (ethz.ch)
- Assessment of pyruvate dehydrogenase flux via the hyperpolarized [13C] bicarbonate signal revealed recovery of aerobic cellular respiration in the hibernating myocardium, which correlated with recovery of local radial strain. (ethz.ch)
- Impact of hibernating and viable myocardium on improvement in perfusion and left ventricular ejection fraction after coronary artery bypass graft', Nucl Med Commun. (yashodahealthcare.com)
Tissue5
- The structure, macromechanical and micromechanical scaffold properties were preserved upon the decellularization and recellularization processes, except for recellularized myocardium micromechanics that was ∼ 2-fold stiffer than native tissue and decellularized scaffolds. (nature.com)
- Positron emission tomography (PET) can identify viable tissue using 18 F-fluorodeoxyglucose (FDG). (amsterdamumc.org)
- Furthermore, our preliminary observations suggest that this approach can identify viable tissue. (amsterdamumc.org)
- Positron emission tomography (PET) can identify viable tissue using 18F-fluorodeoxyglucose (FDG). (amsterdamumc.org)
- Antibiotic crop rotation has been the recognition of clinical estimation of severity, determina-tion of viable tissue immediately subjacent to subeschar space. (albionfoundation.org)
Perfusion defects1
- If the perfusion defects in stress images persist in the rest images, that is, if the perfusion defects are fixed, the myocardium is usually necrotic or fibrotic. (wikidoc.org)
Necrosis2
- Background: Prolonged ischemia and myocardial infarction are followed by a series of dynamic processes that determine the fate of the affected myocardium toward recovery or necrosis. (ethz.ch)
- In addition to the classical cascade of plaque rupture and subsequent thrombus formation followed by necrosis of dependent myocardium, other causes of myocardial infarction (MI), such as myocardial injury due to an imbalance of oxygen supply and demand, have been defined. (biomedcentral.com)
Segments1
- The advantage over other methods like echocardiography and positron emission tomography is that the hyperenhanced MRI (due to high spatial resolution) shows the transmural extent of viable myocardium with the nonviable myocardium being highlighted and has greater accuracy in muscle segments with the most severe dysfunction (while nuclear scintigraphy and echocardiography have reduced predictive accuracy if more severe dysfunction of the myocardial contractionis present). (rjmatthewsmd.com)
Hibernation2
- This finding shows that ischemic but noninfarcted myocardium can exist in a state of hibernation without cell death. (medscape.com)
- Hibernation implies myocardium that fails to contract normally but which may recover after revascularisation. (ecrjournal.com)
Contractility1
- Results of the CADUCEUS study, published online February 13, 2012 in the Lancet , showed not only that scar size was reduced on MRI at six months--something also seen in previous research--but also that the amount of viable heart mass and regional contractility were also improved. (medscape.com)
Scar3
- But as Marbán explained, infusing the cells at this point meant that the baseline MRI images were "stable"--when MRI is performed immediately post-MI, the myocardium is still healing, meaning that serial imaging will suggest that the scar is shrinking. (medscape.com)
- Of note, the amount of viable myocardial mass increased by about 60% more than the scar shrinkage--suggesting that reversal of injury was indeed taking place and explaining the partial restoration of lost LV mass in the cell-treated patients. (medscape.com)
- Changes in LVEF did not track with reductions in scar or increases in viable myocardium, something Marbán said was unsurprising given the relatively high LVEFs at study onset. (medscape.com)
Severely1
- A repeat injection of thallium and scanning 24 hours after stress can distinguish severely ischemic area from viable myocardium. (wikidoc.org)
Reversible1
- Stunned myocardium is myocardium that suffers transient reversible myocardial contractile dysfunction that is caused by acute ischemia during which the blood supply is almost completely restored by reperfusion, with no metabolic deterioration. (medscape.com)
Metabolic1
- Results: Metabolic image data revealed temporarily elevated lactate-to-bicarbonate ratios at day 6 in the infarcted relative to remote myocardium. (ethz.ch)
Identify1
- FDG PET CT scan helps us to identify viable myocardium and is very useful in decision making. (akshaydiagnostics.com)
Extent1
- The latter are more accurate and are therefore used more frequently to assess the presence and extent of ischemic and infarcted myocardium. (wikidoc.org)
Contractile function2
- In cases of less severe ischemia, some myocytes remain viable but have depressed contractile function. (medscape.com)
- When ischemia is prolonged, myocytes have depressed contractile function but remain viable. (medscape.com)
Revascularisation1
- If more than 10 percent of the are in the lad territory is alive or viable then the lad merits revascularisation. (doctorspring.com)
Bypass1
- If viable muscles are present, bypass surgery or angioplasty may benefit the patient. (akshaydiagnostics.com)
Contrast1
- Technetium-99m-sestamibi is an isonitrile compound that, like thallium, is taken up by the myocardium proportional to blood flow but in contrast to thallium does not undergo redistribution. (wikidoc.org)
Blood2
- We investigated whether blood and buccal cells could be viable surrogates for myocardium. (nih.gov)
- HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
Function1
- The regions of myocardium are still viable and can return to normal function. (wikipedia.org)
Area1
- Viable myocardium in the area at risk was identified based on restored pyruvate dehydrogenase flux. (ethz.ch)
Left2
- The myocardium of the heart is supplied by 2 major coronary arteries: the left main coronary artery and the right coronary artery (RCA). (statpearls.com)
- If it is not viable more than 10 percent it could be left alone. (doctorspring.com)
Stress1
- Myocardium that was ischemic during stress but that is not ischemic at rest now extracts the isotope. (wikidoc.org)
Heart muscle1
- It is very important to know if heart muscle is dead or viable. (akshaydiagnostics.com)
Approach1
- Moreover, most available myocardial constitutive models approach myocardium at the length scale of mean fiber orientation and do not explicitly account for different fibrous constituents and possible interactions among them. (tamu.edu)
Studies1
- To obtain model parameters for the healthy passive RVFW, the model was informed by transmural orientation distribution measurements of myo- and collagen fibers and was fit to the mechanical testing data, where both sets of data were obtained from recent experimental studies on non-contractile, but viable, murine RVFW specimens. (tamu.edu)
Cell1
- Irrespective of the scaffold origin or cell recolonization, all scaffolds integrated with the underlying myocardium and showed signs of neovascularization and nerve sprouting. (nature.com)