AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentInformation Science
Vasculitis, Leukocytoclastic, CutaneousVasculitisPurpura, Schoenlein-HenochAntibodies, Antineutrophil CytoplasmicAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisSkin Diseases, VascularSystemic VasculitisMyeloblastinTakayasu ArteritisCryoglobulinsWegener GranulomatosisChurg-Strauss SyndromeSkin DiseasesGlomerulonephritisRetinal VasculitisPeroxidaseBiopsySkinVasculitis, Central Nervous SystemEncyclopedias as TopicMicroscopic PolyangiitisForeign BodiesInflammation
AngiitisSystemic vasculitisLesionsANCAGranulomatosisBiopsyUrticarial vasculitisNecrosisPolyangiitisManifestationsPolyarteritis nodosaVenulesPurpuraMedium-sizedDisordersSymptomsClinicalCapillariesPathophysiologyIdiopathicHypersensitivity vasculitisAcuteImmuneRenalKidneysInvolvementOrgansNeutrophilicPrimaryVasculiticChronicOrganCentral Nervous System VaPatientsWallsInflammatoryDisorderRheumatoid vasculitisLarge-vessel VasculitisFindingsInvolvesKawasakiForms of vasculitis
Angiitis6
  • 831 The condition is also known as hypersensitivity vasculitis, cutaneous leukocytoclastic vasculitis, hypersensitivity angiitis, cutaneous leukocytoclastic angiitis, cutaneous necrotizing vasculitis and cutaneous necrotizing venulitis, It is the most common form of vasculitis seen in clinical practice, usually caused by inflammation of post-capillary venules in the dermis). (wikipedia.org)
  • Vasculitis refers to a large group of diseases, also known as angiitis, that damage blood vessels by causing inflammation. (medicalnewstoday.com)
  • Vasculitis is also called angiitis and arteritis. (medicalnewstoday.com)
  • Granulomatosis with polyangiitis is the third most common type of vasculitis in Iran after Behcet's disease and cutaneous leukocytoclastic angiitis [6]. (rheumres.org)
  • other causes of pulmonary-renal syndrome (see Granulomatosis With Polyangiitis ), cutaneous leukocytoclastic angiitis. (empendium.com)
  • CNS vasculitis has been reported under a variety of descriptive terms including isolated CNS angiitis, idiopathic angiitis of the CNS, and primary angiitis or vasculitis of the CNS. (fortuneonline.org)
Systemic vasculitis11
Lesions19
  • The red-purple color of the lesions is due to the inflammation in the blood vessels causing red blood cells to escape into the dermis skin layer. (wikipedia.org)
  • Vasculitis affecting the small vessels of the skin (eg, arterioles, capillaries, postcapillary venules) tends to cause lesions such as purpura, petechiae, and possibly shallow ulcers. (msdmanuals.com)
  • Skin biopsy of the lesions reveal inflammation of the small vessels, termed leukocytoclastic vasculitis, which is most prominent in postcapillary venules. (wikidoc.org)
  • A clinical diagnosis of cutaneous vasculitis was considered, the primary differential for the cutaneous lesions being erythema elevatum diutinum. (edoj.org.eg)
  • Rheumatoid arthritis was considered as the primary systemic diagnosis (The diagnosis of EED mainly being based on the nature and distribution of the lesions, and the known association of EED with rheumatoid arthritis and vasculitis). (edoj.org.eg)
  • Limited cutaneous lesions are more common than severe necrotizing complications, which are rare. (rheumaknowledgy.com)
  • Nailfold lesions are most common and include prominent periungual vessels, localized infarction, splinter hemorrhages, and tender macules of the fingertips (which may be dark red or brown). (rheumaknowledgy.com)
  • Patients whose vasculitis is limited to fingertip lesions generally do well, whereas involvement of major nerves or arteries in organs such as the heart is associated with a poorer prognosis. (rheumaknowledgy.com)
  • The following data were analysed: age of onset of disease, sex, duration of disease at diagnosis and during follow-up, topography and description of cutaneous lesions, treatment regimen and response, and duration of follow-up. (medicaljournals.se)
  • Many cutaneous side effects have been reported with their use in rheumatoid arthritis including psoriasis , dermatitis , leukocytoclastic vasculitis, lichenoid drug eruptions , and non-infectious cutaneous granulomatous reactions, such as disseminated granuloma annulare , sarcoidosis-like lesions, and interstitial granulomatous dermatitis. (arthritisdaily.net)
  • 2017-11-02 Urticarial vasculitis (also known as "chronic urticaria as a manifestation of venulitis", "hypocomplementemic urticarial vasculitis syndrome", "hypocomplementemic vasculitis" and "unusual lupus-like syndrome") is a skin condition characterized by fixed urticarial lesions that appear histologically as a vasculitis. (netlify.app)
  • Urticarial vasculitis is generally classified as two types: Urticarial vasculitis describes a distinct entity in which the gross cutaneous lesions resemble urticaria and histologically show features of a vasculitis. (netlify.app)
  • The patient's initial pruritic lesions, for which she presented to the clinic years prior to her hospitalization for osteomyelitis , were likely a cutaneous vasculitis due to obstruction of smaller-sized superficial vessels. (medscape.com)
  • [ 5 ] The patient was encouraged to stop smoking to prevent further lesions and vasculitis progression, but she declined assistance with quitting her nicotine dependence and continued to smoke cigarettes. (medscape.com)
  • Mild disease in relation to rheumatoid vasculitis usually involves small lesions to distal extremities (fingers and toes). (medscape.com)
  • It is characterized by chronic and recurrent episodes of lesions which show characteristic of leukocytoclastic vasculitis which is limited to skin and on various organs such as renal, pulmonary, ocular system. (naturalayurvedictreatment.com)
  • [11] Cutaneous lesions are tender to touch but rarely pruritic with an asymmetrical distribution that favors the upper extremities. (eyewiki.org)
  • Cutaneous manifestations can occur in up 75% of patients with Behcet disease and can range from acneiform lesions, to nodules and erythema nodosum. (medscape.com)
  • Cutaneous necrotizing vasculitis (CNV) is characterized by swelling as well as cells damage (necrosis) of blood vessel walls (lumen) as well as linked skin (cutaneous) lesions. (valleyfamilymedicineurgentcarecenter.com)
ANCA7
  • Granulomatosis with polyangiitis (Wegener's granulomatosis) is a type of vasculitis which can be categorized as a sub-branch of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides. (rheumres.org)
  • Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis, is a type of vasculitis which can be categorized as a sub-branch of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides [1]. (rheumres.org)
  • Cutaneous vasculopathy associated with levamisole-adulterated (contaminated) cocaine is an emerging syndrome characterised by a retiform purpura around the ears, the presence of anti- neutrophil cytoplasmic autoantibody ( ANCA ), and leukopenia [3,4]. (dermnetnz.org)
  • MPA and the clinically similar and similarly treated granulomatosis with polyangiitis ( GPA ) are classified as antineutrophil cytoplasmic autoantibody ( ANCA )-associated vasculitides ( AAV s). (empendium.com)
  • These may include tests to check for inflammation, organ involvement, immune complex formation and deposition, and ANCA-related vasculitis. (cohencenters.com)
  • The other differentials considered included rheumatoid neutrophilic dermatosis , rheumatoid vasculitis, non-specific ANCA positive vasculitis and atypical pyoderma gangrenosum. (edoj.org.eg)
  • Both MPA and GPA are considered ANCA-associated vasculitides, although ANCA testing may be negative in some patients. (medilib.ir)
Granulomatosis8
  • Granulomatosis with polyangiitis (Wegener granulomatosis , GPA), MPA, and eosinophilic granulomatosis with polyangiitis ( Churg-Strauss syndrome , EGPA) comprise a category of small vessel vasculitis related to antineutrophil cytoplasmic antibodies (ANCAs) and are characterized by a paucity of immune deposits. (medscape.com)
  • Henoch-Schönlein purpura, granulomatosis with polyangiitis or GPA, eosinophilic granulomatosis with polyangiitis or EGPA, previously referred to as Churg-Strauss syndrome), cutaneous leukocytoclastic vasculitis, microscopic polyangiitis). (printo.it)
  • There is no inflammation extending beyond the blood vessels or granulomatous inflammation, distinguishing it from granulomatosis with polyangiitis. (empendium.com)
  • Polyarteritis nodosa, granulomatosis with polyangiitis, Henoch-Schönlein purpura, scleroderma, and otherwise nonspecified vasculitides also were reported to have caused ESRD during this period. (medscape.com)
  • Granulomatosis with Polyangiitis (GPA) Granulomatosis with polyangiitis is characterized by necrotizing granulomatous inflammation, small- and medium-sized vessel vasculitis, and focal necrotizing glomerulonephritis, often with crescent. (merckmanuals.com)
  • Wegener's granulomatosis is a form of vasculitis that affects the lungs, kidneys and other organs. (checkorphan.org)
  • Wegener's granulomatosis is part of a larger group of vasculitic syndromes, all of which feature the presence of an abnormal type of circulating antibody termed ANCAs (antineutrophil cytoplasmic antibodies) and affect small and medium-size blood vessels. (checkorphan.org)
  • Although Wegener's granulomatosis affects small and medium-sized vessels, it is formally classified as one of the small vessel vasculitides in the Chapel Hill system. (checkorphan.org)
Biopsy7
Urticarial vasculitis17
Necrosis12
  • Neutrophils are seen surrounding blood vessels and their debris within vessel walls, causing fibrinoid necrosis. (wikipedia.org)
  • Overview of Vasculitis Vasculitis is inflammation of blood vessels, often with ischemia, necrosis, and organ inflammation. (msdmanuals.com)
  • There are many hypotheses regarding the pathogenesis of heparin-induced skin necrosis, whose histopathology is characterized by microvascular thrombi of dermal vessels, epidermal necrosis, and a variable inflammatory infiltrate. (clinicaladvisor.com)
  • Other clinical entities that can present similarly to heparin-induced skin necrosis include calciphylaxis, pyoderma gangrenosum, disseminated intravascular coagulation (DIC), leukocytoclastic vasculitis, and other bullous disorders. (clinicaladvisor.com)
  • Vasculitis is an uncommon condition characterized by inflammation and necrosis of blood vessels and impaired blood flow. (cohencenters.com)
  • In small- to medium-sized vessels, the lesion may include an infiltrate consisting of both mononuclear and polymorphonuclear cells, and fibrinoid necrosis. (rheumaknowledgy.com)
  • Vasculitis is a heterogeneous group of blood vessels disorders which characterized by inflammation, necrosis and the obstruction of the inflamed vessels [1]. (fortuneonline.org)
  • At sites of inflammation, varying degrees of cellular inflammation and necrosis or scarring occur in one or more layers of the vessel wall. (merckmanuals.com)
  • Intimal hypertrophy or secondary clot formation can narrow the vessel lumen and cause tissue ischemia or necrosis. (merckmanuals.com)
  • Fibroid necrosis: dead vessel wall - pink anucleate stuff, nuclear debris (black specks of nuclear material). (librepathology.org)
  • Vessel destruction, e.g. fibrinoid necrosis (very pink anucleate arterial wall). (librepathology.org)
  • Biologic agents that specifically target tumor necrosis factor can be used to decrease the inflammatory response that is associated with endothelial dysfunction leading to vasculitis and is a potential medication choice. (medscape.com)
Polyangiitis3
  • Microscopic polyangiitis (MPA) is a vasculitis of small vessels. (medscape.com)
  • Microscopic polyangiitis ( MPA ) is a necrotizing vasculitis with few or no immunologic deposits, which usually affects small vessels (arterioles, capillaries, venules) and may involve small- and middle-sized arteries. (empendium.com)
  • Microscopic polyangiitis (MPA) is a necrotizing vasculitis without granulomatous inflammation that predominantly affects small vessels (ie, capillaries, venules, or arterioles) and can present with pulmonary capillaritis or in the context of interstitial lung disease [ 3 ]. (medilib.ir)
Manifestations8
  • We present a case of small and medium-vessel vasculitis on the lower extremity with cutaneous manifestations, without an identifiable cause. (faoj.org)
  • Cutaneous vasculitis may present with varying clinical manifestations and may be caused by systemic disease or secondarily due to an underlying disorder, drug reaction, or infection [1-2]. (faoj.org)
  • A high prevalence of cutaneous disorders is expected, because most patients with ESRD have an underlying disease process with cutaneous manifestations. (medscape.com)
  • These systemic disorders and the associated renal diseases and cutaneous manifestations are tabulated in Table 1, below. (medscape.com)
  • We report a rare case of neonatal vasculitis presenting with skin manifestations similar to infection-based cellulitis. (scielo.org.za)
  • Clinical manifestations of specific vasculitic disorders are diverse and depend on the size and location of the involved vessels, the extent of the organ involvement, and the degree and pattern of extravascular inflammation. (merckmanuals.com)
  • Issues related to the approach to and management of systemic vasculitides, as well as the pathogenesis, clinical manifestations, diagnosis, therapy, and outcomes in GPA and MPA are discussed separately. (medilib.ir)
  • See Cutaneous Manifestations of HIV Disease and Cutaneous Manifestations of Hepatitis C for information on these viral infections. (medscape.com)
Polyarteritis nodosa2
  • Medium vessel vasculitis typically affects arteries supplying the kidneys, bowels, brain or heart (e.g. polyarteritis nodosa, Kawasaki disease). (printo.it)
  • [6] Takayasu's arteritis is an example of a large-vessel vasculitis in childhood, whereas Kawasaki disease and polyarteritis nodosa are examples of medium-vessel vasculitis disorders. (scielo.org.za)
Venules2
  • The small vessels in the skin affected are located in the superficial dermis and include arterioles (small arteries carrying blood to capillaries), capillaries, and venules (small veins receiving blood from capillaries). (wikipedia.org)
  • Small-sized blood vessels are less than less than 50 µm and include capillaries, postcapillary venules, and nonmuscular arterioles. (faoj.org)
Purpura7
  • For example, if the vasculitis is a manifestation of Henoch-Schönlein purpura, individuals may also experience abdominal pain or blood in the urine. (wikipedia.org)
  • In cases where a cause can be determined, medications and infectious pathogens are most common in adults, while IgA vasculitis (Henoch-Schönlein purpura) frequently affects children. (wikipedia.org)
  • Piette WW, Stone MS. A cutaneous sign of IgA-associated small dermal vessel leukocytoclastic vasculitis in adults (Henoch-Schonlein purpura). (medscape.com)
  • Comparative clinical and epidemiological study of hypersensitivity vasculitis versus Henoch-Schonlein purpura in adults. (medscape.com)
  • Palpable, normally painful, petechiae or purpura (skin vasculitis). (wikidoc.org)
  • Physical exam Palpable purpura is pathognomonic for vasculitis. (symptoma.com)
  • Henoch-Schonlein purpura is a vasculitic process involving small vessels. (scielo.org.za)
Medium-sized9
  • Cutaneous vasculitis refers to vasculitis affecting small- or medium-sized vessels in the skin and subcutaneous tissue but not the internal organs. (msdmanuals.com)
  • Vasculitis can affect the small- or medium-sized vessels of the skin. (msdmanuals.com)
  • In a large number of cases cutaneous vasculitis may present as an idiopathic condition and affect both small and medium sized vessels. (faoj.org)
  • Figure 7 Direct immunofluorescence revealing medium-sized vessel disease. (faoj.org)
  • Medium-sized blood vessels are between 50-150 µm in diameter and contain muscular walls. (faoj.org)
  • The inflammation of small- and medium-sized blood vessels in the skin has a different serological profile from pure cocaine-related vasculopathy, and is probably due to the levamisole component [1,2,7]. (dermnetnz.org)
  • Medium-sized vessels with intramural inflammatory cells. (librepathology.org)
  • Involves small and medium sized vessels. (librepathology.org)
  • It is characterized by a narrowing and occlusion of the lumen of small to medium-sized blood vessels, leading to ischemia and infarction in the involved organ systems. (bvsalud.org)
Disorders9
  • The classification criteria should be applied after a diagnosis of small- or medium-vessel vasculitis has been made, and alternative disorders mimicking vasculitis have been excluded. (medscape.com)
  • Any primary or secondary vasculitis can affect the skin, including that due to serum sickness, infections (eg, hepatitis C), cancers, rheumatologic or other autoimmune disorders, and hypersensitivity to drugs. (msdmanuals.com)
  • In addition, uremia and conditions associated with renal replacement therapy are fraught with numerous and, often, relatively unique cutaneous disorders. (medscape.com)
  • The image below illustrates several uremia-related cutaneous disorders. (medscape.com)
  • Several uremia-related cutaneous disorders are visible. (medscape.com)
  • Many cutaneous disorders experienced by patients undergoing dialysis have little to do with the uremic syndrome and are related to the same underlying pathologic process that caused the renal disease. (medscape.com)
  • Skin eruptions may be a symptom of systemic disorders other than infections, and may be prominent in patients with vasculitis disorders. (scielo.org.za)
  • Vasculitic disorders can be classified according to the size of the predominant vessel affected. (merckmanuals.com)
  • The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls. (nih.gov)
Symptoms10
  • Additional symptoms depend on the cause of the vasculitis and if other organ systems are involved. (wikipedia.org)
  • Disease symptoms vary according to the overall number of inflamed blood vessels (widespread or just a few sites) and their location (vital organs like brain or heart versus skin or muscle) as well as the degree of blood supply compromise. (printo.it)
  • Symptoms of vasculitis can include fever , tiredness , and joint pain. (medicalnewstoday.com)
  • Treatment for vasculitis depends on several factors, including what type of vasculitis the person has, the severity of their symptoms, their age, and their general health. (medicalnewstoday.com)
  • Signs and symptoms of vasculitis vary depending on which blood vessels are affected, and which organs are damaged, if any. (medicalnewstoday.com)
  • iii ) No other causes, such as bona fide vasculitis, primary anti-phospholidpids antibody syndrome or drugs, were accounted for clinical symptoms. (medicaljournals.se)
  • arteritis risk if you don't treat temporal (giant cell) arteritis granulomatous vasculitis that involves aortic arch at branch points age group of takayasu arteritis younger than 50 - Asian females symptoms of takayasu arteritis 1. (symptoma.com)
  • 18 years of age were enrolled this study with diagnosis of cPACNS if they had: a clinical symptoms compatible with primary CNS vasculitis, and MRA findings demonstrating arterial stenosis and or aneurism that are not attributable to other disease and background. (fortuneonline.org)
  • ANCAs can be positive after the use of certain drugs and other forms of vasculitis can present with very similar symptoms. (checkorphan.org)
  • The patient remains well and free from any cutaneous or systemic symptoms 9 months after initial consultation. (cdlib.org)
Clinical6
  • MPA is characterized by pauci-immune, necrotizing, small-vessel vasculitis without clinical or pathological evidence of granulomatous inflammation. (medscape.com)
  • The spectrum of paraneoplastic cutaneous vasculitis in a defined population: incidence and clinical features. (medscape.com)
  • Martinez-Taboada VM, Blanco R, Garcia-Fuentes M, Rodriguez-Valverde V. Clinical features and outcome of 95 patients with hypersensitivity vasculitis. (medscape.com)
  • Clinical, histopathologic, and laboratory evaluation are imperative to appropriately diagnose cutaneous vasculitis. (faoj.org)
  • The clinical spectrum of primary renal vasculitis. (medscape.com)
  • The purpose of this article is to integrate renal and cutaneous aspects of disease as well as highlight some important, although frequently underappreciated, clinical or laboratory findings that ally renal and skin diseases. (medscape.com)
Capillaries4
  • Small vessel disease involves smaller blood vessels including capillaries (e.g. (printo.it)
  • The specific blood vessels affected include arteries, veins, and the tiniest of these known as capillaries. (medicalnewstoday.com)
  • Microscopically, both sites revealed small vascular structures, primarily capillaries, surrounded by abundant polymorphonuclear leukocytes and few eosinophils, evidence that confirmed the diagnosis of leukocytoclastic vasculitis. (consultant360.com)
  • Vasculitis can affect small blood vessels (capillaries), medium size blood vessels and large blood vessels (aorta). (naturalayurvedictreatment.com)
Pathophysiology3
  • Considering the wide range of potential causes leading to cutaneous small vessel vasculitis, there are subtle variations in the underlying pathophysiology for each cause. (wikipedia.org)
  • The classification and severity of disease are determined based on the size and site of involved vessels, underlying pathophysiology and the extent of vascular injury. (scielo.org.za)
  • the vessel inflammation (true vasculitis) is only part of the pathophysiology and there is predominant parenchymal inflammation in a characteristic pattern that involves specific organs. (merckmanuals.com)
Idiopathic2
  • CSVV sometimes refers to small-vessel vasculitis of unknown cause (also called idiopathic cutaneous small-vessel vasculitis). (msdmanuals.com)
  • Cutaneous small-vessel vasculitis is often idiopathic , but all patients should be evaluated for potential underlying causes, including infections (e.g. (amboss.com)
Hypersensitivity vasculitis3
Acute6
  • Some of the acute primary vasculitides are quite common paediatric diseases (e.g. (printo.it)
  • Vasculitis can be acute and short-term or chronic and long-term. (medicalnewstoday.com)
  • The vast majority of cases of cutaneous Leukocytoclastic Vasculitis, also referred to as Small-Vessel Vasculitis (LCV) follow an acute infection or exposure to a new medication. (acadderm.com)
  • It accounts for approximately 10% of acute cutaneous vasculitis. (koreamed.org)
  • CNS vasculitis can cause brain damage with reversible and or irreversible neurologic involvement, including acute ischemic attack, progressive cognitive decline and seizures often with intractable pattern. (fortuneonline.org)
  • Acute and or chronic inflammatory course of vasculitis may causes severe neurological impairment or also death. (fortuneonline.org)
Immune6
  • In general, immune complexes deposit in vessel walls leading to activation of the complement system. (wikipedia.org)
  • The blood vessel wall is attacked by the body's immune system, causing it to swell and resulting in structural disruption. (printo.it)
  • A cutaneous expression of immune complex disease. (medscape.com)
  • Immune complexes lodge in the vessel wall, attracting polymorphonuclear leukocytes who in turn release tissue-degrading substances leading to an inflammatory process. (wikidoc.org)
  • Another theory is that deposition of immune complexes within dermal vessels leads to vasculitis, a type III (Arthus type) hypersensitivity reaction. (clinicaladvisor.com)
  • Immune complexes, probably containing RFs, are passively deposited on blood vessel walls. (rheumaknowledgy.com)
Renal1
Kidneys2
  • Involvement of the vessels supplying vital organs like the brain, kidneys, lungs or heart can be a very serious condition. (printo.it)
  • If the vasculitis is damaging organ systems such as the kidneys, immunosuppressive agents are indicated. (wikidoc.org)
Involvement2
  • Larger vessel involvement often manifests as leg ulcers. (rheumaknowledgy.com)
  • Digital ischemia and gangrene due to involvement of the arteries of the distal extremities was a manifestation of this patient's rheumatoid vasculitis. (medscape.com)
Organs2
  • This term describes vasculitis that affects the skin but not the internal organs. (msdmanuals.com)
  • The pathological mechanism that causes cutaneous small-vessel vasculitis can also cause vasculitides in organs other than the skin , which are categorized as distinct diseases. (amboss.com)
Neutrophilic3
  • Here we identified three unrelated boys with perinatal-onset of neutrophilic cutaneous small vessel vasculitis and systemic inflammation. (nature.com)
  • all presented with systemic inflammation and recurrent neutrophilic small vessel vasculitis. (nature.com)
  • We characterize the role of increased Lyn kinase activity in neutrophils, endothelial cells and lesional liver biopsies and utilized an iPSC-derived endothelial cell platform for disease modeling of neutrophilic vasculitis and to screen and evaluate drug efficacy. (nature.com)
Primary10
  • Based on current understanding of the inflammatory response, cytokine-mediated changes in the expression and function of adhesion molecules coupled with inappropriate activation of leukocytes and endothelial cells are postulated to be the primary factors influencing the degree and location of vessel damage in the vasculitis syndromes. (medscape.com)
  • Cutaneous vasculitis may be limited to the skin, or may be a component of a systemic primary or secondary vasculitic disorder. (msdmanuals.com)
  • The term "primary" means that the blood vessel is a major disease target with no other underlying disease. (printo.it)
  • Primary vasculitides do not usually run in the family. (printo.it)
  • Vasculitis may be due to primary disease or secondary due to an underlying disorder, drug reaction, or infection. (faoj.org)
  • Beyond that, typical treatment plans are aimed at addressing the primary underlying disease associated with vasculitis. (cohencenters.com)
  • The neonatal period is an uncommon time for the presentation of vasculitis and primary neonatal vasculitis is a particularly rare entity. (scielo.org.za)
  • Primary vasculitis has no known cause. (merckmanuals.com)
  • We report an early case of primary cutaneous mucinous carcinoma in a male patient with chronic actinic damage. (cdlib.org)
  • The final diagnosis was primary cutaneous mucinous carcinoma and definitive treatment was carried out via wide local excision. (cdlib.org)
Vasculitic1
Chronic3
  • This tends to occur when the vasculitis is associated with chronic conditions such as connective tissue diseases. (wikipedia.org)
  • Livedo vasculopathy (LV) is a chronic cutaneous disorder characterised by recurrent, painful ulceration ending in stellate scars. (medicaljournals.se)
  • Chronic = thick fibrotic appearing vessels with a small lumen. (librepathology.org)
Organ2
  • The overall goal of treatment is control of vessel inflammation and prevention of irreversible vascular and organ damage. (scielo.org.za)
  • In this review, cases are divided between localised disease, non-organ threatening, generalized organ-threatening disease and severe kidney vasculitis and immediately life-threatening disease. (checkorphan.org)
Central Nervous System Va1
Patients5
Walls4
  • For example, medications are metabolized to smaller molecules that can attach to proteins in the blood or vessel walls. (wikipedia.org)
  • Vasculitis is inflammation of the vessel walls. (medscape.com)
  • Together with the swelling of the vascular walls, this effect may contribute to vessel narrowing or occlusion. (printo.it)
  • Focal deposition of IgA, IgM, and weak C3 into the blood vessel walls in the dermis and dermal papillae. (eyerounds.org)
Inflammatory7
  • The inflammatory cells from the blood stream gather in the vessel wall, causing more damage to the vessel and to the surrounding tissue as well. (printo.it)
  • Vasculitis is a rare, inflammatory condition of the blood vessels whereby excess leukocytes within the vessel leads to a loss of structural integrity, and possible destruction. (faoj.org)
  • This multi-system inflammatory disease can cause serious blood vessel wall destruction, leading to perforation and hemorrhage into adjacent tissues. (cohencenters.com)
  • In a range of inflammatory vascular process, vasculitis may affect the CNS vessels. (fortuneonline.org)
  • Secondary vasculitis may be triggered by an infection, a drug, or a toxin or may occur as part of another inflammatory disorder or cancer. (merckmanuals.com)
  • It refers to breakdown of inflammatory cells that leaves small nuclear fragments (nuclear debris) in and around the vessels. (merckmanuals.com)
  • Inflammatory cells within the blood vessel wall. (librepathology.org)
Disorder2
  • Vasculitis is a rare disorder during the neonatal period. (scielo.org.za)
  • Central nervous system (CNS) vasculitis of childhood is a novel recognized autoimmune brain disorder with significant diagnostic and therapeutic challenges [2,3]. (fortuneonline.org)
Rheumatoid vasculitis7
Large-vessel Vasculitis1
Findings5
  • findings include leukocytoclastic vasculitis . (amboss.com)
  • 2,9 However, biopsies of affected skin generally do not demonstrate findings of vasculitis. (clinicaladvisor.com)
  • Others postulate that the skin findings are the result of cutaneous trauma caused by repeated, improperly performed injections, or that heparin may be poorly absorbed due to decreased vasculature in adipose tissue. (clinicaladvisor.com)
  • The findings were reviewed by a pathologist at the University of Iowa Hospitals and Clinics and were found to be suggestive of leukocytoclastic vasculitis. (eyerounds.org)
  • Leukocytoclastic vasculitis is a histopathologic term used to describe findings in small-vessel vasculitis. (merckmanuals.com)
Involves1
Kawasaki1
  • Kawasaki Disease Kawasaki disease is a vasculitis, sometimes involving the coronary arteries, that tends to occur in infants and children between the ages of 1 year and 8 years. (merckmanuals.com)
Forms of vasculitis2