Vesicular receptor protein tyrosine kinases. Medical search. Frequent questions

To address the possibility that activation of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of rapamycin (mTOR/FRAP), represents one of these pathways, we have examined the effect of simultaneous inhibition of the Ras-MAPK and PI3K-mTOR pathways on transformation of CEF by v-Src. (embl.de)
This effect was found to depend on the Ca 2+ increase mediated by the phospholipase C-β (PLC-β) and protein kinase C (PKC) pathways, as well as by the reverse activity of the Na + /Ca 2+ exchanger. (molvis.org)
ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)
The enhancement in metastatic properties was also found to occur via activation of ERBB2 receptor signaling pathways [2]. (biomedres.us)
The effect of over expression on the synthesis and activities of selected blood coagulation proteins was determined as well as relevant signaling pathways. (biomedres.us)
Such effects were found to be mediated by PI3k/ Akt signaling pathways since the increased these ERBB2 sensitive coagulation proteins in a way that was commensurate with the activity of p-ERK and p-Akt. (biomedres.us)
The finding is the first time shown pro-tumour gene ERBB2 enable to modulate coagulation protein expression and clotting kinetics in breast cancer cells, it is via the PI3k/Akt pathways, which further supports the proposal that the state of the coagulation system in cancer is directly influenced by oncogenic transformation. (biomedres.us)
Although important, the capability to multiplex and assay a wide range of protein focuses on (including intracellular signalling pathways) has been limited20. (irjs.info)
After performing the trafficking protein colocalization experiment, we will gain insight to possible pathways for MYCT1. (ucla-mls.com)
Our analysis indicated that ligand affinity differentially affected signaling pathways associated with specific kinases and biological processes. (nature.com)
Tyrosine metabolism 28 of 317 pathways' ## [1] 'Querying. (tu-dortmund.de)
Phenylalanine, tyrosine and tryptophan biosynthesis 31 of 317 pathways' ## [1] 'Querying. (tu-dortmund.de)

It has been proposed that oncogenes (EGFR (ERBB), MET) and tumor suppressors (PTEN, TP53) may also be capable of altering the vesicular release of tissue factor (TF) from cells [4-6]. (biomedres.us)

Receptor tyrosine-protein kinase ERBB-2 (HER2 - human epidermal growth factor receptor 2) is considered as a marker of aggressiveness in the case of breast cancer in primary tumours as well as in corresponding metastases. (biomedres.us)
Although neither kinase-dead human epidermal growth factor receptor (HER)3 nor orphan HER2 can be activated by HER-related ligands on their own, the formation of HER2/HER3 heterodimers creates the most mitogenic and transforming receptor complex within the HER (erbB) family of transmembrane receptor tyrosine kinases. (biomedcentral.com)
The notion that breast cancer disease can be viewed as a biological process that is driven by overactive human epidermal growth factor receptor (HER)1/2 receptor tyrosine kinases (RTKs) has led to development of various anti-HER tyrosine kinase agents. (biomedcentral.com)

In addition, CTP decreased the levels of Beclin1 and LC3II/LC3I, increased the levels of P62, and activated the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in DOX-treated mice.CTP ameliorated DOX-induced cardiotoxicity by inhibiting oxidative stress, myocardial apoptosis, and autophagy via the AKT-mTOR pathway. (bvsalud.org)

Inhibition of the Ras-MAPK pathway by expression of the dominant-negative Ras mutant HRasN17 or by addition of the MAPK kinase (MEK) inhibitor PD98059 reduced several of these parameters but failed to block transformation. (embl.de)
An AXL-specific inhibitor (bemcentinib) partly blocked PDGF-induced mobile proliferation and decreased phosphorylation of AXL and PDGF receptor as well as the downstream indicators (AKT1 and ERK1/2). (nipponkaigi-tokyo.com)
Such repression persists after Eph receptor activation, but is overridden by Eph receptor inhibition with EphA4/Fc in neonatal cultured cerebellar slices as well as mature acute cerebellar slices, following in vivo infusion of the EphA4/Fc inhibitor and in EphB receptor-deficient mice. (123dok.org)

VSV, vesicular stomatitis virus glycoprotein. (rupress.org)
Nevertheless, despite normal development of GCs in response to vesicular stomatitis pathogen (VSV), antigen particular IgG reactions are decreased. (neighborhoodhousecharterschool.org)

The unique strand switches between the sheets result from two distinct kinks at cis-proline residues 13 and 57 in A. suum protein. (wikipedia.org)
This is consistent with reports that the slow phosphorylation of tyrosine residues of the Lat adaptor associates with recruitment and activation of the phospholipase Plcγ1, thereby constituting an important kinetic bottleneck for ligand discrimination 11 . (nature.com)
While the phosphorylation of tyrosine residues in the immunoreceptor tyrosine-based activation motifs (ITAMs) of Cd3 and the inducible interaction between Cd3 and Zap70 remained largely unaffected, the abundance of activated Zap70 dropped with decreasing peptide affinity. (nature.com)
It was isolated as one of several proteins that became phosphorylated on tyrosine residues in chicken embryo fibroblasts transformed with the v-Src oncogene [ 4 ]. (biomedcentral.com)
A molecular model of the FMDV 3A protein, derived from the nuclear magnetic resonance (NMR) structure of the poliovirus 3A protein, predicted a hydrophobic interface spanning residues 25 to 44 as the main determinant for 3A dimerization. (asm.org)
Replacements L38E and L41E, involving charge acquisition at residues predicted to contribute to the hydrophobic interface, reduced the dimerization signal in the protein ligation assay and prevented the detection of dimer/multimer species in both transiently expressed 3A proteins and in synthetic peptides reproducing the N terminus of 3A. (asm.org)

In this review, the hypothesis is forwarded that nNOS delivered to subcortical cytoskeleton requires interactions with scaffolding proteins prior to docking at the membrane. (frontiersin.org)

PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
Vav1, Vav2, and Vav3 talk about a lot more than 50% homology in the protein sequences, which are composed of the Dbl-homologous (DH) site, pleckstrin homology (PH) site, SH2/SH3 site, proline rich region, and a calponin homology (CH) site (34). (neighborhoodhousecharterschool.org)
Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. (biomedcentral.com)

As a result, formation of the signalosome of the Lat adaptor was severely impaired with low- compared with high-affinity ligands, whereas formation of the signalosome of the Cd6 receptor was affected only partially. (nature.com)
Animal STAM (signal-transducing adaptor molecule), which interacts with Hrs and may therefore be involved in endocytosis/vesicular transport. (expasy.org)

Ephrin ligands and their receptors, the Eph receptor (Eph) tyrosine kinases, are cell surface molecules that mediate commu-nication between cells. (123dok.org)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Although low-affinity ligands induced phosphorylation of the Cd3 chains of the T cell receptor and the interaction of Cd3 with the Zap70 kinase as strongly as high-affinity ligands, they failed to activate Zap70 to the same extent. (nature.com)
After vascular complex pathway is caused on a Electrical snRNP, MAML( other) radicals direct in brain with cyclin C, including protein of followed high-affinity ligands in TAD and PEST cilia of NICD1 by CDK8. (evakoch.com)
In download Dopamine in the Pathophysiology and Treatment of Schizophrenia: to find the place of here shown early ligands, Rev clusters between the synthesis and storage-inducing resulting body homodimer protein proteins( suggested in Li et al. (evakoch.com)

Binding of Sema4D to plexin-B1 stimulates the intrinsic tyrosine kinase activity of ErbB-2, resulting in the phosphorylation of both plexin-B1 and ErbB-2. (rupress.org)
Our data indicate that ErbB-2 is an important component of the plexin-B receptor system and that ErbB-2-mediated phosphorylation of plexin-B1 is critically involved in Sema4D-induced RhoA activation, which underlies cellular phenomena downstream of plexin-B1, including axonal growth cone collapse. (rupress.org)
In this study we used phosphorylation of the transcription factor cAMP response element-binding protein as a functional readout to identify cells responding to EGF and FGF-2. (beauty104.com.tw)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
Here, we used time-resolved high-throughput proteomic analyses to identify and quantify the phosphorylation events and protein-protein interactions encoding T cell ligand discrimination in antigen-experienced T cells. (nature.com)
We defined quantitative signatures of ligand affinity based on protein phosphorylation and protein-protein interaction (PPI) stoichiometry for critical molecular events associated with TCR signaling. (nature.com)

Plexins are widely expressed transmembrane proteins that mediate the effects of semaphorins. (rupress.org)
Their effects are mediated by plexins, a group of transmembrane proteins. (rupress.org)

The recruitment of specific cytosolic proteins to intracellular membranes through binding phosphorylated derivatives of phosphatidylinositol (PtdIns) controls such processes as endocytosis, regulated exocytosis, cytoskeletal organization, and cell signaling. (embl.de)
We report here that Sac1p has a specific role in secretion and acts as an antagonist of the phosphatidylinositol 4-kinase Pik1p in Golgi trafficking. (embl.de)
Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230. (embl.de)
The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. (embl.de)
Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain. (neurotree.org)
Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron. (neurotree.org)
Although it is kinase defective, the HER family member HER3 can be phosphorylated by HER1 or HER2, and HER3 can couple with the pro-survival phosphatidylinositol-3-OH kinase (PI[ 3 ]K)/Akt pathway directly whereas HER1 and HER2 cannot [ 5 ] (Figure 1 ). (biomedcentral.com)

Latest studies analyzing the part of Vav family members proteins, including Vav1, Vav2, and Vav3, in lymphocytes possess revealed their important function to hyperlink lymphocyte antigen receptor activation to actin cytoskeleton dynamics. (neighborhoodhousecharterschool.org)
All three PF-04937319 proteins of Vav1, Vav2, and Vav3 are phosphorylated following the antigen receptor engagement quickly. (neighborhoodhousecharterschool.org)
Reorientation from the MTOC can be set off by engagement from the T cell antigen receptor (TCR) with cognate peptide-major histocompatibility complicated (pMHC) substances on the top of antigen-presenting focus on cell (APC) (2). (tam-receptor.com)

2016). Thus, we will assess MYCT1 colocalization with Syntaxin 6, and other vesicular trafficking candidates such as, EEA1, Rab 5A, APPL1, which are associated with endosomes, Clathrin Heavy Chain (coating protein), Caveolin-1 (membrane protein associated with endocytosis), and GOPC (associated with Golgi). (ucla-mls.com)
This event brings the Golgi apparatus secretory lysosomes and other vesicular compartments associated with the MTOC into close apposition with the synaptic membrane thereby allowing the directional secretion of soluble elements toward the prospective cell. (tam-receptor.com)
Interestingly, VIP21 was isolated as an integral membrane protein component of transport vesicles derived from the trans-Golgi network in Madin-Darby canine kidney (MDCK) cells, suggesting that Cav-1/VTP21 may have a role in molecular trafficking as well as oncogenesis. (biomedcentral.com)
Human Golgi localized γ-ear containing ARF binding (GGA) proteins. (expasy.org)

Members of a subfamily of these enzymes share a specific domain that was first identified in the yeast Sac1 protein [1]. (embl.de)
This induces a membrane proximal tyrosine kinase cascade resulting in the activation of many crucial signaling enzymes included in this phospholipase-Cγ (PLC? (tam-receptor.com)
In multiple cell types DAG signaling is opposed by DAG kinases (DGKs) a family of enzymes that phosphorylate DAG to yield phosphatidic acid (PA) (6 7 The predominant members of this family in T cells are DGK-α and DGK-ζ. (tam-receptor.com)
download Dopamine in the Pathophysiology and Treatment involves a histone of endonucleases, receptor effects catalyzed in solar enzymes. (evakoch.com)

2014). KIT is a type of receptor tyrosine kinase which is internalized to the early endosome upon ligand binding (Rai et al. (ucla-mls.com)
Animal Hrs (hepatocyte growth factor regulated tyrosine kinase substrate) is found on the surface of early endosome and may play a role in vesicular transport. (expasy.org)

VHS domain marks a group of proteins involved in endocytosis and vesicular trafficking. (expasy.org)

Altered vesicular dopamine storage in Parkinson's disease: a premature demise. (neurotree.org)
Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. (neurotree.org)

Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth, proliferation, and survival. (mdpi.com)
The rationale of this organization may be related to important roles of these proteins as "exchange hubs" for the signaling proteins for their migration from the subcortical cytosol to the membrane. (frontiersin.org)
2014). For example, clathrin assembly lymphoid myeloid leukemia protein (CALM) was shown to have a function in KIT signaling in mouse HSCs (Rai et al. (ucla-mls.com)
Clathrin assembly protein CALM plays a critical role in KIT signaling by regulating its cellular transport from early to late endosomes in hematopoietic cells. (ucla-mls.com)
Whereas IP3 diffuses in to the cytoplasm to market calcium mineral (Ca2+) signaling DAG accumulates within the plasma membrane where it activates both Ras and proteins kinase C (PKC) reliant signaling by recruiting protein that contain normal C1 domains. (tam-receptor.com)

For example, shank proteins are located further away from the membrane in the cytosolic faces of the PSDs, facing the actin cytoskeleton. (frontiersin.org)

When electrical activity is blocked in vivo by tetrodotoxin leading to a high spine density in Purkinje cell proximal dendrites, stimulation of Eph receptor activation recapitulates the spine repressive effects of climbing fibres. (123dok.org)
These results suggest that Eph receptor signalling mediates the repression of spine proliferation induced by climbing fibre activity in Purkinje cell proximal dendrites. (123dok.org)

in particular, HER3 signalling buffered against incomplete inhibition of HER2 kinase activity has been suggested to be the mechanism that allows HER2 over-expressing breast cancer cells to escape HER TKIs. (biomedcentral.com)
Failure to reverse breast cancer progression despite apparent inhibition of HER1 and HER2 kinase functions in cell-based assays as well as in patient tissues and tumours is an enigma that is not yet resolved [ 6 ]. (biomedcentral.com)

For example, in EphB1/ EphB2/EphB3-deficient mice dendritic spines (the small protru-sions bearing postsynaptic structures) have reduced density and size [3,7,8] while activation of EphB receptors by ephrins induces rapid dendritic spine formation [7,9]. (123dok.org)

The FH1 domain is also a binding site for diverse SH3-domain containing proteins like Src-like non-receptor tyrosine kinases, WISH (WASP-interacting SH3 protein) and IRSp53 (insulin receptor substrate) in mammals, and Hof1p in yeast [ 6 ]. (biomedcentral.com)

This can either occur by cell surface receptor interactions, as in the case with peptide growth factors, or by interactions with intracellular molecules, as in the case with steroid hormones. (beauty104.com.tw)

Here, we show that plexin-B family members stably associate with the receptor tyrosine kinase ErbB-2. (rupress.org)

CusabioProtein Description: Extracellular DomainAlternative Name (s) : CD137;ILA;TNFRSF9;4-1BB ligand receptor;CDw137;T-cell antigen. (joplink.net)
Also, the growth-inhibitory effects of HER1/2 tyrosine kinase inhibitors (TKIs) were previously found to be attenuated in the presence of heregulin, which is a high-affinity combinatorial ligand for HER3. (biomedcentral.com)
However, it appears that regardless of the mechanism that triggers the formation of oncogenic HER2/HER3 heterodimers (HER2 over-expression or overall low HER2 but high levels of the HER3 ligand heregulin), HER3 transphosphorylation is a common response of breast cancer cells upon treatment with current inhibitors of the HER receptor tyrosine kinase network. (biomedcentral.com)

Its molecular interactions were determined through KEGG analysis, and real-time PCR-based expression analysis was performed to assess its co-expression with another oncogenic cellular pathway (miR-223, KLF9, and PKCε) proteins in ovarian cancer. (biomedcentral.com)
PKCε is usually referred to as an oncogenic kinase as it is involved in the regulation of mitogenesis, cellular invasion, and survival. (biomedcentral.com)
Alveolar RMS can be characterized by a recurrent cytogenetic alteration involving FOXO-1 and PAX3 or PAX7 genes, and the consecutive translocations (t(2;13) or t(1;13) respectively) lead to the excess synthesis of fusion proteins with oncogenic effects [ 5 , 6 ]. (biomedcentral.com)

MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
Caveolins can serve as protein markers of caveolae ('little caves'), invaginations in the plasma membrane 50-100 nanometers in diameter. (biomedcentral.com)
By transmission electron microscopy, they appear as structures resembling 'little caves', which are vesicular invaginations of the plasma membrane of 50-100 nanometer (nm) in size [ 1 ]. (biomedcentral.com)

For decades, researchers have resolved single-stage immunoassay specificity limitations by prepending an upstream polyacrylamide gel electrophoresis (PAGE) protein separation to a downstream immunoassay, therefore developing a two-stage assay known as western blotting. (irjs.info)
According to the kinetic proofreading model, antigen discrimination properties could be explained by the gradual amplification of small differences in binding affinities as the signal is transduced downstream of the T cell receptor. (nature.com)

Turnock-Jones JJ, Jennings CA, Robbins MJ, Cluderay JE, Cilia J, Reid JL, Taylor A , Jones DN, Emson PC , Southam E. Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation. (neurotree.org)

Despite the detailed in vitro characterization of the enzymatic properties of yeast Sac1p, the exact cellular function of this protein has remained obscure. (embl.de)
In vitro, the FH2 domain competes with barbed-end capping proteins and is necessary and sufficient to nucleate actin polymerization, but the FH1 domain, which interacts with profilin-actin, funnels actin to the nucleation vicinity and confers full activity to the molecule [ 1 ]. (biomedcentral.com)

Pioneering studies showed that high expression of kinase-dead HER3 can predict early escape from the anti-HER2 monoclonal antibody trastuzumab. (biomedcentral.com)
It remains to be elucidated whether reactivation of HER3 signalling can also account for the poor efficacy of HER TKIs in treating breast carcinomas that contain low overall levels of HER2 receptors. (biomedcentral.com)

NICD1, which not is a skeletal focus, can be controlled by docking to the hormone-bound addition 1-alpha( HIF1A) which serves in the protein when amine homodimers are progressive. (evakoch.com)

The two main differences between actin and MSP is that MSP does not bind ATP and the lack of polarity in MSP, thus disabling motility through motor proteins, such as myosin. (wikipedia.org)
It has been recently reported that motor proteins like myosin Va play important role in transcytosis of nNOS. (frontiersin.org)
Evidence has suggested the role of motor proteins like myosin Va in transposition of nNOS within the nerve terminals to the membranes to facilitate nitrergic neurotransmission ( 11 , 12 ). (frontiersin.org)

NS proteins are involved in crucial aspects of the viral cycle and pathogenesis, such as rearrangements of intracellular membranes required for endomembrane recruitment and the lysis of host cells ( 1 , 12 , 14 , 18 , 73 ). (asm.org)
in poliovirus (PV), the interaction between the RNA replication complex and intracellular membranes appears to be accomplished by proteins 3A and 2C, which have membrane-binding properties ( 11 , 60 ). (asm.org)

Western blotting showed the levels of autophagy- and pathway-related proteins. (bvsalud.org)
There was also an upregulation in expression of positive regulators and key components of the AMPK pathway, autophagy, proteasome function, and the unfolded protein response. (nature.com)
high bacteria are as proteins of pathway ATM rise, either as acids for greenhouse initiation or for the dehydrogenase of binding eIF2 disorders. (evakoch.com)

2014). Given these findings, if we see colocalization between MYCT1 and any of our selected proteins, we can hypothesize its mechanistic role in hematopoietic cells according to the function of the proteins it colocalizes with. (ucla-mls.com)
Avian EAST (epidermal growth factor receptor-associated protein with SH3 and TAM domains), which colocalizes with clathrin in vesicular structure. (expasy.org)

The FGFs are heparin -binding proteins and interactions with cell-surface associated heparan sulfate proteoglycans has been shown to be essential for FGF signal transduction. (beauty104.com.tw)
Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. (expasy.org)

Proteins G agarose was after that pelleted by centrifugation and cleaned three times with cleaning buffer (20?mmol/L of Tris/HCL, pH 7.4, 150?mmol/L of sodium chloride, 10% glycerol, and 1% Triton X-100 with proteinase and phosphatase inhibitors). (nipponkaigi-tokyo.com)
Several of these have undergone clinical trials, including low-molecular-weight inhibitors with highly selective and reversible tyrosine kinase inhibiting properties [ 1 - 5 ]. (biomedcentral.com)

The lilli gene encodes a nuclear protein related to the AF4/FMR2 family. (sdbonline.org)

Proteins concentration was assessed using Bio-Rad proteins assay package (Bio-Rad Laboratories). (nipponkaigi-tokyo.com)
In this work, FMDV 3A homodimerization was evidenced by an in situ protein fluorescent ligation assay. (asm.org)

In line with this conclusion it was also observed that the expression of coagulation proteins corresponded with the level of expression of ERBB2 in three 'native' breast cancer cell lines (human enriched breast cancer stem cell (CSC), MDA-MB231 and MCF-7). (biomedres.us)
The dominant-negative Cyclin-dependent kinase 9 profiles showed both overlapping and specific differential expression, suggesting involvement in multiple complexes. (sdbonline.org)
A metabolomic study of brain tissues from aged mice with low expression of the vesicular monoamine transporter 2 (VMAT2) gene. (neurotree.org)
Differential gene expression in the striatum of mice with very low expression of the vesicular monoamine transporter type 2 gene. (neurotree.org)
When expressed as a recombinant protein in transfected cells, PV 3A cofractionates with endoplasmic reticulum markers ( 66 ), and its single transient expression can disrupt the secretory apparatus ( 23 ) and decrease major histocompatibility complex (MHC) class I expression ( 22 ). (asm.org)

Major sperm protein (MSP) is a nematode specific small protein of 126 amino acids with a molecular weight of 14 kDa. (wikipedia.org)
Separating proteins by molecular mass (or mobility) before the immunoassay can determine off-target, non-specific antibody binding27. (irjs.info)
Because kinase-inactive HER3 is not presently an amenable target for forthcoming HER TKIs, molecular approaches that can efficiently block heregulin-triggered HER3 transactivation or nucleocytoplasmic trafficking of heregulin might offer novel strategies with which to manage HER-driven breast cancer disease. (biomedcentral.com)

A thesis is proposed here, based on rational argument that depletion of the cytoskeletal organizer protein shank3 may result in defective nNOS membrane localization, resulting in defective nitric oxide synthesis. (frontiersin.org)

The PX domain of Vam7p selectively binds PtdIns-3-P, while the PX domain of the CPK PI-3 kinase selectively binds PtdIns-4,5-P(2). (embl.de)

It was suggested that ATP activates either membrane-bound MSP filament end-tracking proteins or their soluble cofactors. (wikipedia.org)

This study showed for the first time that thrombin promotes specific, dose-dependent glutamate release from RPE cells, induced by the activation of protease-activated receptor 1 (PAR-1). (molvis.org)
Kinomic profiling of principal mesangial cells treated with PDGF uncovered activation of many protein-tyrosine kinases, including AXL. (nipponkaigi-tokyo.com)

Eph receptor tyrosine kinases are involved in many cellular processes. (123dok.org)

T cells have the ability to sense and discriminate a wide range of antigenic peptides bound to major histocompatibility complex (pMHC) molecules according to their affinity for the T cell receptor (TCR). (nature.com)

Formins are multidomain proteins conserved from plants to fungi and vertebrates. (biomedcentral.com)

The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. (embl.de)

Yet, unlike single-cell genomics and transcriptomics, improvements in single-cell protein assays are lagging. (irjs.info)
Strikingly, most single-cell protein assays (for unmodified endogenous focuses on) are single-stage immunoassays, including enzyme-linked immunosorbent assays (with direct or sandwich readout) and immunocytochemistry, as well as newer immunoassay types designed to improve multiplexing using spatial barcoding15,16 or mass cytometry17. (irjs.info)

CTC protein analyses primarily focus on surface and secreted proteins18,19. (irjs.info)

Hydrophobic side-chains from adjacent faces in the sandwich form the interior of the protein. (wikipedia.org)

Anatomy21

Organisms7

Diseases3

Chemicals and Drugs164

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes42

Disciplines and Occupations1

Information Science3

Pathways12

Tumor1

Human Epidermal Growth F3

Mammalian target of1

Inhibitor3

Stomatitis2

Residues6

Interactions with scaffold1

Homology3

Adaptor2

Ligands5

Phosphorylation7

Transmembrane2

Phosphatidylinositol7

Antigen receptor3

Golgi4

Enzymes4

Early endosome2

Endocytosis1

Dopamine2

Signaling5

Cytoskeleton1

Proximal2

Inhibition2

Induces1

Insulin1

Cell surface1

ErbB1

Ligand3

Oncogenic3

Plasma membrane3

Downstream2

Subunit1

Vitro2

HER22

Amine1

Motor proteins3

Intracellular membranes2

Pathway3

Colocalizes2

Signal transduction2

Inhibitors2

Nuclear1

Assay2

Expression5

Molecular3

Synthesis1

Binds1

Membrane-bound1

Activation2

Cellular processes1

Peptides1

Fungi1

Motifs1

Assays2

Analyses1

Hydrophobic1