AcuteTissuesSynaptic vesiclesEndocytosisMutationsClathrinNeoplasmsAP180Carbohydrate-bindingMast cellSynapsesCellularNeutrophilsMembraneIntracellularChronicHematologicalProliferationCellsSerumMammalsGeneTumorHsp90MitochondrialSolubleEncodeLocalizationSynthesisTherapeuticPathwaysMalignanciesExpressionDiagnosticsRoleFragmentsPrimaryEfficacyRegulatory
Acute5
- EVs were isolated from the serum of acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL) patients, and healthy volunteers. (nature.com)
- Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. (nih.gov)
- A study published in the journal Nature Cancer shows promising effects on patient cells in mice and offers hope for patients with acute myeloid leukaemia (AML), a cancer that has proven difficult to treat. (ki.se)
- Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample. (rndsystems.com)
- We identified multiple newly gained SEs in primary mouse acute myeloid leukemia (AML) cells and demonstrate that the inhibitors abolish many SEs and preferentially suppress the transcription elongation of SE-driven oncogenes. (regenerativemedicine.net)
Tissues4
- Monocytes circulate, whereas macrophages are fixed in lymphoid and mucosal tissues. (medscape.com)
- Subsequently, several groups identified new members of the galectin family in protein extracts obtained from various tissues by using their ability to bind galactose residues on rabbit erythrocytes and cloning approaches based on sequence homology. (fdocuments.net)
- Expression of galectins in normal lymphoid cells Each member of the galectin family exhibits a specific expression pattern in distinct tissues, and galectin expression is regulated during development. (fdocuments.net)
- Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)
Synaptic vesicles1
- AP180 is a protein that plays an important role in clathrin-mediated endocytosis of synaptic vesicles. (wikipedia.org)
Endocytosis2
- Clathrin-coated vesicles mediate a variety of endocytosis pathways in cells, including endocytic events at synapses. (elsevierpure.com)
- 2016). Thus, we will assess MYCT1 colocalization with Syntaxin 6, and other vesicular trafficking candidates such as, EEA1, Rab 5A, APPL1, which are associated with endosomes, Clathrin Heavy Chain (coating protein), Caveolin-1 (membrane protein associated with endocytosis), and GOPC (associated with Golgi). (ucla-mls.com)
Mutations2
- reviewed in Roll and Reuther, 2010), as well as mutations of the lymphoid transcription factor gene IKZF1 (IKAROS) (Harvey et al. (atlasgeneticsoncology.org)
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
Clathrin8
- It is capable of simultaneously binding both membrane lipids (via an ANTH domain) and clathrin and is therefore thought to recruit clathrin to the membrane of newly invaginating vesicles. (wikipedia.org)
- A ubiquitous form of the protein in mammals, CALM, (Clathrin-assembly lymphoid myeloid leukaemia protein) is named after its association with myeloid and lymphoid leukemias where some translocations map to this gene. (wikipedia.org)
- AP180 and clathrin assembly lymphoid myeloid leukemia protein (CALM) are clathrin accessory proteins that promote the formation of clathrin-coated vesicles. (elsevierpure.com)
- Both proteins bind to membrane lipids through their epsin N-terminal homology domains and interact with clathrin and related protein components through their carboxyl-terminal peptide motifs. (elsevierpure.com)
- We propose that both AP180 and CALM function as endocytic accessory proteins at synapses, but each may regulate distinct clathrin pathways. (elsevierpure.com)
- A previous publication showed that MYCT1 is localized in cytoplasmic membrane-associated vesicles in Hela cells, where it colocalizes with Clathrin H and Syntaxin 6 (t-SNARE) coated vesicles (Wu et al. (ucla-mls.com)
- 2014). For example, clathrin assembly lymphoid myeloid leukemia protein (CALM) was shown to have a function in KIT signaling in mouse HSCs (Rai et al. (ucla-mls.com)
- Clathrin assembly protein CALM plays a critical role in KIT signaling by regulating its cellular transport from early to late endosomes in hematopoietic cells. (ucla-mls.com)
Neoplasms1
- Hematological malignancies, which include lymphoid, myeloid, histiocytic, and mast cell neoplasms, are a heterogeneous group of diseases of diverse incidence, pathogenesis and prognosis (Kornblau et al . (bbrc.in)
AP1803
- In Drosophila melanogaster (fruit flies), deletion of the AP180 homologue, leads to enlarged but much fewer vesicles and an overall decrease in transmitter release. (wikipedia.org)
- In D. melanogaster it was also shown that AP180 is also required for either recycling vesicle proteins and/or maintaining the distribution of both vesicle and synaptic proteins in the nerve terminal. (wikipedia.org)
- AP180 maintains the distribution of synaptic and vesicle proteins in the nerve terminal and indirectly regulates the efficacy of Ca2+-triggered exocytosis" (PDF). (wikipedia.org)
Carbohydrate-binding2
- At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
- Changes in glycan structures and the interactions of these structures with endogenous carbohydrate- binding proteins, known as lectins, are now considered to be potential biomarkers on cancer cells for monitoring tu- mor progression. (fdocuments.net)
Mast cell1
- Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. (nih.gov)
Synapses1
- We show that both proteins are detected in synapses but demonstrate different distribution patterns. (elsevierpure.com)
Cellular6
- Effective immune surveillance of patients with hematologic malignancies such as leukemia is mediated by cellular and noncellular arms of the innate and adaptive immune system. (nature.com)
- Thus, we asked if MYCT1 localizes in specific type of vesicles that can point to its function, how the deletion of the extracellular domain affects the potential localization of MYCT1 in trafficking vesicles, and what cellular programs MYCT1 may be involved in in HSCs. (ucla-mls.com)
- Moreover, m6A proteins establish molecular linkages between virus genome/viral encode proteins and host cells proteins via their multifunctional roles in cellular RNA metabolism. (bvsalud.org)
- IL23 aims degradative and known in different similar cellular collagens clock-wise as aciduria, Edition, protein and methionine. (evakoch.com)
- Exosomes are a kind of extracellular vesicles (EVs), which was first reported by Pan and Johnstone in 1983 as unwanted cellular components extruding from reticulocytes. (bbrc.in)
- Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. (biomedcentral.com)
Neutrophils2
- [ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)
- Chemotaxis of neutrophils involves movement of pseudopodia and polymerization of cytoskeletal proteins or actin. (medscape.com)
Membrane4
- Our data so far suggest a predominant localization of MYCT1 in the membrane fraction of hematopoietic cells, and our immunofluorescence results suggested the possibility of MYCT1 localizing in vesicles. (ucla-mls.com)
- GzB primarily initiates apoptosis either through direct proteolytic processing and activation of initiator (caspase 8) or executioner (caspases 3 and 7) caspases, or through disruption of mitochondrial outer membrane potential via cleavage of the Bid protein [ 2 ]. (biomedcentral.com)
- This protein can be a membrane-bound or soluble protein. (nih.gov)
- Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)
Intracellular2
- Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
- The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. (nih.gov)
Chronic1
- Introduction B-cell chronic lymphocytic leukemia (CLL) is usually associated with profound defects in T-cell function resulting in failure of antitumor immunity and increased susceptibility to infections. (researchensemble.com)
Hematological2
- In hematological malignancies, exosome-mediated expulsion of a number of key proteins and micro RNAs, resulting in influence of major tumor-related pathways. (bbrc.in)
- Recently, it has been reported by many workers that the potential functions of exosomes contributed to various aspects of hematological tumorigenesis, particularly with a focus on the exosome-mediated tumor progression, metastasis, drug resistance and immune escape by altering the function of receiver cells via diverse exosomal cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs) (Whiteside and Boyiadzis, (2017). (bbrc.in)
Proliferation3
- CLL CD8+ T cells showed functional defects in proliferation and cytotoxicity with the cytolytic defect caused by impaired granzyme packaging into vesicles and nonpolarized degranulation. (researchensemble.com)
- A major potential confounding factor is usually cytomegalovirus (CMV) seropositivity known to influence the major lymphoid subsets in healthy individuals with expanded populations of CMV-specific CD4+ Tnf and CD8+ T cells reported in CMV-seropositive (CMV+) CLL patients.14-17 Here we show that CD8+ T cells from patients with CLL exhibit defects in proliferation cytotoxicity and increased expression of inhibitory receptors irrespective of CMV serostatus. (researchensemble.com)
- We show that blocking CKIα together with CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, and induce apoptosis. (regenerativemedicine.net)
Cells10
- Extracellular Vesicles (EVs) are membranous vesicles produced by all cells under physiological and pathological conditions. (nature.com)
- 2014). Given these findings, if we see colocalization between MYCT1 and any of our selected proteins, we can hypothesize its mechanistic role in hematopoietic cells according to the function of the proteins it colocalizes with. (ucla-mls.com)
- Cancers of both lymphoid and non-lymphoid origin also express GzB, and in some cases this expression has been linked to pathogenesis or sensitizing tumour cells to cell death. (biomedcentral.com)
- Title: Different ability of multidrug-resistant and-sensitive counterpart cells to release and capture extracellular vesicles Abstract: Cancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. (up.pt)
- Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. (lookformedical.com)
- Exosomes, which are 30- to 120-nm vesicles, are released by most types of cells, including tumor cells. (bbrc.in)
- [ 12 ] These cells can capture antigen and migrate to lymphoid organs, where they present the antigens to naive T cells. (medscape.com)
- [ 15 ] The surface of the APC contains 2 peptide-binding proteins (ie, major histocompatability complex [MHC] classes I and II), which can stimulate cytotoxic T (T C ) cells, regulatory T (Treg) cells, and helper T (T H ) cells. (medscape.com)
- TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. (biomedcentral.com)
- TIME primarily consists of myeloid cells, lymphocytes and some other innate immune cells. (biomedcentral.com)
Serum1
- Special EV surface protein patterns in serum have the potential as noninvasive biomarker candidates to distinguish several disease-related patterns ex vivo or in vivo. (nature.com)
Mammals1
- In mammals, the first protein with similar binding properties was purified from calf heart and lung protein extracts and was later named "galectin- 1" [2]. (fdocuments.net)
Gene4
- The protein encoded by P2RY8 gene is composed of 359-amino acids and belongs to the P2Y family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. (atlasgeneticsoncology.org)
- This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancerindex.org)
- What does this gene/protein do? (cancerindex.org)
- What pathways are this gene/protein implicaed in? (cancerindex.org)
Tumor2
- EVs were characterized by transmission electron microscopy and fluorescence nanoparticle tracking analysis, and EV surface protein profiles were analyzed by multiplex bead-based flow cytometry to identify tumor- or immune system-related EVs of AML, ALL, CLL, and healthy samples. (nature.com)
- Ultracentrifugation of the tumor ascites fluid has now revealed a pellet that contains small extracellular vesicles (EV) with an average diameter of 80 nm. (aacrjournals.org)
Hsp901
- is in research from the posttranslational adjustments of Hsp90 itself and Hsp90 co-chaperone protein. (forgetmenotinitiative.org)
Mitochondrial1
- In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (lookformedical.com)
Soluble1
- They were initially de- scribed in the electric eel, Electrophorus electri- cus , as low-molecular-weight, -galactoside- binding, soluble proteins (electrolectins) [1]. (fdocuments.net)
Encode1
- Unlike miRNAs whose central function is to restrain mRNA translation by inducing degradation, lncRNAs can act as numerous roles to exert their functions by directly or indirectly interacting with DNA, RNA or protein, even can encode some short peptides (Fig. 3 a-d) [ 6 ]. (biomedcentral.com)
Localization1
- Immunofluorescence staining and western blot analysis were conducted to determine the protein expression and localization. (bvsalud.org)
Synthesis2
- As m6A modification regulates RNA nuclear exportation, stability, and translation, m6A proteins commonly participate in virus infection by regulating viral genomic RNA synthesis. (bvsalud.org)
- With the histone of synthesis, the signaling glutamate is to introduce released well nuclear after protein. (evakoch.com)
Therapeutic1
- CKIα ablation induces p53 activation, and CKIα degradation underlies the therapeutic effect of lenalidomide in a pre-leukemia syndrome. (regenerativemedicine.net)
Pathways1
- After performing the trafficking protein colocalization experiment, we will gain insight to possible pathways for MYCT1. (ucla-mls.com)
Malignancies1
- Leukemia and lymphoma are blood malignancies that affect people of all ages and result in approximately 23,000 deaths in the United States per year [ 1 ]. (nature.com)
Expression1
- Further, the combination of up-regulated antioxidant enzymes (superoxide dismutase and glutathione peroxidase) and Bcl-2 protein expressions and down-regulated Bax expression. (bvsalud.org)
Diagnostics1
- His current research focuses on developing various MEMS-based tools for the separation and capture of extracellular vesicles for medical diagnostics. (stanford.edu)
Role3
- Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)
- Some studies have previously described the important role of extracellular vesicles (EVs) in the dissemination of a MDR phenotype. (up.pt)
- RNA has a central role in the cell's protein production. (ki.se)
Fragments1
- From Protein Complexes to Subunit Backbone Fragments: a Novel Approach to Native Mass Spectrometry. (chicagobiomedicalconsortium.org)
Primary1
- with us one can be cytosol proteins, " badenova( 2009) is four primary photoreceptors, the most non-crossover-generating of which chloroplasts release, phosphorylated, and ready ataxia bacterial to a cascade of challenging glycoprotein GTPases. (evakoch.com)
Efficacy1
- Flt3 ITD AML mouse models and in several patient-derived AML xenograft models, supporting their potential efficacy in curing human leukemia. (regenerativemedicine.net)
Regulatory1
- This study aims to explore proteins related to neovascularization and elucidate their regulatory roles in PAS, enhancing our understanding of this condition. (bvsalud.org)