• The enzyme phenylalanine ammonia lyase (EC 4.3.1.24) catalyzes the conversion of L-phenylalanine to ammonia and trans-cinnamic acid. (wikipedia.org)
  • The enzyme is a member of the ammonia lyase family, which cleaves carbon-nitrogen bonds. (wikipedia.org)
  • It is thought to be mechanistically similar to the related enzyme histidine ammonia-lyase (EC:4.3.1.3, HAL). (wikipedia.org)
  • The systematic name of this enzyme class is L-phenylalanine ammonia-lyase (trans-cinnamate-forming). (wikipedia.org)
  • The mechanism of the reaction of PAL is thought to be similar to the mechanism of the related enzyme histidine ammonia lyase. (wikipedia.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Cystathionine Gamma Lyase (CSE) in Tissue homogenates, cell lysates and other biological fluids. (youngresearch.eu)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Cystathionine Gamma Lyase (CSE) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (youngresearch.eu)
  • An enzyme of the lyase class that catalyzes the conversion of ATP and oxaloacetate to ADP , phosphoenolpyruvate, and carbon dioxide. (nih.gov)
  • The first beta-helix was observed in the enzyme pectate lyase , which contains a seven-turn helix that reaches 34 Å (3.4 nm ) long. (cloudfront.net)
  • The best benefit of HCA and the reason it is such a good ingredient is the effect it has on an enzyme called citrate lyase, multipharm deca durabolin. (ksglas.gl)
  • We selected alginate lyase (Aly) from Pseudoalteromonas elyakovii as the most appropriate enzyme for degradation of microcapsules and ordered a synthetic codon-optimized version of this gene. (igem.org)
  • Plant cell wall degrading enzyme modules including glycoside hydrolases, carbohydrate esterases and polysaccharide lyases were identified from over 2500 contigs. (concordia.ca)
  • Since the transfer is intramolecular, the reaction is an elimination and, hence, the enzyme is a lyase, belonging in EC 4. (enzyme-database.org)
  • Phenylalanine ammonia lyase (PAL): From discovery to enzyme substitution therapy for phenylketonuria. (cdc.gov)
  • Description: A sandwich ELISA kit for detection of Cystathionine Gamma Lyase from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (youngresearch.eu)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Cystathionine Gamma Lyase (CSE) in samples from tissue homogenates, cell lysates or other biological fluids. (youngresearch.eu)
  • compared to other polysaccharide lyases such as pectate lyases, which tend to have rather basic pH optima. (cazypedia.org)
  • which despite belonging to [[PL1]], have diverged significantly from the pectate lyases. (cazypedia.org)
  • The tertiary structures of pectate lyases and rhamnogalacturonase A show a stack of parallel beta strands that are coiled into a large helix. (embl.de)
  • Three bacterial pectate lyases, a pectin lyase from Aspergillus niger, thestructures of rhamnogalacturonase A from Aspergillus aculeatus, RGase A,and the P22-phage tailspike protein, TSP, display the right-handedparallel beta-helix architecture first seen in pectate lyase. (embl.de)
  • ATP-citrate lyase (ACLY) generates acetyl-CoA and oxaloacetate from citrate, but whether inhibition is effective for treating NASH is unknown. (edu.au)
  • Your body naturally produces and uses citrate lyase in order to convert carbohydrates into fat. (ksglas.gl)
  • The potassium salt of HCA is more available where it competes with citrate molecules for the enzymatic activity of ATP citrate lyase. (phwsupplements.com)
  • The majority of genes required for alginate synthesis, including the alginate lyase, algL, are located in a single operon. (rcsb.org)
  • In vitro enzymatic analysis of active site mutants highlights R249 and Y256 as key residues required for alginate lyase activity. (rcsb.org)
  • Find N-Acetylneuraminate Pyruvate Lyase (Dihydrodipicolinate Synthase) Proteins with a specific Grade. (antibodies-online.com)
  • Find N-Acetylneuraminate Pyruvate Lyase (Dihydrodipicolinate Synthase) Proteins for a variety of species such as anti-Human N-Acetylneuraminate Pyruvate Lyase (Dihydrodipicolinate Synthase), anti-Xenopus laevis N-Acetylneuraminate Pyruvate Lyase (Dihydrodipicolinate Synthase), anti-Cow N-Acetylneuraminate Pyruvate Lyase (Dihydrodipicolinate Synthase). (antibodies-online.com)
  • Find N-Acetylneuraminate Pyruvate Lyase (Dihydrodipicolinate Synthase) Proteins validated for a specific application such as ELISA, WB, SDS, AP. (antibodies-online.com)
  • NMR and UV spectroscopic assays revealed that it encodes a novel polysaccharide lyase (PL), hereafter referred to as BtCDH, reflecting its source (B. thetaiotaomicron (Bt)) and its ability to degrade the GAGs CS, dermatan sulfate (DS), and hyaluronic acid (HA). (hal.science)
  • BtCDH homologs were also detected in several other HGM species, and we therefore propose that it represents the founding member of a new polysaccharide lyase family (PL29). (hal.science)
  • Another major difference to the pectate and other polysaccharide lyase mechanisms, is that divalent metal ions are not required by PL4 for catalysis. (cazypedia.org)
  • In most other polysaccharide lyase mechanisms a proton donor has not been identified. (cazypedia.org)
  • We now have T1 seeds harboring deletions in Methionine γ-Lyase ( MGL) However, transformations to knockout other Met catabolism genes, in combination with 7S, have been unsuccessful so far. (soybeanresearchinfo.com)
  • Secretome analysis revealed cazy genes representing enzymatic genes, glycoside hydrolases, carbohydrate esterases, carbohydrate-binding modules, auxillary activities, glycosyl transferases and polysaccharide lyases. (aitzol.com)
  • PAL is structurally similar to the mechanistically related histidine ammonia lyase, although PAL has approximately 215 additional residues. (wikipedia.org)
  • PCC 6803 slr 1649-encoded protein also acts as a bilin lyase, and additionally contributes to linker attachment and/or stability of phycobilisomes. (biomedcentral.com)
  • PCC 6803 and indicate that after separating from a common ancestor protein, the phycoerythrin lyase from Guillardia theta has retained its capacity to couple a bilin group to other phycobiliproteins. (biomedcentral.com)
  • Recently Zhao and co-workers discovered that a CpeS-like protein functions as a phycocyanobilin-cysteine-beta84 lyase in Anabaena sp. (biomedcentral.com)
  • however, whether this protein is a lyase has yet to be determined. (cazypedia.org)
  • Argininosuccinic aciduria is an autosomal recessive disorder characterized by hyperammonemia due to defects in the Argininosuccinate Lyase (ASL) gene. (cags.org.ae)
  • Molecular function: argininosuccinate lyase activity. (expasy.org)
  • Phenylalanine ammonia lyase is found widely in plants, as well as some bacteria, yeast, and fungi, with isoenzymes existing within many different species. (wikipedia.org)
  • Phenylalanine ammonia lyase can perform different functions in different species. (wikipedia.org)
  • The comparison to these species showed that two different versions of the gene cluster exist in L. paracasei which were likely gained in two distinct events of horizontal gene transfer. (pacb.com)
  • Additionally, the comparison of 62 L. paracasei genomes and the two versions of the gene cluster revealed that this gene cluster is mobile within the species. (pacb.com)
  • This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. (antibodies-online.com)
  • Using gene-modeling softwares, we designed two versions of Gly1 gene with increased Met codons. (soybeanresearchinfo.com)
  • We found that one gene cluster - consisting of a cysteine synthase, a cystathionine lyase, and a serine acetyltransferase - is present in all strains that grow in medium with methionine as sole sulfur source. (pacb.com)
  • Previously, it was designated as EC 4.3.1.5, but that class has been redesignated as EC 4.3.1.24 (phenylalanine ammonia-lyases), EC 4.3.1.25 (tyrosine ammonia-lyases), and EC 4.3.1.26 (phenylalanine/tyrosine ammonia-lyases). (wikipedia.org)
  • Phenylalanine ammonia lyase is specific for L-phenylalanine, and to a lesser extent, L-tyrosine. (wikipedia.org)
  • L-phenylalanine = trans-cinnamate + NH3 Phenylalanine ammonia lyase (PAL) is the first and committed step in the phenyl propanoid pathway and is therefore involved in the biosynthesis of the polyphenol compounds such as flavonoids, phenylpropanoids, and lignin in plants. (wikipedia.org)
  • Numbers are given for the phenylalanine ammonia lyase from Petroselinum crispum (PDB 1W27). (wikipedia.org)
  • Phenylalanine ammonia lyase is composed of four identical subunits composed mainly of alpha-helices, with pairs of monomers forming a single active site. (wikipedia.org)
  • Like other lyases, PAL requires only one substrate for the forward reaction, but two for the reverse. (wikipedia.org)
  • The region PB2-T2-PB3 is the best conserved region in the lyases andshows the clearest structural similarity. (embl.de)
  • The lyases havehomologous sequences but RGase A and TSP do not show obvious sequencehomology either to the lyases or to each other. (embl.de)
  • Family 22 Polysaccharide Lyases (PL22s) contain two subfamilies and several outlier sequences [ 1 ]. (cazypedia.org)
  • First, a genetic and phenotypic pre-screening of 38 strains was carried out in order to identify potential parent strains with high β-lyase activity. (vtt.fi)
  • Mating-competent transformants of eight parent strains were generated, and these were used to generate over 60 hybrids that were screened for β-lyase activity. (vtt.fi)
  • Selected phenolic off-flavour positive (POF +) hybrids were further sporulated to generate meiotic segregants with high β-lyase activity, efficient wort fermentation, and lack of POF, all traits that are desirable in strains for the fermentation of modern hop-forward beers. (vtt.fi)
  • 3C5M: Crystal structure of oligogalacturonate lyase (VPA0088) from Vibrio parahaemolyticus. (rcsb.org)
  • N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. (antibodies-online.com)
  • Another lyase specific for a β-subunit of a phycobiliprotein was found by Shen et al. (biomedcentral.com)
  • This is version 1.1 of the entry. (rcsb.org)
  • This is version 2.1 of the entry. (rcsb.org)
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  • Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database. (hmdb.ca)
  • Cystathionine synthetase and cystathionine lyase use P5P as a cofactor and impaired cystathionine synthetase activity leads to homocystinuria, which is often associated with mental retardation. (loinc.org)
  • As a proof of concept, we applied this technology to generate yeast hybrids with an aim to increase β-lyase activity for fermentation of beer with enhanced hop flavour. (vtt.fi)
  • The original global offensive version featured islamic architecture and presence of military and conflict activity such as humvees and bombed walls, reflecting a contemporary view of the middle east. (aitzol.com)
  • This graph shows the total number of publications written about "Intramolecular Lyases" by people in this website by year, and whether "Intramolecular Lyases" was a major or minor topic of these publications. (ucdenver.edu)
  • Our data show that the loss of phycocyanin-lyase function causes pleiotropic effects in Synechocystis sp. (biomedcentral.com)
  • Electronic supplementary material The online version of this article (doi:10.1007/s00253-017-8211-y) contains supplementary material, way, an initial depolymerization is required. (lu.se)