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  • DENV
  • This finding also has implications for measuring disease burden, understanding transmission dynamics, and hypothesizing effects on DENV vaccine efficacy and uptake. (biomedcentral.com)
  • The objective of this study was to identify some of the compounds that are present in Mammea americana ( M. americana ) and Tabernaemontana cymosa (T. cymosa) plants and, subsequently, to evaluate their cytotoxicity in VERO cells and their potential antiviral effects on DENV and CHIKV infections in those same cells. (biomedcentral.com)
  • The DENV infection process is initiated through the binding of the virus to receptors on the cell surface via the E protein, followed by endocytosis, in which variations in pH trigger the fusion of this protein with the endosomal membrane, releasing the nucleocapsid (RNA bound to the C protein) into the cytoplasm. (biomedcentral.com)
  • infection
  • Importantly, K22 inhibitsa broad range of coronaviruses, including Middle East respiratory syndrome coronavirus(MERS CoV), and efficient inhibition wasachieved in primary human epithelia cultures representing the entry port of human coronavirus infection. (slideshare.net)
  • Vaccines are the most effective tool for controlling viral infection ( 3 ), evidenced by the eradication of smallpox virus ( 4 ) and the substantial reduction in the number of PV, Japanese encephalitis virus, influenza virus, and human papillomavirus infections ( 5 ). (asm.org)
  • At 4 days post-transfection, aliquots of each supernatant were inoculated onto vertebrate (BHK-21 and Vero) and mosquito (C6/36) cells which were then assayed for evidence of viral infection by reverse transcription-PCR, Western blot and plaque assay. (biomedcentral.com)
  • novel
  • Overall, this report describes a novel means for the high-throughput evaluation of sIPV antigenicity and a thermostable lyophilized sIPV with in vivo vaccine potency. (asm.org)
  • virus
  • We assessed whether JE-CV-induced antibodies can also neutralize more recent wt Japanese encephalitis virus (JEV) isolates including a genotype 1 isolate. (biomedcentral.com)
  • Neutralization titers against the three recent JEV strains were comparable to those observed previously against other strains and the vaccine virus. (biomedcentral.com)
  • There is an urgent need for a vaccine that is effective against the 2009 pandemic influenza A (H1N1) virus. (labome.ru)
  • The virus could infect vertebrate but not mosquito cells. (biomedcentral.com)
  • This makes it difficult to find targets for the drug that would interfere with the virus without also harming the host organism's cells. (wikipedia.org)
  • They then introduced into the cultures chemicals which they thought might inhibit viral activity, and observed whether the level of virus in the cultures rose or fell. (wikipedia.org)
  • Viral life cycles vary in their precise details depending on the type of virus, but they all share a general pattern: Attachment to a host cell. (wikipedia.org)
  • INTRODUCTION
  • As oral poliovirus vaccine (OPV) causes vaccine-associated paralytic poliomyelitis, the polio endgame strategy introduced by the Global Polio Eradication Initiative calls for a phased withdrawal of OPV and an introduction of inactivated poliovirus vaccine (IPV). (asm.org)
  • The introduction of IPV creates challenges in maintaining the cold chain for vaccine storage and distribution. (asm.org)
  • children
  • Sera from 12-18 month-old children who received a single dose of JE-CV in a phase III study in Thailand and the Philippines (ClinicalTrials.gov NCT00735644) were randomly selected and pooled according to neutralization titer against JE-CV into eight samples. (biomedcentral.com)
  • serum
  • Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. (labome.ru)
  • Japanese
  • This report updates the 1993 recommendations by CDC's Advisory Committee on Immunization Practices (ACIP) regarding the prevention of Japanese encephalitis (JE) among travelers (CDC. (cdc.gov)
  • transmission
  • JE vaccine is not recommended for short-term travelers whose visit will be restricted to urban areas or times outside of a well-defined JEV transmission season. (cdc.gov)
  • report
  • This report summarizes the epidemiology of JE, describes the two JE vaccines that are licensed in the United States, and provides recommendations for their use among travelers and laboratory workers. (cdc.gov)
  • Here, we report size exclusion high-performance liquid chromatography (SE-HPLC) as a reliable means to identify the leading lyophilized formulation to generate thermostable Sabin inactivated poliovirus vaccine (sIPV). (asm.org)
  • We therefore report preliminary safety and immunogenicity results after one injection of a licensed monovalent pandemic H1N1 vaccine in the USA. (labome.ru)
  • Asia
  • JE occurs throughout most of Asia and parts of the western Pacific. (cdc.gov)
  • For most travelers to Asia, the risk for JE is very low but varies on the basis of destination, duration, season, and activities. (cdc.gov)
  • areas
  • Upon recognition of a pathogen via TLRs, the immature DCs at the site of pathogen entry undergo a maturation process during which they exit the site and migrate to the T cell-rich areas of the neighboring lymph nodes, where the mature DCs present their acquired antigens and stimulate antigen-specific T cells, thus initiating adaptive immunity and immune memory. (rupress.org)