• Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. (wikipedia.org)
  • We also illustrated that the proteinoid NPs are non-toxic to human umbilical vein endothelial cells, and apart from P(KEf) also to lettuce plants. (nature.com)
  • Human umbilical vein endothelial cells (HUVECs) were treated with ginkgolide B. The expression of PXR, CYP3A4, MDR1, VCAM-1, E-selectin and caspase-3 were quantified with qRT-PCR and Western blot analysis. (greenmedinfo.com)
  • Doxorubicin is usually injected into a vein through a specially prepared site on your skin. (pharmasave.com)
  • These drugs are usually injected into a vein, either at your doctor's office or at a hospital. (healthline.com)
  • Liposomal doxorubicin is an anthracycline-type chemotherapy drug that is used to treat certain types of cancer (such as ovarian cancer , AIDS-related Kaposi's sarcoma , multiple myeloma ). (webmd.com)
  • Liposomal doxorubicin may cause heart problems, including possibly fatal heart failure . (webmd.com)
  • Heart problems may occur during liposomal doxorubicin therapy or months to years after receiving this medication . (webmd.com)
  • Depending on how severe your hand-foot syndrome is, your doctor may give you something to reduce the symptoms, or decrease or delay your next dose of liposomal doxorubicin . (webmd.com)
  • Initial studies show it seems to work as well as liposomal doxorubicin and its main side effect is a low white blood cell count. (cancer.org)
  • The NDC code 0069-4004 is assigned by the FDA to the product Doxorubicin Hydrochloride which is a human prescription drug product labeled by Pfizer Laboratories Div Pfizer Inc. The product's dosage form is injection, solution and is administered via intravenous form. (ndclist.com)
  • What are the uses for Doxorubicin Hydrochloride? (ndclist.com)
  • What are Doxorubicin Hydrochloride Active Ingredients? (ndclist.com)
  • Which are Doxorubicin Hydrochloride UNII Codes? (ndclist.com)
  • What is the NDC to RxNorm Crosswalk for Doxorubicin Hydrochloride? (ndclist.com)
  • Which are the Pharmacologic Classes for Doxorubicin Hydrochloride? (ndclist.com)
  • The risk of developing secondary acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) is increased following treatment with doxorubicin hydrochloride. (medscape.com)
  • Each mL of sterile, isotonic, non-preserved solution contains 2 mg of doxorubicin hydrochloride, Ph.Eur. (rxhealthmed.ca)
  • Chemotherapeutic drugs such as doxorubicin are cytotoxic agents that are effective at killing cancer cells, but are also toxic to healthy cells. (confex.com)
  • For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
  • When the drugs are given into a vein or by mouth, they enter the bloodstream to reach almost all areas of the body. (cancer.org)
  • 28 Cycle 2 Day 1 Brentuximab vedotin Doxorubicin Vinblastine Dacarbazine Page 2 AAVD Possible drug interactions o AAVD may interact with other drugs you are taking. (ivcanceredsheets.com)
  • Clinically it is mainly used for high levels of estrogen in breast cancer patients, which combines with androgen and other anticancer drugs (such as doxorubicin, etc., enhancing the effectiveness and showing good effect in postmenopausal patients with advanced breast cancer. (lookchem.com)
  • ON013 trade name] is given with a taxane (a type of cancer medicine such as paclitaxel or docetaxel) or if you have ever used an anthracycline (another type of cancer medicine that includes medicines called doxorubicin and epirubicin). (who.int)
  • The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence about 4% when the dose of doxorubicin is 500-550 mg/m2, 18% when the dose is 551-600 mg/m2 and 36% when the dose exceeds 600 mg/m2. (wikipedia.org)
  • The rate of this side effect limits the dose of this formulation that can be given as compared with plain doxorubicin in the same treatment regimen, thereby limiting potential substitution. (wikipedia.org)
  • Functionally, ginkgolide B dose-dependently attenuated doxorubicin- or staurosporine-induced apoptosis, which was reversed by transfection with PXR siRNA. (greenmedinfo.com)
  • The recommended dose of doxorubicin varies according to the specific condition being treated, the response to therapy, the other medications being used, and body size. (pharmasave.com)
  • Each single-dose vial of sterile, lyophilized red powder, contains doxorubicin HCl 10 mg. (pharmasave.com)
  • Intravenous - Administration within or into a vein or veins. (ndclist.com)
  • Treatment schedule Your treatment will be given into your vein through an intravenous (IV) line. (ivcanceredsheets.com)
  • Ways to give chemotherapy include an intravenous (IV) tube placed into a vein using a needle or in a swallowed pill. (zenonco.io)
  • The definition of an IV is an abbreviation for intravenous, a procedure where a needle inserted directly into a vein to deliver liquids to the blood stream. (moviecultists.com)
  • Does Lymphoma Cause Deep Vein Thrombosis? (everydayhealth.com)
  • The only box I checked was cancer (non-Hodgkin's lymphoma for five years) and the reply was that I was at risk for deep vein thrombosis. (everydayhealth.com)
  • Patients with lymphoma can develop deep vein thrombosis and are particularly at risk when enlarged lymph nodes in the abdomen or pelvis compress the veins draining the legs. (everydayhealth.com)
  • The symptoms of deep vein thrombosis typically also include swelling, not just pain. (everydayhealth.com)
  • I do have numbness in my left foot and had deep vein thrombosis in that leg. (everydayhealth.com)
  • Patients with large lymph nodes in the pelvis or groin may develop deep vein thrombosis (DVT) , which is treated with blood thinners . (everydayhealth.com)
  • Several days later, deep vein thrombosis developed in her right leg. (cdc.gov)
  • Doxorubicin is given by injection into a vein. (wikipedia.org)
  • This medicine is given as an IV injection into a vein. (cigna.com)
  • This medication is given by injection into a vein over 30-60 minutes or longer by a health care professional. (webmd.com)
  • Tumor and tissue biodistribution in vivo was performed in athymic NCR mice using a human xenograft model by labeling the nanocomposites with DiR and dosing via tail vein injection, followed by imaging 48 hours post-treatment. (confex.com)
  • This medication comes in an injectable form and is given by injection into a vein (intravenously) by a healthcare provider. (medicap.com)
  • METHODS: We overexpressed CTRP5 in the hearts using an adeno-associated virus 9 (AAV9) system through tail vein injection. (bvsalud.org)
  • The presence of the liposomal carriers and the intratumoral distribution of doxorubicin were imaged ex vivo with autoradiography and fluorescence microscopy, respectively, for 2 different time points after injection (90 minutes and 48 hours). (maastrichtuniversity.nl)
  • Doxorubicin is a traditional chemotherapeutic agent for a wide variety of cancers. (oncotarget.com)
  • Doxorubicin is in the anthracycline and antitumor antibiotic family of medications. (wikipedia.org)
  • Doxorubicin is an anthracycline type of chemotherapy that is used to treat several different types of cancer. (clarksnutrition.com)
  • The "drug sponge" is an absorbent polymer coating a cylinder that is 3D printed to fit precisely in a vein that carries the blood flowing out of the target organ - the liver in liver cancer, for example. (scienceblog.com)
  • In early tests in pigs, the polymer-coated drug absorber took up, on average, 64 percent of a liver cancer drug - the chemotherapy agent doxorubicin - injected upstream. (scienceblog.com)
  • Doxorubicin comes as a solution (liquid) or as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
  • Materials and Methods: In-111-labeled temperature-sensitive liposomes encapsulating doxorubicin and [Gd(HPDO3A) (H2O)] were injected intravenously in the tail vein of rats (n = 12) bearing a subcutaneous rhabdomyosarcoma tumor on the hind leg. (maastrichtuniversity.nl)
  • Nevertheless, the potential role of CTRP5 in doxorubicin (DOX)-induced cardiotoxicity and the potential mechanisms remain largely unclear. (bvsalud.org)
  • Doxorubicin can cause a severe decrease in the number of blood cells in your bone marrow. (medlineplus.gov)
  • While this drug is first being given into your vein, this medication may cause severe (rarely fatal) reactions, including allergic reactions. (webmd.com)
  • I'm not sure what you mean by a "shunt," but if a patient cannot take blood thinners, sometimes a filter is placed in the large vein in the abdomen (called the inferior vena cava) to prevent a blood clot from traveling from the leg to the lung. (everydayhealth.com)
  • A central venous catheter, or central line is a long, flexible IV tube that empties into a very large vein next to the heart. (ivcanceredsheets.com)
  • The most dangerous side effect of doxorubicin is dilated cardiomyopathy, leading to congestive heart failure. (wikipedia.org)
  • Doxorubicin-induced cardiomyopathy typically results in dilated cardiomyopathy, with all four cardiac chambers being enlarged. (wikipedia.org)
  • In this study, we aim to explore the feasibility of a novel tumor target therapeutic strategy: Targeting PEPT1 to improve the antitumor efficacy of Doxorubicin in human HCC therapy. (oncotarget.com)
  • Doxorubicin-tripeptide conjugate was then observed to clarify the target delivery by PEPT1 and the antitumor effect on human hepatocarcinoma in vivo and in vitro . (oncotarget.com)
  • Doxorubicin may increase your risk for developing leukemia (cancer of the white blood cells), especially when it is given in high doses or together with certain other chemotherapy medications and radiation (x-ray) therapy. (medlineplus.gov)
  • Doxorubicin should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. (medlineplus.gov)
  • Doxorubicin is also used alone and in combination with other medications to treat certain types of thyroid cancer and certain types of soft tissue or bone sarcomas (cancer that forms in muscles and bones). (medlineplus.gov)
  • Doxorubicin should only be given by health care professionals familiar with the use of chemotherapy medications used to treat cancer. (pharmasave.com)
  • Another common and potentially fatal complication of doxorubicin is typhlitis, an acute life-threatening inflammation of the bowel. (wikipedia.org)
  • apalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • enzalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • In the EU doxorubicin pegylated liposomal (as Caelyx) is indicated to treat breast cancer, ovarian cancer, and AIDS-related Kaposi's sarcoma. (wikipedia.org)
  • Doxorubicin was originally made from the bacterium Streptomyces peucetius. (wikipedia.org)
  • Doxorubicin prevents the growth of cancer cells by interfering with the genetic material DNA, which is necessary for reproduction of cells. (pharmasave.com)
  • Doxorubicin works by slowing or stopping the growth of cancer cells. (clarksnutrition.com)
  • Doxorubicin treats certain types of cancer. (medicap.com)
  • Doxorubicin is a prescription medication used to treat certain types of cancer in adults and children including breast cancer, lung cancer , and ovarian cancer . (medicap.com)
  • Following administration of this form of doxorubicin, small amounts of the drug can leak from capillaries in the palms of the hands and soles of the feet. (wikipedia.org)
  • Excess drug is captured by the absorber in the vein draining the organ (vena cava, top). (scienceblog.com)
  • If the drug leaks outside the vein, it can damage the surrounding tissue. (macmillan.org.uk)
  • Our results reveal that targeting PEPT1 may contribute to the efficient delivery of Doxorubicin to hepatocarcinoma cells and the reduction of drug toxicity. (oncotarget.com)
  • Objectives: The aim of this study was to investigate the intratumoral distribution of a temperature-sensitive liposomal carrier and its encapsulated compounds, doxorubicin, and a magnetic resonance (MR) imaging contrast agent after high-intensity focused ultrasound (HIFU)-mediated hyperthermia-induced local drug release. (maastrichtuniversity.nl)
  • Fluorescence images showed perivascular doxorubicin in control tumors, whereas in the HIFU-treated tumors, the delivered drug was spread over a much larger area and also taken up by tumor cells at a larger distance from blood vessels. (maastrichtuniversity.nl)
  • An anticancer drug, doxorubicin, was successfully incorporated into these microspheres for local release and thus for killing cancerous cells. (umn.edu)
  • Doxorubicin may cause serious or life-threatening heart problems at any time during your treatment or months to years after your treatment has ended. (medlineplus.gov)
  • Your doctor will order tests before and during your treatment to see if your heart is working well enough for you to safely receive doxorubicin. (medlineplus.gov)
  • Your periods may or may not return after you complete your treatment of Doxorubicin. (medicap.com)
  • Assess left ventricular ejection fraction before and regularly during and after treatment with doxorubicin. (medilib.ir)
  • Despite of being highly effective, the use of Doxorubicin has many limitations due to the significant toxicity and side effects occurred during and after HCC treatment. (oncotarget.com)
  • First, Doxorubicin was conjugated with Glycylglycylglycine (Gly-Gly-Gly) − a tripeptide which was known as the substrate of PEPT1 and characterized by HPLC and MS successfully. (oncotarget.com)
  • Tell your nurse straight away if you have any stinging, pain, redness or swelling around the vein. (macmillan.org.uk)