- angiogenesis
- Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. (mybiosource.com)
- The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. (origene.com)
- binds
- VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. (origene.com)
- sFlt-1 (soluble fms-like tyrosine kinase-1 - also known as soluble VEGF receptor-1) binds and reduces free circulating levels of the proangiogenic factors VEGF (vascular endothelial growth factor) and PlGF (placental growth factor). (wikipedia.org)
- proliferation
- It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. (mybiosource.com)
- Promotes proliferation, survival, migration and differentiation of endothelial cells. (mybiosource.com)
- Expression of VEGF-D has been shown to have a vascular protective role and inhibit SMC neointimal proliferation, therefore expression of VEGF-D should prolong graft survival. (clinicaltrials.gov)
- inhibition
- VEGF-B levels are overexpressed in vitreous of diabetic patients, and the levels are higher in developed stages of DR. Correlation results show that CRT and MV increase with increased levels of VEGF-B. Targeting VEGF-B inhibition may have therapeutic beneficial implications. (mdpi.com)
- Kendall R, Thomas K. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. (wikipedia.org)
- gene
- This gene encodes one of the two receptors of the VEGF. (mybiosource.com)
- It is a combination product consisting of a replication deficient Adenovirus containing the human Vascular Endothelial Growth Factor D (Ad-VEGF-D) gene and a biodegradable local delivery device (collar) made of collagen. (clinicaltrials.gov)
- Vascular endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene. (wikipedia.org)
- lymphangiogenesis
- Vascular endothelial growth factor-C (VEGF-C), a homologue of VEGF family, plays a key role in lymphangiogenesis. (ahajournals.org)
- splice
- Soluble Flt-1 (sFlt-1) is a splice variant of VEGF receptor 1 (Flt-1) which is produced by a variety of tissues.These proteins act as a receptor of vascular endothelial growth factor (VEGF), a potent angiogenic growth factor. (wikipedia.org)
- permeability
- Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. (ajtmh.org)
- Vascular permeability factor: a unique regulator of blood vessel function. (ajtmh.org)
- protein
- The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. (mybiosource.com)
- There was an association between VEGF CSF , CSF protein, white cell count, and eosinophil counts. (ajtmh.org)
- Serum levels of VEGF-C, VEGF-A and high-sensitivity C-reactive protein (hsCRP) were determined employing specific enzyme-linked immunosorbent assays. (ahajournals.org)
- This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. (origene.com)
- Soluble fms-like tyrosine kinase-1 (sFlt-1 or sVEGFR-1) is a tyrosine kinase protein that disables proteins that cause blood vessel growth. (wikipedia.org)
- SERUM
- The VEGF SERUM fluctuated during the 6-month follow-up period. (ajtmh.org)
- However, the relationship between serum VEGF-C levels and cardiovascular events in patients with atherosclerotic disease is unknown. (ahajournals.org)
- receptor
- Another VEGF receptor is KDR). (wikipedia.org)
- VEGF-B exerts its effects via the FLT1 receptor. (wikipedia.org)
- Therapy
- Khalil A, Muttukrishna S, Harrington K, Jauniaux E, 2008 Effect of Antihypertensive Therapy with Alpha Methyldopa on Levels of Angiogenic Factors in Pregnancies with Hypertensive Disorders. (wikipedia.org)
- kinase
- Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. (wikipedia.org)
- First Trimester Placental Growth Factor and Soluble Fms-Like Tyrosine Kinase 1 and Risk for Preeclampsia. (wikipedia.org)
- Establishing Reference Values for Both Total Soluble Fms-Like Tyrosine Kinase 1 and Free Placental Growth Factor in Pregnant Woman. (wikipedia.org)
- cells
- Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. (mybiosource.com)
- Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. (mybiosource.com)
- Growth factor for endothelial cells. (origene.com)
- reduces
- VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. (ajtmh.org)
- family
- Vascular endothelial growth factor B (VEGF-B) is one of the enigmatic members of the VEGF family. (mdpi.com)
- VEGF-B is a growth factor that belongs to the vascular endothelial growth factor family, of which VEGF-A is the best-known member. (wikipedia.org)
- role
- To assess the role of vascular endothelial growth factor in eosinophilic meningitis, vascular endothelial growth factor was measured in the cerebrospinal fluid (CSF) and blood of 9 patients with eosinophilic meningitis in a cohort study. (ajtmh.org)
- In contrast to VEGF-A, VEGF-B plays a less pronounced role in the vascular system: Whereas VEGF-A is important for the formation of blood vessels, such as during development or in pathological conditions, VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. (wikipedia.org)
- VEGF-B plays also an important role on several types of neurons. (wikipedia.org)
- therapeutic
- This report provides information on the therapeutic development based on the Vascular Endothelial Growth Factor D (VEGF-D) Inhibitors dealing with mechanism of action, comparative analysis at various stages covering Filed, Phase III, Phase II, Phase I, IND filed, Preclinical, Discovery and unknown stages, therapeutics assessment by monotherapy and combination products and molecule type drug information. (sbwire.com)
- contrast
- In contrast, levels of the anti-angiogenic factor sFlt-1 remain stable during the early and middle stages of gestation and increase steadily until term. (wikipedia.org)
- FLT1
- Vascular endothelial growth factor B has been shown to interact with FLT1. (wikipedia.org)
- beneficial
- sFlt-1 thereby blunts the beneficial effects of these proangiogenic factors on maternal endothelium, with consequent maternal hypertension and proteinuria. (wikipedia.org)
- levels
- The knowledge gap about VEGF-B expression and how its levels are altered in diabetic eyes were the focus of this investigation that was addressed by comparing and correlating vitreous VEGF-B between diabetic and non-diabetic patients. (mdpi.com)
- VEGF-B levels were measured by enzyme-linked immunosorbent assay in vitreous samples ( n = 33) from diabetic ( n = 25) and non-diabetic ( n = 8) patients. (mdpi.com)
- mean
- The mean VEGF CSF at presentation, 1 week, and 2 weeks after admission was 568 pg/mL, 751 pg/mL, and 1031 pg/mL, respectively. (ajtmh.org)
- Optical coherence tomography from diabetic patients was evaluated for central retinal thickness (CRT) and macular volume (MV). Mean vitreous VEGF-B concentration was higher in diabetic (18.82 ± 1.44 pg/mL ) vs. non-diabetic patients (17.90 ± 0.32 pg/mL) ( p = 0.006), and in proliferative diabetic retinopathy (PDR) (19.03 ± 1.52 pg/mL) vs. non-PDR (NPDR) patients (18.18 ±0.96 pg/mL) ( p = 0.025). (mdpi.com)
- presentation
- VEGF CSF was detected in 8 (90%) of 9 eosinophilic meningitis patients (range, 45-2190 pg/mL) at presentation. (ajtmh.org)
- patients
- These results indicate that vascular endothelial growth factor may be associated with blood-brain barrier disruption in patients with eosinophilic meningitis. (ajtmh.org)
- Patients in renal failure on hemodialysis depend on adequate and sustained vascular access. (clinicaltrials.gov)
- A low VEGF-C value may serve as a predictive marker of cardiovascular events in patients with ASO. (ahajournals.org)
- risk
- P=0.04), but not hsCRP or VEGF-A, were inversely and significantly associated with MACEs after adjustment for age, gender, and established risk factors. (ahajournals.org)
- Urinary Placental Growth Factor and Risk of Preeclampsia. (wikipedia.org)
- delivery
- Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies. (wikipedia.org)
- several
- Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. (mybiosource.com)