• Coronary artery vasospasm, or smooth muscle constriction of the coronary artery, is an important cause of chest pain syndromes that can lead to myocardial infarction (MI), ventricular arrhythmias, and sudden death. (medscape.com)
  • Internal medicine is a component of his Nitric oxide, Myocardial infarction, Endothelium, Ejection fraction and Pulmonary hypertension studies. (research.com)
  • In his study, Rivaroxaban is strongly linked to Stroke, which falls under the umbrella field of Myocardial infarction. (research.com)
  • His is doing research in Myocardial infarction, Pulmonary hypertension, Angina, Coronary artery disease and Stroke, both of which are found in Internal medicine. (research.com)
  • Occurrence of chest pain during an allergic reaction is a typical manifestation of the Kounis syndrome, defined in 1991 by Nicholas Kounis and George Zavras as an "allergic angina", whose clinical course can range from a simple coronary spasm without troponin elevation to an acute myocardial infarction with all the possible complications, including sudden cardiac death. (bvsalud.org)
  • This syndrome became known as Prinzmetal or variant angina, and was believed to be due to vasospasm in coronary arteries without obstructive lesions. (medscape.com)
  • His work on Ejection fraction, Artery and Coronary arteries as part of general Cardiology study is frequently linked to In patient, bridging the gap between disciplines. (research.com)
  • We report a case of Kounis syndrome type III (coronary thrombosis) variant in a 48-year-old man who had experienced recurrent acute myocardial infarctions after scallion-induced hypersensitivity reactions. (bvsalud.org)
  • His Angina, Ejection fraction, Chest pain and Ischemia study, which is part of a larger body of work in Cardiology, is frequently linked to Vasospasm, bridging the gap between disciplines. (research.com)
  • Consequences depend on degree and location of obstruction and range from unstable angina to non-ST-segment elevation. (msdmanuals.com)
  • Subsequently, Maseri et al described the clinical, ECG, and angiographic features of 138 patients with variant angina and concluded that the syndrome was considerably more polymorphic than was initially inferred by Prinzmetal. (medscape.com)
  • The reported prevalence of vasospastic angina varies considerably between clinical studies, depending in large part on the geographic location of the population studied, as well as on the criteria used to test and define the condition. (medscape.com)
  • [ 1 ] Unlike patients with typical angina, these patients characteristically had normal exercise tolerance, and their pain patterns tended to be cyclical, with most episodes occurring in the early morning hours without regard to cardiac workload. (medscape.com)
  • In some patients with partial vasoconstriction, symptoms can arise with activities that exceed a threshold of myocardial demand. (medscape.com)
  • [ 3 ] In other patients, constriction may be so severe that myocardial ischemia develops at rest. (medscape.com)
  • Statin therapy appears to improve clinical outcomes in patients with coronary spasm-induced acute myocardial infarction with nonobstructive coronary arteries. (medscape.com)
  • VF can result from acute myocardial infarction (MI) or ischemia, or from myocardial scarring from an old infarct. (medscape.com)
  • Yasue H, Touyama M, Kato H, Tanaka S, Akiyama F. Prinzmetal's variant form of angina as a manifestation of alpha-adrenergic receptor-mediated coronary artery spasm: documentation by coronary arteriography. (medscape.com)
  • Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm. (medscape.com)
  • Intracoronary injection of acetylcholine (Ach) has been shown to induce significant coronary artery spasm (CAS) in patients with vasospastic angina. (koreamed.org)
  • However, in this situation, intracoronary injection of acetylcholine (Ach) during CAG is useful for induction of significant coronary artery spasm (CAS) in patients with vasospastic angina. (koreamed.org)
  • Bet -blockers are beneficial in most patients with atherosclerotic coronary stenoses and exertional angina pectoris and are sometimes helpful in combination with the above drugs to achieve control of symptoms in these patients. (medscape.com)
  • Variant" angina: one aspect of a continuous spectrum of vasospastic myocardial ischemia. (medscape.com)
  • Yasue H, Omote S, Takizawa A, Nagao M, Miwa K, Tanaka S. Circadian variation of exercise capacity in patients with Prinzmetal's variant angina: role of exercise-induced coronary arterial spasm. (medscape.com)
  • Basal release of endothelium-derived nitric oxide at site of spasm in patients with variant angina. (medscape.com)
  • Ergonovine maleate testing during cardiac catheterization: a 10-year perspective in 3,447 patients without significant coronary artery disease or Prinzmetal's variant angina. (medscape.com)
  • The calcium channel blockers nifedipine, amlodipine, verapamil, and diltiazem effectively prevent coronary vasospasm and variant angina, and they should be administered in preference to beta blockers. (medscape.com)
  • Compared with the non-RAS inhibitor group, the RAS inhibitor group had a lower incidence of recurrent angina, total death, and total major adverse cardiovascular events during the 5-year clinical follow-up. (medscape.com)
  • In this situation, a diagnosis of vasospastic angina may be incorrectly applied, and important interventions to treat and prevent further atherosclerotic events may be delayed. (medscape.com)
  • Because atherosclerosis is common in patients with vasospastic angina, medical and lifestyle interventions for preventing or treating atherosclerosis should be implemented when appropriate. (medscape.com)
  • Nitroglycerin administered by any route (intracoronary, IV, topical, or sublingual) effectively treats episodes of angina and myocardial ischemia within minutes, and long-acting nitrate preparations reduce the frequency of recurrent events. (medscape.com)
  • However, nonselective beta blockers may be detrimental in some patients because blockade of the beta receptors, which mediate vasodilation, allows unopposed alpha receptor-mediated coronary vasoconstriction to occur and may worsen vasospastic angina in selected cases. (medscape.com)
  • Intracellular calcium accumulation, the action of free radicals, metabolic alterations, and autonomic modulation are important influences on the development of VF during ischemia. (medscape.com)