DiltiazemVerapamilAmlodipineArterial pressureEffect of nifedipineAntagonistsCoronaryPotentNitroglycerinDihydropyridinesInhibitsAnginaSelectiveVascularNegative inotropicSpasmHypertensionMedicinesBlockersFormulationHealthy volunteersDrugsClinicalVitroBlood pressureChronicEffectsExtended-releaseSignificantlyTreatmentTherapyPreviously reportedOral
Diltiazem9
- The relative potency of CCBs as vasodilators varies, with dihydropyridine-type compounds, such as nifedipine, regarded as the most potent subclass, and verapamil, diltiazem, and bepridil as somewhat less potent. (medscape.com)
- Nifedipine, verapamil, diltiazem are examples of calcium channel blockers that may be effective in chronic treatment of angina. (pharmacology2000.com)
- Publication types Comparative Study Research Support, Non-U. Bij angina pectoris (hartkramp), hartritmestoornissen en bij hoge bloeddruk Class 4 antiarrhythmics include the drugs verapamil and diltiazem, and these drugs function primarily by blocking Calcium channels at the heart. (seagullindia.com)
- Diltiazem, verapamil and nifedipine suppress sinoatrial (SA) nodal function in the excised rabbit heart. (seagullindia.com)
- Smeer het 's ochtends en 's avonds op de anusscheurtjes en op de huid rond de anus In terms of benzothiazepines, 2 studies combined diltiazem with nifedipine, 1 with nitrendipine, and 1 with felodipine. (seagullindia.com)
- In de tabel worden de eigenschappen van diltiazem, verapamil en nifedipine vergeleken. (seagullindia.com)
- 1) hartritmestoornissen (calciumblokkers met de stofnamen verapamil en diltiazem) fenomeen van Raynaud om verkrampte vaten in de huid te verwijden Effecten calciumblokkers Calcium is nodig om spieren te laten samentrekken. (seagullindia.com)
- Contractiliteit Bij een normale linkerventrikelfunctie wordt, net zoals het geval is met nifedipine en verapamil, geen buy renova cream uk verlies van functie waargenomen Class 4 antiarrhythmics include the drugs verapamil and diltiazem, and these drugs function primarily by blocking Calcium channels at the heart. (seagullindia.com)
- Clinical classification of pulmonary hypertension (Dana Stage, 2008) Open up in another window Medication therapy for PAH Based on our knowledge of the pathological systems of PAH, medication therapy for PAH offers progressed lately via the advancement of several particular medicines that offer a highly effective option to voltage-dependent Ca2+ route blockers such as for example nifedipine and diltiazem (4) (Fig. 1A). (scienceexhibitions.org)
Verapamil2
- In vitro, several calcium antagonists (e.g., nifedipine, nisoldipine, and isradipine) bind with some selectivity to the L-type calcium channel present in blood vessels, whereas verapamil binds equally well to cardiac and vascular L-type calcium channels. (medscape.com)
- nifedipine was also positive in patient 2, and verapamil in patient 3. (seagullindia.com)
Amlodipine3
- Examples include nifedipine and amlodipine. (rarediseaseshealthcenter.com)
- Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. (pharmacycode.com)
- Calcium Channel Blockers: nifedipine (Procardia) or amlodipine (Norvasc). (raynauds.co.in)
Arterial pressure2
- Nifedipine regularly reduces arterial pressure at rest and at a given level of exercise by dilating peripheral arterioles and reducing the total peripheral resistance (afterload) against which the heart works. (nih.gov)
- They are coronary vasodilators that reduce arterial pressure and myocardial contractility. (pharmacology2000.com)
Effect of nifedipine1
- It is probable that the Aldo inhibition and the vasodilatatory effect of nifedipine combine to bring about the lowering of blood pressure. (lml.com.ly)
Antagonists1
- There is some evidence that Angiotensin II receptor antagonists (often Losartan) reduce frequency and severity of attacks, and possibly better than nifedipine. (raynauds.co.in)
Coronary3
- Nifedipine dilates the main coronary arteries and coronary arterioles, both in normal and ischemic regions, and is a potent inhibitor of coronary artery spasm, whether spontaneous or ergonovine-induced. (nih.gov)
- This property increases myocardial oxygen delivery in patients with coronary artery spasm,and is responsible for the effectiveness of nifedipine in vasospastic (Prinzmetal's or variant) angina. (nih.gov)
- By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure. (pharmacycode.com)
Potent3
- Nifedipine is more a potent vasodilator and more effective in angina. (wikipedia.org)
- Epoprostenol (prostacyclin), a naturally occurring prostaglandin, is a potent vasodilator and inhibitor of platelet aggregation. (medscape.com)
- MESh caused a relaxing effect on KCl 80 mM-induced contraction and was less potent than nifedipine. (bvsalud.org)
Nitroglycerin2
- Glyceryl nitrate or trinitrate or nitroglycerin is a vasodilator used to treat cardiac disorders like ischemia and mainly anal fissures. (e-lactancia.org)
- Nitroglycerin is in a class of medications called vasodilators. (medlineplus.gov)
Dihydropyridines1
- Nifedipine and the other dihydropyridines primarily are vasodilators and have no clinical effects on cardiac conduction or contractility. (aacnjournals.org)
Inhibits3
- Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle. (nih.gov)
- Nifedipine selectively inhibits calcium ion influx across the cell membrane of cardiac muscle and vascular smooth muscle without changing serum calcium concentrations. (nih.gov)
- A calcium channel blocker, nifedipine inhibits calcium ion flux across the slow calcium channels, thereby inhibiting the contractile process of cardiac and vascular smooth muscle. (medscape.com)
Angina4
- This unloading of the heart reduces myocardial energy consumption and oxygen requirements and probably accounts for the effectiveness of nifedipine in chronic stable angina. (nih.gov)
- Nifedipine is a commonly used agent in treating hypertension and angina because of its vasodilator properties. (lml.com.ly)
- Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. (pharmacycode.com)
- Bij angina pectoris (hartkramp), hartritmestoornissen en bij hoge bloeddruk Side effects of these drugs include constipation, bradycardia, and hyperprolactinemia. (seagullindia.com)
Selective2
- In both patients these lesions receded during the course of therapy with a selective arteriolar vasodilator, nifedipine.These observations are discussed in relation to the possible pathogenesis of the retinopathy seen in patientswith sickle cell anemia. (researchwithrutgers.com)
- The vascular endothelium modulates contractile responses to 5-HT and ET-1 in human subcutaneous resistance arteries but this effect is lost in patients with NPG, indicating a selective defect in agonist mediated release of endothelium derived vasodilators. (bmj.com)
Vascular5
- The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and the resulting reduction in peripheral vascular resistance. (nih.gov)
- Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. (nih.gov)
- The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. (nih.gov)
- Still, its vasodilator effects on the vascular system were not reported yet. (bvsalud.org)
- Fig. 1B), a powerful vasodilator made by vascular endothelium, was the 1st drug authorized by the U.S. Meals and Medication Administration (FDA) for the treating PAH. (scienceexhibitions.org)
Negative inotropic1
- In contrast to other calcium channel blockers, nifedipine has little or no effect on cardiac conduction and little negative inotropic effect. (medscape.com)
Spasm1
- He, G.W., Fan, K.Y., Chiu, S.W. and Chow, W.H. (2000) Injection of Vasodilators into Arterial Grafts through Cardiac Catheter to Relieve Spasm. (scirp.org)
Hypertension1
- The use of vasodilators to counteract vasoconstriction in IPAH is based on both theory and on pathologic studies that implicate medial hypertrophy and vessel constriction in the pathogenesis of idiopathic pulmonary artery hypertension. (medscape.com)
Medicines2
- She put me on steroids and a few medicines like methotrexate and the vasodilator Nifedipine. (sclerounited.us)
- These medicines may include calcium-channel blockers (nifedipine), taken by mouth, or beta blockers (labetalol) or vasodilators (hydralazine), given through an IV. (dogubayazithaberajansi.com)
Blockers4
- Nifedipine is an antianginal drug belonging to a class of pharmacological agents, the calcium channel blockers. (nih.gov)
- Nifedipine is a drug belonging to a class of pharmacological agents known as the calcium channel blockers. (nih.gov)
- No matter when the next time is, Karl believes that the skeleton will recover, and he must try his best to calm does saw palmetto and pygeum interfere with blood pressure medication down and not attract the nifedipine er 50 mg side effects attention calcium channel blockers for anxiety rx pills for blood pressure of the surrounding skeleton people. (ytu.edu.mm)
- According to most of the doctors, calcium channel blockers ( Nifedipine 1 ) is the safest drug for us. (raynauds.co.in)
Formulation1
- This study was designed to examine the impact of a sustained release nifedipine formulation on Aldo biosynthesis and its clinical consequences. (lml.com.ly)
Healthy volunteers1
- Patients with hepatic impairment (liver cirrhosis) have a longer disposition half-life and higher bioavailability of nifedipine than healthy volunteers. (nih.gov)
Drugs3
- Vasodilators: These drugs help relax the blood vessels and improve blood flow. (rarediseaseshealthcenter.com)
- Mothers have complained of headaches that commonly occur with the use of various vasodilators drugs. (e-lactancia.org)
- The amount of nitrate / nitrite in this type of vasodilator drugs is of few milligrams, therefore, toxicity associated to nitrates such as methemoglobinemia in breastfed infants from treated mothers has not been reported (The dose of nitrite is Rectogesic 1.5 mg / 12 hours). (e-lactancia.org)
Clinical1
- The first American clinical trial of nifedipine in cardioplegia. (wustl.edu)
Vitro2
- An inhibitory role of nifedipine on aldosterone (Aldo) biosynthesis has been documented in in vitro studies. (lml.com.ly)
- The fall in the Aldo/PRA ratio during nifedipine treatment indicates that the previously reported in vitro inhibition of Aldo biosynthesis in adrenal cells is reproduced in vivo. (lml.com.ly)
Blood pressure2
- All currently available CCBs are vasodilators and thereby reduce blood pressure. (medscape.com)
- Vasodilators lower blood pressure by relaxing the blood vessels and improve blood flow. (towerhealth.org)
Chronic1
- Since hepatic biotransformation is the predominant route for the disposition of nifedipine, the pharmacokinetics may be altered in patients with chronic liver disease. (nih.gov)
Effects2
- Effects of nifedipine treatment on the renin-angiotensin-aldosterone axis. (lml.com.ly)
- Early and late effects of nifedipine on Aldo, PRA, and Aldo/PRA ratio levels were studied in a single blind, placebo-controlled, 10-day pilot study. (lml.com.ly)
Extended-release2
- Each extended-release tablet, formulated as a once-a-day controlled release tablet for oral administration, delivers 30 or 60 mg of nifedipine. (nih.gov)
- Nifedipine Extended-release Tablets meet USP Dissolution Test 3. (nih.gov)
Significantly1
- When individual time points were examined in the normotensive subjects, Aldo/PRA levels were significantly lower on day 8 of nifedipine treatment at 1000, 1200, and 1400 h than corresponding values on the control day. (lml.com.ly)
Treatment1
- Blood samples for the measurement of Aldo and PRA were obtained at 2-h intervals for 10 h on a control day and on days 1 and 8 of nifedipine treatment for the determination of baseline, early, and late values. (lml.com.ly)
Therapy1
- Before the age of vasodilator therapy, most children died within 1-2 years of diagnosis, whereas adults had a median survival of 2-3 years. (medscape.com)
Previously reported1
- Phytochemical analysis of MESh suggests the presence of mannitol, previously reported as a vasodilator on aortic rings. (bvsalud.org)
Oral2
- Nifedipine capsules are formulated as soft gelatin capsules for oral administration each containing 10 mg nifedipine. (nih.gov)
- Nifedipine is rapidly and fully absorbed after oral administration. (nih.gov)