• impairment
  • In conclusion, our observations indicate that during the developmental phase of hypertension in the SHR model, namely, during the prehypertensive as well as the early established hypertensive stage, NO-dependent vasodilation is preserved (if not enhanced) so that a putative impairment of this function provides no significant pathogenic contribution to the onset of hypertension in this experimental model. (ahajournals.org)
  • Rats
  • Studies were undertaken to determine whether defective renal vasodilation in Dahl salt-sensitive rats is due to impaired production of cGMP. (ahajournals.org)
  • 8 To define the role of cGMP in renal vasodilation in DR and DS rats, we compared cGMP excretion with RVR in response to various levels of salt intake and to NP infusion in both strains of rats. (ahajournals.org)
  • Thus
  • Thus, vasodilation works mainly either by lowering intracellular calcium concentration or by dephosphorylation (really substitution of ATP for ADP) of myosin. (wikipedia.org)
  • 15 16 17 18 NO thus formed in endothelial cells causes vasodilation by stimulating vascular smooth muscle soluble guanylyl cyclase and elevating cGMP levels. (ahajournals.org)
  • An experiment has shown cold acclimation minimizes the hunting reaction (reduced mean temperature of the digits and a prolonged time of cold exposure prior to initial vasodilation), thus putting the hand at a greater risk of cold injury when it is exposed to cold. (wikipedia.org)
  • clinical
  • Further clinical studies would be needed to determine whether the higher incidence of vasodilation may also be attributed to the increased BAK concentration in the bimatoprost 0.01% formulation. (dovepress.com)
  • time
  • Incidence of vasodilation was calculated as the percent of total eyes in each 2-hour time interval with scores ≥2. (dovepress.com)
  • The incidence of vasodilation was higher in the bimatoprost 0.01% treatment group (range, 45.0% to 60.0%) than the bimatoprost 0.03% treatment group (range, 30.0% to 52.2%) at all post-dosing time points. (dovepress.com)
  • primary
  • Research carried out in 1989 found PGD2 is the primary mediator of vasodilation (the "niacin flush") after ingestion of niacin (nicotinic acid). (wikipedia.org)
  • higher
  • 6 hours) in the guinea pig model, with the bimatoprost 0.01% treatment group showing a higher incidence of ocular vasodilation than the bimatoprost 0.03% treatment group. (dovepress.com)
  • measure
  • Animals were hand-held under 2.75 × magnification to score ocular vasodilation (a measure of hyperemia), using a scoring system developed at Alcon Research, Ltd. Following baseline ocular scoring, each animal received a 30 μL dose to the left eye of either bimatoprost 0.01% (3 μg) or bimatoprost 0.03% (9 μg). (dovepress.com)
  • function
  • Conclusions- These data demonstrate a strong association between aldosterone excess and impaired endothelial function in human subjects as indexed by flow-mediated arterial vasodilation. (ahajournals.org)