Loading...



  • RCVS
  • Acquiring these data at multiple time points during RCVS progression, the investigators will assess the relationship between vasoconstriction and downstream perfusion and determine the role of these imaging techniques in early and accurate diagnosis of RCVS. (clinicaltrials.gov)
  • depending on the degree of vasoconstriction, RCVS may be associated with cortical subarachnoid haemorrhage (in approximately 34% of patients), ischaemic infarction (6-39% of patients), or concomitant posterior reversible encephalopathy syndrome (PRES, 9-38% of patients). (clinicaltrials.gov)
  • The hallmark of RCVS is vasoconstriction seen on vascular imaging scans and typically reverses within 3 months. (clinicaltrials.gov)
  • Prevalence of radiological vasoconstriction seen on magnetic resonance angiography (MRA) in RCVS is reported to be between 60-90% and typically appears as diffuse segmental constriction of large and medium sized vessels lasting 4-12 weeks. (clinicaltrials.gov)
  • RCVS is diagnosed by detecting diffuse reversible cerebral vasoconstriction. (wikipedia.org)
  • systemic
  • Depending on the vascularity of the injection site, vasoconstriction induced by local anesthetic and the addition of epinephrine may contribute to decreased absorption of local anesthetics into systemic circulation [ 14 ]. (hindawi.com)
  • Causes
  • This depolarization activates voltage-dependent calcium channels, which increases intracellular calcium and activates smooth muscle contractile machinery which in turn causes vasoconstriction. (wikipedia.org)
  • partially
  • The vasoconstriction was only partially inhibited by calcium channel blockade with verapamil. (ahajournals.org)
  • This leads to prolonged nerve exposure to local anesthetics and reduced plasma levels, in addition to the potency of intrinsic vasoconstriction being partially associated with duration of anesthesia produced by the local anesthetic [ 3 , 14 ]. (hindawi.com)
  • receptors
  • 20 - 26 Furthermore, inhibitory effects of 17β-estradiol on COX-dependent responses to vasoconstrictors have suggested a role of estrogen receptors, 27 although the specific estrogen receptor(s) involved in endothelium-dependent vasoconstriction have not been identified. (ahajournals.org)
  • decrease
  • Similar postangioplasty vasoconstriction was observed in the pig carotid arteries (decrease in minimal vessel cross-sectional area of 41% [angioplasty segment] versus 2% [control segment]) (p less than 0.005). (ahajournals.org)
  • concentration
  • Regression analyses were performed to determine the relationship between the reported physicochemical properties of local anesthetics and the local anesthetic concentration that produced 50% (ED 50 ) of the local anesthetic-induced maximum vasoconstriction. (hindawi.com)
  • However
  • However, to our knowledge, the physicochemical property of local anesthetics that is primarily responsible for determining the local anesthetic-induced vasoconstriction potency has not yet been identified. (hindawi.com)
  • aims
  • Therefore, the aims of this in vitro study were to investigate the potency of local anesthetic-induced vasoconstriction and to determine which physicochemical property is principally involved in determining this potency in isolated rat aortic rings. (hindawi.com)
  • induced by local
  • The potency of the vasoconstriction in the endothelium-denuded aorta induced by local anesthetics is determined primarily by lipid solubility and, in part, by other physicochemical properties including potency and pKa. (hindawi.com)
  • local
  • The goals of this in vitro study were to investigate the potency of local anesthetic-induced vasoconstriction and to identify the physicochemical property (octanol/buffer partition coefficient, pKa, molecular weight, or potency) of local anesthetics that determines their potency in inducing isolated rat aortic ring contraction. (hindawi.com)