Vascular smooth basic helix loop helix transcription factors. Medical search. Frequent questions

Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179. (jefferson.edu)
These include efficient drug delivery, infiltration of immune cells by reducing the heterogeneity of intratumoral blood flow, and increased vascular permeability caused by tight associations between endothelial cells and perivascular cells [ 9 , 10 ]. (biomedcentral.com)

bFGF is a more potent angiogenic factor than VEGF ( vascular endothelial growth factor ) or PDGF ( platelet-derived growth factor ). (beauty104.com.tw)

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. (jax.org)
MECs were found to express numerous proteinase inhibitors, anti-angiogenic factors, and tumour suppressors proteins. (biomedcentral.com)
Mesp1 (mesoderm posterior 1) is a basic helix-loop-helix-type transcription factor, which along with its related proteins, has an essential role in both segmentation and rostro-caudal patterning of somites in the anterior pre-somitic mesoderm. (thermofisher.com)
We also discuss normal synthesis of tachykinins and their receptors, yet focus on their regulation by microRNA, messenger RNA stabilizing proteins, and transcription factors like Restrictive Element-1 Silencing Factor (REST). (brainimmune.com)
Id proteins belong to the helix-loop-helix (HLH) family of transcriptional regulators, acting as dominant negative repressors of basic-HLH (bHLH) transcription factors [ 11 - 13 ]. (oncotarget.com)
Mechanistically, Id proteins dimerize with bHLH factors to repress their functions. (oncotarget.com)
Proteins that act both at the cell surface and intracellularly will be discussed in this thesis, with particular emphasis on the fibroblast growth factors. (beauty104.com.tw)
These proteins were found to be identical to the acidic and basic FGFs described by Gospodarowicz and coworkers. (beauty104.com.tw)

To search for mechanisms for the development of hypoxia, the morphology and function of the tumor vascular networks were studied with intravital microscopy and immunohistochemistry, and the expression of several angiogenesis-related genes was measured with quantitative PCR. (biomedcentral.com)
To overcome this limitation, we developed nanoparticles with antiseptic activity that target tumor vascular abnormalities. (biomedcentral.com)

Id1 is a member of the helix-loop-helix (HLH) family of transcriptional repressors that act as dominant-negative inhibitors of basic-HLH factors. (oncotarget.com)

Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro. (jax.org)
Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
Radcliff K, Tang TB, Lim J, Zhang Z, Abedin M, Demer LL, Tintut Y. Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways. (jefferson.edu)
Epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF-2) induce the proliferation of neural precursor cells isolated from specific regions of the embryonic and adult brain. (beauty104.com.tw)
Not long after FGF1 and FGF2 were isolated, another group isolated a pair of heparin -binding growth factors which they named HBGF-1 and HBGF-2, whilst a third group isolated a pair of growth factors that caused proliferation of cells in a bioassay containing blood vessel endothelium cells which they called ECGF-1 and ECGF-2. (beauty104.com.tw)

The receptor protein has seven transmembrane α-helices connected by alternating cytosolic and extracellular loops. (pancreapedia.org)
The TME consists of various cellular components, including immune cells, stromal cells, and extracellular matrix, along with soluble factors and signaling molecules. (biomedcentral.com)

Tumor hypoxia is a consequence of inadequate oxygen supply caused by extensive abnormalities in the vascular network [ 2 ]. (biomedcentral.com)
These morphological abnormalities collectively increase the geometric resistance to blood flow and impair vascular function [ 7 ]. (biomedcentral.com)
Studies of macroscopic experimental tumors have shown that the severity of the vascular abnormalities increases during tumor growth, resulting in reduced blood supply and increased extent of hypoxia [ 8 ]. (biomedcentral.com)

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. (jax.org)
Fibroblast growth factors , or FGFs , are a family of growth factors involved in wound healing and embryonic development. (beauty104.com.tw)

Two of the four investigated melanoma models developed hypoxic regions in microscopic tumors, and the development of hypoxia was associated with poor vascular pericyte coverage and inadequate vascular function. (biomedcentral.com)
Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation. (ox.ac.uk)
Even though the exact mechanisms underlying ischemic injury in the muscle are not completely understood, hypoxia-inducible factor-1 alpha (HIF-1α) has emerged as an attractive target to enhance post ischemic angiogenesis. (frontiersin.org)

In an effort to identify novel bHLH factors related to dHAND and eHAND (a novel subclass of cell type-restricted bHLH factors shown to play important roles in cardiac morphogenesis), they screened expressed sequence tag (EST) databases for sequences with homology to the bHLH regions of these factors. (wikipedia.org)

Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells. (targetmol.com)
Although vascular endothelial growth factor (VEGFA-165) is primarily known for its role in angiogenesis, it also plays important neurotrophic and neuroprotective roles for spinal motor neurons. (jneurosci.org)
Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signaling pathway. (biomedcentral.com)

Transcription factor 21 (TCF21), also known as pod-1, capsuling, or epicardin, is a protein that in humans is encoded by the TCF21 gene on chromosome 6. (wikipedia.org)
Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
In this study we used phosphorylation of the transcription factor cAMP response element-binding protein as a functional readout to identify cells responding to EGF and FGF-2. (beauty104.com.tw)
In conclusion, short-term activation of protein kinase C leads to a transient increase in Na/H antiporter activity that is independent of transcription and translation, whereas long-term activation of protein kinase C causes a persistent increase in antiporter activity that is dependent on transcription and translation and is associated with increased mRNANa/H abundance. (jci.org)

COX-2 is also regulated by epidermal growth factor receptor signaling which is important in the pathogenesis of GBMs. (oncotarget.com)

HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. (jax.org)

Phortress is a potent AhR ligand with strong binding affinity, which subsequently triggers the transcription of CYP1A1 and induces antitumor activity. (targetmol.com)

Therefore, damaging the MECs layer resulted in the release of various factors (such as SDF1/CXCL12, CXCL14, MMP, and tenascin) [ 11 , 12 ] with a potential to modify the tumour microenvironment and facilitate the paracrine communication between the tumour epithelial cells and the enclosed stroma enhancing the tumour aggressiveness [ 11 , 13 ]. (biomedcentral.com)

Because another growth/trophic factor that signals via a receptor tyrosine kinase (brain derived neurotrophic factor) elicits a long-lasting facilitation of respiratory motor activity in the phrenic nerve, we tested the hypothesis that VEGFA-165 elicits similar phrenic motor facilitation (pMF). (jneurosci.org)

PCNs induced PAR-1/PAR-3 heterodimerization through EPCR occupation and PAR-1 activation, which resulted in Gα13-RhoA-mediated-Tie2 activation and stabilized vascular tight junctions via the Akt-FoxO3a signaling pathway. (biomedcentral.com)

It was concluded that capsulin heterodimerizes with E12 and binds the specific E-box consensus sequence (CANNTG), though not activating transcription through this sequence on its own. (wikipedia.org)
Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs (Olsen et al. (beauty104.com.tw)

Morphologic and functional parameters of vascular networks were assessed with intravital microscopy, and the expression of angiogenesis-related genes was assessed with quantitative PCR. (biomedcentral.com)
However, FGFs 11-14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functional differences compared to the FGFs. (beauty104.com.tw)

This can either occur by cell surface receptor interactions, as in the case with peptide growth factors, or by interactions with intracellular molecules, as in the case with steroid hormones. (beauty104.com.tw)
Each plasmodesma allows the transport of molecules between cells through the connected cytoplasm as well as through a desmotubule, the tubular continuation of the smooth endoplasmic reticulum. (jove.com)

In addition to temporal changes in growth factor presentation, mechanical stiffness of tissues is also dynamically altered over time. (5dok.org)

The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. (jax.org)
The three peptides are encoded by distinct genes and are regulated at the level of mRNA transcription. (biomedcentral.com)

Knowledge about how growth factors and hormones function is pivotal in order to rationally try to stimulate or inhibit their effects for therapeutical purposes. (beauty104.com.tw)

The aryl hydrocarbon receptor (AHR) is a member of the basic helix-loop-helix-period-aryl hydrocarbon receptor nuclear translocator-single-minded (bHLH-PAS) family of transcription factors, which act as biological sensors by initiating gene expression programs in response to endogenous and exogenous signals. (targetmol.com)

This factor has been shown to be regulated by COX-2 in breast carcinoma cells and recent studies suggest that Id1 may also be involved in the genesis/progression of gliomas. (oncotarget.com)
After growth factor treatment for 6 d, a population of nestin-positive cells responding to both EGF and FGF-2 were identified. (beauty104.com.tw)

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. (jax.org)
The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina. (jax.org)
Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism. (springer.com)

Inadequate vascular function was not caused by low vessel diameters or long vessel segments, but was associated with poor vascular pericyte coverage. (biomedcentral.com)

While the antithrombotic activity of APC is based on its ability to inactivate clotting factors Va and VIIIa, leading to adverse bleeding, the cytoprotective effect is based on its anti-inflammatory, antiapoptotic, and endothelial barrier stabilization activities [ 12 , 14 ]. (biomedcentral.com)
physical activity [Term] id: XCO:0000008 name: running def: "Condition in which the major influencing factor is the action of rapid movement of feet that propels the organism forward or is done on an exercise machine so that the organism performs the activity in place. (mcw.edu)

The development of hypoxic regions was not caused by low vessel density, but was rather a result of inadequate vascular function. (biomedcentral.com)

however, mRNAs encoding a subset of factors important for error-free replication and chromosome segregation, including TIPIN, PLK2 and PLK3, remain at low abundance. (babraham.ac.uk)

To keep the cognitive symptoms BMS 794833 of schizophrenia a target of intensive research to discover both the pathophysiological relevant factors, and highlight potential Pharmacotherapeutic strategies. (cd177signaling.com)

The coadministration of cisplatin with PCNs induced a synergistic suppression of tumor growth by improving drug delivery as evidenced by increased blood prefusion and decreased vascular permeability. (biomedcentral.com)

running [Term] id: XCO:0000006 name: swimming def: "A condition in which the main influencing factor is the action of moving one's appendages to propel oneself through water. (mcw.edu)

Unlike skeletal muscles, smooth muscles present in the walls of internal organs are innervated by the autonomic nervous system and undergo involuntary contractions. (jove.com)

Today, the distance from basic science to applied therapy is not always long. (beauty104.com.tw)

If you have using wholesale malformations and Transcending factors, you genealogists walk an graduate and developmental frame Please. (cutechabeads.com)

Fibroblast growth factor was found in a cow brain extract by Gospodarowicz and colleagues and tested in a bioassay which caused fibroblasts to proliferate (first published report in 1974). (beauty104.com.tw)

Anatomy9

Organisms3

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes23

Information Science3

Endothelial cells2

VEGF1

Proteins8

Tumor vascular2

Transcriptional repressors1

Proliferation5

Extracellular2

Abnormalities3

Embryonic2

Hypoxia3

BHLH factors1

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Protein4

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