• We have previously demonstrated that a failure of pulmonary endothelial cell survival induced by vascular endothelial growth factor (VEGF) receptor blockade results in lung alveolar septal cell apoptosis and emphysema. (nih.gov)
  • In this study, we used an inducible transgenic mouse model in which c-Myc was targeted to the epidermis and, after activation, gave rise to hyperplastic and dysplastic skin lesions and to dermal angiogenesis, involving both vascular endothelial growth factor (VEGF) receptor-1 and VEGF receptor-2. (ox.ac.uk)
  • Blocking VEGF signaling in vivo significantly reduced dermal angiogenesis, demonstrating the importance of VEGF as a mediating factor for the c-Myc-induced angiogenic phenotype. (ox.ac.uk)
  • Vascular endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene. (wikipedia.org)
  • VEGF-B is a growth factor that belongs to the vascular endothelial growth factor family, of which VEGF-A is the best-known member. (wikipedia.org)
  • In contrast to VEGF-A, VEGF-B plays a less pronounced role in the vascular system: Whereas VEGF-A is important for the formation of blood vessels, such as during development or in pathological conditions, VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. (wikipedia.org)
  • In this study, we explore the role of HMGB1 in advanced glycation end products (AGEs)-induced vascular endothelial growth factor A (VEGF-A) production in rat retinal ganglion cell line 5 (RGC-5) cells. (molvis.org)
  • The other inhibitor blocks the action of vascular endothelial growth factor (VEGF), which stimulates the growth of new blood vessels that tumors need to grow beyond a certain size. (sciencedaily.com)
  • To measure intravitreal low-density lipoprotein receptor-related protein 6 (LRP6) and vascular endothelial growth factor (VEGF) levels in the eyes of patients with proliferative diabetic retinopathy (PDR) and to observe their correlation with PDR activity. (molvis.org)
  • 2005). The vascular endothelial growth factor (VEGF) is a 46 kD dimeric glycoprotein secreted by neoplastic cells, macrophages, plasma cells and lymphocytes, which triggers endothelial cell proliferation by interacting with specific receptors in a paracrine or autocrine fashion (Ferrara 2004). (vin.com)
  • Vascular endothelial growth factor (VEGF) is an essential angiogenic factor for formation of the embryonic vasculature, and also has important roles in pathological conditions such as diabetic retinopthy, rheumatoid arthritis and cancer. (figshare.com)
  • The present study investigated the effects of GSK2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (ATF4), CCAAT/enhancer‑binding protein homologous protein (CHOP) and vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells under endoplasmic reticulum (ER) stress. (spandidos-publications.com)
  • In addition, RPE cells proliferate and secrete various proangiogenic factors, including vascular endothelial growth factor (VEGF), which serves an important role in AMD-associated CNV ( 4 ). (spandidos-publications.com)
  • Since 2000, the intravitreous vascular endothelial growth factor (VEGF) inhibitors bevacizumab, aflibercept and ranibizumab accounted for 99 ICSRs. (smw.ch)
  • In particular, new ocular drugs, such as vascular endothelial growth factor (VEGF) inhibitors, which have increasingly been prescribed since their approval in the middle of the last decade, are potentially related to numerous systemic ADRs. (smw.ch)
  • Tumor angiogenesis is a consequence of an imbalance between pro-angiogenic factors, such as the vascular endothelial growth factor (VEGF) family and IL-8/CXCL8, and inhibitors of angiogenesis, including endostatin, angiostatin and other related molecules [ 14 - 16 ]. (biomedcentral.com)
  • ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)
  • VEGF as an angiogenic growth factor and 20 weeks of pregnancy. (who.int)
  • They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. (bvsalud.org)
  • c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. (ox.ac.uk)
  • Although vascular endothelial growth factor (VEGFA-165) is primarily known for its role in angiogenesis, it also plays important neurotrophic and neuroprotective roles for spinal motor neurons. (jneurosci.org)
  • Results Our findings indicate that the platelets in HD are dysfunctional with respect to the release of angiogenic factors and functions including thrombosis, angiogenesis and vascular haemostasis. (bmj.com)
  • Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. (drugbank.com)
  • Anticoagulant medication (low-molecular weight heparin) could inhibit this effect by reducing levels of von Willebrand Factor and also preventing the migration of cancer cells across an endothelial cell layer in the lab. (b-s-h.org.uk)
  • 2022) "Breast cancer cells mediate endothelial cell activation, promoting von Willebrand Factor release, tumour adhesion and transendothelial migration. (b-s-h.org.uk)
  • Diabetes causes retinal microvasculopathy associated with pericyte cell death, microaneurysms, abnormal vascular permeability, and macular edema. (molvis.org)
  • vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. (who.int)
  • My research work delves into the involvement of TGFbeta signaling pathway components in vascular biology and cancer. (ucsf.edu)
  • Existing studies have shown that there is crossover between Renin-Angiotensin-Aldosterone (RAAS) signaling pathway and TGF-β pathway, but little is known about whether ARB drug losartan can block Angiotensin-II (Ang-II) signaling pathway, inhibit the activation of Transforming Growth Factor- Beta (TGF-β) pathway, and regulate vascular remodeling. (ijpsonline.com)
  • Numerous randomized controlled trials have found that statins reduce myocardial infarction (MI), ischemic stroke , and vascular mortality, starting with the Scandinavian Simvastatin Survival Study. (medscape.com)
  • A meta-analysis of randomized controlled trials including 170,000 participants found that participants on statin therapy had a 22% reduction in risk, per every 1-mmol/L (39 mg/dL) reduction in low-density lipoprotein cholesterol (LDL-C), for major vascular events ( coronary heart disease , ischemic stroke, and revascularization procedures) compared with those on placebo or standard therapy. (medscape.com)
  • The association of potential effector proteins with the VEGFRs were assessed in both yeast and mammalian cells, and the identity of the interacting residues was probed using site-directed mutagenesis and peptide competition experiments. (figshare.com)
  • Heparin and HS have been associated with cell-biological processes, cell adhesion and regulation of enzymatic catalysis while HS chains have been shown to interact with a variety of growth factors (fibroblast growth factors and vascular endothelial growth factor), chemokines, ECM proteins, enzymes, and antithrombin. (caslab.com)
  • Here we demonstrate that the Arabidopsis HAIRY MERISTEM (HAM) family of transcription regulators act as conserved interacting cofactors with WUS/WOX proteins. (caltech.edu)
  • Losartan has protective effect on aortic wall of rats with aortic dissection, and the mechanism may be through inhibiting transforming growth factor-beta 1 pathway, which activates downstream phosphoinositide 3-kinase/protein kinase B pathway related proteins, and then inhibits the expansion and progression of aortic dissection. (ijpsonline.com)
  • These prompted us to hypothesize that the secreted IbeA may interact with membrane proteins expressed on host cell surface. (microbialcell.com)
  • Then, we used a yeast two-hybrid system to screen the interacting proteins of IbeA in human brain microvascular endothelial cells (HBMECs). (microbialcell.com)
  • MRI was performed at 3Tesla and cardiovascular risk factors (eg, age, smoking history, and hypertension), cerebral small vessel disease (CSVD) markers (eg, white matter hyperintensities, lacunar infarction, and enlarged perivascular space) and genetic information (eg, APOE, CR1) were recorded. (dovepress.com)
  • Further analysis found that in addition to the above three risk factors, hypertension (OR=2.98, 95% CI: 1.16- 7.64), lacunar infarction (OR=2.39, 95% CI: 1.19- 4.81) also increased the risk of deep/mixed CMBs. (dovepress.com)
  • Hypertension, physical trauma, smoking, previous cardiac surgery, male sex and genetic diseases are risk factors for AD[ 2 ]. (ijpsonline.com)
  • hypertension, smoking, obesity, physical inactivity, unhealthy diet, high cholesterol, excessive alcohol consumption and diabetes .5,6 These risk factors are amenable to prevention or control through the adoption of appropriate health policies by governments which encourage the adoption of healthy lifestyles by individuals. (who.int)
  • The endothelium appears to be damaged both by AF and various other vascular diseases (e.g. hypertension) that frequently co-exist with the arrhythmia, with similar disruption to endothelial repair (normally effected by endothelial progenitor cells). (bham.ac.uk)
  • 14.9% (95% confidence interval [CI]: 13.8%-16.0%) of reported sociodemographic and descriptive characteristics eligible respondents who reported regular aspirin use and included age, sex, race/ethnicity, education, and selected who had ASCVD also reported using aspirin for pain relief, ASCVD risk factors (hypertension, diabetes, high cholesterol, and 4.2% (CI: 3.5%-4.9%) of eligible respondents reported current smoking). (cdc.gov)
  • High-mobility group box 1 protein (HMGB1) has been reported to be a potent proangiogenic factor induced by inflammatory stress. (molvis.org)
  • VHL disease is characterized by retinal capillary hemangiomas (also called benign vascular hamartomas). (medscape.com)
  • ATF4 induces expression of the proapoptotic transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP), which mediates PERK-induced apoptosis ( 16 ). (spandidos-publications.com)
  • Abnormal vascular remodeling is the core cause of neointimal formation, mediator degeneration and cell dysfunction, which leads to atherosclerosis and vascular dilatation and other diseases[ 3 ]. (ijpsonline.com)
  • 4. The growth in the incidence of CVDs in Africa is linked to the adoption of lifestyles that, along with other factors, increase the possibility of being affected by these diseases. (who.int)
  • When a patient presents with myopathy, the statin should be stopped and an evaluation conducted for other causes, such as strenuous exercise or other diseases, as well as for medications that interact with statins . (medscape.com)
  • This process activates protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 and activating transcription factor (ATF) 6, and initiates unfolded protein response (UPR) signaling pathways ( 13 , 14 ). (spandidos-publications.com)
  • When they also examined in lab experiments how breast cancer triggers high levels of von Willebrand Factor, they found breast tumour cells cause the release of the clotting protein from endothelial cells, the cells which form the inside lining of blood vessels. (b-s-h.org.uk)
  • Dr Jamie O'Sullivan, of the Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI, said: "Our findings now show, for the first time, that this blood clotting may be caused by increased levels of a key pro-clotting protein, von Willebrand Factor, and that the breast tumour cells directly interact with the blood vessel wall to promote release of this protein. (b-s-h.org.uk)
  • To investigate the effect of losartan on vascular remodeling and transforming growth factor-beta and phosphoinositide 3-kinase/protein kinase B pathway. (ijpsonline.com)
  • Hematoxylin and eosin staining was used to measure the thickness and diameter ratio of the aortic media of mice in each group, Masson staining was used to observe the content of collagen fibers in the aorta of mice in each group, elastic fibers in the aorta of mice in each group were stained, and transforming growth factor-beta and phosphoinositide 3-kinase/protein kinase B pathway protein expression. (ijpsonline.com)
  • CR001 is a fragment of a naturally occurring human protein that inhibits the tissue factor-initiated pathway of coagulation. (bioworld.com)
  • B. Identify and understand the mechanisms by which infections, inflammation, environment, vascular changes, perinatal exposures or insults, trauma, and other causes and risk factors, alone and in combination, contribute to the development of the epilepsies and epilepsy-related conditions. (nih.gov)
  • Significantly, the endothelium also links a number of processes including inflammation, growth factors, the renin-angiotensin-aldosterone system among others, which may directly or indirectly lead to activation of the coagulation cascade. (bham.ac.uk)
  • A luciferase reporter assay was used to examine the transcriptional activity of nuclear factor kappa - light - chain - enhancer of activated B cells (NF-κB). (biomedcentral.com)
  • Because another growth/trophic factor that signals via a receptor tyrosine kinase (brain derived neurotrophic factor) elicits a long-lasting facilitation of respiratory motor activity in the phrenic nerve, we tested the hypothesis that VEGFA-165 elicits similar phrenic motor facilitation (pMF). (jneurosci.org)
  • In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
  • It physically binds to the receptor, which prevents another substance, called epithelial growth factor, from contacting the receptor and stimulating the cancer cells to grow. (sciencedaily.com)
  • In a recent paper (Nat Commun 9:2296), we identify Caspr1 as a host receptor for E. coli virulence factor IbeA to pave the way the penetration of bacteria through the BBB. (microbialcell.com)
  • Vascular Smooth Muscle Cells (VSMCs) are highly specialized cells that maintain vascular tone and ensure vascular contractility under physiological conditions. (ijpsonline.com)
  • How much is deposited depends on particle properties such as size, and physiological factors such as oral or nasal inhalation and exercise or rest. (lu.se)
  • Many studies suggested that deep CMBs may relate to hypertensive small vessel disease (HTN-SVD) and strictly lobar CMBs for cerebral amyloid angiopathy (CAA), 1 but the risk factors of CMBs are not entirely clear. (dovepress.com)
  • The iron then interacts with other cellular molecules to form DNA-damaging hydroxyl radicals. (diabeticlive.com)
  • C. Determine how alterations in molecular and cellular function interact with alterations in circuit and network function in the pathogenesis of cortical hyperexcitability and the clinical epilepsies. (nih.gov)
  • Heparin, low molecular weight heparins (LMWH) and ultra-low molecular weight heparins (ULMWH) are widely used as anticoagulant drugs and they have been shown to regulate cellular process by binding, stabilizing and activating various growth factors. (caslab.com)
  • Writing in the Journal of Thrombosis and Haemostasis , they say analysing von Willebrand Factor levels may be useful to help predict clinical outcomes in patients with breast cancer. (b-s-h.org.uk)
  • The reported drugs were categorised as "suspected" in 51.1%, "concomitant" in 43.3% and "interacting" in 2.6% of cases. (smw.ch)
  • The first cases were described in 1988 in patients taking lovastatin, including several patients with a kidney transplant using concomitant cyclosporine , which is now known to be an interacting medication. (medscape.com)
  • Furthermore, the minor amounts of fetal cells and tissue debris that may accompany the amniotic fluid into the maternal circulation are too small to mechanically obstruct enough of the pulmonary vascular tree to cause the marked hemodynamic changes that occur in this syndrome. (msdmanuals.com)
  • The placenta responds by releasing a variety of substances, including chemicals that affect the lining of blood vessels (the vascular endothelium). (medlineplus.gov)
  • Trinam uses a biodegradable collagen collar to deliver vascular endothelial growth factor gene via an adenoviral vector. (bioworld.com)
  • Tissues cultured in the multi-organ chip (from left to right: skin, heart, bone, liver, and endothelial barrier) maintained their tissue-specific structure and function after being linked by vascular flow. (columbia.edu)
  • Plant stem cells in the shoot apical meristem (SAM) and root apical meristem are necessary for postembryonic development of aboveground tissues and roots, respectively, while secondary vascular stem cells sustain vascular development. (caltech.edu)
  • It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)
  • Additionally, heparin and HS molecules were found to mediate the viral adhesion and the infection process and considered as important factors in the host-pathogen interactions. (caslab.com)
  • IR promotes a cascade of molecular events that lead to renal vascular and tubular damage and, ultimately, acute kidney injury (AKI) [ 2 - 4 ]. (hindawi.com)
  • 2017 ). The current paper focuses on epidemiological and molecular genetic research studies in MZs with the purpose of unravelling useful insights on factors that can lead to SCZ and ASD. (springer.com)
  • Further characterization of these bacterial virulence factor in the context of pathogen-host interaction is necessary to elucidate the molecular mechanism of E. coli meningitis (ECM), which is helpful to design novel strategies for therapeutic interventions. (microbialcell.com)
  • Cardiovascular risk factors, CSVD markers, and genetic factors (APOE ϵ4, CR1 non-F/F isoform) were associated with CMBs, suggesting an interaction of multiple pathogenesis in Chinese stroke-free community population. (dovepress.com)
  • Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. (drugbank.com)
  • In contrast to the negative effects of Ang II on the renal circulation, Ang1-7 as a renoprotective agent improves endothelial function, which increases RBF and decreases renal vascular resistance (RVR) [ 16 ]. (hindawi.com)
  • Although happiness may vary between people based on personal experiences, the researchers found that life satisfaction - one of the factors that determines happiness - decreases after the age of nine and increases between the ages of 70 and 96. (medicaldaily.com)
  • Vascular endothelial growth factor B has been shown to interact with FLT1, NRP1 and NRP2. (wikipedia.org)
  • Researchers suggest that preeclampsia, heart disease, and stroke may share common risk factors. (medlineplus.gov)
  • A cross-sectional study focusing on the prevalence and risk factors of CMBs was conducted in stroke-free elderly from Shanghai Wuliqiao community. (dovepress.com)
  • In vitro methods for producing antibodies are amenable to large-scale production, meaning antibody availability is unlikely to become a limiting factor. (cellsignal.com)
  • Aim To test predictions of different large-scale biodiversity hypotheses by analysing species richness patterns of vascular plants in the Austrian Alps.Location The Austrian part of the Alps (c. 53,500 km2).Methods Within the floristic inventory of Central Europe the Austrian part of the Alps were systematically mapped for vascular plants. (researchgate.net)
  • Objectives Seeking to elucidate the origin of these vascular and BBB abnormalities, we studied platelets that are known to play a role in maintaining the integrity of the vasculature and thrombotic pathways linked to this, given they surprisingly contain the highest concentration of mHtt of all blood cells. (bmj.com)
  • The scientists designed one of the agents to prevent human epithelial growth factor from interacting with HER-2, a molecule that marks a particularly aggressive form of breast cancer. (sciencedaily.com)
  • Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION. (bvsalud.org)
  • Adipose cells organized in small clusters under the reticular dermis closely interact with hair follicular cells and regulate the hair cycle. (jcadonline.com)
  • These GAGs play an intricate role in the ECM, as polyelectrolytes by specifically interacting with growth factors and other transient components of the ECM. (caslab.com)
  • Bacterial IbeA interacts with endothelial Caspr1 to trigger intracellular focal adhesion kinase activation, leading to E. coli internalization into the brain endothelial cells. (microbialcell.com)
  • Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
  • The main risk factors for HCC include alcohol, tobacco, nonalcoholic fatty liver disease, and hepatitis B and C viruses, and an increase in incidence is anticipated due to the rise in hepatitis C infection corresponding to the opioid epidemic. (ajmc.com)
  • We also analyzed the associations between host factors, organism factors, and death versus survival, and quantifed the marginal contribution of key factors to risk for death. (cdc.gov)
  • However, data on the prevalence and risk factors of CMBs in the general population of China are lacking. (dovepress.com)
  • Poisson regression was used to analyze the risk factors of the presence and location of microbleeds. (dovepress.com)
  • These are called risk factors. (who.int)
  • The first set of risk factors for CVDs, which include family or personal history of cardiovascular disease, race ,2 gender 3 and age ,4 are not modifiable by interventions. (who.int)
  • 6Other established or probable risk factors have been identified. (who.int)
  • Hence, the focus is only on the "core" CVD risk factors which are being considered in this paper. (who.int)
  • Clinicians should therefore emphasize strategies to reduce cardiovascular risk even further among low-risk adults by treating modifiable risk factors (smoking, diabetes, blood pressure, hyperlipidemia, overweight, and exercise). (medscape.com)
  • In general, respondents risk factors. (cdc.gov)
  • Amniotic fluid embolism incidence, risk factors and outcomes: a review and recommendations. (msdmanuals.com)
  • As with exposure to fetal antigens, many of the risk factors are commonplace or at least much more likely than amniotic fluid embolism, and there is no good pathophysiologic understanding of why only a few women with risk factors develop the syndrome. (msdmanuals.com)
  • Effects on vascular disease and mortality were found to be similar in men and women of equivalent CV risk. (medscape.com)
  • D. Identify and understand the mechanisms by which factors related to age, sex, race/ethnicity, socioeconomic status, and other demographic features modulate epilepsy risk, drawing from discoveries in basic, translational, clinical, and population-level investigation. (nih.gov)
  • A neuroendocrine interaction with the physical environment accompanies (contributes to) a severe twice-yearly adynamia (possibly a beat cycle of cortisol and an unknown factor underlying the vigor's f (melatonin? (heartmath.org)
  • It is thought that vascular insuf- pre-eclampsia, and 24 patients with severe ficiencies during placentation contribute pre-eclampsia). (who.int)
  • The pathogenesis of eczema is complicated and is associated with genetic and environmental factors [ 6 ]. (hindawi.com)
  • As a result, twin studies of psychiatric disorders are greatly contributing to the elucidation of genetic and environmental factors in the etiology of psychiatric conditions. (springer.com)
  • Thus, genetic factors are thought to play a major role as compared to environmental factors (Rutter 2006 ). (springer.com)
  • The similarity of the genetic information in MZs provides a useful means for determining the disorder-causing role of environmental factors. (springer.com)
  • It is thought that different fetal antigens in varying amounts probably interact with unknown maternal susceptibility factors. (msdmanuals.com)
  • WUSCHEL (WUS), a homeodomain transcription factor expressed in the rib meristem of the Arabidopsis SAM, is a key regulatory factor controlling SAM stem cell populations, and is thought to establish the shoot stem cell niche through a feedback circuit involving the CLAVATA3 (CLV3) peptide signalling pathway. (caltech.edu)
  • Eczema is a complex chronic inflammatory skin disease impacted by environmental factors, infections, immune disorders, and deficiencies in skin barrier function. (hindawi.com)
  • The development of AD is also associated with vascular remodeling, according to pathological studies. (ijpsonline.com)
  • Treated mice also produced almost threefold more vascular endothelial growth factor. (diabeticlive.com)
  • Today, a team of researchers from Columbia Engineering and Columbia University Irving Medical Center reports that they have developed a model of human physiology in the form of a multi-organ chip consisting of engineered human heart, bone, liver, and skin that are linked by vascular flow with circulating immune cells, to allow recapitulation of interdependent organ functions. (columbia.edu)
  • WOX4, expressed in Arabidopsis procambial cells, defines the vascular stem cell niche. (caltech.edu)
  • 26,27 Dermal adipocytes are organized in small clusters under the reticular dermis and interact with the hair follicular cells regulating the hair cycle. (jcadonline.com)
  • However, these factors are either already taken care of through other initiatives or programmes (reproductive health, HIV/AIDS prevention and control), need more research or are not amenable to cost-effective preventive interventions. (who.int)
  • I have also taken on the role of Principal Investigator in numerous research projects funded by the NIH, focusing on areas like vascular stability, cancer immunotherapy, and vascular pathobiology. (ucsf.edu)
  • New research from RCSI University of Medicine and Health Sciences, Dublin, found that patients with breast cancer had very high levels of von Willebrand Factor in their blood and that individuals with the highest levels had the poorest outcomes. (b-s-h.org.uk)
  • In this review, we discuss the potential influence of stromal vascular fraction from adipose tissue in the management of alopecia as well as its involvement in preclinical and clinical trials. (jcadonline.com)