Four splice variants exist for this gene. (wikipedia.org)
Four alternatively spliced transcript variants encoding the same protein exist for this gene. (thermofisher.com)
Transcript variants1
Alternative splicing results in multiple transcript variants encoding different isoforms. (genemedi.net)
Proteins2
Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII. (wikipedia.org)
This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. (thermofisher.com)
Protein2
Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. (wikipedia.org)
The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. (genemedi.net)
Proprotein1
11 amino acids are removed from the N-terminus by the enzyme proprotein convertase 2 (PC2) while 16 are removed from the C-terminus of the proIAPP molecule by proprotein convertase 1/3 (PC1/3). (wikidoc.org)
Terminal2
Our laboratory has shown that up to 40 carboxy terminal residues of each subunit contribute to the stabilization of tetramers (R.M. Blong, E. Bedows, O. Lockridge, The tetramerization domain of butyrylcholinesterase is at the carboxy-terminus, Biochem. (inrae.fr)
[4] At the C-terminus Carboxypeptidase E then removes the terminal lysine and arginine residues. (wikidoc.org)
Peptides2
The K-variant (A539T) and C571A peptides showed interaction similar to that of the wild type. (inrae.fr)
Amylin also acts in bone metabolism, along with the related peptides calcitonin and calcitonin gene related peptide . (wikidoc.org)
FGL11
In humans, FGL-1 is encoded by the FGL1 gene. (wikipedia.org)
Tissue1
Validation of important genes in the GSE41571 dataset, cellular assays, and tissue samples. (bvsalud.org)
Expression3
Methods: Microarray data of atherosclerosis and foam cells were downloaded from the Gene Expression Omnibus (GEO) database. (bvsalud.org)
Differentially expression genes (DEGs) were screened using the "LIMMA" package in R software. (bvsalud.org)
HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
Common2
FGL-1 is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of that are common to all members of the fibrinogen family. (wikipedia.org)
CSF1R and PLAUR were identified as common hub genes and validated in GSE41571. (bvsalud.org)