MMPsExtracellularProteins2020SpliceInhibitorsIntracellularGene VariantsProteinTissueInhibitionSusceptibilityGeneticMutationProteolyticCytokinesFibroblastsChromosomeExpressionAorticMetastasisGenesRegulationHomozygousInvasionLevels of matrixAssayTranscriptsAmino AcidZincBiologyRoleMutationsAdultJournalOrganFoundCasesAnalysisCellDiseaseResearchResponseCells
MMPs9
- The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs).The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. (tati.hu)
- Here, we have performed the first direct comparison of the safety and efficacy of three engineered anthrax lethal toxin variants requiring activation by either matrix-metalloproteinases (MMPs), urokinase plasminogen activator (uPA) or co-localized MMP/uPA activities. (johnshopkins.edu)
- Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. (biomedcentral.com)
- It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-418 G/C or C/C). Tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring inhibitors of MMPs, which inhibit the activity of MMPs and control the breakdown of ECM. (biomedcentral.com)
- Tissue inhibitors of matrix metallo-proteinases (TIMPs) are known to have the ability to inhibit the catalytic activity of MMPs. (biomedcentral.com)
- Turpeenniemi-Hujanen et al suggested that the expressions of matrix expression of MMPs as well as their tissue inhibitors the TIMPs are associated with the clinical behaviour in head and neck malignancy [ 12 ]. (biomedcentral.com)
- This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). (cancerindex.org)
- Matrix metalloproteinases (MMPs) have been considered to be associated with tumor progression or poor prognosis. (cancerindex.org)
- Increased activity of certain matrix metalloproteinases (MMPs), enzymes that regulate cell behavior, may explain the risk for developing aggressive pulmonary fibrosis in people with Hermansky-Pudlak syndrome (HPS), a rare genetic disorder, according to new research. (pulmonaryfibrosisnews.com)
Extracellular5
- The CD44 , an 85-90 kDa transmembrane glycoprotein, is a receptor of the extracellular matrix component hyaluronan (HA) ( 8 ). (iiarjournals.org)
- Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (cancerindex.org)
- OPN is encoded by the SPP1 gene , which is comprised of 7 exons and is located on the long arm of chromosome 4 near four other SIBLING (small integrin-binding N-linked glycoproteins) that are contained in bine and dentin - bone sialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE). (shu.edu)
- This study was designed to determine the effects of the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 ( PVT1 ) on vascular smooth muscle cell (VSMC) apoptosis and extracellular matrix (ECM) disruption in a murine abdominal aortic aneurysm (AAA) model. (molcells.org)
- Sjöberg A., Önnerfjord, P., Mörgelin, M., Heinegård, D. and Blom A. M. (2005) Extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. (lu.se)
Proteins1
- It constitutes fibrous proteins such as collagen and elastin, elongated glycoproteins such as fibronectin and laminin, which provide cell matrix adhesion. (biomedcentral.com)
20201
- Mol Cancer Res (2020) 18 (9): 1414-1426. (aacrjournals.org)
Splice4
- In particular, the splice variants of CD44v6 are associated with aggressiveness of cancer and correlate with poor prognosis in breast cancer ( 11 ). (iiarjournals.org)
- Three splice variants (OPN-a, OPN-b, and OPN-c) have been identified. (shu.edu)
- Splice variants of osteopontin (OPN). (shu.edu)
- a, b and c refer to OPN splice variants a, b and c. (shu.edu)
Inhibitors2
- Clark IM, Swingler TE, Sampieri CL, Edwards DR. (2008) The regulation of matrix metalloproteinases and their inhibitors. (guidetoimmunopharmacology.org)
- Devel L, Czarny B, Beau F, Georgiadis D, Stura E, Dive V. (2010) Third generation of matrix metalloprotease inhibitors: Gain in selectivity by targeting the depth of the S1' cavity. (guidetoimmunopharmacology.org)
Intracellular1
- RT-PCR and Western blots analysis were performed to examine the expression levels of matrix metalloproteinase 9 (MMP9) and chloride intracellular channel 4 (CLIC4). (tmu.edu.tw)
Gene Variants1
- Meta-analyses have revealed many positive associations between gene variants and susceptibility to chronic obstructive pulmonary disease (COPD). (geneticsmr.com)
Protein3
- Pseudoachondroplasia is inherited in an autosomal dominant manner and is caused solely by mutations in the cartilage oligomeric matrix protein COMP gene. (wikipedia.org)
- One of these variants found in ADAMTS10 results in the substitution in the ADAMTS10 protein (NCBI GI: 73986982) of an arginine for a highly conserved glycine residue at amino acid position 661 (Gly661Arg), a change predicted to have deleterious effects on protein function. (arvojournals.org)
- In a retrospective study of 171 patients with NSCLC, OPN and thrombospondin-1 (a matrix protein that induces proliferating endothelial cells to secrete Fas ligand, which mediates apoptosis) levels were compared. (shu.edu)
Tissue2
- The standard form of CD44 is usually ubiquitously expressed on epithelial cells and lymphocytes, but inclusion of one or more of 10 variant exons produces tissue-specific multiple variant isoforms (CD44v2-v10) by alternate mRNA splicing ( 9 ). (iiarjournals.org)
- Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1 . (molcells.org)
Inhibition1
- Thus, we conclude that As2O3 can reduce metastasis potential of NPC cells, involving inhibition of MMP-9 expression. (scielo.br)
Susceptibility1
- The study, "Novel idiopathic pulmonary fibrosis susceptibility variants revealed by deep sequencing," was published in the journal ERJ Open Research. (pulmonaryfibrosisnews.com)
Genetic1
- Genetic variants of the MUC5AC gene may contribute to the development of idiopathic pulmonary fibrosis (IPF), a study suggests. (pulmonaryfibrosisnews.com)
Mutation2
- Pamidronate does not improve peripheral osteolysis in multicentric osteolysis and nodular arthropathy caused by a mutation in the matrix metalloproteinase 2 gene. (medscape.com)
- Results We identified a homozygous 2 bp deletion in MMP21, encoding matrix metalloproteinase-21, as the sole coding mutation that segregated with the phenotype. (bmj.com)
Proteolytic1
- Khan F, Liu H, Reyes A, Witkowska HE, Martinez-Avila O, Zhu L, Li W, Habelitz S. The proteolytic processing of amelogenin by enamel matrix metalloproteinase (MMP-20) is controlled by mineral ions. (medlineplus.gov)
Cytokines1
- Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines. (molcells.org)
Fibroblasts2
- [ 9 ] emphasize the abnormal function of the fibroblasts, which causes some of the pathologic changes in this syndrome. (medscape.com)
- 2007. Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent . (cardiff.ac.uk)
Chromosome1
- Previously, we mapped the disease locus in the beagle model of autosomal recessive primary open angle glaucoma (POAG) to a 4-Mb interval on chromosome 20, and identified a Gly661Arg variant in ADAMTS10 as the candidate disease-causing variant. (arvojournals.org)
Expression9
- The expression of CD44 and its variants is associated with poor prognosis in breast cancer. (iiarjournals.org)
- Interestingly, we observed that EGFR ligand-induced CD44 and matrix metalloproteinase-9 (MMP-9) expression was reduced by silibinin treatment in a dose-dependent manner. (iiarjournals.org)
- In a previous study, we also reported that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression is inhibited by silibinin through inactivation of the RAF/MEK/ERK pathway ( 6 ), as well as augmenting the cell cycle arrest at the G 2 /M phase through the induction of p21 and the reduction of cyclin B1 in breast cancer cells ( 7 ). (iiarjournals.org)
- Zymography assay demonstrated that KLF6 inhibited the activities of matrix metalloproteinase 9 (MMP-9) and weakened the expression of mesenchymal markers, such as snail, slug, and vimentin. (medsci.org)
- KLF6 downregulation enhances MDM2 gene expression that deregulates the p53 pathway [ 9 ]. (medsci.org)
- Expression of Matrix Metalloproteinases in Intraductal Papillary Mucinous Neoplasm of the Pancreas. (cancerindex.org)
- The expression of MMP-1,2,7,9 in 51 cases of IPMN were investigated. (cancerindex.org)
- MicroRNAs (miRNAs) negatively regulate the expression of the target genes by binding to ʻseed sequences' in the 3'‑untranslated region (3'‑UTR) mRNA transcripts, and the variants within or nearby ʻseed sequences' may compromise or enhance miRNA/mRNA interaction leading to either ʻloss‑of‑function' or ʻgain‑of‑function' effects. (spandidos-publications.com)
- The current study demonstrated that the rs78378222 polymorphism minor allele introduces a novel potential miR‑125b binding site in the TP53 3'‑UTR with a consecutive 8‑bp perfect match, creating a ʻgain‑of‑function' variant and affecting the regulation of TP53 expression. (spandidos-publications.com)
Aortic3
- Low transcriptional activity haplotype of matrix metalloproteinase 1 is less frequent in bicuspid aortic valve patients. (cdc.gov)
- Rare GATA5 sequence variants identified in individuals with bicuspid aortic valve. (cdc.gov)
- Variants in the NOTCH1 gene in patients with aortic coarctation. (cdc.gov)
Metastasis3
- Degradation of matrix is a key event in progression, invasion and metastasis of potentially malignant and malignant lesions of the head and neck. (biomedcentral.com)
- Degeneration of matrix is a key event in invasion and metastasis of malignant lesions of the head and neck. (biomedcentral.com)
- MMP-9 (matrix metalloproteinase 9) cleaves OPN-c, thereby releasing a 5 kDa fragment that binds to CD44 receptors and induces hepatocellular carcinoma invasion and metastasis . (shu.edu)
Genes1
- Dogs of various breeds, affected or unaffected with primary glaucoma, were genotyped for the Gly661Arg variant of ADAMTS10 , as well as 7 other nonsynonymous single nucleotide polymorphisms (SNPs) in other genes in the beagle POAG locus that segregate with disease. (arvojournals.org)
Regulation1
- Taken together, these observations suggest a role of matrix metalloproteinases in the establishment of asymmetric organ development, likely through the regulation of morphogenetic signals. (bmj.com)
Homozygous2
- For the nonsynonymous SNPs other than the ADAMTS10 variant, control dogs were identified that were homozygous for the alternative alleles, ruling out those variants as causative. (arvojournals.org)
- The only dog found homozygous for the Gly661Arg variant of ADAMTS10 was an affected beagle, unrelated to the POAG colony. (arvojournals.org)
Invasion1
- Previously, we have found that PDT-derived variants A375/3A5 and A375/6A5 have reduced invasion ability. (tmu.edu.tw)
Levels of matrix1
- Studies have revealed increased levels of matrix metalloproteins, tumor necrosis factor-alpha, type IV collagenase, and plasminogen activators in mucoceles compared with that of whole saliva. (medscape.com)
Assay1
- The changes of MMP-9 were examined by RT-PCR assay and Western blot. (scielo.br)
Transcripts1
- Single colony selection and microarray analysis were performed to examine the differentially expressed transcripts in parental A375 and PDT-derived variants. (tmu.edu.tw)
Amino Acid2
- 1 Sequencing the entire locus revealed eight variants that segregated with disease and caused amino acid substitutions ( Fig. 1 ), all of which were single nucleotide polymorphisms (SNPs). (arvojournals.org)
- The Gly661Arg variant of ADAMTS10 was identified as the likely cause of POAG in the beagle colony because it was the only rare nonsynonymous variant that caused a highly nonconservative amino acid substitution in a highly conserved region of a gene. (arvojournals.org)
Zinc1
- Matrix metalloproteinase are a family of zinc dependent endopeptidases that are capable of degrading most components of the extra cellular matrix (ECM) [ 7 - 9 ]. (biomedcentral.com)
Biology2
- Aiken A, Khokha R. (2010) Unraveling metalloproteinase function in skeletal biology and disease using genetically altered mice. (guidetoimmunopharmacology.org)
- Matrix Biology 25(5), pp. 317-320. (cardiff.ac.uk)
Role1
- 2007) Role of matrix metalloproteinases in renal pathophysiologies. (guidetoimmunopharmacology.org)
Mutations1
- Inactivating mutations in MMP2, encoding matrix metalloproteinase-2, are known to cause this disorder. (nih.gov)
Adult1
- pational factors have been implicated in 9 to 15% of all cases of adult asthma. (cdc.gov)
Journal2
- The Journal of Laryngology & Otology 119(9), pp. 746-749. (cardiff.ac.uk)
- American journal of epidemiology, 162 (9). (lshtm.ac.uk)
Organ1
- While target organ toxicity and effective doses were similar amongst the variants, the dual MMP/uPA-activated anthrax lethal toxin exhibited the highest I.P. MTD6 and was 1.5-3-fold better tolerated than the single MMP- and uPA-activated toxins. (johnshopkins.edu)
Found1
- iii) The reduction of MMP-9 was found in As2O3-treated groups, more evident in HNE1-LMP1 cells. (scielo.br)
Cases1
- Thirty postoperative complications were observed, including 9 infections, 14 dislocations, 5 cases of deep vein thrombosis, and 2 cases of sciatic nerve palsy. (researchgate.net)
Analysis1
- Microarray analysis and RT-PCR showed CLIC4 was down-regulated in the PDT-derived variants. (tmu.edu.tw)
Cell1
- It is influenced by angiogenesis, cell-cell and cell-extra cellular matrix (ECM) interactions. (biomedcentral.com)
Disease3
- Congenital heart disease 0 9 (5): 391-6. (cdc.gov)
- Variants ity of longitudinal studies of the disease. (cdc.gov)
- The superficial mucocele, a special variant, has features that resemble a mucocutaneous disease. (medscape.com)
Research1
- The rapid development of next-generation sequencing (NGS) technology and instruments has supported quick and efficient genomics research [ 9 , 10 ]. (genominfo.org)
Response1
- This is called the Cushing reflex and is a variant of the cerebral ischemic response. (tati.hu)
Cells1
- This study attempted to further elucidate the possible molecules associated with the altered invasiveness in the PDT-derived variants and cancer cells treated with PDT. (tmu.edu.tw)