• peptide
  • The same hierarchy was observed with synthetic precursors of HLA-B27 ligands, but the effects were peptide-dependent. (pubmedcentralcanada.ca)
  • The hydrolysis of fluorogenic and peptide substrates by an HLA-B27 ligand or a shorter peptide, respectively, was increasingly inhibited as a function of ERAP1 activity, indicating that residues 528 and 575 affect substrate inhibition of ERAP1 trimming. (pubmedcentralcanada.ca)
  • Naive CD4+ T cells (those that have not encountered any antigens before) recovered from these mice 36 hours post-anti-MHC administration showed decreased responsiveness to the antigen pigeon cytochrome C peptide, as determined by Zap-70 phosphorylation , proliferation, and Interleukin-2 production. (wikidoc.org)
  • Endoplasmic reticulum signal sequence facilitated transport of peptide epitopes restores immunogenicity of an antigen processing defective tumour c. (growkudos.com)
  • The image off to the side shows a piece of a poisonous bacterial protein (SEI peptide) bound within the binding cleft portion of the HLA-DR1 molecule. (wikipedia.org)
  • molecules
  • Diversity of HLAs in the human population is one aspect of disease defense, and, as a result, the chance of two unrelated individuals with identical HLA molecules on all loci is extremely low. (wikipedia.org)
  • genes
  • HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system. (wikipedia.org)
  • The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants. (wikipedia.org)
  • Aside from the genes encoding the 6 major antigen-presenting proteins, there are a large number of other genes, many involved in immune function, located on the HLA complex. (wikipedia.org)
  • HLA genes have historically been identified as a result of the ability to successfully transplant organs between HLA-similar individuals. (wikipedia.org)
  • Coding and regulatory regions in the TNFAIP3 gene and other auto-inflammation-implicated genes were sequenced by next-generation sequencing and variants identified. (frontiersin.org)
  • class
  • MHC class I proteins associate with β2-microglobulin, which unlike the HLA proteins is encoded by a gene on chromosome 15. (wikipedia.org)
  • HLAs corresponding to MHC class II (DP, DM, DOA, DOB, DQ, and DR) present antigens from outside of the cell to T-lymphocytes. (wikipedia.org)
  • HLA class I negative .221 cells were a gift from Salim Khakoo (Imperial College, London, U.K.), and were cultured in RPMI 1640 with 5% FBS. (jimmunol.org)
  • mice
  • Computational mouse genetics: To reduce the cost and the time frame for genetic research, we developed a more efficient method for performing genetic analysis in mice. (stanford.edu)
  • disease
  • The laboratory develops and uses state of the art genomic methods to identify genetic factors affecting disease susceptibility, and to translate these findings into new treatments. (stanford.edu)
  • The metabolomic results are integrated with the genetic data to identify new disease mechanisms and to develop new diagnostics. (stanford.edu)
  • human
  • The association between geographic tongue and psoriasis has been demonstrated in various studies, based on observation of its fundamental lesions, microscopic similarity between the two conditions and the presence of a common genetic marker, human leukocyte antigen (HLA) HLA-C*06. (scielo.br)
  • clinical
  • Herein we propose an updated classification scheme based on the molecular insights garnered over the past decade, supplanting a clinical classification that has served well but is opaque to the genetic, immunologic, and therapeutic interrelationships now before us. (pubmedcentralcanada.ca)
  • Clinical trials are currently underway that test the efficacy of 2 therapies that were generated by these genetic discoveries: a pilot study at Stanford to alleviate incisional pain after surgery and a multi-center NIH funded trial for preventing narcotic drug withdrawal in infants born to narcotic consuming mothers was begun in 2012. (stanford.edu)
  • among
  • HLA-B27 is particularly common among Native Americans from North America. (eupedia.com)
  • In Europe, HLA-B*27:02 is common among Mediterranean populations (outside of Sardinia). (eupedia.com)
  • found
  • HLA-B*27:09, found in Sardinia, and HLA-B*27:06 common in Southeast Asia, do not carry a risk for HLA-B27 syndromes. (eupedia.com)
  • HLA may also be related to people's perception of the odor of other people, and may be involved in mate selection, as at least one study found a lower-than-expected rate of HLA similarity between spouses in an isolated community. (wikipedia.org)
  • However, rather than the partially misfolded HLA-B27 H chain homodimers implicated in AS, we found the exosome-associated HLA-B27 dimers to be fully folded. (jimmunol.org)
  • common
  • We observed that the frequency of oral lesions is relatively common, but to establish a correct diagnosis of oral psoriasis, immunohistochemical and genetic histopathological analyzes are necessary, thus highlighting the importance of oral examination in psoriatic patients and cutaneous examination in patients with geographic tongue. (scielo.br)
  • person
  • I am rs6919835=GG and therefore rs6919835=A does not mean the person is positive for HLA-B27 . (eupedia.com)
  • Both 23andMe and DNA.land 'paint' this segment as 'Finnish' and a person who carries HLA-B27:05 may come out as '4% Finnish' in their ancestry estimates. (eupedia.com)
  • Any cell displaying that person's HLA type belongs to that person and, therefore, is not an invader. (wikipedia.org)
  • years
  • rs13202464=G rs4349859=A Of all the ancient DNA samples in Gedmatch, only Ajvide58 (Gedmatch ID F99924) from the Pitted Ware Culture of the Scandinavian Hunter-Gatherers, c. 5000 years ago, appears to carry HLA-B27. (eupedia.com)
  • This enables genetic analyses to be completed in far less time (days vs. years) and with far fewer personnel than conventional methods. (stanford.edu)
  • system
  • The misconception that an individual's immune system is totally incapable of recognising self antigens is not new. (wikidoc.org)
  • For example, if the cell is infected by a virus, the HLA system brings fragments of the virus to the surface of the cell so that the cell can be destroyed by the immune system. (wikipedia.org)
  • Being overexpressed and mutated, B-Raf is a potential target for the immune system and as this mutation seems to be an early event, a humoral immune response against this antigen might serve as a diagnostic tool for detection of high risk patients. (pubmedcentralcanada.ca)
  • several
  • The exact genesis of immunological tolerance is still elusive, but several theories have been proposed since the mid-twentieth century to explain its origin. (wikidoc.org)