ProteinTYROSINE KINASE INPhosphatidyl cholineMitochondrial structuralOverexpressionEnzymeInhibitorPhosphorylationBiosynthesis of phosphatidylcholineCHKBAcetyltransferaseIsoformsPhosphocholinePathwayGeneSerumCellsProteinsReceptorUptakeAcidActivityHumansDomainHumanBreastOverexpressed in variousFutureCellBrainPatientsTime
Protein16
- Phosphorylation of human choline kinase beta by protein kinase A: Its impact on activity and inhibition. (mpg.de)
- The PTK2 gene encodes a cytosolic protein tyrosine kinase. (faksignaling.com)
- Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C. Serine/Threonine Kinases (STKs), Atypical Protein Kinase C (aPKC) subfamily, catalytic (c) domain. (umbc.edu)
- The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
- Additionally, we detected increased levels of active glycogen synthase kinase 3 β, a physiological kinase of TAU, in neurons derived from AD iPSCs, as well as significant upregulation of amyloid precursor protein (APP) synthesis and APP carboxy-terminal fragment cleavage. (biomedcentral.com)
- Catalytic domain of the Protein Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4. (umbc.edu)
- Serine/threonine kinases (STKs), mammalian Ste20-like protein kinase 4 (MST4) subfamily, catalytic (c) domain. (umbc.edu)
- It plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. (umbc.edu)
- In one aspect, there is provided an antigen-binding protein, or an antigen-binding fragment thereof that competes with the antigen binding protein as defined herein for binding to AXL receptor tyrosine kinase. (justia.com)
- DNA-PKcs: A Targetable Protumorigenic Protein Kinase. (jefferson.edu)
- Protein kinase domain [Interproscan]. (ntu.edu.sg)
- The "Gratiaviridae" phages encode a HipA-family protein kinase and glycosyltransferase, suggesting these phages modify the host cell wall, preventing superinfection by other phages. (biomedcentral.com)
- PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
- Description: A sandwich ELISA kit for detection of Protein Kinase C Alpha from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Protein Kinase C Alpha (PKCa) in serum, plasma, tissue homogenates and other biological fluids. (scalegen.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Protein Kinase C Alpha (PKCa) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (scalegen.com)
TYROSINE KINASE IN1
- Neratinib (INN), sold under the brand name Nerlynx, is a tyrosine kinase inhibitor anti-cancer medication used for the treatment of breast cancer. (hki-272inhibitor.com)
Phosphatidyl choline2
- Choline and phosphatidyl choline may maintain cognitive performance by multiple mechanisms. (uml.edu)
- 7] The medication was found to improve the quantity of type II cells thus BRL-49653 improving the incorporation of labeled precursors like palmatic acidity into alveolar phosphatidyl-choline and storage space of lamellar bodies thus indicating that it up regulates the creation of BRL-49653 surfactant. (bioerc-iend.org)
Mitochondrial structural1
- CHKB gene variants lead to loss-of-function of choline kinase b and lipid metabolism defects and mitochondrial structural changes. (bvsalud.org)
Overexpression1
- AXL receptor tyrosine kinase belongs to the TAM subfamily of receptor tyrosine kinases (RTKs) and overexpression has been detected in various cancers. (justia.com)
Enzyme7
- Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene. (wikipedia.org)
- Choline kinase beta, lipid transport enzyme, catalyzes the biosynthesis of phosphatidylcholine and phosphatidylethanolamine, two major components of the mitochondrial membrane, on which respiratory enzyme activities are dependent. (bvsalud.org)
- Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer. (mpg.de)
- Fluorescence-activated cell sorting of human l-asparaginase mutant libraries for detecting enzyme variants with enhanced activity. (mpg.de)
- Cells covert choline into phosphocholine via the activity of the enzyme choline kinase, and a change of other enzyme mediated chemical reactions leads to the conversion of phosphocholine into cell membrane elements, in the case of human cells, and into cell wall elements, in the case of bacteria. (atlasofscience.org)
- Since the initial step leading to the production of certain cell wall and cell membrane elements is the conversion of choline and phosphocholine via the enzyme choline kinase, measuring the capacity of the cell to carry out this enzyme mediated reaction can tell something about the health of the cell. (atlasofscience.org)
- However, in order to follow whether or not the activity of choline kinase is efficiently being blocked, we need to measure how well the enzyme is working in the presence of the drug. (atlasofscience.org)
Inhibitor4
- Endoglin CD105 selelck kinase inhibitor is probably the classical markers expressed by mesenchymal stem cells and applied for the definition of those cells. (faksignaling.com)
- Our reporter assay indicates that the Smad1 and Smad2 kinase inhibitor Rigosertib signaling pathways is probably not appropriate for proliferation of chondrosarcoma cells. (faksignaling.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Cyclin Dependent Kinase Inhibitor 3 (CDKN3) in samples from tissue homogenates or other biological fluids. (jemsec.com)
- Description: A sandwich ELISA for quantitative measurement of Human Cyclin dependent kinase inhibitor 3(CDKN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (jemsec.com)
Phosphorylation1
- Loss of the PPM1H phosphatase that is specific for LRRK2-phosphorylated Rab GTPases yields the same cilia loss phenotype seen in mice expressing pathogenic LRRK2 kinase, strongly supporting a connection between Rab GTPase phosphorylation and cilia loss. (elifesciences.org)
Biosynthesis of phosphatidylcholine2
- The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. (wikipedia.org)
- The de novo biosynthesis of phosphatidylcholine and phosphatidylethanolamine in Entamoeba histolytica is largely dependent on the CDP-choline and CDP-ethanolamine pathways. (bvsalud.org)
CHKB3
- To date, many megaconial congenital muscular dystrophy cases due to CHKB gene variants have been reported worldwide. (bvsalud.org)
- We describe thirteen Iranian megaconial congenital muscular dystrophy cases related to CHKB gene variants, including clinical presentations, laboratory and muscle biopsy findings, and novel CHKB gene variants. (bvsalud.org)
- Eleven different CHKB gene variants including six novel variants were found in our patients. (bvsalud.org)
Acetyltransferase1
- HFD ± NDEA caused T2DM, neurodegeneration with impairments in brain insulin, insulin receptor, IGF-2 receptor, or insulin receptor substrate gene expression, and reduced expression of tau and choline acetyltransferase (ChAT), which are regulated by insulin and IGF-1. (biomedcentral.com)
Isoforms1
- Two transcript variants encoding different isoforms have been found for this gene. (wikipedia.org)
Phosphocholine6
- Simplified schematic of our new colorimetric method for measuring choline and phosphocholine. (atlasofscience.org)
- That is, we need to be able to measure how much choline is being turned into phosphocholine over time in the presence of a drug. (atlasofscience.org)
- In order to know that, we measure both the amount of choline left, and the amount of phosphocholine that appears over time. (atlasofscience.org)
- There are several techniques we can use to accomplish choline and phosphocholine measurements, but all currently either require huge capital investments and specialized knowledge (as in mass spectrometry) or require extra safety measures (as in radioactive labelling). (atlasofscience.org)
- This method is a twostep method that allows us to measure choline via the intensity of the color orange in a solution (Fig. 1) and measure phosphocholine via the intensity of the color blue in a solution. (atlasofscience.org)
- Parallel Colorimetric Quantification of Choline and Phosphocholine as a Method for Studying Choline Kinase Activity in Complex Mixtures. (atlasofscience.org)
Pathway1
- It influences cell growth and transformation by modulating the extracellular signal-regulated kinase (ERK) pathway. (umbc.edu)
Gene1
- Functional Assessment of Missense Variants in the ABCC6 Gene Implicated in Pseudoxanthoma Elasticum, a Heritable Ectopic Mineralization Disorder. (jefferson.edu)
Serum1
- Serum creatine kinase (CK) is elevated in several cases but not all. (medscape.com)
Cells1
- In this study, we investigated the correlation between CKα expression and 11C-choline accumulation in breast cancer cells. (bvsalud.org)
Proteins3
- The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to a glycan on the AXL receptor tyrosine kinase. (justia.com)
- The present invention also relates to antigen-binding proteins, or antigen-binding fragment conjugated to a radioisotope or cytotoxin, and wherein said antigen-binding proteins, or antigen-binding fragment is internalised into a cell upon binding to AXL receptor tyrosine kinase. (justia.com)
- Continuous reports will help clarify these types of, including regardless of whether way of measuring regarding triglyceride amounts may help boost heart disease chance examination, and study regarding anatomical variants might help far better understand virtually any causal part.The hexosamine biosynthesis process (HBP) regulates the actual post-translational modification associated with nuclear along with cytoplasmic proteins by simply O-linked N-acetylglucosamine (O-GlcNAc). (hki-272inhibitor.com)
Receptor1
- Specifically, the present invention relates to anti-AXL tyrosine kinase receptor antibodies and their uses thereof. (justia.com)
Uptake1
- The maximum standardised uptake value was recorded for evaluating 11C-choline accumulation. (bvsalud.org)
Acid1
- The aim of this review is to highlight current insights into the roles of choline and docosahexaenoic acid (DHA) in maternal and infant nutrition, with special emphasis on dietary recommendations, gaps in dietary intake, and synergistic implications of both nutrients in infant brain and eye development. (mdpi.com)
Activity1
- We can do this by designing drugs that specifically block the activity of choline kinase. (atlasofscience.org)
Humans1
- Choline is an important nutrient for the growth and sustenance of living things, from humans to bacteria. (atlasofscience.org)
Domain1
- R1441C) and kinase domain (e.g. (elifesciences.org)
Human2
Breast1
- A correlation was observed between CKα expression and 11C-choline accumulation, suggesting their role as prognostic indicators of breast cancer. (bvsalud.org)
Overexpressed in various1
- Choline kinase (CK) is reportedly overexpressed in various malignancies. (bvsalud.org)
Future1
- Look up your genotype for any SNP in our database of 83M+ genetic variants and bookmark variants for future reference. (selfdecode.com)
Cell1
- A designed equine herpes thymidine kinase (EHV4 TK) variant improves ganciclovir-induced cell-killing. (mpg.de)
Brain2
- Choline and DHA play a significant role in infant brain and eye development, with inadequate intakes leading to visual and neurocognitive deficits. (mdpi.com)
- [ 1 ] Other diseases involving the muscle, eye, and brain were subsequently described: a Finnish variant (originally called muscle-eye-brain disease and Walker-Warburg syndrome. (medscape.com)
Patients1
- All the patients underwent 11C-choline PET/computed tomography imaging prior to surgery. (bvsalud.org)
Time1
- 11C-choline accumulation was also negatively correlated with survival time (P (bvsalud.org)