• Acid
  • In sickle-cell disease, a single glutamic acid in β-globin is replaced with valine. (wikipedia.org)
  • The name valine comes from valeric acid, which in turn is named after the plant valerian due to the presence of the acid in the roots of the plant. (wikipedia.org)
  • The valine catabolite 3-hydroxyisobutyrate promotes skeletal muscle insulin resistance in mice by stimulating fatty acid uptake into muscle and lipid accumulation. (wikipedia.org)
  • Other names in common use include valyl-tRNA synthetase, valyl-transfer ribonucleate synthetase, valyl-transfer RNA synthetase, valyl-transfer ribonucleic acid synthetase, valine transfer ribonucleate ligase, and valine translase. (wikipedia.org)
  • whereas
  • According to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons. (wikipedia.org)
  • essential
  • Dietary valine is essential for hematopoietic stem cell (HSC) self-renewal, as demonstrated by experiments in mice. (wikipedia.org)
  • levels
  • Mice fed a valine deprivation diet for one day have improved insulin sensitivity, and feeding of a valine deprivation diet for one week significantly decreases blood glucose levels. (wikipedia.org)
  • diet
  • Successful stem cell transplantation was achieved in mice without irradiation after 3 weeks on a valine restricted diet. (wikipedia.org)
  • Long term survival of the transplanted mice was achieved when valine was returned to the diet gradually over a 2 week period to avoid refeeding syndrome. (wikipedia.org)
  • change
  • Editing results in a codon (I/V) change from (ATT) to (GTT) resulting in translation of a valine instead of an isoleucine at the position of the editing site. (wikipedia.org)