• peptide-based
  • This review summarise the current stand and future perspective on synthetic peptide-based vaccines. (rsc.org)
  • First was the development of a synthetic peptide based HIV 1 test and later an HIV 1,2 diagnostic test for blood screening, which received U.S. Food and Drug Administration approvals in 1989 and 1996, respectively. (wikipedia.org)
  • Her other inventions in this area include synthetic peptide-based blood screening diagnostics for HTLV I/II, HCV Hepatitis C virus, which has CE certification and has been sold in the global market through Organon Teknika /Biomerieux since 1991, and the SARS Coronavirus, as well as diagnostic tests for the differentiation of infected vs. vaccinated animals for Foot and mouth disease. (wikipedia.org)
  • particles
  • Watertown, Mass. - December 23, 2014 - Selecta Biosciences, a clinical-stage biotechnology company developing novel drugs that use immune-modulating nanomedicines based on Synthetic Vaccine Particles (SVP™), announced today that it has been awarded a $3.2 Million grant from Skolkovo Foundation in support of Selecta's program to develop an SVP immunotherapy to treat cancers caused by infections with Human Papilloma Virus (HPV), such as cervical, head and neck cancers. (selectabio.com)
  • pandemic
  • Novartis Vaccine and Diagnostics, among other companies, developed a synthetic approach that very rapidly generates vaccine viruses from sequence data in order to be able to administer vaccinations early in the pandemic outbreak. (wikipedia.org)
  • H5N1: Can synthetic vaccines stop a flu pandemic? (typepad.com)
  • Influenza vaccines based on mRNA may offer a solution as sequence-matched, clinical-grade material could be produced reliably and rapidly in a scalable process, allowing quick response to the emergence of pandemic strains. (typepad.com)
  • Most of the vaccine against that virus became available well after the pandemic was past its peak. (blogspot.com)
  • WHO forecasts 'it may be six to nine months before a vaccine for a pandemic virus strain becomes available. (blogspot.com)
  • In a separate report on pandemic influenza, the WHO described several challenges to producing sufficient volumes of vaccine using current, egg based protein-production technology, including the likelihood that two doses per person could be required due to the absence of pre-existing immunity. (blogspot.com)
  • mRNA
  • Here we show that mRNA vaccines induce balanced, long-lived and protective immunity to influenza A virus infections in even very young and very old mice and that the vaccine remains protective upon thermal stress. (typepad.com)
  • Thus, mRNA vaccines could address substantial medical need in the area of influenza prophylaxis and the broader realm of anti-infective vaccinology. (typepad.com)
  • Using synthetic messenger RNA (mRNA) instead of proteins purified from viruses, German scientists have shown they can protect mice, ferrets, and pigs against influenza. (blogspot.com)
  • vaccination
  • For the case of Chlamydia, we now have a mechanistic explanation for the failure of traditional vaccines combined with an SVP-based vaccination strategy that can overcome these challenges and create a vaccine with the potential to engender the desired robust immunoprotection. (vaccinenewsdaily.com)
  • The administration of vaccines is called vaccination. (wikipedia.org)
  • The terms vaccine and vaccination are derived from Variolae vaccinae (smallpox of the cow), the term devised by Edward Jenner to denote cowpox. (wikipedia.org)
  • The efficacy or performance of the vaccine is dependent on a number of factors: the disease itself (for some diseases vaccination performs better than for others) the strain of vaccine (some vaccines are specific to, or at least most effective against, particular strains of the disease) whether the vaccination schedule has been properly observed. (wikipedia.org)
  • The following are important considerations in the effectiveness of a vaccination program:[citation needed] careful modeling to anticipate the impact that an immunization campaign will have on the epidemiology of the disease in the medium to long term ongoing surveillance for the relevant disease following introduction of a new vaccine maintenance of high immunization rates, even when a disease has become rare. (wikipedia.org)
  • immunotherapy
  • WATERTOWN, Mass.--( BUSINESS WIRE )-- Selecta Biosciences, Inc. , and JDRF , announced today that they have extended their joint research collaboration and attracted Sanofi as a partner in support of their program to develop a Synthetic Vaccine Particle (SVP™) immunotherapy with the long-term goal to treat and potentially prevent the underlying cause of type 1 diabetes. (businesswire.com)
  • proteins
  • In other work described at the Cambridge meeting, Pam Silver , a synthetic biologist at Harvard Medical School, presented methods for "cell-based computing," in which logic gates can be built from engineered proteins. (technologyreview.com)
  • Now, most flu vaccines consist of hemagglutinin and neuraminidase, the two proteins covering the surface of the virus. (blogspot.com)
  • One of the research avenues explores plant made proteins for candidate vaccine production. (blogspot.com)
  • A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. (wikipedia.org)
  • H1N1
  • citation needed] During the H1N1 outbreak in 2009, vaccines only became available in large quantities after the peak of human infections. (wikipedia.org)
  • viruses
  • Current vaccine production based on inactivated viruses (live attenuated vaccines), has been successful in reducing significant disease burden associated with major epidemics of the 19th and 20th centuries. (blogspot.com)
  • Research is also being done dealing with the manipulation of certain wild-type traits in viruses to develop new vaccines. (wikipedia.org)
  • biology
  • Synthetic biology could be a source of new medical treatments. (technologyreview.com)
  • Synthetic biology is breathing new life into the old-fashioned world of vaccine production, raising hopes that manufacturers could release vaccines much more quickly when outbreaks occur. (technologyreview.com)
  • At a meeting on synthetic biology held at MIT, the drug company Novartis said it has synthesized hybrid flu genomes in a process that could shave weeks off the time required to produce vaccines. (technologyreview.com)
  • Mammalian synthetic biology, which involves modifying mammalian genetic circuits, is still in "relative infancy," says Jim Collins , a synthetic biologist at Boston University. (technologyreview.com)
  • Some efforts to apply synthetic biology to health focus on programming stem cells to behave like naturally occurring cells that have been lost because of disease. (technologyreview.com)
  • See planetary protection and interplanetary contamination), and In synthetic biology (referring to the risks associated with this type of lab practice) The international Cartagena Protocol on Biosafety deals primarily with the agricultural definition but many advocacy groups seek to expand it to include post-genetic threats: new molecules, artificial life forms, and even robots which may compete directly in the natural food chain. (wikipedia.org)
  • High-security facilities are necessary when working with synthetic biology as there are possibilities of bioterrorism acts or release of harmful chemicals and or organisms into the environment. (wikipedia.org)
  • A complete understanding of experimental risks associated with synthetic biology is helping to enforce the knowledge and effectiveness of biosafety. (wikipedia.org)
  • Scientist that favor the development of synthetic biology claim that the use of biosafety mechanisms such as suicide genes and nutrient dependencies will ensure the organisms cannot survive outside of the lab setting in which they were originally created. (wikipedia.org)
  • They also signed a collaborative agreement with New England Biolabs to Launch Gibson Assembly Master Mix Product for Synthetic and Molecular Biology Applications in 2012. (wikipedia.org)
  • strain
  • How well a given strain grows in either eggs or cells is hard to predict, however, and producing enough virus for millions of vaccine doses takes many months every year. (blogspot.com)
  • Antibody
  • Phase I data of UB-311, a synthetic peptide vaccine targeting amyloid beta, showed that the drug was able to generate antibodies to specific amyloid beta oligomers and fibrils with no decrease in antibody levels in patients of advanced age. (wikipedia.org)
  • 3 The study's hypothesis was that these two adjuvants function by different means to increase antibody titer to a synthetic peptide immunogen. (springer.com)
  • Kirkley J.E., Naylor P.H., Marciani D.J., Kensil C.R., Newman M., Goldstein A.L. (1992) QS-21 Augments the Antibody Response to a Synthetic Peptide Vaccine Compared to Alum. (springer.com)
  • AIDS
  • This study compared two adjuvants, alum and QS-21, given separately and together in a candidate p17-based subunit AIDS vaccine, HGP-30-KLH. (springer.com)
  • simplified Chinese: 王长怡), is an immunologist and astute organic chemist, best known for establishing a new platform in vaccines technology that employs designer peptide as key ingredients to be formulated into vaccines for the prevention and treatment of AIDS, HIV, Alzheimer disease, allergy and other emerging infectious diseases in both humans and animals. (wikipedia.org)
  • Dr. Wang's United Biomedical, Inc. also received Bill and Melinda Gates Foundation Grand Challenges Explorations grant for a new approach to an AIDS vaccine. (wikipedia.org)
  • In 2009 he founded Butterfly Sciences in Davis, California to develop a gene therapy to treat HIV AIDS using a combination of GHRH and an intracellular vaccine. (wikipedia.org)
  • doses
  • Six years later, they have successfully manufactured 10 million doses of H1NI (flu) vaccine within a month. (blogspot.com)
  • biological
  • A technological solution to increase the speed and adaptability of vaccine production is urgently needed to match the broad biological threat. (blogspot.com)
  • Building on a previous DARPA program, Accelerated Manufacture of Pharmaceuticals, Blue Angel targets new ways of producing large amounts of high quality, vaccine grade protein in less than three months in response to emerging and novel biological threats. (blogspot.com)
  • A vaccine is a biological preparation that provides active acquired immunity to a particular disease. (wikipedia.org)
  • approaches
  • Traditional vaccines and approaches have not been effective in treating many of the serious and chronic infectious diseases that survive in mucosa. (vaccinenewsdaily.com)
  • The self-amplifying RNA triggers rapid and immediate antigen expression within host cells, stronger T-cell response (including when the host is already infected), and lower dose requirements compared to traditional RNA-based vaccine approaches. (syntheticgenomics.com)
  • research
  • To sum it up, the report concludes with an all-inclusive research result on the industry chain of Synthetic Peptide Vaccine Sales Industry facilitating the market participants in making well-informed strategic decisions. (beforeitsnews.com)
  • We're looking at plant based solutions to vaccine production as a more rapid and efficient alternative to the standard egg-based technologies, and the research is very promising. (blogspot.com)
  • Competition
  • Most of the international pharmaceutical companies are facing challenges such as price pressure, regulatory constraints, and competition from local and other international pharmaceutical companies in the Synthetic Peptide Vaccine markets. (equityinsider.org)
  • infections
  • There are several examples where conventional vaccines exacerbated infections in human clinical trials, including Chlamydia and RSV," Dr. Ulrich von Andrian, Mallinckrodt Professor of Immunopathology at Harvard Medical School and the co-founder of Selecta, said. (vaccinenewsdaily.com)
  • The World Health Organization (WHO) reports that licensed vaccines are currently available for twenty-five different preventable infections. (wikipedia.org)
  • develop
  • Consistent with our company's strategy for infectious disease indications, we will actively seek value-adding partners with whom to develop and commercialize SVP for mucosal vaccines. (vaccinenewsdaily.com)
  • The company's efforts in bio-based production are intended to improve both existing production hosts and develop entirely new synthetic production hosts with the goal of more efficient routes to bioproducts. (wikipedia.org)
  • Scientist
  • The world's first synthetic vaccine was created in 1982 from diphtheria toxin by Louis Chedid (scientist) from the Pasteur Institute and Michael Sela from the Weizmann Institute. (wikipedia.org)