• immune
  • Subjects will receive 2 vaccinations with the Biojector® 2000, and will be followed for 6 months to evaluate the safety of and the immune system's response to the vaccine. (clinicaltrials.gov)
  • Researchers will measure the volunteers' immune response to the vaccine, compare its potency with that of more traditional vaccines, and assess its safety, the NIH said. (umn.edu)
  • He said DNA vaccines generate some level of cellular immune response, whereas traditional flu vaccines generate only a humoral immune (neutralizing antibody) response. (umn.edu)
  • The federal government has a small stockpile of a traditional egg-based vaccine for H5N1, which has generated modest immune responses in trials. (umn.edu)
  • When the team introduced a new flu strain, the 'universal' vaccine induced an immune response too. (nebraska.tv)
  • The high rates of immune responses at all dose levels in this initial human Ebola vaccine study support continued development of this vaccine and further evaluation of our technology for potential additional biodefense and emerging disease applications," said David C. Kaslow, M.D., Vical's Chief Scientific Officer, "particularly where antibody responses may be protective. (rxpgnews.com)
  • It comprises a DNA sequence obtained from bacteria to shut down the T-helper (Th2) cells that trigger the body's inflammatory immune responses. (bio-medicine.org)
  • Other important endpoints include immune responses against the specific CMV features targeted by the vaccine. (emaxhealth.com)
  • Vaccine approaches using live, attenuated viruses can induce both antibody and cellular immune responses, but pose a potential safety concern, particularly for immunocompromised patients, of causing the disease they are intended to prevent. (emaxhealth.com)
  • Vical's novel DNA vaccine approach is designed to induce both antibody and cellular immune responses against specific features of the CMV virus without the risk of causing CMV disease. (emaxhealth.com)
  • In all three species, the vaccine induced robust immune responses capable of preventing the virus from infecting cells. (cnbc.com)
  • Inovio's antigen-targeting DNA immunotherapies are designed to activate robust, durable and functional immune responses against cancers or infectious diseases. (cnbc.com)
  • This DNA is injected into host body and produces protein for which the body generates immune response. (medgadget.com)
  • The result has been the development and ongoing refinement of so-called RASVs (for recombinant attenuated Salmonella vaccines), capable of provoking an intense, system-wide immune response and conferring effective immunity. (labspaces.net)
  • Two studies from the Peter O'Donnell Jr. Brain Institute demonstrate in animals how a vaccine containing DNA of the toxic beta-amyloid protein elicits a different immune response that may be safe for humans. (utsouthwestern.edu)
  • DNA vaccines have potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types. (wikipedia.org)
  • DNA vaccines elicit the best immune response when highly active expression vectors are used. (wikipedia.org)
  • Companies pursuing the vaccine as of 2009 and 2010 include BiondVax, Theraclone, Dynavax Technologies Corporation, VaxInnate, Crucell NV, Inovio Pharmaceuticals, Immune Targeting Systems (ITS) and iQur. (wikipedia.org)
  • However, it was soon found that more scrupulous attention to cleanliness actually seemed to reduce the effectiveness of the vaccines, and that the contaminants - "dirt" - actually enhanced the immune response. (wikipedia.org)
  • Adjuvants in immunology are often used to modify or augment the effects of a vaccine by stimulating the immune system to respond to the vaccine more vigorously, and thus providing increased immunity to a particular disease. (wikipedia.org)
  • Because immune systems have evolved to recognize these specific antigenic moieties, the presence of an adjuvant in conjunction with the vaccine can greatly increase the innate immune response to the antigen by augmenting the activities of dendritic cells (DCs), lymphocytes, and macrophages by mimicking a natural infection. (wikipedia.org)
  • It has been speculated that the dying cells release DNA which serves as an immune alarm. (wikipedia.org)
  • In order to understand the links between the innate immune response and the adaptive immune response to help substantiate an adjuvant function in enhancing adaptive immune responses to the specific antigen of a vaccine, the following points should be considered: Innate immune response cells such as Dendritic Cells (DCs) engulf pathogens through a process called phagocytosis. (wikipedia.org)
  • Infectious Diseases
  • The vaccine was designed by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH. (umn.edu)
  • The Phase 1, randomized, placebo-controlled, dose-escalation study, the first human trial for any Ebola vaccine, was sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), and conducted at the NIH Clinical Center. (rxpgnews.com)
  • Inovio has reported on the preventive power of its synthetic DNA-based vaccines in a variety of infectious diseases including HIV, influenza, hepatitis B, Ebola and dengue. (cnbc.com)
  • Dr. J. Joseph Kim, President and CEO, Inovio, said: "Once again, our data demonstrates we can rapidly turn our SynCon ® DNA-based immunotherapy platform to create innovative products with the potential to prevent and treat multiple infectious diseases and cancers. (cnbc.com)
  • To advance this quest, a research team led by Roy Curtiss, director of the Center for Infectious Diseases and Vaccinology, and Wei Kong, a research assistant professor, at Arizona State University's Biodesign Institute have taken a dramatic step forward, revealing the design of a universal platform for delivering highly potent DNA vaccines, by employing a cleverly re-engineered bacterium to speed delivery to host cells in the vaccine recipient. (labspaces.net)
  • He has also done done extensive work on vaccine development against infectious diseases such as rabies, hepatitis B and Japanese encephalitis and he and his colleagues were successful in developing a new DNA-based vaccine against rabies. (wikipedia.org)
  • antigen
  • DNA vaccination is a technique for protecting against disease by injection with genetically engineered DNA so cells directly produce an antigen, producing a protective immunological response. (wikipedia.org)
  • Paoletti, Enzo, Bernard R. Lipinskas, Carol Samsonoff, Susan Mercer, and Dennis Panicali (1984) "Construction of Live Vaccines Using Genetically Engineered Poxviruses: Biological Activity of Vaccinia Virus Recombinants Expressing the Hepatitis B Virus Surface Antigen and the Herpes Simplex Virus Glycoprotein D" Proc. (wikipedia.org)
  • A 'vaccine'/antigen based on the hemagglutinin (HA) stem was the first to induce 'broadly neutralizing' antibodies to both HA-group 1 and HA-group 2 influenza in mice. (wikipedia.org)
  • Adjuvants accomplish this task by mimicking specific sets of evolutionarily conserved molecules, so called PAMPs, which include liposomes, lipopolysaccharide (LPS), molecular cages for antigen, components of bacterial cell walls, and endocytosed nucleic acids such as double-stranded RNA (dsRNA), single-stranded DNA (ssDNA), and unmethylated CpG dinucleotide-containing DNA. (wikipedia.org)
  • influenza
  • Flu vaccines, according to the best scientific evidence available today, will only work against 10% of the circulating viruses that cause the symptoms of seasonal epidemic influenza. (greenmedinfo.com)
  • Jan 4, 2007 (CIDRAP News) - Federal officials have announced the launch of the first clinical trial of an H5N1 avian influenza vaccine made from a piece of the virus's DNA rather than from the whole virus, an approach that may facilitate faster vaccine production. (umn.edu)
  • We need to determine whether the DNA vaccine can work and can generate a sufficient amount of the right type of immunity to protect against influenza infections. (umn.edu)
  • Development of this vaccine technology has the potential to improve our production capacity for vaccines to prevent seasonal influenza and other diseases," NIAID Director Anthony S. Fauci, MD, commented in the news release. (umn.edu)
  • The experimental vaccine described in the new research demonstrated complete protection from influenza in mice, but Wei Kong, the leading author of the new study stresses that the innovative technique could be applied to the rapid manufacture of effective vaccines against virtually any infectious invader at dramatically reduced cost and without risk to either those vaccinated or the wider public. (labspaces.net)
  • The group demonstrated the effectiveness of this delayed-lysis bacteria in vaccine experiments with a variety of pathogens, including influenza and mycobacteria (causative agent of tuberculosis) and an RASV vaccine developed in the Curtiss lab against infant pneumonia is currently in FDA Phase I clinical trials. (labspaces.net)
  • They altered the DNA of cowpox virus by inserting a gene from other viruses (namely Herpes simplex virus, hepatitis B and influenza). (wikipedia.org)
  • Paoletti and his colleague, Dennis Panicali, a virologist, altered the DNA of vaccinia virus by inserting a gene from another virus (namely herpes, hepatitis B or influenza). (wikipedia.org)
  • USA 81:193-197 Panicali, Dennis, Stephen W. Davis, Randall L. Weinberg, Enzo Paoletti (1983) "Construction of Live Vaccines by Using Genetically Engineered Poxviruses: Biological Activity of Recombinant Vaccinia Virus Expressing Influenza Virus Hemagglutinin" Proc. (wikipedia.org)
  • F16 is the only known antibody that binds (its neutralizing activity is controversial) to all 16 subtypes of the influenza A virus hemagglutinin and might be the lynchpin for a universal influenza vaccine. (wikipedia.org)
  • The subdomain of the hemagglutinin that is targeted by FI6, namely the stalk domain, was actually successfully used earlier as universal influenza virus vaccine by Peter Palese's research group at Mount Sinai School of Medicine. (wikipedia.org)
  • Gene
  • DNA Vaccines: Design of a Gene to Eradicate HIV offers an innovative and new strategy to combat deadly viral infections. (iuniverse.com)
  • The experimental vaccine uses a modified version of the hemagglutinin gene from a recent strain of the deadly H5N1 virus, the NIH reported. (umn.edu)
  • They designed and produced a 'Gene Gun', which releases a painless puff-like injection of DNA into the skin, which goes directly into the skin cells. (nebraska.tv)
  • Vical has secured a nonexclusive license from the NIH to proprietary gene sequences used in the vaccine. (rxpgnews.com)
  • Preliminary studies suggest that immunisation of balb/c mice by gene gun with DNA from the extracellular region of Tie-2 resulted in cessation of tumor growth. (aacrjournals.org)
  • Using a gene gun HLA-A2 transgenic mice were immunized with the Tie-2 DNA construct. (aacrjournals.org)
  • This press release contains certain forward-looking statements relating to our business, including our plans to develop electroporation-based drug and gene delivery technologies and DNA vaccines, our expectations regarding our research and development programs and our capital resources. (cnbc.com)
  • Michal Šmahel, Ingrid Poláková, Eva Sobotková, and Eva Vajdová, "Systemic Administration of CpG Oligodeoxynucleotide and Levamisole as Adjuvants for Gene-Gun-Delivered Antitumor DNA Vaccines," Clinical and Developmental Immunology , vol. 2011, Article ID 176759, 7 pages, 2011. (hindawi.com)
  • These are plasmids that usually consist of a strong viral promoter to drive the in vivo transcription and translation of the gene (or complementary DNA) of interest. (wikipedia.org)
  • A gene gun or a biolistic particle delivery system, originally designed for plant transformation, is a device for delivering exogenous DNA (transgenes) to cells. (wikipedia.org)
  • which is a gene used to enable detection or removal of those cells which didn't integrate the construct into their DNA. (wikipedia.org)
  • For example, if the delivered DNA construct contains a gene that confers resistance to an antibiotic or herbicide, then stably transformed cells may be selected by including that antibiotic or herbicide in the tissue culture media. (wikipedia.org)
  • HMGB1 is an intracellular protein that can translocate to the nucleus where it binds DNA and regulates gene expression. (wikipedia.org)
  • The first attempt at modifying human DNA was performed in 1980 by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. (wikipedia.org)
  • The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990. (wikipedia.org)
  • The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. (wikipedia.org)
  • immunity
  • When responding to an emerging pandemic virus, for which no precisely matched vaccine would be immediately available, the cellular immunity conferred by a DNA vaccine might be of some help, he said. (umn.edu)
  • Results from Inovio's MERS vaccine development efforts appear in the peer-reviewed journal Science Translational Medicine in an article entitled, "A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East Respiratory Syndrome Coronavirus in non-human primates. (cnbc.com)
  • When tested in trials an emulsion of oil in water and the added adjuvants of monophosphoryl A and QS21 (SBAS2), the vaccine gave protective immunity to 7 out of 8 volunteers when challenged with P. falciparum. (wikipedia.org)
  • Live, attenuated vaccines, such as smallpox and polio vaccines, are able to induce killer T-cell (TC or CTL) responses, helper T-cell (TH) responses and antibody immunity. (wikipedia.org)
  • Ebola
  • The vaccine now being tested is similar to other DNA vaccines in development, including vaccines for HIV, Ebola, SARS (severe acute respiratory syndrome), and West Nile virus. (umn.edu)
  • By Porter Novelli, Life Sciences, Vical Incorporated (Nasdaq:VICL) announced today that an Ebola vaccine candidate administered using Vical's proprietary DNA delivery technology was safe and well tolerated, and produced both antibody and T-cell Ebola-specific responses in all healthy volunteers who received the full 3 doses of vaccine. (rxpgnews.com)
  • The DNA vaccine used in the Phase 1 trial incorporates genetic material encoding core and surface proteins from two strains of Ebola. (rxpgnews.com)
  • The vaccine used in the Phase 1 trial vaccine included three plasmids (closed loops of DNA), one each encoding the surface glycoprotein (GP) from the Zaire strain of Ebola, GP from the Sudan/Gulu strain, and the internal nucleoprotein (NP) from the Zaire strain. (rxpgnews.com)
  • The company believes that the Animal Rule creates a potentially favorable regulatory pathway for certain DNA-based products such as the Ebola vaccine. (rxpgnews.com)
  • Those funds included an initial procurement of $90 million and long-term procurement of $260 million for Ebola vaccines or treatments. (rxpgnews.com)
  • The Ebola DNA vaccine under development by the NIH may be eligible for this stockpiling program. (rxpgnews.com)
  • plasmids
  • In prokaryotes, nonviral extrachromosomal DNA is primarily found in plasmids whereas in eukaryotes extrachromosomal DNA is primarily found in organelles. (wikipedia.org)
  • Extrachromosomal DNA exists in prokaryotes outside the nucleoid region as circular or linear plasmids. (wikipedia.org)
  • Circular bacterial plasmids are also the basis for the production of DNA vaccines. (wikipedia.org)
  • The linear plasmids of prokarykotes are found either containing a hairpin loop or a covalently bonded protein attached to the telomeric ends of the DNA molecule. (wikipedia.org)
  • The linear plasmids which contain a protein that has been covalently attached to the 5' end of the DNA strands are known as invertrons and can range in size from 9 kb to over 600 kb consisting of inverted terminal repeats. (wikipedia.org)
  • These types of linear plasmids represent the largest class of extrachromosomal DNA as they are not only present in certain bacterial cells, but all linear extrachromosomal DNA molecules found in eukaryotic cells also take on this invertron structure with a protein attached to the 5' end. (wikipedia.org)
  • DNA vaccines, such as VGX-3400X (aimed at multiple H5N1 strains), contain DNA fragments (plasmids). (wikipedia.org)
  • Organism
  • It was also confirmed that the sequences of cytoplasmic DNA was different from nuclear DNA in the same organism, showing that cytoplasmic DNAs are not simply fragments of nuclear DNA. (wikipedia.org)
  • diseases
  • This development will not only make vaccinations less harrowing, but also allow for developing and delivering vaccines for diseases too dangerous for conventional techniques . (slashdot.org)
  • Is there a relationship between the burgeoning epidemic of chronic diseases and the vaccine trials that took place decades ago? (greenmedinfo.com)
  • Vical researches and develops biopharmaceutical products based on its patented DNA delivery technologies for the prevention and treatment of serious or life-threatening diseases. (emaxhealth.com)
  • The report also includes pipeline analysis based on the type of phase, therapeutic indications, and type of diseases for which the vaccines have been designed, such as infectious and vector borne diseases, and various types of cancers. (medgadget.com)
  • Vaccines have eliminated naturally occurring smallpox, and nearly eliminated polio, while other diseases, such as typhus, rotavirus, hepatitis A and B and others are well controlled. (wikipedia.org)
  • Conventional vaccines cover a small number of diseases, while other infections kill millions of people every year. (wikipedia.org)
  • While killed vaccines do not have this risk, they cannot generate specific killer T cell responses and may not work at all for some diseases. (wikipedia.org)
  • His work on rat brains help identify Mov34 protein which has assisted in the development of vaccines for flaviviral diseases like Japanese encephalitis and Dengue. (wikipedia.org)
  • proteins
  • Once inside the body, the DNA instructs human cells to make proteins that act as a vaccine against the virus," the agency said. (umn.edu)
  • The DNA is injected into cells, whose "inner machinery" uses the DNA to synthesize the proteins. (wikipedia.org)
  • After binding, HMGB1 bends DNA, which facilitates the binding of other proteins. (wikipedia.org)
  • He demonstrated that treatment with immunocytokines, which are antibody-cytokine fusion proteins, is effective in this model and that this approach is synergistic with inhibition of angiogenesis as well as tumor vaccines. (wikipedia.org)
  • therapeutic
  • The report also contains detailed and in-depth analysis of the segmentation of the DNA vaccines market based on types of DNA vaccines, therapeutic indication, end-users, and geography. (medgadget.com)
  • The product is a therapeutic vaccine to be administered to dogs with stage II or stage III oral melanoma to aid in extending survival times. (agr.ca)
  • trials
  • The NIH said the DNA vaccine was brought "from the research bench into clinical trials in less than 6 months. (umn.edu)
  • If the vaccine performs well in trials and if the H5N1 virus evolves into a pandemic strain within the next couple of years, the vaccine could possibly be of some use in combating it, Nabel said. (umn.edu)
  • To Michael's mind, a DNA vaccine offers a promising short-term solution while an inactivated vaccine-which won't be tested in efficacy trials for at least 18 months but could be made in very large quantities at a lower cost-and other long-term solutions are still being developed. (the-scientist.com)
  • The 'universal' vaccine needs more testing, including human clinical trials. (nebraska.tv)
  • He said, "The next step for this vaccine is phase III trials, after which the vaccine c ould receive government approval if all goes well. (bio-medicine.org)
  • The CSP vaccine presented problems in trials due to its poor immunogenicity. (wikipedia.org)
  • Two vaccines have been selected to move forward in clinical trials. (wikipedia.org)
  • By 2010 some universal flu vaccines had started clinical trials. (wikipedia.org)
  • pathogen
  • However, attenuated forms of a pathogen can convert to a dangerous form and may cause disease in immunocompromised vaccine recipients (such as those with AIDS). (wikipedia.org)
  • mice
  • To validate the use of Tie-2 as a target, human Tie-2 was used as a xenogenic vaccine in mice. (aacrjournals.org)
  • To determine if we could design a syngeneic vaccine that would work in both mice and humans a conserved region of Tie- 2 was cloned. (aacrjournals.org)
  • Vical's
  • Vical's vaccine has received orphan drug designation for hematopoietic stem cell transplant and solid organ transplant patients. (emaxhealth.com)
  • efficacy
  • Nabel and his colleagues have previously shown the efficacy of DNA flu vaccines in lab animals, including animals exposed to H5N1 viruses and the H1N1 virus that caused the 1918 pandemic, the NIH said. (umn.edu)
  • Because most HCT recipients are expected to face a natural viral challenge as pre-existing CMV infection reactivates under immunosuppression, the primary efficacy endpoint in the double-blind, placebo-controlled Phase 2 trial is the occurrence rate of clinically significant CMV levels in HCT patients receiving vaccine compared with patients receiving placebo. (emaxhealth.com)
  • Due to low efficacy, WHO does not recommend the use of RTS,S vaccine in babies between 6 and 12 weeks of age. (wikipedia.org)
  • The development of resistance could cause a significant reduction in efficacy of any potential vaccine thus rendering useless a carefully developed and effective treatment. (wikipedia.org)
  • conventional
  • Conventional flu vaccines use viruses that are grown in chicken eggs and administered in weakened or killed form, the NIH noted. (umn.edu)
  • From start to finish it's probably a couple of months," he said, as compared with about 6 to 8 months for the conventional process of growing the vaccine virus in chicken eggs. (umn.edu)
  • The work earned Rangarajan and his colleagues Patent Cooperation Treaty and Indian patents and the vaccine, reportedly cheaper to produce than conventional cell culture rabies vaccines, is being marketed by Indian Immunologicals Limited, under the brand name, Dinarab. (wikipedia.org)
  • placebo
  • Qualified normal healthy volunteers will be enrolled in the study to receive the vaccine or placebo vaccine. (clinicaltrials.gov)
  • Thirty volunteers will receive three vaccine injections over 2 months and will be followed for a year, while 15 will receive placebo injections. (umn.edu)
  • Each cohort included two additional subjects who received placebo instead of active vaccine. (rxpgnews.com)
  • The trial also is comparing safety of the vaccine against placebo in up to 80 matched, related HCT donors and recipients, and up to 80 additional HCT recipients. (emaxhealth.com)
  • Adjuvants
  • A magazine article about vaccine adjuvants in 2007 was headlined "Deciphering Immunology's Dirty Secret" to refer to the early days of vaccine manufacture, when significant variations in the effectiveness of different batches of the same vaccine were observed, correctly assumed to be due to contamination of the reaction vessels. (wikipedia.org)
  • These are the most common adjuvants in human vaccines. (wikipedia.org)
  • However, organic adjuvants are more commonly used in animal vaccines. (wikipedia.org)
  • An increasing number of vaccines with squalene and phosphate adjuvants are being tested on humans. (wikipedia.org)
  • Research
  • Here is a 300+ page research download of National Library of Medicine abstracts showing there are over 200 adverse effects of the vaccines in the CDC schedule, including death. (greenmedinfo.com)
  • It was made in the Vaccine Pilot Plant at the NIAID's Vaccine Research Center (VRC). (umn.edu)
  • This is a reassuring development and critical advance," said Nelson Michael of the Walter Reed Army Institute of Research in Silver Spring, Maryland, whose team is testing a formalin-inactivated viral particle vaccine . (the-scientist.com)
  • The UW research team also developed a way to deliver the DNA. (nebraska.tv)
  • Fuller called it a new direction of vaccine research. (nebraska.tv)
  • The data were presented at the American Society for Microbiology (ASM) 2006 Biodefense Research Meeting in Washington, D.C., by Julie E. Martin, D.O., a trial investigator and research scientist at NIAID's Dale and Betty Bumpers Vaccine Research Center (VRC), which developed the vaccine. (rxpgnews.com)
  • DNA vaccine for ragweed allergies ( A recent research reported that ragweed. (bio-medicine.org)
  • A recent research reported that ragweed or hay fever symptoms could be reduced by 60% with the help of an experimental //DNA-based vaccine developed at Johns Hopkins in Baltimore. (bio-medicine.org)
  • Conclusively, the research will prove to be a useful resource for all debut makers in DNA vaccine industry, and potential investors. (medgadget.com)
  • Research led by Dr. Roger Rosenberg shows the potential of a new DNA vaccine in the fight against Alzheimer's Disease. (utsouthwestern.edu)
  • Anna-Lise Williamson is the Director of University of the Cape Town vaccine Research group GLP. (wikipedia.org)
  • Extrachromosomal DNA is often used in research of replication because it is easy to identify and isolate. (wikipedia.org)
  • bacteria
  • The vaccine is produced by growing bacteria that have been engineered to make the viral DNA, he told CIDRAP News. (umn.edu)
  • He said a batch of the bacteria can be grown in a matter of days, and purification and quality-control steps add a few weeks to the process of making the vaccine. (umn.edu)
  • Development
  • Our processes allow rapid development and manufacturing of vaccines without handling potentially dangerous pathogens. (rxpgnews.com)
  • The technology that we're describing in this paper can be used to develop a vaccine against any virus, any parasite, any fungus, whereas this was never possible before the development of recombinant attenuated bacterial strains like those produced in our lab," Curtiss says. (labspaces.net)
  • Known for his studies in the fields of RNA virus replication and vaccine development, Vrati is an elected fellow of the National Academy of Sciences, India and the Indian Academy of Sciences. (wikipedia.org)
  • Vrati's early researches at THSTI focused on JEV life-cycle like receptor binding and entry mechanisms, molecular mechanisms of virus replication, assembly, egress as well as the clinical development of an oral rotavirus vaccine. (wikipedia.org)
  • Later, he concentrated on the development of DNA vaccines and the details of the work has since been published as an article, DNA vaccines: Getting closer to becoming a reality, in 2013. (wikipedia.org)
  • Naked DNA approaches have also been explored, especially in the context of vaccine development. (wikipedia.org)
  • Her publications mainly consists of her area of expertise addressing HIV vaccine development, HIV virus, and HPV virus. (wikipedia.org)
  • 2022
  • This comprehensive report by RNCOS entitled "Global DNA Vaccine Market Outlook 2022" provides an in-depth analysis of the global DNA Vaccines market, presenting readers a profound understanding of the various challenges, drivers, and developments in this industry. (medgadget.com)
  • manufacture
  • He is also a visiting scientist at the Pasteur Institute, Paris and an executive director of Bharat Immunologicals and Biologicals Corporation, a Government of India undertaking involved in the manufacture of vaccines and immunizers. (wikipedia.org)
  • responses
  • Vaccine approaches that result in predominantly antibody responses to CMV have not proven highly effective in transplant patients. (emaxhealth.com)
  • viral
  • Binding a transcription factor directly to a viral genome is intended to silence the genome, preventing transcription if embedded in the DNA or interfering with translation if the genome is present in a cell's cytoplasm as RNA. (iuniverse.com)
  • In addition to DNA found outside the nucleus in cells, infection of viral genomes also provides an example of extrachromosomal DNA. (wikipedia.org)
  • pathogens
  • New and increasingly sophisticated vaccines are taking aim at a broad range of disease-causing pathogens, targeting them with greater effectiveness at lower cost and with improved measures to ensure safety. (labspaces.net)