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  • antigen
  • The choice of virus and antigen is based on work showing that injection vaccination with DNA plasmids encoding the G protein of SVCV is highly successful. (europa.eu)
  • The breakthrough is in the modification of the bacteria in a way that allows them to enter fish cells and transfer a DNA plasmid to the cell itself not only in a petri dish, but also in living zebrafish larvae, leading to the expression of the vaccine antigen," Dr Forlenza points out. (europa.eu)
  • Inovio's antigen-targeting DNA immunotherapies are designed to activate robust, durable and functional immune responses against cancers or infectious diseases. (cnbc.com)
  • RTS,S attempted to avoid these by fusing the protein with a surface antigen from hepatitis B, hence creating a more potent and immunogenic vaccine. (wikipedia.org)
  • DNA vaccination is a technique for protecting against disease by injection with genetically engineered DNA so cells directly produce an antigen, producing a protective immunological response. (wikipedia.org)
  • These are subunit vaccines, consisting of specific protein antigens (such as tetanus or diphtheria toxoid) or recombinant protein components (such as the hepatitis B surface antigen). (wikipedia.org)
  • Plasmid DNA vaccines are genetically engineered to contain a gene which encodes for an antigen or a protein produced by a pathogenic virus, bacterium or other parasite. (wikipedia.org)
  • Paoletti, Enzo, Bernard R. Lipinskas, Carol Samsonoff, Susan Mercer, and Dennis Panicali (1984) "Construction of Live Vaccines Using Genetically Engineered Poxviruses: Biological Activity of Vaccinia Virus Recombinants Expressing the Hepatitis B Virus Surface Antigen and the Herpes Simplex Virus Glycoprotein D" Proc. (wikipedia.org)
  • A 'vaccine'/antigen based on the hemagglutinin (HA) stem was the first to induce 'broadly neutralizing' antibodies to both HA-group 1 and HA-group 2 influenza in mice. (wikipedia.org)
  • An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens. (wikipedia.org)
  • Adjuvants accomplish this task by mimicking specific sets of evolutionarily conserved molecules, so called PAMPs, which include liposomes, lipopolysaccharide (LPS), molecular cages for antigen, components of bacterial cell walls, and endocytosed nucleic acids such as double-stranded RNA (dsRNA), single-stranded DNA (ssDNA), and unmethylated CpG dinucleotide-containing DNA. (wikipedia.org)
  • Because immune systems have evolved to recognize these specific antigenic moieties, the presence of an adjuvant in conjunction with the vaccine can greatly increase the innate immune response to the antigen by augmenting the activities of dendritic cells (DCs), lymphocytes, and macrophages by mimicking a natural infection. (wikipedia.org)
  • In order to understand the links between the innate immune response and the adaptive immune response to help substantiate an adjuvant function in enhancing adaptive immune responses to the specific antigen of a vaccine, the following points should be considered: Innate immune response cells such as Dendritic Cells (DCs) engulf pathogens through a process called phagocytosis. (wikipedia.org)
  • Gene
  • DNA Vaccines: Design of a Gene to Eradicate HIV offers an innovative and new strategy to combat deadly viral infections. (iuniverse.com)
  • The experimental vaccine uses a modified version of the hemagglutinin gene from a recent strain of the deadly H5N1 virus, the NIH reported. (umn.edu)
  • They designed and produced a 'Gene Gun', which releases a painless puff-like injection of DNA into the skin, which goes directly into the skin cells. (nebraska.tv)
  • Vical has secured a nonexclusive license from the NIH to proprietary gene sequences used in the vaccine. (rxpgnews.com)
  • Preliminary studies suggest that immunisation of balb/c mice by gene gun with DNA from the extracellular region of Tie-2 resulted in cessation of tumor growth. (aacrjournals.org)
  • Using a gene gun HLA-A2 transgenic mice were immunized with the Tie-2 DNA construct. (aacrjournals.org)
  • This press release contains certain forward-looking statements relating to our business, including our plans to develop electroporation-based drug and gene delivery technologies and DNA vaccines, our expectations regarding our research and development programs and our capital resources. (cnbc.com)
  • They altered the DNA of cowpox virus by inserting a gene from other viruses (namely Herpes simplex virus, hepatitis B and influenza). (wikipedia.org)
  • These are plasmids that usually consist of a strong viral promoter to drive the in vivo transcription and translation of the gene (or complementary DNA) of interest. (wikipedia.org)
  • A gene gun or a biolistic particle delivery system, originally designed for plant transformation, is a device for delivering exogenous DNA (transgenes) to cells. (wikipedia.org)
  • which is a gene used to enable detection or removal of those cells which didn't integrate the construct into their DNA. (wikipedia.org)
  • For example, if the delivered DNA construct contains a gene that confers resistance to an antibiotic or herbicide, then stably transformed cells may be selected by including that antibiotic or herbicide in the tissue culture media. (wikipedia.org)
  • HMGB1 is an intracellular protein that can translocate to the nucleus where it binds DNA and regulates gene expression. (wikipedia.org)
  • The first attempt at modifying human DNA was performed in 1980 by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. (wikipedia.org)
  • The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990. (wikipedia.org)
  • The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. (wikipedia.org)
  • Paoletti and his colleague, Dennis Panicali, a virologist, altered the DNA of vaccinia virus by inserting a gene from another virus (namely herpes, hepatitis B or influenza). (wikipedia.org)
  • She based her research on discovering if small portions of gene-stopping DNA (called antisense oligonucleotides) could be created to bind up the viral RNA in retroviruses like HIV so that the virus could not make more copies of itself to continue the infection. (wikipedia.org)
  • immunity
  • We need to determine whether the DNA vaccine can work and can generate a sufficient amount of the right type of immunity to protect against influenza infections. (umn.edu)
  • When responding to an emerging pandemic virus, for which no precisely matched vaccine would be immediately available, the cellular immunity conferred by a DNA vaccine might be of some help, he said. (umn.edu)
  • Results from Inovio's MERS vaccine development efforts appear in the peer-reviewed journal Science Translational Medicine in an article entitled, "A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East Respiratory Syndrome Coronavirus in non-human primates. (cnbc.com)
  • When tested in trials an emulsion of oil in water and the added adjuvants of monophosphoryl A and QS21 (SBAS2), the vaccine gave protective immunity to 7 out of 8 volunteers when challenged with P. falciparum. (wikipedia.org)
  • Live, attenuated vaccines, such as smallpox and polio vaccines, are able to induce killer T-cell (TC or CTL) responses, helper T-cell (TH) responses and antibody immunity. (wikipedia.org)
  • Adjuvants in immunology are often used to modify or augment the effects of a vaccine by stimulating the immune system to respond to the vaccine more vigorously, and thus providing increased immunity to a particular disease. (wikipedia.org)
  • plasmids
  • The vaccine used in the Phase 1 trial vaccine included three plasmids (closed loops of DNA), one each encoding the surface glycoprotein (GP) from the Zaire strain of Ebola, GP from the Sudan/Gulu strain, and the internal nucleoprotein (NP) from the Zaire strain. (rxpgnews.com)
  • Plasmids are small, circular, double-stranded DNA molecules, which are distinct from a cell's chromosomal DNA. (europa.eu)
  • LABVaccFish showed that LAB can deliver DNA plasmids to fish cells. (europa.eu)
  • In prokaryotes, nonviral extrachromosomal DNA is primarily found in plasmids whereas in eukaryotes extrachromosomal DNA is primarily found in organelles. (wikipedia.org)
  • Extrachromosomal DNA exists in prokaryotes outside the nucleoid region as circular or linear plasmids. (wikipedia.org)
  • Circular bacterial plasmids are also the basis for the production of DNA vaccines. (wikipedia.org)
  • The linear plasmids of prokarykotes are found either containing a hairpin loop or a covalently bonded protein attached to the telomeric ends of the DNA molecule. (wikipedia.org)
  • The linear plasmids which contain a protein that has been covalently attached to the 5' end of the DNA strands are known as invertrons and can range in size from 9 kb to over 600 kb consisting of inverted terminal repeats. (wikipedia.org)
  • These types of linear plasmids represent the largest class of extrachromosomal DNA as they are not only present in certain bacterial cells, but all linear extrachromosomal DNA molecules found in eukaryotic cells also take on this invertron structure with a protein attached to the 5' end. (wikipedia.org)
  • DNA vaccines, such as VGX-3400X (aimed at multiple H5N1 strains), contain DNA fragments (plasmids). (wikipedia.org)
  • Zika
  • A preventive DNA vaccine encoding two Zika structural proteins protected Rhesus macaques from viral infection. (the-scientist.com)
  • While another DNA vaccine -generated by a team including Michael and researchers from Harvard Medical School and University of São Paulo, Brazil-is not intended for the clinic, the DNA vaccine examined in the present study and another immunization-being developed by Inovio Pharmaceuticals-could both eventually be used to protect people against Zika infection. (the-scientist.com)
  • When challenged with the Puerto Rican Zika strain eight weeks later, 17 of 18 animals immunized with either the single 4 mg dose or two 1 mg doses showed no detectable virus, while one animal contained a low level of Zika DNA. (the-scientist.com)
  • No DNA vaccine against Zika has yet been approved for human use. (the-scientist.com)
  • U.S. health officials have begun enrolling volunteers for critical next-stage testing of an experimental vaccine to protect against Zika, the mosquito-borne virus that can cause devastating birth defects in pregnant women. (medicalxpress.com)
  • In 2016 a DNA vaccine for the Zika virus began testing at the National Institutes of Health. (wikipedia.org)
  • Separately, Inovio Pharmaceuticals and GeneOne Life Science began tests of a different DNA vaccine against Zika in Miami. (wikipedia.org)
  • Ebola
  • The vaccine now being tested is similar to other DNA vaccines in development, including vaccines for HIV, Ebola, SARS (severe acute respiratory syndrome), and West Nile virus. (umn.edu)
  • By Porter Novelli, Life Sciences, Vical Incorporated (Nasdaq:VICL) announced today that an Ebola vaccine candidate administered using Vical's proprietary DNA delivery technology was safe and well tolerated, and produced both antibody and T-cell Ebola-specific responses in all healthy volunteers who received the full 3 doses of vaccine. (rxpgnews.com)
  • The DNA vaccine used in the Phase 1 trial incorporates genetic material encoding core and surface proteins from two strains of Ebola. (rxpgnews.com)
  • The high rates of immune responses at all dose levels in this initial human Ebola vaccine study support continued development of this vaccine and further evaluation of our technology for potential additional biodefense and emerging disease applications," said David C. Kaslow, M.D., Vical's Chief Scientific Officer, "particularly where antibody responses may be protective. (rxpgnews.com)
  • The company believes that the Animal Rule creates a potentially favorable regulatory pathway for certain DNA-based products such as the Ebola vaccine. (rxpgnews.com)
  • Those funds included an initial procurement of $90 million and long-term procurement of $260 million for Ebola vaccines or treatments. (rxpgnews.com)
  • The Ebola DNA vaccine under development by the NIH may be eligible for this stockpiling program. (rxpgnews.com)
  • diseases
  • This development will not only make vaccinations less harrowing, but also allow for developing and delivering vaccines for diseases too dangerous for conventional techniques . (slashdot.org)
  • Development of this vaccine technology has the potential to improve our production capacity for vaccines to prevent seasonal influenza and other diseases," NIAID Director Anthony S. Fauci, MD, commented in the news release. (umn.edu)
  • Vical researches and develops biopharmaceutical products based on its patented DNA delivery technologies for the prevention and treatment of serious or life-threatening diseases. (emaxhealth.com)
  • DNA vaccines have been shown to be extremely effective in protecting fish against various viral diseases. (europa.eu)
  • Vaccines have eliminated naturally occurring smallpox, and nearly eliminated polio, while other diseases, such as typhus, rotavirus, hepatitis A and B and others are well controlled. (wikipedia.org)
  • Conventional vaccines cover a small number of diseases, while other infections kill millions of people every year. (wikipedia.org)
  • While killed vaccines do not have this risk, they cannot generate specific killer T cell responses and may not work at all for some diseases. (wikipedia.org)
  • His work on rat brains help identify Mov34 protein which has assisted in the development of vaccines for flaviviral diseases like Japanese encephalitis and Dengue. (wikipedia.org)
  • RIGHT is a non-profit organization based in the United States and Italy that funds research to develop immunologic technologies, create new therapies, and research vaccines for many chronic diseases like HIV/AIDS. (wikipedia.org)
  • efficacy
  • Nabel and his colleagues have previously shown the efficacy of DNA flu vaccines in lab animals, including animals exposed to H5N1 viruses and the H1N1 virus that caused the 1918 pandemic, the NIH said. (umn.edu)
  • Because most HCT recipients are expected to face a natural viral challenge as pre-existing CMV infection reactivates under immunosuppression, the primary efficacy endpoint in the double-blind, placebo-controlled Phase 2 trial is the occurrence rate of clinically significant CMV levels in HCT patients receiving vaccine compared with patients receiving placebo. (emaxhealth.com)
  • Scientists will also determine the optimal administrative dose and determine the efficacy of the vaccine when delivered orally. (europa.eu)
  • Due to low efficacy, WHO does not recommend the use of RTS,S vaccine in babies between 6 and 12 weeks of age. (wikipedia.org)
  • The development of resistance could cause a significant reduction in efficacy of any potential vaccine thus rendering useless a carefully developed and effective treatment. (wikipedia.org)
  • influenza
  • Flu vaccines, according to the best scientific evidence available today, will only work against 10% of the circulating viruses that cause the symptoms of seasonal epidemic influenza. (greenmedinfo.com)
  • F16 is the only known antibody that binds (its neutralizing activity is controversial) to all 16 subtypes of the influenza A virus hemagglutinin and might be the lynchpin for a universal influenza vaccine. (wikipedia.org)
  • The subdomain of the hemagglutinin that is targeted by FI6, namely the stalk domain, was actually successfully used earlier as universal influenza virus vaccine by Peter Palese's research group at Mount Sinai School of Medicine. (wikipedia.org)
  • Organism
  • It was also confirmed that the sequences of cytoplasmic DNA was different from nuclear DNA in the same organism, showing that cytoplasmic DNAs are not simply fragments of nuclear DNA. (wikipedia.org)
  • doses of vaccine
  • Subjects received three doses of vaccine or placebo at one-month intervals via intramuscular needleless injection. (rxpgnews.com)
  • Three doses of vaccine plus a booster reduced the risk of clinical episodes by 26 percent over three years, but offered no significant protection against severe malaria. (wikipedia.org)
  • GeneOne Life Science
  • Under a previously announced collaboration agreement with GeneOne Life Science Inc. (KSE:011000), Inovio's MERS vaccine product will advance into a clinical trial in healthy volunteers in the fourth quarter of this year. (cnbc.com)
  • proteins
  • Once inside the body, the DNA instructs human cells to make proteins that act as a vaccine against the virus," the agency said. (umn.edu)
  • The DNA is injected into cells, whose "inner machinery" uses the DNA to synthesize the proteins. (wikipedia.org)
  • After binding, HMGB1 bends DNA, which facilitates the binding of other proteins. (wikipedia.org)
  • He demonstrated that treatment with immunocytokines, which are antibody-cytokine fusion proteins, is effective in this model and that this approach is synergistic with inhibition of angiogenesis as well as tumor vaccines. (wikipedia.org)
  • Small pieces of messenger RNA (or mRNA) carry a copy of the cell's DNA to the ribosomes where the mRNA directs the ribosomes to create the proteins that the cells need. (wikipedia.org)
  • therapeutic
  • The report also contains detailed and in-depth analysis of the segmentation of the DNA vaccines market based on types of DNA vaccines, therapeutic indication, end-users, and geography. (medgadget.com)
  • The product is a therapeutic vaccine to be administered to dogs with stage II or stage III oral melanoma to aid in extending survival times. (agr.ca)
  • antibodies
  • A single immunization dose of either vaccine generated neutralizing antibodies in mice, the researchers reported. (the-scientist.com)
  • Ideally a vaccine would enable the development of anti-plasmodial antibodies in addition to generating an elevated cell-mediated response. (wikipedia.org)
  • Some studies found that DNA from dying cells causes them to adhere more tightly to helper T cells which ultimately leads to an increased release of antibodies by B cells. (wikipedia.org)
  • mice
  • To validate the use of Tie-2 as a target, human Tie-2 was used as a xenogenic vaccine in mice. (aacrjournals.org)
  • To determine if we could design a syngeneic vaccine that would work in both mice and humans a conserved region of Tie- 2 was cloned. (aacrjournals.org)
  • Vical's
  • Vical's novel DNA vaccine approach is designed to induce both antibody and cellular immune responses against specific features of the CMV virus without the risk of causing CMV disease. (emaxhealth.com)
  • Vical's vaccine has received orphan drug designation for hematopoietic stem cell transplant and solid organ transplant patients. (emaxhealth.com)
  • antibody
  • He said DNA vaccines generate some level of cellular immune response, whereas traditional flu vaccines generate only a humoral immune (neutralizing antibody) response. (umn.edu)
  • Further, previously tested vaccines -including the DNA-based candidate being tested on healthy volunteers-similarly have not shown signs of antibody-dependent enhancement (ADE). (the-scientist.com)
  • Vaccine approaches that result in predominantly antibody responses to CMV have not proven highly effective in transplant patients. (emaxhealth.com)
  • Vaccine approaches using live, attenuated viruses can induce both antibody and cellular immune responses, but pose a potential safety concern, particularly for immunocompromised patients, of causing the disease they are intended to prevent. (emaxhealth.com)
  • conventional
  • Conventional flu vaccines use viruses that are grown in chicken eggs and administered in weakened or killed form, the NIH noted. (umn.edu)
  • From start to finish it's probably a couple of months," he said, as compared with about 6 to 8 months for the conventional process of growing the vaccine virus in chicken eggs. (umn.edu)
  • DNA vaccines have potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types. (wikipedia.org)
  • The work earned Rangarajan and his colleagues Patent Cooperation Treaty and Indian patents and the vaccine, reportedly cheaper to produce than conventional cell culture rabies vaccines, is being marketed by Indian Immunologicals Limited, under the brand name, Dinarab. (wikipedia.org)
  • placebo
  • Qualified normal healthy volunteers will be enrolled in the study to receive the vaccine or placebo vaccine. (clinicaltrials.gov)
  • Thirty volunteers will receive three vaccine injections over 2 months and will be followed for a year, while 15 will receive placebo injections. (umn.edu)
  • Each cohort included two additional subjects who received placebo instead of active vaccine. (rxpgnews.com)
  • The trial also is comparing safety of the vaccine against placebo in up to 80 matched, related HCT donors and recipients, and up to 80 additional HCT recipients. (emaxhealth.com)
  • genetically
  • HIV-1 is a genetically diverse collection of viruses, making it a moving target in vaccine development. (medicalxpress.com)
  • The first prostate cancer vaccine could be a step away after ministers gave their approval for a human trial of a new genetically modified therapy. (telegraph.co.uk)
  • Because the vaccine, known as Prostvac, has been genetically modified researchers had to seek approval from the Department for Environment, Food and Rural Affairs, which assesses potential environmental and human health risks, as well as medical regulators for the trial to begin. (telegraph.co.uk)
  • experimental
  • A recent research reported that ragweed or hay fever symptoms could be reduced by 60% with the help of an experimental //DNA-based vaccine developed at Johns Hopkins in Baltimore. (bio-medicine.org)
  • Other experimental vaccines and antiviral agents are being researched. (wikipedia.org)
  • Research
  • Here is a 300+ page research download of National Library of Medicine abstracts showing there are over 200 adverse effects of the vaccines in the CDC schedule, including death. (greenmedinfo.com)
  • It was made in the Vaccine Pilot Plant at the NIAID's Vaccine Research Center (VRC). (umn.edu)
  • This is a reassuring development and critical advance," said Nelson Michael of the Walter Reed Army Institute of Research in Silver Spring, Maryland, whose team is testing a formalin-inactivated viral particle vaccine . (the-scientist.com)
  • The UW research team also developed a way to deliver the DNA. (nebraska.tv)
  • Fuller called it a new direction of vaccine research. (nebraska.tv)
  • The data were presented at the American Society for Microbiology (ASM) 2006 Biodefense Research Meeting in Washington, D.C., by Julie E. Martin, D.O., a trial investigator and research scientist at NIAID's Dale and Betty Bumpers Vaccine Research Center (VRC), which developed the vaccine. (rxpgnews.com)
  • DNA vaccine for ragweed allergies ( A recent research reported that ragweed. (bio-medicine.org)
  • The project will benefit the fish vaccine and feed industry, following research to determine whether such bacteria can deliver DNA vaccines to the cells of a range of commercially important fish species. (europa.eu)
  • Researchers intend to conduct a full trial of the vaccine on about 30 patients across 10 British sites including Southampton and Surrey Universities, the Royal Marsden Hospital and a Cancer Research UK institute in Leeds. (telegraph.co.uk)
  • Dr Kat Arney of Cancer Research UK said: "Many researchers around the world are investigating the potential of vaccines for treating cancer. (telegraph.co.uk)
  • Dr Kate Holmes, Head of Research at The Prostate Cancer Charity said: "This vaccine will not prevent prostate cancer, however results to date show it may be an exciting breakthrough for the treatment of men in the final stages of the disease. (telegraph.co.uk)
  • Conclusively, the research will prove to be a useful resource for all debut makers in DNA vaccine industry, and potential investors. (medgadget.com)
  • Anna-Lise Williamson is the Director of University of the Cape Town vaccine Research group GLP. (wikipedia.org)
  • Extrachromosomal DNA is often used in research of replication because it is easy to identify and isolate. (wikipedia.org)
  • Development
  • Our processes allow rapid development and manufacturing of vaccines without handling potentially dangerous pathogens. (rxpgnews.com)
  • He added: "Right now this is the only cancer vaccine in this late stage of development with this large-scale potential for patients to benefit from it. (telegraph.co.uk)
  • Known for his studies in the fields of RNA virus replication and vaccine development, Vrati is an elected fellow of the National Academy of Sciences, India and the Indian Academy of Sciences. (wikipedia.org)
  • Vrati's early researches at THSTI focused on JEV life-cycle like receptor binding and entry mechanisms, molecular mechanisms of virus replication, assembly, egress as well as the clinical development of an oral rotavirus vaccine. (wikipedia.org)
  • Later, he concentrated on the development of DNA vaccines and the details of the work has since been published as an article, DNA vaccines: Getting closer to becoming a reality, in 2013. (wikipedia.org)
  • Naked DNA approaches have also been explored, especially in the context of vaccine development. (wikipedia.org)
  • Her publications mainly consists of her area of expertise addressing HIV vaccine development, HIV virus, and HPV virus. (wikipedia.org)
  • AIDS
  • However, attenuated forms of a pathogen can convert to a dangerous form and may cause disease in immunocompromised vaccine recipients (such as those with AIDS). (wikipedia.org)
  • This strain is known to be the most Virulent, and known to be the principle strain that leads to AIDS.The goal of the investigation is to create affordable and effective HIV-1 C vaccines, that would increase the longevity of memory T cells and develop a more functional use of the CD4+ and CD8+ cell response. (wikipedia.org)
  • In The South African Aids Vaccine Initiative (SAAVI) is where the vaccines were developed. (wikipedia.org)
  • genes
  • Scientists added four human genes to the DNA of the viruses which caused them to develop chemical signals which are found in cancerous cells but not healthy ones. (telegraph.co.uk)
  • bacteria
  • The vaccine is produced by growing bacteria that have been engineered to make the viral DNA, he told CIDRAP News. (umn.edu)
  • He said a batch of the bacteria can be grown in a matter of days, and purification and quality-control steps add a few weeks to the process of making the vaccine. (umn.edu)
  • It comprises a DNA sequence obtained from bacteria to shut down the T-helper (Th2) cells that trigger the body's inflammatory immune responses. (bio-medicine.org)
  • An EU-funded initiative has developed a fast and cost-effective approach that will allow using bacteria in feed to deliver vaccines. (europa.eu)
  • According to Dr Forlenza: "The use of food-grade lactic acid bacteria as a vaccine vehicle is an attractive strategy for delivering vaccines to the surface of mucosal membranes, which has never been investigated in fish. (europa.eu)
  • viral
  • Binding a transcription factor directly to a viral genome is intended to silence the genome, preventing transcription if embedded in the DNA or interfering with translation if the genome is present in a cell's cytoplasm as RNA. (iuniverse.com)
  • In addition to DNA found outside the nucleus in cells, infection of viral genomes also provides an example of extrachromosomal DNA. (wikipedia.org)
  • These complementary DNA pieces can bind to the HIV viral mRNA and prevent the HIV virus from replicating itself. (wikipedia.org)
  • Inovio Pharmaceuticals
  • A vaccine against cervical cancer, being developed by Inovio Pharmaceuticals Inc. of Blue Bell, Pa. (medicalxpress.com)
  • Aug. 19, 2015 (GLOBE NEWSWIRE) -- Inovio Pharmaceuticals (NASDAQ:INO) today announced its DNA vaccine targeting the virulent Middle East Respiratory Syndrome (MERS) induced 100% protection from a live virus challenge in a preclinical study. (cnbc.com)
  • Companies pursuing the vaccine as of 2009 and 2010 include BiondVax, Theraclone, Dynavax Technologies Corporation, VaxInnate, Crucell NV, Inovio Pharmaceuticals, Immune Targeting Systems (ITS) and iQur. (wikipedia.org)
  • effective
  • Now and then they get that wrong, and there is a mix match like there is a little bit this year, and the vaccine is a little less effective than what it would be if it was a complete match," Fuller said. (nebraska.tv)
  • This medical advancement is notable because there is no vaccine or effective treatment for the MERS virus, which is clearly able to transmit from human to human. (cnbc.com)
  • The vaccine was shown to be less effective for infants. (wikipedia.org)
  • There is no effective vaccine. (wikipedia.org)
  • strain
  • VRC Director Gary Nabel, MD, PhD, said the vaccine uses DNA from a 2005 strain of H5N1 from Indonesia. (umn.edu)
  • Approximately the same timeline would apply in using the technique to make a vaccine for a new H5N1 strain, according to Nabel. (umn.edu)
  • When the team introduced a new flu strain, the 'universal' vaccine induced an immune response too. (nebraska.tv)
  • She believes the vaccine would be useful should a deadly pandemic strain of the virus emerge. (nebraska.tv)
  • proven
  • Men with advanced prostate cancer currently have very few treatment options available to them and if proven successful in the third trial phase this new vaccine would offer these men an urgently needed additional life extending treatment once other available options have stopped working. (telegraph.co.uk)
  • cancer
  • No vaccines have yet been approved in Britain to treat any type of cancer, and scientists believe it could not only double the survival rate of prostate cancer sufferers but give way to a new range of similar treatments for other tumour types. (telegraph.co.uk)
  • TREOS Bio is a company that develops precision vaccines to treat and prevent cancer using computational immune-oncology. (wikipedia.org)
  • virus
  • Medical Xpress) -- A University at Buffalo microbiologist whose lab has been studying the human papilloma virus for years, says that parents should have their children vaccinated with Gardasil, the HPV vaccine. (medicalxpress.com)
  • We engineered the bacterium Lactococcus lactis, which is used extensively in the production of buttermilk and cheese, to deliver a DNA-based prototype vaccine against spring viraemia of carp virus (SVCV)," explains Dr Forlenza. (europa.eu)
  • A veterinary DNA vaccine to protect horses from West Nile virus has been approved. (wikipedia.org)
  • Later, they improved the vaccine performance by combining the DNA-based rabies vaccine with a controlled quantity of inactivated virus prepared through cell culture. (wikipedia.org)
  • The initial approach incorporated DNA into an engineered virus to deliver the DNA into a chromosome. (wikipedia.org)
  • There, Williamson and a team of over 30 people are developing vaccines for HIV-1subtype C virus. (wikipedia.org)
  • Researchers
  • SEATTLE -- Researchers at the University of Washington have developed a DNA vaccine they believe could last for years and supplement the flu shot. (nebraska.tv)
  • 2000
  • Subjects will receive 2 vaccinations with the Biojector® 2000, and will be followed for 6 months to evaluate the safety of and the immune system's response to the vaccine. (clinicaltrials.gov)