• outbreaks
  • I]t is not likely that the mainstream media 'TV doctors' will even discuss this as they falsely vilify parents who choose not to administer the MMR vaccine to their children as the cause of these outbreaks," explains Health Impact News . (wordpress.com)
  • This is believed to be a rare event, but outbreaks of vaccine-associated paralytic poliomyelitis (VAPP), caused by a circulating vaccine-derived poliovirus (cVDPV), have been reported, and tend to occur in areas of low coverage by OPV, presumably because the OPV is itself protective against the related outbreak strain. (wikipedia.org)
  • Administration of B. bronchiseptica and canine-parainfluenza vaccines may then be continued routinely, especially during outbreaks of kennel cough. (wikipedia.org)
  • The CDC and corresponding national organisations are carefully observing the failure rate which may be high compared with other modern vaccines-large outbreaks of chickenpox having occurred at schools which required their children to be vaccinated. (wikipedia.org)
  • Increasing uptake of the vaccine following outbreaks in 1971 and 1977 brought this down to thousands of cases per year in the 1980s. (wikipedia.org)
  • virulent strain
  • Comprehensive studies have revealed that the PEDV virulent strain suppressed protein synthesis of Vero cells through down-regulating mTOR as well as its downstream targets 4EBP1 and p70S6K activities, which were validated by immunoblotting. (sigmaaldrich.com)
  • In addition, the virulent strain could activate NF-κB pathway more intensively than the CV777 vaccine strain-like isolate, and elicit stronger inflammatory cascades as well. (sigmaaldrich.com)
  • Dogs which had been administered intranasal vaccine 4 weeks prior to virulent B. bronchiseptica challenge displayed little to no bacterial shedding within 3 weeks of exposure to the virulent strain. (wikipedia.org)
  • World Health Organ
  • Therefore, a new candidate vaccine virus(CVV) derived from a HPAI A/Guangdong/17SF003/2016-like virus was proposed by the World Health Organization(WHO). (flu.org.cn)
  • Two sewage samples from Cairo were analysed and found to resemble a recently discovered strain in the Pakistani city of Sukkur, a joint statement by health officials, the World Health Organization (WHO) and UNICEF said. (rawstory.com)
  • doses
  • We have all gotten two doses of the MMR vaccine (unless we have medical issues or our parents hate us). (scienceblogs.com)
  • with vaccine production hoped to increase until one billion doses are produced by one year after the virus is first identified. (wikipedia.org)
  • The companies receiving the contracts were: GlaxoSmithKline $274.8 million MedImmune Inc $169.5 million Novartis Vaccines and Diagnostics $220.5 million DynPort Vaccine Company, LLC $41 million Solvay Pharmaceuticals $298.6 million The US government purchased from Sanofi Pasteur and Chiron Corporation several million doses of vaccine meant to be used in case of an influenza pandemic due to H5N1 and is conducting clinical trials on them[when? (wikipedia.org)
  • Oral polio vaccines cause about three cases of vaccine-associated paralytic poliomyelitis per million doses given. (wikipedia.org)
  • Two doses of vaccine are more effective than one. (wikipedia.org)
  • Either one or two doses of the vaccine is recommended. (wikipedia.org)
  • abortus
  • Preliminary results demonstrate that the bivalent vaccine is capable of producing protection against a live challenge with B. abortus and some protection against live non-disease producing spores of B. anthracis. (vt.edu)
  • infections
  • To dissect out the underlying pathogenic mechanism of virulent PEDV and clarify the differences between virulent and CV777 vaccine strain-like PEDV infections, we performed an iTRAQ-based comparative quantitative proteomic study of Vero cells infected with both PEDV strains. (sigmaaldrich.com)
  • The immunomodulation and pathogenesis between PEDV and host, as well as the difference between virulent and attenuated strains of PEDV infections are still largely unknown. (sigmaaldrich.com)
  • In this study, we presented for the first application of proteomic analysis to compare whole cellular protein alterations induced by virulent and CV777 vaccine strain-like PEDV infections, which might contribute to understand the pathogenesis of PEDV and anti-viral strategy development. (sigmaaldrich.com)
  • There are differences in effectiveness, depending on region, due to factors such as genetic differences in the populations, changes in environment, exposure to other bacterial infections, and conditions in the lab where the vaccine is grown, including genetic differences between the strains being cultured and the choice of growth medium. (wikipedia.org)
  • RB51
  • Twenty clones of strain RB51/pBBSOD were show to express a 30kDa PA protein. (vt.edu)
  • Three clones of strain RB51/pBBGroE-PA were shown to express a 63-83kDa protein as detected by antiserum specific for PA. (vt.edu)
  • pandemic
  • Cristina, Juan 2011-01-01 00:00:00 The first influenza pandemic of this century was declared in April of 2009, with the emergence of a novel H1N1 influenza A virus strain (H1N1pdm). (deepdyve.com)
  • How to best spend pandemic mitigation funds and poultry farming protection funds is a question that to be answered requires billions in flu research and new flu vaccine manufacturing factories. (wikipedia.org)
  • The information being gathered is increasing the world's ability to keep H5N1 contained, limiting its speed and extent of mutation, and buying time for new flu vaccine manufacturing methods and factories to come on line so that when the next flu pandemic happens the death toll can be minimized. (wikipedia.org)
  • citation needed] See Prospects for universal flu vaccines The US government on May 4, 2006 awarded five-year contracts for "more than $1 billion to five drug manufacturers developing technology for speedier mass production of vaccines in the event of a pandemic" from the $3.8 billion pandemic preparedness bill passed in 2005. (wikipedia.org)
  • The federal government says its goal is to be able to distribute a vaccine to every American within six months of a pandemic. (wikipedia.org)
  • immune
  • Improved influenza countermeasures require basic research on how viruses enter cells, replicate, mutate, evolve into new strains and induce an immune response. (wikipedia.org)
  • vitro
  • Nancy Hilda, J., Selvaraj, A. and Das, S. D. (2012), Mycobacterium tuberculosis H37Rv is more effective compared to vaccine strains in modulating neutrophil functions: an in vitro study. (wiley.com)
  • Nine medicinal plants with good activities against other bacteria were selected to determine their in vitro antibacterial activity against Bacillus anthracis Sterne strain. (up.ac.za)
  • It has been reported that diflunisal has some antibacterial activity in vitro against Francisella tularensis live vaccine strain (LVS). (wikipedia.org)
  • induce
  • The combined MMR vaccine was introduced to induce immunity less painfully than three separate injections at the same time, and sooner and more efficiently than three injections given on different dates. (wikipedia.org)
  • selected for inclusion
  • In the United States, in a recent 10 year interval of influenza seasons, the predominant circulating influenza B lineage was different in 5 seasons from the one selected for inclusion in the vaccine," Robert Belshe, MD, director of the Center for Vaccine Development at Saint Louis University, commented in the release. (umn.edu)
  • virus
  • With a genetically modified, vaccine strain measles virus. (scienceblogs.com)
  • novel H1N1 influenza A virus strain (H1N1pdm). (deepdyve.com)
  • Sivasagar district joint director of health services Ripun Borpujari said, "This could be a new JE strain and the virus may have developed resistance to the vaccine. (medindia.net)
  • It could be that this is the new JE strain that we are encountering and it is possible that the virus has gained more virulence," said Borpujari. (medindia.net)
  • Gerlach s legislation became necessary as of last December, when the U.S. Food and Drug Administration approved a new vaccine developed to fight the four-strain flu virus. (dailylocal.com)
  • The vaccine, that came from an XJ strain of the Junin virus, was continually passaged a total of 44 times in newborn mouse brains, and a total of 19 times along with cloning in FRhL cells. (wikipedia.org)
  • People in laboratories that come in constant contact with Junin virus are also recommended to take the Junin vaccine to prevent transmission. (wikipedia.org)
  • The Influenza Genome Sequencing Project was initiated in 2004 to create a library of influenza sequences to understand what makes one strain more lethal than another, what genetic determinants most affect immunogenicity, and how the virus evolves over time. (wikipedia.org)
  • ABC News reported on April 1, 2006 that "Beginning in late 1997, the human trials have tested 30 different vaccines, all pegged to the H5N1 virus. (wikipedia.org)
  • The live virus used in the vaccine is shed in the stool and can be spread to others within a community. (wikipedia.org)
  • As with other live-virus vaccines, immunity initiated by OPV is probably lifelong. (wikipedia.org)
  • In 1960, it was determined that the rhesus monkey kidney cells used to prepare the poliovirus vaccines were infected with the SV40 virus (Simian Virus-40). (wikipedia.org)
  • Several intranasal vaccines have been developed that contain canine adenovirus in addition to B bronchiseptica and canine-parainfluenza virus antigens. (wikipedia.org)
  • It is a product of Merck & Co., Inc. The vaccine is a component of Merck's three-virus MMR vaccine. (wikipedia.org)
  • Mumpsvax is administered by a subcutaneous injection of live virus reconstituted from freeze-dried (lyophilized) vaccine. (wikipedia.org)
  • The resulting strains of virus were less well-suited for human cells, and are thus said to be attenuated. (wikipedia.org)
  • The cells used in culture, virus stocks used, and animal fluids are all screened for extraneous material as part of the vaccine production. (wikipedia.org)
  • With the advent of highly sensitive molecular techniques, such as reverse transcription polymerase chain reaction (RT-PCR) and restriction fragment length polymorphism (RFLP), it became possible to detect the vvIBDV, to differentiate IBDV strains, and to use such information in studying the molecular epidemiology of the virus. (wikipedia.org)
  • Another vaccine, known as zoster vaccine, is simply a larger-than-normal dose of the same vaccine used against chickenpox, and is used in older adults to reduce the risk of shingles (also called herpes zoster) and postherpetic neuralgia, which are caused by the same virus. (wikipedia.org)
  • Persons exposed to the virus after vaccine tend to experience milder cases of chickenpox. (wikipedia.org)
  • An analysis of 13,000 samples of influenza A/H3N2 virus that were collected across six continents from 2002 to 2007 by the WHO's Global Influenza Surveillance Network showed the newly emerging strains of H3N2 appeared in East and Southeast Asian countries about six to 9 months earlier than anywhere else. (wikipedia.org)
  • seasonal
  • Seasonal flu vaccines for many years have targeted three flu subtypes: A/H1N1, A/H3N2, and B. But in recent years type B viruses from two different lineages-Yamagata and Victoria-have circulated at varying and unpredictable levels. (umn.edu)
  • Because of production timelines, the strains to be used in seasonal flu vaccines must be chosen more than 6 months before the season starts. (umn.edu)
  • In recent years the FDA's Vaccines and Related Biological Products Advisory Committee (VRBPAC), which recommends the flu strains to include in the seasonal vaccine, has discussed including two B strains, but so far the panel has not recommended that step. (umn.edu)
  • Richards noted that, since the vaccine strains change in most years, flu vaccine manufacturers submit a supplemental license application each year for their seasonal vaccine. (umn.edu)
  • immunity
  • OPV also provided longer lasting immunity than the Salk vaccine as it provides both humoral immunity and cell-mediated immunity. (wikipedia.org)
  • viruses
  • Practicing nephrologist, or kidney specialist, Dr. Suzanne Humphries spoke about this during a recent lecture, in which she highlighted the technological advancements that have allowed for vaccine-strain viruses to be identified in children. (wordpress.com)
  • More than likely, the exact opposite is true , as those recently vaccinated with MMR have been scientifically proven to carry around the three vaccine viruses and possibly spread them to others. (wordpress.com)
  • Viruses related to MDV appear to be benign and can be used as vaccine strains to prevent Marek's disease. (wikipedia.org)
  • investigational
  • A investigational new drug (in US) vaccine (Candid1 ) was developed at the US Army Medical Research Institute for Infectious Disease (USAMRIID) at Ft. Detrick, MD in the last 1980s which has shown to be safe, well tolerated and effective in reducing mortality and morbidity due to AHF. (wikipedia.org)
  • To address the H9N2 threat, NIAID contracted with Chiron Corporation to produce investigational batches of an inactivated vaccine, which will be evaluated clinically by NIAID early next year[when? (wikipedia.org)
  • For H5N1, Aventis-Pasteur and Chiron are both producing investigational lots of inactivated H5N1 vaccine preparations[when? (wikipedia.org)
  • dose
  • The program is funded by a 75-cent levy on each dose of the flu shot and several other vaccines recommended by the Centers for Disease Control and Prevention. (dailylocal.com)
  • A "fractional" dose is when health officials split a normal dose of vaccine into smaller parts to stretch their supply. (wemu.org)
  • In the United States, the vaccine was licensed in 1971 and the second dose was introduced in 1989. (wikipedia.org)
  • The MMR vaccine is generally administered to children around the age of one year, with a second dose before starting school (i.e. age 4/5). (wikipedia.org)
  • Bacillus
  • RESULTS : The minimum inhibitory concentration (MIC) values of the extracts against Bacillus anthracis Sterne strain ranged from 0.02 to 0.31 mg/ml. (up.ac.za)
  • Two strains of bacteria, Enterobacter asburiae and Bacillus sp, isolated from the guts of Plodia interpunctella waxworms, have been shown to decompose polyethylene in laboratory testing. (wikipedia.org)
  • Bacillus Calmette-Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis. (wikipedia.org)
  • replicate
  • Like other intracellular bacteria that break out of phagosomal compartments to replicate in the cytosol, F. tularensis strains produce different hemolytic agents, which may facilitate degradation of the phagosome. (wikipedia.org)
  • sequences
  • In order to gain insight into these matters, phylogenetic analysis was performed using 29 hemagglutinin (HA) gene sequences from H1N1pdm strains isolated in South America. (deepdyve.com)
  • mild
  • People who do not develop enough protection when they get the vaccine may develop a mild case of the disease when in close contact with a person with chickenpox. (wikipedia.org)
  • meanwhile
  • Brazil meanwhile is also facing a significant shortage of vaccine. (wemu.org)
  • Meanwhile another flu vaccine stalwart, Novartis, seems to be lagging somewhat behind its peers as it has been concentrating its resources on the development of cell-based production techniques. (pmlive.com)
  • cases
  • Despite the best efforts of regulators and industry there has been some mismatch between the selected A and B strains in recent years, and a second B strain will reduce the risk of breakthrough cases. (pmlive.com)
  • known
  • The Croatian study referenced by Dr. Humphries focuses on a child vaccinated with MMR who tested positive more than a week later with a vaccine strain of measles known as Schwarz, which is contagious . (wordpress.com)
  • disease
  • FDA approval of the new vaccine occurred in the midst of a flu season in which the Centers for Disease Control and Prevention reported over 12,000 people were hospitalized with flu complications. (dailylocal.com)
  • Rumours about the vaccine being a plot to sterilise Muslims have long dogged efforts to tackle the disease in Pakistan. (rawstory.com)
  • For example, the related Herpesvirus of Turkeys (HVT), causes no apparent disease in turkeys and continues to be used as a vaccine strain for prevention of Marek's disease (see below). (wikipedia.org)
  • current
  • This is never spoken about by the sell-out talking heads on TV, but it's a scientific fact that simply can't be ignored in light of the current national conversation on vaccines. (wordpress.com)
  • Solutions to limitations in current vaccine methods are being researched. (wikipedia.org)
  • Nonetheless, there is still hope it will mutate into some low pathogenic strain over time and no longer exist in its current high pathogenic set of strains. (wikipedia.org)
  • children
  • Three children, aged 10 to 12 years, died and five others fell sick after being administered the vaccine in different areas of western Tripura. (medindia.net)
  • Adults tend to have cross-reacting responses to a varying degree, so the need to have a response to both vaccine strains is most important in children. (umn.edu)
  • As of 2012 most European countries either recommend it for all children or just those at high risk, but not all countries provide the vaccine due to its cost. (wikipedia.org)
  • This has been the case of children who get the vaccine in their early childhood and later have contact with children with chickenpox. (wikipedia.org)
  • As of 2004 the vaccine is given to about 100 million children per year globally. (wikipedia.org)