Plant saponins from Quillaia (the bark of a soap bark tree), soybean, Polygala senega Cytokines: IL-1, IL-2, IL-12 CpG oligonucleotides Combinations: Freund's complete adjuvant, Freund's incomplete adjuvant, AS01 (combining MPL and Quillaia saponins), Matrix-M (combining Quillaia saponins and two types of fat) There are many adjuvants, some of which are inorganic, that carry the potential to augment immunogenicity. (wikipedia.org)
Freund's complete adjuvant is a solution of inactivated Mycobacterium tuberculosis in mineral oil developed in 1930. (wikipedia.org)
A version without the bacteria, that is only oil in water, is known as Freund's incomplete adjuvant. (wikipedia.org)
Vaccines can contain aluminum , mercury , formaldehyde , antibiotics, human fetal cells, GMOs , animal proteins and DNA , glyphosate and other substances that are potentially dangerous when injected. (learntherisk.org)
Substances2
Some vaccines contain small amounts of these substances as a part of the manufacturing process. (harpocratesspeaks.com)
This table includes not only vaccine ingredients (e.g., adjuvants and preservatives), but also substances used during the manufacturing process, including vaccine-production media. (learntherisk.org)
Unfortunately, vaccine ingredients include many synthetic chemicals that are known to be toxic to humans, as well as foreign human fragments (from aborted babies) and animal cells and DNA . (learntherisk.org)
Disease1
Adjuvants in immunology are often used to modify or augment the effects of a vaccine by stimulating the immune system to respond to the vaccine more vigorously, and thus providing increased immunity to a particular disease. (wikipedia.org)
Vaccines are injected into muscle tissue, where they form a slow-release reservoir intended to stimulate the production of antibodies for some time. (learntherisk.org)
The ingredients are not simply flushed out like they might be if taken in as food, and some ingredients such as aluminium and mercury make their way to the brain and accumulate over time. (learntherisk.org)
Include1
Adjuvants accomplish this task by mimicking specific sets of evolutionarily conserved molecules, so called pathogen-associated molecular patterns, which include liposomes, lipopolysaccharide, molecular cages for antigens, components of bacterial cell walls, and endocytosed nucleic acids such as RNA, double-stranded RNA, single-stranded DNA, and unmethylated CpG dinucleotide-containing DNA. (wikipedia.org)
Autoimmunity1
Aluminium in adjuvant form carries a risk for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences. (brmi.online)
Alum was the first aluminium salt used for this purpose, but has been almost completely replaced by aluminium hydroxide and aluminium phosphate for commercial vaccines. (wikipedia.org)
An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens. (wikipedia.org)
Adjuvants accomplish this task by mimicking specific sets of evolutionarily conserved molecules, so called pathogen-associated molecular patterns, which include liposomes, lipopolysaccharide, molecular cages for antigens, components of bacterial cell walls, and endocytosed nucleic acids such as RNA, double-stranded RNA, single-stranded DNA, and unmethylated CpG dinucleotide-containing DNA. (wikipedia.org)
No matter what the mechanism is, alum is not a perfect adjuvant because it does not work with all antigens (e.g. malaria and tuberculosis). (wikipedia.org)
These can include: Cell culture materials, used to grow the vaccine antigens. (brmi.online)
Alum4
However, recent research indicates that alum formulated in a nanoparticle form rather than microparticles can broaden the utility of alum adjuvants and promote stronger adjuvant effects. (wikipedia.org)
Aluminum-containing adjuvants are often simply referred to as "alum. (brmi.online)
Precipitation of a solution of alum and antigen was originally used for the preparation of aluminum-adjuvanted vaccines. (brmi.online)
The second reason to avoid the term alum is that it fails to specify which type of aluminum-containing adjuvant was used for the vaccine preparation. (brmi.online)
Immune response5
In immunology, an adjuvant is a substance that increases or modulates the immune response to a vaccine. (wikipedia.org)
However, it was soon found that more scrupulous cleaning actually seemed to reduce the effectiveness of the vaccines, and some contaminants actually enhanced the immune response. (wikipedia.org)
Because immune systems have evolved to recognize these specific antigenic moieties, the presence of an adjuvant in conjunction with the vaccine can greatly increase the innate immune response to the antigen by augmenting the activities of dendritic cells, lymphocytes, and macrophages by mimicking a natural infection. (wikipedia.org)
Aluminum is used as a vaccine adjuvant-a substance that when mixed with an antigen from a virus or bacteria, elicits a greater inflammatory immune response and theoretically a higher response of protective antibodies. (brmi.online)
Adjuvants used to stimulate a stronger immune response. (brmi.online)
Widespread2
There are many known adjuvants in widespread use, including aluminium salts, oils and virosomes. (wikipedia.org)
Despite almost 90 years of widespread use of aluminium adjuvants, medical science's understanding about their mechanisms of action is still remarkably poor. (brmi.online)
Vaccination5
HPV vaccines had significantly higher risk of any injection site symptom compared to placebo or other vaccines (hepatitis A and B vaccines), and the incidence of solicited local symptoms was no difference between 2vHPV vaccination and 4vHPV vaccination. (biomedcentral.com)
Socialstyrelsen tillsatte i januari 2007 en expertgrupp, med uppdrag att utarbeta ett kunskapsunderlag till grund för Socialstyrelsens bedömning om och hur HPV vaccination ska kunna inkluderas i barnvaccinationsprogram- met. (folkhalsomyndigheten.se)
Kunskapsunderlaget är en sammanställning av de vetenskapliga data som finns tillgängliga inom experternas respektive ämnesområden, vilka krävs för ett ställningstagande till vaccination mot HPV inom ramen för det nationella vaccinationsprogrammet. (folkhalsomyndigheten.se)
The following text comprises brief summaries of different aspects of intro- ducing the HPV vaccine in a vaccination program, as described in the chap- ters below. (folkhalsomyndigheten.se)
General vaccination is a long-term strategy and has to be coordinated with maintenance of current screening procedures, which effectively protects already infected women against all HPV types, including those not included in the vaccines. (folkhalsomyndigheten.se)
Commercially1
Adjuvant 65 (based on peanut oil) was tested in influenza vaccines in the 1970s, but was never released commercially. (wikipedia.org)
Immunogenicity1
Plant saponins from Quillaia (the bark of a soap bark tree), soybean, Polygala senega Cytokines: IL-1, IL-2, IL-12 CpG oligonucleotides Combinations: Freund's complete adjuvant, Freund's incomplete adjuvant, AS01 (combining MPL and Quillaia saponins), Matrix-M (combining Quillaia saponins and two types of fat) There are many adjuvants, some of which are inorganic, that carry the potential to augment immunogenicity. (wikipedia.org)
Orally2
Thus an orally administered, attenuated vaccine virus will replicate in the intestinal tract, leading to prolonged local synthesis of IgA antibody and providing an 'antiseptic paint' even on distant mucosal surfaces. (abcdcatsvets.org)
When you orally ingest aluminium, your body will absorb between 0.2 to 1.5% of it. (brmi.online)
Humans2
By preventing infection, such a vaccine may allow eradication of the virus from the local population or even globally (as for poliomyelitis in humans). (abcdcatsvets.org)
Experimental research clearly shows that aluminium adjuvants have a potential to induce serious immunological disorders in humans. (brmi.online)
Eradication1
Human papillomavirus (HPV) vaccines have been shown to be effective for the eradication of HPV and prevention of cervical cancer. (biomedcentral.com)
Contamination1
In the early days of vaccine manufacture, significant variations in the efficacy of different batches of the same vaccine were correctly assumed to be caused by contamination of the reaction vessels. (wikipedia.org)
Types1
We evaluated the safety of three types of HPV vaccines separately in young women and the difference in the risk of adverse reactions between HPV and other vaccines by conducting a meta-analysis. (biomedcentral.com)
However, the number of women who receive HPV vaccinations has decreased over the last several years in Japan, due to concerns about adverse reactions associated with the vaccines. (biomedcentral.com)
Studies3
Prospective controlled studies with participants consisting exclusively of healthy women who received bivalent, quadrivalent, or 9-valent HPV (2vHPV, 4vHPV or 9vHPV) vaccines were included. (biomedcentral.com)
Of the 24 studies, 16 were placebo-controlled and eight were active-controlled (different HPV vaccine or hepatitis vaccine). (biomedcentral.com)
Numerous studies provide compelling evidence that injected aluminium is detrimental to health. (brmi.online)
Risk1
A significantly higher incidence of solicited local symptoms was observed following injection of HPV vaccines (2vHPV and 4vHPV) compared to placebo, but there was no difference between HPV vaccines [risk ratio (RR) for 2vHPV: 1.25, 95% confidence interval (CI): 1.09 to 1.43, RR for 4vHPV: 1.16, 95% CI: 1.11 to 1.20]. (biomedcentral.com)
Provide1
The ABCD has been created with the feline practitioner in mind: to provide him/her with a rational base for vaccine use and with advise for the management of feline infectious diseases. (abcdcatsvets.org)
Show1
In a paper by Lyons-Weiler and colleagues published in the Journal of Trace Elements in Medicine and Biology , the researchers methodically show that current levels of aluminum in vaccines are wrongly termed "safe" by the Food and Drug Administration and derive from "outdated information, unwarranted assumptions and errors. (brmi.online)
Current1
The guidelines are based on current scientific knowledge of the diseases and available vaccines concerned. (abcdcatsvets.org)
Effective1
a vaccine must be very effective to prevent latency, and indeed only few are able to achieve this. (abcdcatsvets.org)